rational polypharmacology: systematically identifying and
TRANSCRIPT
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Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets to Promote Axon Growth Hassan Al-Ali 1,, Do-Hun Lee 1, Matt C. Danzi 1, Houssam Nassif 5, Prson Gautam 6, Krister Wennerberg 6, Bill Zuercher 7, David H. Drewry 7, Jae K. Lee 1, 3, Vance P. Lemmon 1,2,3, and John L. Bixby 1,2,3,4,*
1 Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami FL 33136, USA 2 Center for Computational Sciences, University of Miami Miller School of Medicine, Miami FL 33136, USA 3 Neurological Surgery, University of Miami Miller School of Medicine, Miami FL 33136, USA 4 Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami FL 33136, USA 5 Core Machine Learning Science Team, Amazon, Seattle WA 98109, USA 6 Institute for Molecular Medicine Finland, University of Helsinki, Helsinki FI-00014, Finland 7 Department of Chemical Biology, GlaxoSmithKline, Research Triangle Park, NC 27709, USA
Supporting Information
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Supplementary Figures
Figure S1. High content analysis of neurons in culture. Neurons in 96 well plates were immunostained for III-tubulin (cell bodies and neurites), and nuclear DNA (Hoechst). Top row shows representative images of fields within wells that received the indicated treatment. Images were acquired using a Cellomics ArrayScan VTI imager and automatically traced using the Neuronal Profiling Bioapplication version 3.5. Bottom row shows the same fields with the automated traces laid over the images.
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Figure S2. MR-SVM. a) Compounds were stratified by their maximum %NTL prior to matching them with their kinase inhibition data for MR-SVM analysis (see Methods). b) Flowchart outlines the steps of one run (out of ten) in a ten-fold cross-validation cycle. Profiled compounds were divided into 10 parts, and each part was used once as a test example. For each test, the MAXIS kinases are determined from the other 9 parts and used to predict the category (hit/non-hit) of the test compounds. Accuracy, specificity, and sensitivity are calculated at the end.
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Figure S3. Inhibition bias assessed using Bk. Kinases can exhibit inhibition bias by either hits or non-hits, depending on how effectively their inhibition influences neurite outgrowth. Bk detects such bias be it in frequency of inhibition, extent of inhibition, or both. In this example, kinases 1 and 2 exhibit inhibition bias by hit compounds (possible targets), as is reflected by their positive Bk values. The opposite is true for kinases 5 and 6 (possible anti-targets). Kinases 3 and 4 exhibit no detectable inhibition bias. Details for calculating Bk are provided in Methods.
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Figure S4. Co-inhibiting targets significantly improves neurite outgrowth promotion. a) Two compounds exhibiting complementary polypharmacology towards the identified targets. (b, c, d) Combined treatment with compounds showing complementary constructive polypharmacology strongly promotes neurite outgrowth. b) Dose-response data for combinations of RO0480500-002 and ASP3026; additive effects on %NTL are evident. c) %NTL data for experiments imaged in d, using RO0480500-002, ASP3026, and their combinations at the indicated concentrations. Average %NTL SEM (2 biological replicates with 4 technical replicates each; *** p < 0.001, **p < 0.01, one way ANOVA with Tukeys multiple comparisons test). d) Hippocampal neurons treated with compounds or DMSO as indicated for 2 days, then stained for III tubulin (cell bodies and neurites, green) and nuclear DNA (blue).
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Figure S5. RO0480500-002 promotes neurite outgrowth in postnatal (P3) cortical neurons. %NTL (relative to DMSO control) for cortical neurons treated with RO0480500-002 at the indicated concentrations; DMSO control: Average %NTL SEM from 12 technical replicates; Compound treated: Average %NTL SEM from 3 technical replicates (* p < 0.05, one way ANOVA with Tukeys multiple comparisons test).
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Figure S6. Structurally diverse hits selected from various libraries. Twelve kinase inhibitors were chosen out of screen hits to represent several different molecular scaffolds. The effects of these compounds on the phosphorylation state of six intracellular signaling markers (that had previously been associated with neurite outgrowth regulation) were investigated by western blotting.
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Figure S7. Effect of lower concentrations of ROCK1 and ROCK2 siRNAs on neurite total length and length of longest neurite. While knockdown of the candidate targets ROCK1/2 using Accell siRNA at 1 uM expectedly increased length of the longest neurite, it seemed to decrease neurite total length. It is possible that strong ROCK knockdown increases elongation but decreases initiation 50. We repeated the knockdown with half the amount of siRNA (0.5 M vs. 1 M) and in this case observed an increase of both neurite total length and length of longest neurite. Off-target effects may also be contributing to this observation. Results indicate that knockdown of either ROCK1 or ROCK2 at this concentration increases both mean neurite total length and mean length of longest neurite compared to cells treated with non-targeting siRNA. Values represent averages SEM (** p < 0.01, * p < 0.05, one way ANOVA with Tukeys multiple comparisons test).
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Figure S8. Assessing axon sprouting in the spinal cord of pyramidotomized mice. a) Three vertical lines, adjacent, 500 m, 1000 m lateral (lines 1, 2, 3 in a) to the central canal were drawn, and fibers crossing each line were manually counted in each section. The results were presented after normalization with the number of counted CST fibers at the medulla level: sprouting axon number index is represented as the ratio of the total number of sprouted axons in the denervated spinal cord over the number of labeled axons at the level of medulla. b) Labeled axons in pyramidal tract of pyramidotomized mice with vehicle (DMSO) or RO0480500-002. c) Total number of axons labeled between the two groups were not significantly different; two-tailed student t-test, p > 0.05; values represent averages SEM. d) Crossing axons counted in different regions normalized against the numbers of labeled axons in pyramidotomized mice with vehicle (DMSO) or RO0480500-002; values represent averages SEM; n =9/group.
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Supplementary Tables
Table S1. Effect of kinase inhibitor treatment on neurite total length of cultured hippocampal E18 neurons. Values are expressed as relative neurite total length (%NTL, percentage relative to DMSO control) at the five screened concentrations. The standard library stock concentration was [10 mM] in 100% DMSO. Compounds were batch diluted to yield the indicated concentrations [nM] in culture. Some of the FIMM library compounds were provided at concentrations below [10 mM], thus their final concentration in culture is obtained by dividing the indicated concentrations by the compounds corresponding X diluted value.
Table S2. Five compounds selected from the PKIS-I library to represent highly active hits with distinct mechanisms from the neurite outgrowth assay. Hits from the PKIS-I library were clustered by their kinase inhibition profiles and divided into eight groups. Five highly active hits were selected on the basis of having distinct kinase inhibition profiles and dissimilar molecular structures. Activity values indicate %inhibition of kinase activity at [0.1 M] of compound.
Table S3. Kinase activity profiles of stratified hits and non-hits from the neurite outgrowth assay. Stratified hits and non-hits (Figure S1A), along with their inhibition activity (at [0.1 M]) against 190 kinases. This table comprised the input for MR-SVM analysis.
Table S4. Inhibition bias (Bk) of profiled kinases in the neurite outgrowth assay. The Bk value for each profiled kinase was calculated as described in Methods. A positive value indicates increased inhibition by hits, while a negative value indicates increased inhibition by non-hits.
Table S5. MR-SVM output and kinase selection scheme for the neurite outgrowth assay. Table lists kinase groups with MAXIS scores > 0, group average Bk values, as well member Bk values (where available).
Table S6. Activity profiles of hits and non-hits against kinases representing robust target/anti-target groups from the neurite outgrowth assay. Matrix depicts the ten target and anti-target representatives and the compounds which inhibit (at [100 nM]) at least one representative by 10%. Maximum %NTL indicates the maximum %NTL produced by each drug at any screen concentrations [160 nM]. Compounds are arranged top to bottom in order of decreasing Maximum %NTL.
Table S7. In vitro kinase assay conditions. Assay conditions for all 190 kinases assayed in the profiling panel, including ATP and enzyme concentrations, incubation times, and enzyme source.
Table S8. Complete kinase profiling data set. Kinase activity data for all profiled compounds (at [0.1 M]) against 190 kinases.
Table S9. PKIS-I hits from neurite outgrowth assay clustered by kinase activity profiles. Hits identified in the PKIS-I library were clustered by their kinase inhibition profiles and divided into 8 clusters. A single compound was selected from every cluster showing > 200 %NTL. This resulted in the selection of five compounds, highlighted in yellow.
Table S10. Kinase pharmacological linkage groups. Kinases were grouped if they had Pij15 score 60% (direct measure) or if their catalytic kinase domains had sequence similarity 70% (indirect measure). This resulted in 303 kinase groups.
Table S11. Accell siRNA SMARTpools. List of Gene IDs, codes, and SMARTpool Cat# for kinases that were tested in the knockdown experiment.
Table S12. Kinase activity profiles of stratified hits and non-hits from cell viability assay with SK-BR-3 cells. Stratified hits and non-hits from the cell viability screen, along with their inhibition activity (at [0.1 M]) against 190 kinases. This table comprised the input for the second MR-SVM analysis.
Table S13. MR-SVM output of cell viability assay with SK-BR-3 cells. Table lists kinase groups with MAXIS scores > 0, average Bk values, as well as Bk value for member kinases (where available).
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3*8
3*
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3*
3*
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3*
3*
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3*
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3*
3*
3*
3*
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3*8
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3) "2-.B'-#
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1I
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1I
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1I
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1I
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1I
1I
1I
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1I
1I
1I
1I
1I
1I
1I
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1I
1I
1I
1I
1I
1I
1I
1I
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1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
-
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
-
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
1I
-
1I
1I
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1I
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1I
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1I
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Table S2.
-
Compound Name
Str
ati
fie
d s
cre
en
ca
teg
ory
(1
=h
it,
0=
no
n-h
it)
AB
L1
AB
L2
AK
T1
AK
T2
AK
T3
ALK
AU
RK
A
AU
RK
B
AU
RK
C
AX
L
BLK
BM
X
BR
AF
BR
SK
1
BR
SK
2
BT
K
CA
MK
1D
CA
MK
2A
CA
MK
2D
CA
MK
4
CD
C4
2B
PA
CD
C4
2B
PB
CD
K1
CD
K2
CD
K3
CD
K4
CD
K5
CD
K6
CH
EK
1
CH
EK
2
CH
UK
CLK
2
CLK
3
CS
F1
R
CS
K
CS
NK
1A
1
CS
NK
1G
1
CS
NK
1G
2
CS
NK
1G
3
DA
PK
1
DC
LK2
DD
R2
DY
RK
1A
DY
RK
1B
DY
RK
2
EG
FR
EP
HA
2
EP
HA
3
EP
HA
4
EP
HB
2
EP
HB
3
EP
HB
4
ER
BB
2
ER
BB
4
FE
R
FE
S
FG
FR
1
FG
FR
2
FG
FR
3
FG
FR
4
FG
R
FLT
1
FLT
3
FLT
4
FR
K
FY
N
GR
K6
GS
K3
A
GS
K3
B
HC
K
HIP
K1
IGF
1R
IKB
KB
IKB
KE
INS
R
INS
RR
IRA
K4
ITK
JAK
1
JAK
2
JAK
3
KD
R
KIT
LCK
LRR
K2
LTK
LYN
MA
P2
K1
MA
P4
K2
MA
P4
K4
MA
PK
1
MA
PK
11
MA
PK
12
MA
PK
13
MA
PK
14
MA
PK
3
MA
PK
9
MA
PK
AP
K2
MA
PK
AP
K3
MA
PK
AP
K5
MA
RK
1
MA
RK
2
MA
RK
3
MA
RK
4
ME
LK
ME
RT
K
ME
T
MIN
K1
MK
NK
1
MK
NK
2
MS
T1
R
MS
T4
MU
SK
NE
K1
NE
K2
NE
K6
NE
K7
NE
K9
NT
RK
1
NT
RK
2
NT
RK
3
NU
AK
1
PA
K1
PA
K2
PA
K3
PA
K6
PA
K7
PA
SK
PD
GF
RA
PD
GF
RB
PD
PK
1
PH
KG
1
PH
KG
2
PI4
KB
PIK
3C
A
PIK
3C
D
PIM
1
PIM
2
PIM
3
PLK
1
PR
KA
A2
PR
KA
CA
PR
KC
A
PR
KC
B
PR
KC
G
PR
KD
1
PR
KD
2
PR
KD
3
PR
KG
1
PR
KG
2
PR
KX
PT
K2
B
PT
K6
RA
F1
RE
T
RO
CK
1
RO
CK
2
RO
S1
RP
S6
KA
1
RP
S6
KA
2
RP
S6
KA
3
RP
S6
KA
4
RP
S6
KA
5
RP
S6
KA
6
RP
S6
KB
1
SG
K1
SG
K2
SG
K3
SIK
1
SIK
2
SR
C
SR
MS
SR
PK
1
SR
PK
3
ST
K1
0
ST
K3
ST
K4
SY
K
TB
K1
TE
C
TE
K
TN
K2
TS
SK
1B
TS
SK
2
TT
K
TX
K
TY
K2
TY
RO
3
YE
S1
ZA
P7
0
ASP3026 1 22 15 0 1 3 93 7.4 0.2 0 4.7 3.1 0 0 0 0 20 9.4 0.1 30 0 0 0.2 0 0 0.1 0 1.5 2 0 11 0.6 5.7 0 54 4.6 0 0 0 1.4 0 0.2 0 0 0 0 15 1.5 0 8.8 6.7 3 6.7 0 14 0 20 0 0 4.5 0 13 0 36 2.2 23 3.2 4.8 0 0 16 0 31 0.5 1.3 23 0 0 5.2 0 3.2 0 2.5 30 25 45 52 0 0 0 0 0 0 0 0 0 0 0 1.2 0 0.9 0 2 0 3 0 4.2 3.9 0 58 81 85 2.8 4.9 5.7 2.7 1.3 0 1.6 0 3.3 0 13 0 0.2 0.4 1.5 2.3 0 22 14 3.1 19 0.4 0 3.9 22 0 1 1.1 0 2.8 2.1 0.6 11 1.4 0 0.8 7.4 0 0.8 2 62 24 2.5 1.1 0.1 0 0 0.3 3.7 2.8 0.6 0 0.4 0 0 0 0 31 44 22 1.9 0 0 26 0 0 0.9 0 4 3.6 89 32 6.1 1.2 3.3 0 0.2 62 0
Bafetinib 1 95 92 0 0 2.1 1.9 0 1.3 0 0 3.1 0 0.6 0 0 1.7 8.7 0.1 0.6 0.5 0 0 0 0 0 0 1.6 1 0 0.7 0.1 0 0 88 12 0 0 0 0.7 0 0 90 0 0 0 0 58 26 64 82 17 41 0 38 0 0.6 0 0 4.7 0 32 0 0 0.1 5.2 38 3.5 0 0 39 0 0 0.6 1.3 1.8 0 0 4.5 0.5 3.5 0 5.4 81 82 0.7 0 83 0 0 0 0 2.7 0 0 16 0 0 3.7 3.1 0.8 0 0 0 0 0 2.2 4.3 0 4.9 3.4 3.3 0 0 3.2 6 0.8 2 1.2 0 4.7 1.4 2 4.3 0 0.8 0.8 0 1.2 97 88 3.9 9.3 0 0.9 7.4 23 0 1.3 1.4 0 0.2 1.2 0.3 12 0.3 0 0.1 7.4 0 0.3 1.4 14 0 55 8.3 1 0 0 0 2.6 2.2 1.5 1.6 0.2 0 0 0.4 0 3.3 2.6 11 0.5 0 0 0 0 0 2.4 0 2.1 1.2 0 11 2.2 0 6.4 0 0 40 0
Bisindolylmaleimide I 1 0 0 0 1.1 13 2.8 0 3.8 0 0 0 0 8.1 2.8 11 0 11 0 26 0 3.2 5 3.3 2.8 0 6.7 0.1 6 7.3 1.4 0 52 2.2 5.3 2.5 1.1 0 0 0 0 0 0 21 4.4 4.1 1 0 0 0 0 0.5 0 0 0 0 0 0.9 3 0 0 0 25 62 56 1.1 0 4.5 58 62 1.8 8 0 0 2 1.3 2 0 0 0 10 13 21 28 0.6 9.5 2.2 1.3 0 0.7 1.7 0 0 0 0 0 0 0 0 0 0.4 6.3 12 9.1 9.6 5.8 5.8 3.3 0 1.5 0 10 9.4 4.6 0 0 0 0 0 0.2 4.9 5.4 20 0 0 0 0.5 0 3.8 32 32 0.9 16 0 0 1.5 22 64 13 77 0 11 13 94 93 93 0.5 0.3 0 16 59 1 3 0 0.5 2.4 0 0 3.4 64 88 75 35 39 82 35 19 16 9.5 2.5 5.1 0 0 0 1.4 37 14 24 0 0 0.5 0.3 0 1.9 0 0 0 5.6 5.7 3.1 0
EMD1214063 1 0 0 1.9 2.6 0 3.3 0 5 0 17 0 0 0 1.2 2.4 0.9 1.4 0.1 0 0 0.9 0.4 0.5 1.4 1.3 0 1.4 6.4 1.5 5.5 2.3 1.8 6.1 7.8 1.6 4 1.9 0 2.7 0.5 0 0 1.6 2.1 4.4 2.9 0 0 0 0 1.8 0 0 0 0 2.9 0.7 0 11 0 0 0 5.3 6.8 6.5 0.3 3.9 0.1 2.4 6.5 0.6 3.3 0 1 1.1 1.5 1.4 6.8 0 5.7 0 8 22 3.8 0.3 0.3 0 1.2 3 1.9 0.5 0 1.8 0.5 0 0.8 0 4.5 0 3.5 0 4.2 3 2.6 3.5 3.1 84 0 4.4 4.3 3.9 2.6 0 4.2 4.3 1.2 2.1 0 3.2 4.5 0 2.1 0 0.6 4.3 0.7 0 0.8 0.9 1.7 3.9 0 5.6 1.7 3.2 2.4 0.3 1.1 0 1 0.9 4.5 0 0 0 0 1.7 4.8 2.4 0 1.4 1.8 1.6 0 4.9 0.9 0 3.5 0 3 0 1.4 1.6 1.2 3.5 2.3 1.4 1.8 1.6 3.7 0 0 0 1.2 2.5 1.4 1.8 0 0 2.3 0 0 0 1.2 0 2.5 2.5 6.3 2.8 0
Flt-3 Inhibitor III 1 36 15 0 1.3 0 1.7 0 8.9 0 2.2 0 0.7 5.8 0 3.1 0.6 3.8 0 10 0 0 0 3.2 2.7 0.7 23 5.5 54 0 2.2 0 3.9 0 51 0.1 3.6 1 0 2.5 0 0 2.8 2.5 3.5 7.5 1.7 1.2 1.3 0 0 2.4 0 0 0 0 0.7 3.3 5 3.1 0 5.6 6.1 82 19 2.8 4.9 0 0 0 6.5 10 0 0 1.5 2.2 2.1 0 9.7 1.7 2.1 0 13 58 16 3.3 4.6 5.1 0 1.9 17 0 0 0 0.2 0 0 0 0 0 0.7 6.9 6.2 6.5 7.3 4.3 6.7 3.5 26 26 77 6.4 1.3 42 0.2 2.2 1.5 0 0.2 3.4 5.3 3.4 16 0 0 0.5 1.5 0 0 52 80 3.7 25 4.2 0 0 0.3 0 1.2 0.3 1.6 4.6 4.2 0.6 0.6 5.9 1.5 0.9 2.4 0.8 0.3 1.4 3.9 2.8 0 9.3 0 0 1.8 0.1 1.2 0 2.2 0 0.9 1.2 3.3 1.8 0.2 9 62 7.5 0 1.9 0 0.8 0 0 0 0.5 1.6 1.8 1.7 0 0.7 3.5 1 5.9 7.8 20 0
GI261520A 1 1.7 2.7 0.4 0.3 0.8 0.7 2 2.3 1.8 0 2.2 2.7 3.6 0 2.2 0 0.6 0.7 0.8 0 0.5 0.5 0.7 1.4 1.7 0.8 0.4 0 0.9 1.7 2.2 1.1 0.4 3.1 2.5 6.3 1.5 1.7 0 3.3 0 1.3 1.1 0 1.3 63 1.1 2.5 5.9 3.2 4.3 2.6 1.7 56 0 0.7 1.9 1.2 1.6 1.5 3.7 0.1 0.3 0 0.4 2.4 1.7 1.6 1.1 2.8 0.3 0.7 2.7 3.7 1 1.4 3.1 0.5 1.4 1 0.3 1.5 3.2 1.4 1.6 2.3 2.3 4 0.8 3.8 2.4 2.8 0 0.3 5.9 4.1 3.9 1.4 2.7 1 1.9 0.5 1.6 0.1 0 2.2 0 3.7 2.2 1.4 2 0 1.3 0.8 1.7 4.5 2.5 0 0.3 2.6 0 0.3 0.3 0 2.3 0 0 0 4.3 0.5 1 4.4 1.9 1.6 2.1 2 0.2 0 0.3 3 0.5 2.1 0 0.6 0 3.9 0.2 0.9 0.8 0.9 1.2 0 0.5 0 3.2 0 1.4 1.1 0.3 0.9 1.8 0 1.3 1 1.1 0.2 0 2.6 1.1 3.2 2.8 0 0 0 4.5 1.6 1.9 0 1.7 2.8 2.8 0.7 2 0.6 2.9 2.7 0 1.2 5.8 2
GSK1220512A 1 3.8 0 0.9 1.6 1.6 88 2.9 3 0.8 3.9 1.9 1.9 2.3 2.2 0.2 0 11 9.8 29 4.5 9.7 1.2 1.4 2.7 0 1.6 0.7 0 3.1 50 0.5 37 1.6 12 1.4 12 9.9 8 15 5.1 0 1 45 49 5.4 5.2 0.9 1.8 5 4.6 2.8 1.8 2.4 35 63 40 7 7.7 7.9 4.7 0.9 0 2.5 3.5 2.9 2.5 3.9 3.9 2.7 3.1 34 100 2.6 0.8 100 76 0.7 2.7 3.7 2.1 0.1 5 0 2.3 85 93 2.8 2.2 4.5 18 2.9 1.5 0.9 0.1 4.4 2.9 65 0.9 3 2 7.7 5.8 12 4.2 18 4.5 7.2 14 0.9 1.8 0.6 0.2 1.7 3.2 3.3 2.3 2.1 4.1 0 0 0 67 3.6 0.5 2.9 0 8.2 0 3.8 5.8 0 58 19 0.5 0.5 0 3.3 0 1.7 16 6.3 7.9 0.5 1.8 3.7 62 60 39 11 6 5.4 95 4.8 0.3 0 1.8 4.7 52 22 8.2 15 1.8 1.9 14 1.8 0 3.5 1 7.5 3.2 6.3 1.4 0 5 3.3 4.3 5.3 0.2 3 6.3 4.4 11 83 59 83 8.7 0 0.6 0.8 6.3
GSK1392956A 1 0 0 0 0.2 0 83 0 0 0 0 0 3.8 7 0 2.4 0 0.9 4.1 3.5 0 0 0 0 0 3.4 0 0 0 2.2 17 7 29 0 1.2 5.7 4.5 2.3 2.1 2.7 9.9 2.2 0.3 0.9 0 3 0 0 0.2 9.3 3.1 0.9 0 3.2 9.3 18 4.5 0 1.1 1.1 0 4.4 1.4 1.5 0 2.9 0 9.6 0 0 4 9.4 81 7.9 8.4 100 27 3 0 3.8 0.3 0 5.5 4.5 0 11 55 4.4 6.5 1.3 4.2 0.6 4.9 0 0 2.1 6.5 15 1.8 4.4 2.4 3.9 2 1 2 3.6 0.9 0 7.5 3.3 1 7.4 0 1.4 2.8 5.3 1.8 5.5 3 3.8 3.3 3.4 4.4 4.8 1.3 4.9 5.3 2.5 0 6.2 1.4 0 21 6.8 0 4.6 1.4 0 0 1.4 9.8 2.4 0 0 1.6 0 1.7 3.2 3.9 7.7 2.8 3 87 4.8 0 5.6 1.2 4.2 18 3.3 3.5 2.7 3.1 2.2 2.5 1.3 4.4 2.7 2.6 1.9 4.5 3.8 0 0 0 6.3 6.4 4.9 0 1.7 1.3 2.6 3.3 46 16 74 0 0 2.9 2 0
GSK1511931A 1 1.9 4.9 0 0 0.9 52 0.6 0.7 0.3 1.7 0.1 5.3 0 0 0 0 1.8 0 0 1.2 0 0.9 1.4 2 1.3 0 1.7 1 0.3 0 4.1 4.2 0 1.9 0 0 0 0 0 0 0 4.8 0.2 1.4 0 1.4 0 0.2 0.2 5.1 1.2 0.2 0 0 7.7 0.4 0 0 0.3 0.6 0 1.5 0.1 0.2 0.8 2.1 0 0.1 0.3 0.8 0 12 1.1 0 23 0 5.4 0 0 0 1.4 2 0 0.4 13 35 0.4 0 2 1.9 0 0 0 0 1.4 0 0.2 0 0 0.2 0.5 0 0.2 0.5 0 0.5 0 0.6 0.1 0 0 0 5.1 0 0 0 1.5 4.6 1.9 0.7 0.9 13 0.3 0.9 0 1.6 0 0 3 1.3 0 2.9 0 5.9 0 0 0.1 0 0 0 0.6 0 0 0 0 0 0.7 0 0 0.8 0 15 0 0 4.6 0.1 0 7.8 0.2 1.4 1.7 1 0.1 0.6 0.4 1.2 0 0.4 0 0 2 0 0 0 1.5 0 0 0 0 0.9 3.2 1.1 5.2 0.3 52 0.5 0 0 0 0
GSK180736A 1 3.5 2.2 0 0.3 0.5 0.4 7.8 4 2.1 0 0.5 0 3.6 1.5 2 0 0.5 0 1.5 0.3 2 5.6 0.2 3.8 3.1 1.8 0.4 0 0.9 1.2 0.5 0 3.3 1.1 0.8 0.5 1.5 1.4 0.3 1.6 1.4 0.4 1.8 0 0.9 0 0 2.5 4.2 2.8 3.4 0 0 4.2 0.1 0.6 0 3.5 4.3 1.2 0.2 0 0.8 18 1.9 1.7 5.2 0 0 3 0 9.1 1.7 1.7 5 0.9 2.1 0.7 14 2.6 1.1 4.2 5.1 0 2.2 0.9 2.1 2.3 2 7.5 1.6 2.9 0.9 0.8 2.7 2.2 1.8 1.5 1.5 2.2 2.8 0 0.2 0.8 2.1 1.4 3 7.4 2.3 3.9 4.7 0.7 1.5 2.1 3.1 0.8 3.5 2.9 0.9 0.9 0.1 4.1 4.3 0 2.6 2.4 0 0 4.4 3.7 0.6 5 0.6 1.4 2.5 2.4 0.1 0 0.2 2 3.6 3.8 0.7 0 0.4 3.2 3.8 3.5 4.6 1.7 13 10 1.8 2 6.6 62 64 7.2 2.4 2.4 2.3 3.3 8.5 2.1 1.6 1.1 0 4 0.8 3 0 0.2 0 0 1.3 1.3 1.1 0.2 2.8 2.1 0.7 0.8 1 1.2 3.8 1.3 1.3 1.6 2.9 2.8
GSK1819799A 1 5.4 4 0.1 1.3 0.7 68 3.5 4.8 0.7 2.7 2.9 2.2 6.1 0 1.7 0 0 4 3.3 0 0 0 1.3 2 4.5 2.6 1.7 5 2 5 4.2 5.6 3.7 2.8 5.1 6.8 3.6 2.7 1.8 3.9 0.9 1.7 5.6 5.5 2.9 0.2 0.7 3 8.5 10 3.7 2.8 3.7 12 33 19 2.2 7.3 4.7 0 4.8 1.4 0.4 2.5 4 0 6.6 5 4 4.6 5 66 6.7 5.2 83 22 2 1.4 4.2 6.7 0 4.7 2.9 1.9 6.6 66 4.9 4.9 0.9 7.4 5.2 3.2 1 5 6.3 5.8 26 2.1 4.4 1.4 3.2 1.1 5 1.9 2.9 1 9.7 4.9 3.1 1.6 0.4 0 4.2 2.1 5.2 2.6 3.6 9.9 4.7 3.8 2.6 5.3 6.2 1.3 4.4 0.2 3.7 0.7 11 7.6 2.2 8.1 6.2 2.4 2.9 0 0 0 1 6.3 0.5 1.5 1.4 0 1.8 3.9 3.7 4.6 1.6 1.8 1.2 91 4.6 1.8 4.9 0.4 2.1 14 4.1 1 2.2 0.5 2.9 2.2 1.2 0.4 0.2 3.6 2.8 5.3 0 0 0 0 5.7 5 5.2 0 4.5 4 2 1.9 21 9.9 62 2 0 2.7 1.7 2.7
GSK192082A 1 3.6 3.5 1.2 3.4 1.3 1.9 1.2 0.3 1.9 0 2.3 0 4.3 0.7 2.3 1.2 1.2 3.5 3.6 2.5 0.4 1.1 0.6 2.6 1.1 2.4 0.4 9.7 4 2.2 2.8 1.6 0.8 3 5.6 1.8 2.2 1.8 3.8 3.2 1.2 2.7 1.7 0.7 3.1 87 3.3 7 9 8.4 3.9 3.3 8.6 94 4.9 2.7 3.9 2.7 4.9 1.1 1.3 2.5 2.1 5.2 1.7 3.3 2.1 3.4 2 5.7 2.5 3.3 3.3 2.9 0.8 0.8 0 1.3 7 3.5 0 6.2 4.3 3.4 3.1 3.2 5.7 2.4 0.2 4.2 1.5 4.8 0 1.7 1.9 0.5 1.6 1.6 2.9 0.9 1.9 0 2.8 0.9 4.2 0.3 3.8 4.3 2.8 0.7 4 0 2.4 1.8 3.3 3.9 3.9 12 4.7 3 2.5 1.7 1.9 1.2 3.7 8.1 5.9 0.3 5.4 2.8 4.9 0.8 3.7 0 3.2 3 0.8 0 0 3.2 0.4 1.6 0.4 0.6 0 2.7 2.2 2.4 2.3 0 0 9 3.2 0 2 1 2.9 4.7 1.3 1.6 0 1.6 3.2 1.4 1.7 2.3 8.1 4.4 9.2 4.4 0.3 0 0 1.5 3.5 6.2 5.6 0 1.5 4.9 1.2 1.3 2.9 3.5 2.7 3.1 0 2.9 1.7 0
GSK237701A 1 7.3 5 1.4 2.5 0.8 4.2 2.7 8.7 4.6 0 5.3 2.1 4.3 30 42 1.8 1 3.2 5.1 0 1.9 0.4 0.9 2.8 2.7 2.4 0.9 0 3.5 0 6.1 3.4 2.1 8.1 4.3 3 3.3 2.6 2.2 0 0.6 9 0 0 2.5 3.1 5.4 3.6 19 17 3.8 4.3 2.2 8 4.6 3.8 4.4 12 9.5 3.7 8.5 4.8 6.1 32 2.2 2 3.8 5.3 5.1 12 3.8 2.5 4 8.5 2.1 1.5 0 2.6 8.6 1.7 0.3 36 7.1 5.7 5.9 3.8 6.6 4.7 14 4.5 5.6 3.7 3 2.4 5.7 2.9 2.7 0 0 2.1 6 2.3 3.5 4.6 4.9 5.6 4.9 5.7 3.5 3.5 15 0 29 30 12 2.7 3.6 62 1.3 8.3 16 24 6.5 0.6 4.2 0.9 7.1 1.6 73 60 2.2 3.7 6.6 2.4 7.2 14 1.2 0.3 2.4 96 2.6 2.3 0 3.1 3 1 2.7 2.9 3.6 3.5 2.9 10 0 1.3 18 1.2 4.5 11 3.9 2.9 3.4 4.3 0 3.6 1.4 5 2.7 5.7 13 11 7.8 2.7 0.4 0 99 35 40 1.8 3.1 5.6 13 6.3 4.5 2.7 9 5 0 7.6 4.2 2.5
GSK269962B 1 3.4 4.6 1.6 2.7 2 1.2 6.1 2.2 1.5 0 2.2 0.6 4.9 1.9 1.6 0 0 1.5 1.8 2.1 6.6 18 0.5 2.6 0 3.3 0 0 0 3.2 11 0 0.6 1.4 3 0.7 3.1 2.6 1.6 0 1 1.3 0.9 0.1 3.7 1.4 0 3.3 7.5 5.7 6.9 3.2 4.7 5.2 3.9 2.8 1.8 4.8 3.4 0 4.1 0.6 0.9 0 2.3 1.1 6.3 14 10 6.5 1.8 0 5.7 7.9 5.6 1.3 3.2 0.8 4.4 5.7 0.3 5.7 5.5 1 0.8 2.7 5.8 3.5 0.1 6.1 3.2 0.8 8.6 0 2 2.4 3.9 1.4 3.5 0.8 3.3 1.2 0.5 1.3 10 1.1 3.9 6.2 3.5 3.7 3.1 0 2.1 1.5 3.3 2.6 6.1 7.6 4.3 3.2 2.9 5.2 3.7 0 0 0 1 0 5.9 2.1 2.1 0 3.3 0 2.8 1.3 0.5 0 0 4.5 2.8 18 3.1 37 14 2.5 3 2.2 60 27 19 4.6 0.9 0 6.9 92 90 8.6 26 16 12 57 67 2.2 85 7.6 16 36 4.8 8.6 3.9 0 0 0 3.1 2.3 2.1 0 0.7 3.4 3.8 0 24 2.3 10 5.3 0 3.3 3.5 0
GSK270822A 1 2.9 3.1 0.5 0.7 1.2 2.8 7.3 4 3.1 0 13 0 8.2 1.9 4 0.2 0 0 0.3 1.1 3.1 5.9 0.8 3 0.4 2.4 1.1 3.5 1 1.3 0 1.3 2.4 7.2 4.4 1.6 1.7 1.2 0.9 0.6 0.8 1.3 3.4 2.6 1 1.3 0 3.8 6.9 7.7 4.2 3.2 0.9 13 2.1 1.8 1.5 5.6 9.5 0.6 3.2 2.4 0.1 1.3 2.7 2 2.9 2.6 2.7 4.8 1.5 4 1.5 3.1 4.7 0.9 3.1 2.6 4.1 2.1 0.9 5.3 2.5 21 4.7 2.8 6.7 8.1 1.5 2.5 5.5 0 0 3.1 3.6 3.9 0.7 0.7 0.7 0.7 1.9 0 0.6 0.2 3.7 0.9 8.8 4.6 3 1.2 34 0 2.1 1.7 2.9 0 0.4 3.1 3.4 1.2 5.9 7.8 0.8 0 2.1 0 0 0 8.1 2.2 2.2 2.2 2.4 0 5.3 4.4 0.2 0.5 0 3 2.5 7.2 1.3 1.8 0.7 2.8 2 3.5 13 13 34 4 3.8 1.1 20 74 77 7.1 3.9 2.3 2.4 6.2 11 1 2.4 2.1 3 1.3 4 5.8 13 1.1 0 0 2.7 3.3 3.6 2.4 0 2.8 3 2.9 1.4 1.4 5.3 2.8 0.1 3.6 17 3.1
GSK299115A 1 2.4 2.2 0 1.1 1 0.6 9.4 1.3 3.2 0 2 0 5.8 1.1 1.6 0.5 0 1.9 2.7 1.2 1.5 5.8 0 0.5 0 0.9 0 2.5 0 1.4 5.1 0.1 0.3 0 1.7 0 0.8 0.3 0 0 0 3.1 0 0.8 1.4 6.8 0 3.1 6.5 7.7 3.3 1.2 0.3 8.3 1.5 1.6 0.7 0.2 2.2 1.3 2 0.2 1.4 0 1 1.9 4.3 0.2 0 6.2 0.5 0 3.2 0.8 1.5 0.6 0 1.2 5.4 1.9 0.8 3.1 3.2 4.6 2.4 1.1 3.4 4.7 0 2.2 3.9 0.5 0 0 1.5 2.5 1.2 0.9 2.5 0.1 0.3 0 3 0 0 0.8 0 1.7 2.3 0.3 3.9 0 2.9 0.1 1.9 0 2.3 7.9 2.4 1.7 2.3 0 2.7 0.5 0.9 6.1 5 0 6.8 1.3 3.6 1 2.9 0.4 0 0.2 0 0.1 0 2.6 1.1 7.3 0.4 0 1.5 0.9 1.4 1.1 10 5.2 15 6.3 3.2 4.6 5.7 69 71 2.1 3.4 0.6 1.9 7.4 10 0.1 3.8 0.5 1 1.4 6.5 0 17 2 0 0 3.8 1.3 1.3 0 0 2.3 2.3 0.3 2.8 1.9 2.2 1.6 0.3 1.7 4.2 0.7
GSK317354A 1 4 3.7 0.8 1.4 1.4 4.2 5 3.4 3.5 0 3 0 1.9 1 0.2 0.1 0.3 0.6 0.7 0.8 0 0 0 2.2 0.1 2.3 0.6 2.2 0.2 1.5 7.6 0.5 1.3 3 1.4 0.9 3.2 0.6 0.9 0.9 0 1.5 1.9 1.2 1.4 3.4 0 3.5 5.8 8.5 3.8 1.2 1.7 8 0.9 1.4 6.7 4.4 4.9 0.8 1.4 2.1 0 1.9 0 4.2 3.1 1.5 2 4.2 0.2 3.5 2.1 2 3.8 1.9 0 1.6 1.3 1.3 0.6 5.9 4.1 3.1 2.8 1.7 2.3 0 1.6 2.9 0 0.2 0.9 2.4 6.9 1.8 1.6 1.4 1.5 0.6 1.7 0 1 0.4 2.2 1.5 3.7 4.2 2.6 0.9 7.5 0 2.3 1.8 3.4 1.9 3.1 2.7 4 1 2.9 2.7 2.3 0.9 1.4 8.3 5.1 0 6.3 1 2.6 0.4 1.7 4.3 2.9 2.9 0.3 0.4 0.1 1.9 0.8 3.6 1.3 0.1 0.5 2 2.6 3.1 7.5 5 3.9 6.2 2.1 1.1 7.8 31 36 5 0.6 1.1 0 2.1 3.5 0.6 1 1.4 2.3 4.4 4.9 2.1 0 1.7 0 0.4 0.3 2.2 2.3 3.1 0 3 2.7 1.2 1.7 0.9 4 3 0 2.5 1.3 2.6
GSK466314A 1 7.7 7.6 1.2 0.8 0.5 3.3 18 7.5 7.7 0 3.4 0 6.3 4.3 6.4 1.3 0.5 1.5 1.8 0.1 1.9 5.5 2 2.5 0.4 4.2 2.6 7.1 2.5 2 3.3 1.9 2.3 1.6 1.9 2.1 2 1.2 2.2 3.4 1.4 3.3 2.9 1.7 2.3 2.8 2.9 2.7 5.5 5.5 5.3 2 0.4 9.2 1.3 1.6 0 4.5 5.6 0 1.2 1 0 5.9 1.3 2.9 3.7 6.5 6.1 4.6 3.1 2.4 2.2 0.9 0 2.6 0 1.8 39 31 16 5.4 2.4 5.9 5.5 1.5 4.5 6.2 0.8 4.2 6.1 0 0 1.2 1.3 3.9 2.4 1.7 0.9 0.3 1.4 0.8 0 0 3.7 2.2 1.4 4.7 3.5 1.5 5.1 0 5.3 1.6 3.2 1.2 3.3 1.9 4.4 1 2.4 6.8 4.1 1.8 2.4 0 10 0.2 7.1 8.6 1.1 4.3 2.5 4.3 2.1 2.9 1.1 0 0.2 3.3 0 3.3 0.7 0 4.5 2.9 2.8 3.5 3.9 5.6 7.3 11 3.2 3.8 7.8 68 70 4.2 2.7 1.8 1.6 1.3 6 3.5 1.6 2.1 0.4 1.3 0.7 4.1 1.6 0.8 0 1.2 2 5 5 0 0 4.4 1.7 3.5 1.9 1.4 4.1 3.6 0.3 2.1 2.7 0.7
GSK466317A 1 2.6 3.6 0.5 1.3 3 2.2 3.1 3 0.7 0 4.4 0.6 9.3 0 1.6 0 0 1 1.8 0 17 24 0 0 2.1 2.4 0.5 0 8.3 6.5 4.4 1.2 1.2 5.2 4.4 1.9 2.9 2.3 1.6 9.1 3.6 1.8 1.7 0 2.6 0 0 2.2 8 1.6 5.6 0 2.7 12 4.3 2.1 0 3.4 9.2 2.4 2.8 0 1.7 0 3.6 0.1 4.5 0.2 0.1 4.7 0 2.7 3.3 4.6 5.1 0.8 2 1.1 9.6 3 2.5 4.7 4.2 4.9 2.6 2.4 5.3 9.8 2 2.9 7.4 1.4 2.6 0.3 0 6.6 3.9 4.5 9.3 1.4 3.8 1.6 3.4 1.6 5.5 1.7 0.1 4.7 2.7 2.2 13 0.1 50 3 4.1 2.7 4.4 5.8 3.8 2.5 3.4 1.2 3.8 0.7 4.1 0 0.4 0 4.9 0.6 1.8 3.8 3 3.7 2.9 1.4 0.7 0.3 0 4.2 5.4 22 0.9 0.2 3.9 2.8 3.4 4.1 28 17 45 5.7 5.9 0.8 4.2 71 72 4.6 28 13 22 32 56 7.7 8.5 4.9 4.3 8.7 4.9 4.6 1.8 0 0 0 6.3 1.9 3.1 0 2.8 3.4 4.8 0.7 3.5 2.4 5.9 2.4 0 3.7 7 3.2
GSK571989A 1 5.8 8.5 0.8 1.7 1 8.6 3.8 4.5 0 0 2.9 0.1 8.7 28 39 0 1.6 6.4 9 0.7 4 1.2 1.7 3.1 0 2.8 1.3 0.4 7.2 2.6 5 1.5 1.6 4.5 5.2 5.4 5.3 5.7 3.9 7.7 0.9 2.6 2.9 1.5 4.7 3 1.4 4 8.9 9.8 2.8 5.2 41 9.6 1.3 5 5.3 9.5 11 3.9 2.8 1.4 6.8 5.4 3.5 4.3 4.3 4.4 2.7 8.1 0 6.3 2 2.7 6.6 2.3 2.7 2.8 9 1.6 0 7.1 5.2 7.4 8.2 4.4 6 6.4 2.6 4.3 7.6 3.7 3.5 5.7 5.8 4.7 7.2 2.1 3 1.8 3.8 3.5 4.9 6.4 7.6 1.9 2.2 6.3 2.4 2 0.9 0 42 18 22 0.1 4.3 77 1.9 3 4.4 30 9.4 3 6 0 5.7 0 26 40 2.8 2.4 8.6 0 8.2 16 18 0.6 11 98 9 3.4 1.1 1.4 3.2 6.2 7.7 5.8 3.9 3.5 1.8 5.7 5.9 3.9 6.3 2.6 3.4 10 3.4 5.7 4.2 3.2 5 8.1 2.9 2.6 4.9 2.4 11 7.3 12 0 0 0.9 63 12 15 0 4.9 6.5 4.8 3.1 6.8 3.6 94 5.5 0 3 2.7 4.6
GSK635416A 1 3.1 2.2 0.7 1.2 0.7 1.9 0.8 2.9 0 0 2.2 2.1 3.7 1.4 0.9 0 0 0.9 3.1 0 1.9 0 0 1 0 1.7 0.1 0 8 6.6 7 1.8 0.7 0.5 0 2.3 2.3 2.4 3.3 11 0 1.1 2.9 0 2.2 5.9 0 2.6 5.2 2.7 0.3 2 2.2 5.8 3 2.3 3.7 9.8 4.6 2.8 0.3 2.2 3 0.7 2.4 1.2 1.6 3.5 2.7 2.7 0 0.6 5.5 2.9 4.8 0 0.7 1.4 0.2 1.8 0 1.7 3.9 2.6 1.4 2.8 2.7 2.8 1 3.3 4.2 1.4 2.8 3.4 5 2.4 1.8 4.5 7.6 0.5 2.1 2.4 1.7 0.6 4.2 0.7 3.9 4.7 0.6 0 1.9 0 2.8 1.1 4.2 3.4 3.4 5.4 2 2.2 2.5 1.2 3.7 1.5 3.4 0 2.3 0.5 3.7 3.5 1.5 2.9 3.8 0 2.3 0.8 0.1 0 0 3 6.3 0.9 0.5 0 2.3 3.9 2.4 3.2 1.6 1.4 2.6 2.7 1.9 0.5 2.9 1.6 1.7 4.6 0.9 2.7 1.3 1.2 9.1 0.1 0.6 2.3 2.9 2.6 6.2 3.2 5.5 2.1 0 0 2.5 0.8 0.8 0 0.4 2.9 2.3 0.5 2.6 1.5 4.7 2.2 0 1.6 2.2 0
GW566221A 1 4.9 3.1 0.5 0 0 2.9 2.4 1.5 1.5 0 2.9 4.6 3.1 1.9 1.3 0 0.9 2.9 3 2.1 2.2 0.7 2.5 2.9 0 1.3 0.7 0.4 1.9 5.3 4.1 3.2 0 0.2 0.4 1.6 2 1.6 1.7 2.7 0 1.8 1.5 0 3 80 2.6 7.8 8 3.9 3.8 2.9 6.1 55 0 2.8 3.2 3.3 5.1 4.2 3.9 3.2 3.3 4.5 1.1 1.5 4.1 3 2.2 4.8 0 0.6 3.4 4.2 3.1 0 1.8 0.7 0 1.1 0 4.6 0 3.8 0.9 4.9 3.6 2.3 0.9 3.4 2.5 1.1 1.9 1.6 3.5 3.4 1.8 1.3 2.6 1.4 2.1 0 1.5 1.8 3.5 5 9.6 5.1 3.5 3.4 0 0 2.2 2.2 4.2 1.5 2.4 9 1.7 2 3 2.5 2.4 0.8 3.4 0 3.6 0.5 7.3 3 6.3 2.3 3.9 0 2.2 0.4 1.5 0 1.2 4.3 3.8 1.6 0.5 0.5 0 2 2.5 2.3 1.7 1.7 1.1 3.8 0 2.1 3 0.7 1.7 4.8 2.1 3.4 2.7 2.5 1.5 2.4 0.8 2.6 0 0 1.7 0 8.9 3.4 0 0.6 8 4.3 2.8 2.3 2.6 4.1 3.2 1.2 1.8 3 5.5 4.2 2 2.4 4.1 1.2
GW567808A 1 6.5 4.2 0.7 0.7 1 3 3.8 5.7 1.9 0 2.5 3.2 6.1 4 5 0 0 1.4 3 0 1.3 0.7 1.3 2.3 0 3.7 0.2 0.4 5.1 4.2 3.3 1 1.1 3.9 2.1 5.1 3.5 3.1 3.1 6.7 0.3 0.9 2.8 0 3.5 16 0.3 3 6.4 7.1 3 0.6 4.9 7.3 0 3.5 6.3 6.1 9.1 4.2 0.2 1.2 10 8.7 2.7 2.8 6.2 2.8 1.7 9.3 0 18 4.5 4.7 11 1.5 2.1 1.7 1.7 4.3 0 5.2 4.5 3.9 1.6 6 4.7 3.3 0 2.7 5.6 1.8 3.4 5.4 12 4.2 3.8 3.1 5.9 1.3 1 0.7 0.3 1.5 3.5 1.3 2.2 5.3 2.3 0.5 0 0 2.7 3.1 7.3 0.8 3 4 2.2 4.9 3 0.1 8.4 1.4 5.6 0 4.7 0 9.7 7.3 0.1 2.4 6 1 4.4 0.9 2 0 1.2 5.1 6.2 2 1.1 1.3 2.7 4.6 5.3 5 3.5 2.3 2.6 1.9 2.7 2 3.2 2.1 2.1 6.2 1 1.2 0 1.7 4.2 0.1 1.4 2.4 4.4 3.9 1.7 6.4 9 0 0 0 9.9 4.6 3.4 0 3.2 6.6 3.4 0.5 5.8 2.3 7.2 5.9 0 0.6 0.5 3.2
GW574782A 1 5.3 4.6 1.5 1.4 0.3 4.3 2.9 1.7 0 0 3.5 2.5 5.9 0.1 3.2 1.5 0.1 2.9 1.8 0 0 0 0.3 6.2 0.5 2.4 0.2 0 8.5 7.5 5.2 0.8 0.6 0 0.5 2.3 3.9 3.8 3.2 13 7.4 1.8 2.4 0 3.2 13 2.2 8.5 6.3 7.7 2.9 3.2 0 9.7 4 3.3 1.1 3.7 4.8 2.5 2 1.3 3.6 1.6 3.4 1.6 0 3.4 3.1 4.6 0 0 9.5 6.5 0.4 2.8 0.7 0.4 3 1.9 0 4.7 6.7 3.6 2.2 3.9 4.4 3.8 0.9 3 4.6 4.3 2.6 3.7 5.6 3.6 2.5 5 9 1.1 2.7 0.2 3.9 2.9 3 0 0.5 5.4 2.1 0 0 0 1.4 1.7 4.3 0.9 2.3 7.5 2 2.6 2.7 0 4.3 1.2 5 0 1.9 0 6.2 1.6 0 7.2 5.4 0 4 0.6 0 0.5 0 3.6 0 1.4 0.6 0.2 2.7 3.9 3.3 4.3 2.9 1.8 2.4 8.3 3.1 1.8 5 10 2.7 3 0.9 2.3 1.5 1.9 8.2 0.9 1.2 3.4 1.6 2.5 4.5 4.8 6.4 0 0 0 5.1 4 2.7 0 0.2 0.4 0.1 1 3.8 0.5 9.3 0 0 5.9 2.9 0.5
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GW576609A 1 2.5 1 3 3.7 2.4 3.3 4.7 5 0.9 0 1.7 7.1 6.5 1.2 3.1 0 0.8 3.1 2.6 0.3 0 0 2 3.6 0.6 3.9 4 0.9 7.4 1.9 8.2 1 1.2 1.8 6.7 5 4 3.7 4.2 6.6 0.5 2.5 4.1 0.1 4.9 81 1.2 5.2 7.3 9.5 3.7 2.8 78 89 2.6 5 4 7.7 8.1 5.9 3.7 0.4 4.6 4.7 4 1.6 3.2 3.3 3.1 6.1 0 3.1 9.1 11 5.3 3 1.7 1.1 6.2 1.5 0 5.2 4.5 2.9 3.7 7 6.2 5.4 1.8 7.5 7.2 7.7 3 4.7 16 5.7 3.4 1.7 7 2 4.1 2.2 3.3 3.5 7.2 2.5 12 8 2.7 1.5 3.8 0.5 3.5 1.8 6 13 3 12 3.5 3.5 3 0.9 8.3 2 6.2 0 3.4 0.3 7.4 4.7 4.4 5.9 7 0.6 5.7 2.2 0.8 0.7 0.2 4.1 5.7 2.3 1.2 0 3 5.6 4.6 4.7 3.9 3.5 2.9 4.8 4.8 0 3.9 2.1 2.9 4.2 2.3 3.1 0.6 3.4 3.5 1.7 2.9 3.4 0 4.5 5.7 8.9 8.6 0.4 0 0 9.6 8.1 6.3 2.1 5.4 2.1 3.7 1.6 5.7 3.3 15 0 0 3.7 6 0.4
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GW621823A 1 6.1 7.3 0.2 1 0.6 1.7 1.5 3.1 1.2 0 1.4 0.9 3.1 1.2 1.7 0 0.2 0.9 1.6 1 0 0 2.2 0.8 0.7 1.3 2.1 2 7.6 5.4 3.8 1.5 1.5 0.8 2 1.5 1.2 0.8 0 8.2 1 1.1 4.8 4.9 1.9 78 0 2.6 6 4.7 4.4 3.9 19 76 2.1 1.4 3 0 3.6 1.6 3.7 0 0.9 0 0.5 1.1 5.1 7.6 6.9 4.4 6.5 0.6 0.5 2.2 5.4 0.9 0 0.5 0 0.7 0.2 4.9 2.9 2.1 3.7 2.1 4.6 1.5 0.8 1.7 1.7 0.8 0.9 4.4 10 1.8 2.7 3.3 7.9 0.4 0.1 0 0 0.6 3.6 4.1 2.9 3 3.8 3 3 0.6 3.5 2.4 3.3 0 3.7 6.9 2.6 0.2 2.2 0 5 0.7 1.6 0 3.3 0.2 7.2 3.1 1.3 1.1 1.9 1.7 0.8 0.1 0.8 0 0.8 1.3 2.5 0.7 0.1 0.3 1.3 1.1 1 1.3 1.7 1 1.9 3.3 4.1 1.6 4.7 0.4 1.9 2.7 1.4 1.6 0.4 1.8 7.1 1.4 1.2 0.9 0.2 2.2 5.7 4.1 3.8 1.1 0 0 2.2 0.9 2.7 0 2.5 2.9 1.6 0.3 2.6 1 2.1 2.3 0 2.1 1.9 0
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GW651576X 1 4.2 3.2 0.5 1.3 0.7 2.5 2.3 0 1.2 0 3.2 0 6.8 0 0.9 1.2 0 4.4 2.8 0 0 0 0.4 1.7 1.6 2.3 1 3.3 3.3 3.5 6.1 1.5 2.4 3.3 2.8 5.1 4.3 3.1 4.3 5.1 1.9 1.3 2.9 0.4 3.7 24 4.2 4.5 9.3 8 5 1.3 3.7 9.3 2.2 2.6 2.9 4 5 0.3 5.4 1.5 2.7 4 1.2 1.2 7 3.3 2.3 5.1 3.9 3.7 8.5 7.7 2.8 0.8 0.7 1.6 2.4 1.3 0 5.8 3.6 1.7 3.7 4.4 6.3 6 0.8 6.2 5.2 3.8 2.2 0 6.3 4.9 3 2.6 4.7 2.1 4.1 1 4.6 0.5 3.3 0.1 8.2 7.7 3.3 2.5 1.1 0 3.8 3.3 5.6 1.9 2.4 11 2.9 2.6 2.8 1.2 4.2 1.9 4.8 1.9 1.6 0.8 13 7 3.1 3.8 5.6 1 3.9 1.5 0.5 0.5 0 3.4 1.4 2 1 1 3.7 4.7 5.2 6.1 3.8 3.4 2.6 14 6 0 0 1.2 3.8 7.6 3.4 3.2 1.9 2.5 3.9 1.2 1.7 3.2 5.3 5.2 3.7 9 4.7 0 0 0 2.8 6.8 6.9 0 5.2 4.7 1.9 1.8 3.6 2.5 7.5 1.9 0 2.1 4.1 2.3
GW659386A 1 0.8 4.1 0.5 0 1 0 1 0 0 0 0 1.8 0 1.7 1.4 0 0.5 0.6 0.5 1.4 0.9 0 2.7 0.4 0 1.8 0.7 0 0 0 0 0 0 4.4 0 0 0.2 0 0 0.4 5.5 13 0 0 0 0.9 0 0.5 1.6 0 2.9 0.7 0 4 0.8 0 0 0 0.6 0 1.2 3 0 1.3 0 1.1 2.3 1.8 0.7 1.1 0 0 0.5 1.5 2.7 0 3.5 0.3 0.8 0 1.1 19 4.2 1.2 0.6 0.1 7.9 0.6 1.3 3.2 0 1 0.3 0 2.4 0 2.8 0 0 0 1.2 0.9 0.8 1.1 0 0 1 1.2 1 3 6.3 0.7 4.6 0 0.8 1.5 2.7 0 0 0 0 0.1 4 0 0 6.4 0.9 0.1 49 11 1.1 2.7 0 1.2 0 0.2 0 0 0.1 1.6 0.4 2.3 0.4 0 1.1 0.2 0.7 0.2 2.3 1.2 0.8 0.2 0 0 17 0 0 1.8 0.5 0 0.4 0 0.1 0 0 0.3 0 0 0.4 0 9.2 0.4 0 0 4 0 0 0.2 0 1.5 1.1 0 0 0 0.4 2.1 1.5 0 0.2 0.9
GW659893X 1 3.7 3.4 0.2 1.1 0.3 3.7 2.2 3.4 0.3 0 2.3 4 4.8 1.6 1.8 0 0.3 1.2 0.7 1.8 0 1 1.1 1.4 0 1.2 0.2 0 0.7 1.8 0.4 0.1 0.8 0.1 0 3.5 2.5 1.6 2.5 4.6 0 1.3 3.2 0.5 1.7 45 0.4 3.7 6.5 1.3 3.4 0.5 5.6 13 2.9 2.4 2.5 3.9 3.1 2.4 3.8 0.4 0.5 1 0.8 1.7 0.6 2 2 4.6 0 1.8 4.1 3.6 1.2 2.3 0.8 0.6 0.2 0.7 0 1.1 5.5 2.6 2.7 3.5 3.5 2.6 0.2 2.1 4.3 5.6 2.2 2.4 7.8 3.6 1.9 2.2 4.2 1.7 2.2 0 2.9 2.4 3 1.5 1.7 3.7 2 0.6 7.9 0 0 3.4 3.5 2.7 1.3 3.6 4.3 1.9 2.2 1.3 0.6 0.8 3.6 0 0.6 1.1 3 3 0 4.2 3.7 5.6 2.3 1 0.2 0.4 0 0.9 0 3.6 0.4 1.2 0 4.1 3.8 2.6 3 2.3 1.3 0 0.2 0 6.1 0.7 1.9 1.6 1.2 1.6 1 1.9 1.3 0.9 0.9 1.9 4.8 2.2 5.2 0 6 0 0 0 5.1 3.2 2.1 0 2.5 0 1.8 1.6 2.7 1.1 4.2 0 0.7 2.5 1.9 0
GW680191X 1 8.1 5.9 0 0 0 3.4 0 0 0 0 2.3 3.2 8.1 1.8 4 0 0 3.2 3 0 0 0.6 0 0 3.2 0 0 0 1.5 2.6 5.9 1 0 4.1 3.2 2.5 0.8 0.6 0 3.3 0 4.7 0.9 0 2.9 76 0 1.3 12 10 4.2 1.7 6.4 25 2.8 2.7 0.4 1.4 5.8 0 11 2.5 1.3 0 5.2 0 7.5 0 0 11 0 0 6.7 7.9 8.8 2.7 4.3 0 0.3 1 0 14 4.9 0.2 0 5.1 7.9 6.9 1.4 5.7 5.1 4.7 1.7 6.4 3.4 4.4 3.9 2.2 4.8 2.3 5.1 1.7 5.2 2.3 3.6 2 3.3 9.2 9.1 4.7 1.5 0 1.9 3.1 5.3 3.7 4.8 8.1 3 3.9 3.6 4.6 9.3 2.7 4.6 0 2.6 0 16 9.5 1.8 5.7 5.8 0 5 2.6 6.3 0 6.2 2.9 4.1 0 0 1.6 3.3 2.6 4.1 3.4 1 2.8 2.5 12 6.2 0 14 1.9 3.8 3.7 3.9 3.3 2.1 3.1 2.7 1.8 2.6 3.7 3.9 3.8 8.3 5.7 1.2 0.8 0 0 23 5.5 4.4 0 1.7 6 5.1 2 6 2.3 9.5 5.2 0 2.7 4.1 0
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GW680975X 1 4.1 2.5 0.1 1.7 1 4.1 3.2 2.5 0 0 3 0 6.7 0 1.5 0.3 0 3.3 2.9 0 0 0 0.9 2.5 2 2 0 0 1.2 4.9 5.3 2.5 1.3 0.1 5.1 3.3 4.5 4 4.1 0.7 1.1 1.1 3 0 3.4 0 1.3 3.9 12 3.6 7.2 3.7 4.8 8.5 4.5 2.6 6.2 5.4 4.3 0 5.9 1.1 2.4 0 2.8 3.5 7.9 2.1 1.4 5.6 1.6 0.3 5.8 8.7 6.5 2.5 2.7 1 4.8 1 0 7.3 5.3 1.9 2.2 4.6 6.3 5.3 0 14 6.7 5.1 2.2 0 5.1 6.4 3.7 2.5 7.7 2.2 4.1 0 2.5 1.1 0.5 2 6.7 11 4.5 2.8 4.7 0 2.1 2.8 4.4 4.1 6.1 7.4 2.2 4 4.1 0 6 1.2 4.1 0 6.2 0 5.9 3.9 0.8 5.7 5.1 0 4.4 2.1 0 0.2 0 3.3 2.6 1.9 0.5 1.9 0 4.8 6.4 6.2 1.5 1.4 2 7.4 5 0.7 5.1 0 2.9 6.8 1.7 1.6 0.8 2.2 2.4 0 1 3.9 3.9 5.1 3.5 7.7 0.3 0 0 0 6.2 6.4 4.5 0.3 0.4 3.7 2.3 2.5 6.3 4.4 11 3.6 0 3.7 5.6 2.7
GW683109X 1 2.2 2.3 0.5 1.3 1.4 2.2 2.7 2.4 0 0 1.7 0 5.4 0.8 1.7 0 0 2.9 3.7 0 0 0.6 1.5 1.1 1 2.2 0.2 0 0.3 2.7 8.1 1.8 0.4 0 5.8 2.7 3.6 3.1 1.8 0 1.5 2 6.3 6.8 2 0 0 2.9 10 6.8 7 1.2 1.8 8 0.8 2.2 1.3 1 3.6 0 2.2 1.7 0.8 0 0.2 2.5 4.9 2.5 1.4 8.4 0 3.6 5.8 9.9 4 2.2 2 1 2.8 2.3 0 5.6 5.6 1.6 1.7 2.9 5.5 4.9 0 4.7 3 2.4 0 0 1.9 2.5 3.3 1.8 4.6 1.1 1.8 0 2.6 1.1 4.4 3.2 0 5 4.1 1.6 7.5 0 2 1.9 4.2 0.5 6 15 2.7 3.2 3.5 0 6.4 1.4 3.1 0 2.7 0 5.5 0.5 1.4 4.5 4.4 1.6 6.1 7.1 0 0 0 4.2 3.2 2.7 0.9 2.7 3.5 2.8 3.6 3.9 3.1 3.4 1.1 9.9 2.3 2.8 4.8 2 4.5 5.2 1.7 1.9 1 5.9 6.6 0 2.1 1.8 0.3 5.7 3.5 3.4 2.3 0.1 0 0 4.8 3.8 2 0 0.8 2.6 2.8 0.2 3.6 2.3 9.5 1.7 0 3.2 2.7 2.1
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GW700494A 1 0 0 0 0 0 0 0 0 0 0.9 0 0 2.3 2.5 1.2 0 2.3 3.3 3.7 1.9 1.8 2.5 0 0 0.7 0 0 0 0 1.3 3.4 2.2 0 3.6 0 1.8 0 0 0 0 0 74 0 0 0.8 0 0 0 6 9.5 0 0 0 3.4 3.9 1.6 0 0 0 0 1.3 13 15 0 0 0 0.3 0 0 4.7 0 0 0.2 0 0 1.2 0 0 6.5 3.8 0 39 49 0 0.2 0 1.8 2.3 3.1 2.2 1.5 5.1 0 0.5 8.1 1.6 3.1 0 3.3 0 0.8 0 5.1 1.5 0.4 2 5.7 1.7 2.8 0.7 0 1.4 15 1.4 0.7 3.7 3.6 2.5 2.9 1.7 4.1 0.9 3.8 1.2 1.6 0 1.3 1.1 33 14 2.9 0 2.2 1.5 2.1 1.3 0.7 0 1.1 1.8 2.9 0 0 2.1 1.3 0 0 0 3.2 3.6 2.5 6.2 0 2.4 76 1.9 0.4 5.6 1.1 1 1.5 1.9 1.1 1.3 1.1 4.5 0.8 3.1 0.8 0 4.9 2.3 0 2.1 16 2.6 3.6 0.3 1.9 0.7 9.9 2.6 0.9 0 1.9 1 0 1.9 0 0
GW708336X 1 3.7 3.7 0.7 3.2 1.4 2.1 1.8 7.4 7.4 0 2.3 0.9 6.2 2.4 3.7 1.6 1.7 4.7 3.8 1.3 0.2 0.9 2.3 6.5 2.4 15 2.7 12 3.6 3.1 6.7 9.3 1.9 6.9 11 5.4 3.4 3.4 2.9 3.5 0 1.4 7.5 6.1 5.6 4 2.1 5.2 10 10 2.9 0.5 1.5 14 0.5 3.4 8.3 4.7 6.6 1.7 3.2 3.8 4.3 5.9 1.7 0.5 0.9 4.5 3 7.1 3.4 4.8 3.8 2.7 4.7 2.7 0 1.1 0.5 2.2 0 13 6.8 1.3 4.6 2.2 3.6 4.8 0 6.4 1.5 3.1 0.6 6.3 6.7 4.1 5 1.3 5.3 1.1 3.6 0.9 4.8 1 8.3 1.2 0 4.9 4.3 7.7 0 0 4.2 3.1 4.5 1 3.9 0 4.2 1.8 1.5 5.4 0 3.7 4.3 4.4 6.6 0.5 32 13 4.3 3.9 6.1 0.8 2.1 1.9 0.2 0 0 2.6 0 1.2 1.2 0 6.1 4 6.4 5.9 3 2.3 1.1 16 6.4 1.8 5.6 1.7 2.6 5.7 2.2 1.9 0.9 0.9 3.8 0.3 1.3 2.3 9.2 4.4 7 6.3 10 0.7 0 2.2 5.7 8.2 7.3 3.5 3 5.1 0.4 1.2 2.7 0.2 18 3.3 0 0 0.8 0
GW768505A 1 7.5 14 1.2 3.2 1.2 2.3 1.7 8.5 3.6 21 5.1 8.1 7 5.4 8.1 1.4 1.1 4.7 6 0.6 0.5 0.6 0.9 1.7 4.8 3.1 1 3.2 8.4 2.1 1.2 3.7 2 22 11 3.3 2.4 2.2 0.8 5.3 1.7 56 0.7 0 1.9 2.4 88 82 87 86 93 84 4.1 13 8.1 3.9 10 31 10 5.7 17 48 22 47 12 8 4.2 3.9 3.2 31 14 4.6 7 8.1 5 2 0 5 15 2 1 75 38 21 6.2 4.2 48 6.7 8.4 5.3 7.1 5.3 0 2 4.6 3.5 7.4 2.3 4.1 2.6 3 0 0.8 1.5 4.4 12 9.3 6.6 9.8 9.4 4.8 0.5 97 5.7 5.1 2.4 3.6 6 71 88 87 4.6 6.7 3.2 4.7 2.2 17 1.5 39 20 1.1 4.9 6.4 6.9 2.3 2.3 0 0.3 0.4 5.6 1.6 3.3 0.7 3.4 1.6 2.7 3.4 3 4.5 3.4 4.2 19 3.1 2 89 2.2 6.5 33 11 1.7 4.3 4.9 5.2 0.7 12 3.8 4.6 3.7 6.6 12 43 1.8 1.2 2.7 49 13 12 0 1.5 5.4 79 4.1 4.9 3.6 8.9 3.7 0 8.3 16 0.2
GW769076X 1 0 0 0 0 0 0.4 0.2 2 0 0 0 2.8 8.2 3.9 2.8 0 0.9 4.5 4.6 0 1 1.8 0 0 9.7 0.8 2.5 0 3.5 3.3 0.6 3.1 0 1.6 2.5 5.3 1 0 1 2.4 0 3.8 0.1 0 2.8 0 0 0 7 4.6 1.7 0 2.3 6.4 0.8 5.3 0 1.8 7 0 1.5 0 1.1 0 2.3 0 2.5 1.3 0.1 4.6 0 0 9.1 5.8 6.4 2.4 0 0 4.6 1.4 0 9.6 5.5 0 1.6 2.3 3.6 6 3.8 10 4.3 41 4.5 3.5 38 3 2.7 0.7 20 1 5.5 0.1 6.2 4.2 4.9 1.6 9.4 12 1.8 0 8.6 4.4 4.4 2.7 5.4 1.4 6.4 5.8 1.9 3.5 3.2 5.1 5.5 1.7 4.5 0 0 0 9.9 6.3 2.2 6.4 5.9 0 4 3.4 0.9 0 0 3.7 6.9 0 0 0.1 1.1 3.1 3 3.2 2.1 3.9 1.5 12 4.2 4 7 10 5.2 6.8 3.2 3.9 2.4 3.4 2.8 2.5 1.5 5.7 2.7 1.3 1.1 0.3 4.4 0 0 0 3.5 9.4 8.8 0 7 0.5 1 1.1 3.8 1.1 15 0 0 2.2 2.2 0
GW775608X 1 1.5 5.4 1.6 0.2 1.6 0.7 0.6 0.7 0.6 0 1.6 1.5 3.8 0 0 0.6 1.5 1.3 1.1 1.1 0 0 0.1 0.8 0 1.8 0 5.8 0 0 1.9 0.3 0 0.6 1 0.8 0.1 0.5 0 0 4.2 9.1 0 2.1 0.7 0.1 1.9 4.3 6.5 4.3 3.1 0.7 0 0 1.6 0.4 5.3 0.5 0.4 4.1 0.7 0.4 1 3.1 0.1 0.2 4.9 1 2 3.5 0.7 2.6 0 2.1 1.7 4.1 0 0.8 3.7 2.9 0.1 2.4 0 1.8 0 1.3 0.9 0 2.3 1.6 0 69 0.5 1.7 65 2.3 3.4 0 22 0 0.6 0 0 0 0 0 4.9 0.5 0.1 0.8 5.7 1.2 2.6 0.5 0 4.1 0 5.8 1.4 0 0.2 0.7 0 0 0 5.7 4.5 1.3 3.7 3.4 1.8 0 1.4 7.5 0 2.1 1.1 0 0.3 0.9 0 0.2 0.5 1 0 1.2 0.5 0.7 0.8 0.7 1 0 1.3 0 2 0 0.8 0 0.4 0.6 0.3 0.2 0 0.5 2.2 0.3 2.4 0 5.2 0.8 0 0.9 0 1 3.1 0.2 0.9 4 1.3 2 1.6 0 1.2 0.5 0 1.8 0 1 0.5 0.5
GW781673X 1 1.1 3.2 0.6 0.2 2.1 0 0.3 0 2.6 1.2 1.3 0 0.1 0.4 1.7 0.7 1.7 2.5 2.1 1.9 0 0 7 4.1 3 3.9 7.1 14 2.8 4.3 1.9 7.3 1.3 1.5 3.9 2.8 0.1 1.4 0 9.3 0 1.9 16 29 0.8 0.8 1.9 2.2 5 7.9 2.1 0.8 0 3.3 3.9 0 0.6 0.2 0 4.7 3.6 0 1.2 0 0 0 5.4 2.4 2.8 6 15 2.5 1 0.3 0 2.2 0 0 0 1.5 0 1 5 2.3 1.2 0.6 3.2 0.1 2.8 3.9 4.2 1.1 0.7 0 2.6 3 3.5 3.9 7.4 0.4 1.6 0 1 0 0 0 2 1.4 1.1 1.9 0 0 3.2 0.3 0.9 3.9 0 0 1.4 0.5 0.4 3.3 0 0.8 0 0 8.4 0.9 4.9 3.9 2.1 0 2.6 2.2 0 0 1.6 0 1.8 2.4 0 0.4 0.9 0.3 0.4 1.2 1.1 0.8 2.1 0 0.6 0 0.7 1.4 0.9 0.2 2 0.9 1.4 0.6 0.1 1.1 7 2.6 1.8 0.3 3.3 0.6 0.9 4.1 0.8 0.4 0.9 0 2.7 2.5 3.2 2.9 0.1 3.1 0.6 0.4 0.5 0.2 0.1 2.1 0 1.5 0 0
GW784684X 1 4 4.5 0.8 3.3 1.8 4.3 3 13 3.4 0 3.6 6.4 8.5 0 1.1 0 0.9 4.6 4 0 0 0 0 0.8 4 3.6 1.2 3.1 3.6 5.6 11 2.4 1.2 7.7 5.6 3.1 5 3.7 2.7 6.6 1.3 0.4 3.7 1.7 3.2 84 1.5 5.8 10 6.6 7.7 3.7 8 91 6.3 4.1 7.5 3.5 6.5 0 11 1.6 0.5 5 3.1 2 8.4 13 11 4.4 2.8 3.7 6 4.9 7.2 2.4 1.5 2.3 6.9 0.7 0 7.8 6.8 7.2 2.8 4.2 7.6 7.8 2 6.9 6.2 7.8 3.6 1.1 3.5 7 7.1 2.1 4.3 1.5 3.4 0.3 1.6 1.9 3.2 10 6 8.2 7.2 3.5 3.6 0 4.7 4 4.6 5.8 6.1 6.2 0 3.6 4.3 0.8 11 1.4 6.6 0 0 0 7.3 3.4 0.1 0 7.2 0 4.7 2.8 0.2 0.7 0 1.2 4.1 3.3 0.9 0 2.6 5.6 5.1 5.4 4.5 2.4 3.4 11 7.9 16 5.7 1.8 3.9 6.5 2.4 1.8 2.2 2.9 3.6 1.2 0.6 4.6 4.5 4.4 8.1 4.9 0 0 0 0 22 6.7 5.5 0 5 4.8 4 2.1 6.2 4.6 12 3.1 0 4.8 16 6.4
GW807930X 1 0 0 0 0 0.7 0 1.6 2 1 0 0 2.3 1.1 1.9 1.3 0 0.7 25 0.4 1 0.2 0.1 0.3 1 1.8 1.5 1.7 0 0 0 0 1 0.3 1.1 0 0 0.6 0 0 0 1.4 1.3 1.8 0.7 1.2 61 0 0 0 0.6 2.8 0.6 0 12 2.7 0.3 0 0 0.9 0.4 0 0 0.3 2.3 1.6 1.1 1.8 3.2 2.8 2.8 0 0.8 0 0.4 2.9 0 2.9 0.4 0.7 0 0 0.7 0 0.3 0.4 1.6 0 1.5 0.7 2.6 0.7 1.3 0.1 0 1.1 0 0.9 0 0 0 1.9 0.4 1.7 2.3 0.8 0.6 4.9 2.5 3.8 2.6 5.4 0 0 0.6 1 0 4.1 0.4 1.3 0.6 0.2 3.5 4.2 0 0 4 2.6 0 0.6 0.9 0 3.3 0 0 0 0 1.1 0.4 0 1.8 2.2 0.5 0.2 0 0 3.3 0.5 1.1 1.1 1.3 1.1 4 0.1 4.5 4 0 3.8 3.9 0 1.5 0.8 0.5 0 0.2 0.3 0.9 4.4 0 1.3 0 0.5 0.3 0 0 0.7 0.7 1.6 0 0 0.6 1 0 1.8 0.5 8.8 2.3 0.8 1.2 0.6 0
GW876790X 1 3.3 2.4 2 3.3 4.3 2 3.1 2.8 0.6 0 3.1 3.8 7.9 0.7 2.5 0 0 2.4 3.5 0 15 23 0.5 0.6 0 1.7 0 0 3 4.6 8.8 1.2 0 0 3.4 4.4 4.4 3.8 3.7 3.2 1.5 1.5 21 9.7 8 0.3 0.8 1.2 7.3 12 3 0 5 11 4.1 4.5 2.1 3.8 2 0.7 1.3 2 0.3 1 3.2 2.4 0 10 6.8 5 0.3 1.1 6.6 7.7 5.9 3.3 2.5 0 0.5 2.5 0 4.5 6.2 2.2 6.1 5.2 5.6 4.8 0.7 4.5 6.9 4.1 3.9 5.8 7.8 6.2 4.6 2.3 3.5 1.4 1.8 0 1.8 2.2 15 3.1 1.8 7.4 2.9 0.8 1.5 0 5.7 2.7 6.7 0 3.5 7.8 2 3 4 0 6.2 2 5.1 0.4 4 0.1 5.6 16 1.6 4.6 5 1.3 4.3 0.3 46 1.8 26 6.2 2.6 42 16 61 6.2 5.3 5.4 5.7 36 62 18 4.6 2.4 2.6 6.5 72 81 3.3 62 25 54 35 55 9.7 32 3.8 2.3 21 3.2 2.5 8.8 0 0 0 12 6 3.8 0 4.1 2.6 5.5 2.7 7.1 2.4 9.4 0 0 3.7 2.4 0.6
IKK Inhibitor VII 1 44 21 0 3.4 0.7 5.2 33 36 11 43 0 4.5 3.9 8.9 18 3.8 11 0 4.6 0 0 0 3.7 15 1.9 26 16 37 4 0 34 42 17 48 6 0 0.2 0 1 36 0 10 6.7 4.2 90 0 5.7 0.5 4.5 14 3.4 15 0 0.2 0 14 1.7 21 4.3 0 6.6 48 54 81 1.2 0.9 0 21 20 8.8 42 5.9 61 19 8.7 0 0 24 12 41 67 45 49 32 62 2.1 0 0 6 18 0.9 2.1 0 0 0 1 0 0 0 2.4 17 31 26 40 3.8 4.4 6.6 7.4 48 52 33 2.2 22 33 0 1.9 0.4 3.1 3.6 4.1 5.5 69 3.3 0.9 1.4 1.1 0.6 0.9 65 80 5.7 12 0.7 0.3 0 4.1 5.6 0.3 2.8 0 20 4.2 19 5.2 17 13 18 22 0.4 29 2.3 12 27 2.9 17 26 34 18 1.7 1.9 1.1 1.5 0.3 0.7 8.7 51 12 0.7 2.1 35 20 1.5 0 0 26 2.6 0.6 0 19 6.6 19 39 5.4 1.3 5.8 3.9 60 44 30 30
KN-93 1 0.4 0 0 2.2 3.3 3.9 1.1 3.5 0 0.7 0 0 4 0 0 0.3 2 0.1 1.3 0.4 1.1 2.4 0.5 2.5 0 0 1 4 0 0.8 1 0 0 0.9 0.5 0 0 2.5 0 0 0 0 0 0 0 0 0.5 0.4 0 0 0.4 0 0.2 4.3 0 0 0 1.4 0 0 0.3 0.4 0.6 0 1.2 0 3.4 0 0 0.2 0 1.6 0.2 1.8 2.8 0 0 0 0 3.9 3.1 2.6 30 3.5 2.3 3.8 1.1 0 0.1 0 0.8 0 0 0 0 0 0 0 0 0 0 1.7 0 0 0.6 1 2.1 0 0 0 2 4.4 0.1 2.1 1.6 0.6 0 0.5 0 1.9 7.6 3.3 1.4 0 1.2 0.5 0 1 0.8 0 2.2 4.8 0 0 0 17 0 1.9 1.2 0 2.5 3.5 3.1 4.1 5.2 0 1.6 4.4 2.6 3.2 2.6 2.6 0 0.3 2.5 2.6 2.4 0 3 3.7 2.9 3.5 0.4 1.9 1 1.5 1.7 1.7 0 2 4.7 2.6 0 0 0 0 0 6.3 0 2.3 1.1 0 4.5 0.7 0 0 0 0 0.1 0
MEK1/2 Inhibitor 1 4 1.2 0 0.2 1.3 3 0.5 3.6 0 1.5 0 0 2.7 0 0.3 1.1 0 0 0 0 0 0 0 2.2 0 0 0.7 5.9 0 0 0 0.4 0 3.9 2.3 0 0 0 1.1 0.1 0 0 0.8 0.3 0 0 1.5 0.4 1.1 0 1 0 1.1 1.9 0 0 0 0 0 0 0 0 2.1 2.1 1.9 0 2.2 0 0 2.9 0 0.4 0 0.8 3.4 0 0 0 0 4.6 0 3.6 29 2.9 2.4 2.5 0 0 1.1 0 0 0 0 0 0 0 0 0 0 0.4 0 3.3 0 3.2 0 2.1 3.1 0 4.8 0.3 3.1 3.9 1.2 1.4 0 0.9 1.8 0 0.7 2.2 2.6 2.9 0.9 0 1.6 0.1 0 0 1 0 1.8 2.8 0 0.4 0 0 0 0.7 0 0 0 1.8 0 1.8 0.2 0 0.1 4.2 0.1 2.6 1.4 3 1 0 3 0.1 0 0 0 1.5 0.3 1.5 0 0.4 0 0.6 0.1 0.3 0 0.6 2.4 1.5 0 0 0 0 0 0.6 0 2.4 1.6 0 2.5 1.6 0 0 0 0.4 0.4 0
ML-7, Hydrochloride 1 0 0 0.2 2.2 0 0 0 5.2 2.4 0 0 0 0 2 4.2 0 0.7 0 0 0 1.7 0.8 1 2.7 0 0 4 6 0 5.3 3.7 0 5.4 6.1 1.9 3.6 2.4 0 2 0.5 0 0 3.6 2.6 4.7 4 0 0.5 0 0 1.8 0 0 0 0 2 0.1 0 6.9 0 0 0 6.2 7.5 4.8 0 4.2 0 0 3 1.7 2.8 0 0 3.7 1.5 0 2.3 0 7.7 0 6.8 27 2.5 1.5 3.1 0 0 3.9 0.4 1.1 0 1.5 2 0 0 0 6.5 0 3.6 0 5.6 6 0.8 3 4.6 2.7 0 6.2 4.2 4.4 9.1 2.3 1.9 0 1.3 0 0 4.2 3.5 0 4.4 1.1 0.3 3.9 2 0 2.8 7.1 3 4.2 0 6.3 1.7 0 46 5.1 2.8 6 2.7 1.8 5.7 1.6 0 0 0 1.8 3.8 5.5 2.6 3 0 0.3 0 4.2 1.6 0.8 3.2 0 3.6 0.4 4 1.8 0 3.4 2.3 2.9 2 0 3.1 0 0 0 0 0 1.4 1.7 0 0 0.3 0 0 0 3.5 0.1 0.9 2.4 5.3 2.4 0
ML-9 1 0 0 0 0.4 1.1 0 0 0 0 0 0 0 0 0 0 0 5.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.3 2.6 1.6 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3.2 0 0 0 17 0 0 1.8 0 0 0 0 0 3.7 0 1 0 0 0 0 0 0.9 1.3 0.8 0 0 5.6 1.4 3.9 0 2.8 22 0 0.5 0 0 0 0 0 0 0 0 0 0 0 0 3.8 0 0 0 0 0 0 0 0.3 6.6 0 0 0 3 0 0.5 2.5 2.4 0 0 0 0 7.2 0.5 3.8 9.2 0 0 0 0 1.1 0 0 2.2 12 0 0 28 34 0 2.1 1.1 0.3 0 0.9 0.4 7.8 0.6 0 0 5.7 0 0 2.2 8.3 0 1 2.6 2.2 0 0 0 4.5 1.7 1.1 0.4 0.5 0 0 0 0 0 1.2 0 0.4 0 0.3 0 0 0 0 0 0.4 1.5 0 7.5 1 0 4 0.7 0 0 0
NVP-BGJ398 1 0 0.2 0 1.7 0 0 0 4.6 0 0 0 0 0 0 3.2 0.3 7.4 0.1 0 0 0 0 4.7 1.5 1.1 0 4.2 8.2 1 5.5 1.5 0.8 5.8 31 2.3 3.1 4.6 0 1.8 0.4 0 0 0 3.5 3.1 3.7 0 0 2.4 0 0.7 0 0 0 0 2.1 68 69 45 5.4 0 0 3.4 6.2 5.2 0 0.4 0 1.5 2.2 0 2.4 0 1.6 5.2 1.9 0 7.9 2.2 3.5 0 10 21 3.5 0 0 0 2.5 3.5 0.4 1.8 0 1 0.2 3.7 1.1 0 7.5 0 3.8 0.1 0.2 3.2 0 2.8 9.5 1.5 0 4.1 3.3 6 10 0 7.2 3.2 1.1 0 0 2.6 4.3 0 5.9 0.4 0 4 0.6 1.4 1.6 6.3 0.6 0 0 5.5 2.2 0 28 0.2 1 0 2.1 1 3.7 0.7 4.3 0.4 0 1.4 3.6 1.8 0 1.5 3.2 3 0.1 19 1.1 0 2.3 0 4.2 1.1 1.7 1.7 1 2.3 0.1 0.8 1.5 2.1 3.7 0 0 0 0.4 0 2.9 1.1 0 0 1.9 1.3 0 2.3 2.5 0 1.7 3.5 6 2.6 0
Rho Kinase Inhibitor IV 1 0.9 0 0 0.6 2.5 7 10 55 8.3 2.7 0 0 2.9 0 2.5 2.9 2.5 0 1.4 0 0 0 0 2.5 0 0 0 4.7 0 0 0 1.6 2.7 2 3.3 0 0 0 0 5.7 0 0 0 2.8 0 0 1.9 0 2 0 2.3 0 2 5.1 0 0 0 1.8 0 0 0 0 0.6 2 0.7 0 0 0 0 1.1 0 1.3 0 1 2.6 0 0 0 0 5 2.2 1.2 31 3.9 16 2.7 2.9 0 0 0 0 0 0 0 0 0 0 0 0 0 1.5 5.8 0 0 3.1 1.2 2.3 0 3.6 1.1 11 0 1.5 1.3 1.5 3.1 3.3 0.3 0 1.2 9.1 4.7 1.2 0 0.2 1.3 0 0.8 0.1 0 0.1 13 0.5 1.6 0 24 0 1.5 0 0 2.4 4.6 1 4.9 1.6 0.4 0.1 2.8 3.2 0 10 3.5 0.7 0 2.2 90 90 0 4.7 2.4 2.1 5.8 1.5 1 0 0 0.1 1.1 1.6 1.9 2.3 0 0 0 11 0.4 0 2.1 0 2.1 2.2 0.4 6.6 1.1 0 0.4 0 0 0.3 1.7
RO0480500-002 1 8.9 0 58 76 92 0 75 84 81 1.8 0 0 1.8 0 18 0.5 0 0 0 0 61 91 2.1 6.9 0 0 0.6 0 98 70 1.3 0 0 0 1.1 0 0 0 0 25 5 0 0 0 0 0 0.9 0 0 0 0 0 2.7 2.8 0 0 0 0 0 0 0 0 0 0 0.3 0.3 7.2 0 0 0 0 0 0 0.8 0 0 1.5 1 0 0 5.1 0 0 0 7 0.9 40 0 0 2.2 0 0 0 0 0 1.4 1 0 0 0 0 6 2.9 0 0 0 0 14 0 0 2.4 40 0 0 1.1 0 1.1 0.5 0 0 0.2 98 0.7 0 0 0.2 0 0.2 88 78 0.2 4.9 0 5.3 0 2.9 0 1.3 2.1 0 96 99 88 71 96 32 57 24 98 80 99 0 0 0 0 98 97 0 84 64 78 99 99 57 94 98 98 98 13 9.7 0 0.8 0 0.1 0 0 0 2.4 0 1.2 0.6 0 0.4 0 0 0 0 0 0.6 2.8
RO1153583-001 1 2.8 1.1 0 0 1.8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0.4 0.4 0.9 0.6 0 0 0 0 0 0 1.8 0 0 1 0 0 0 0 0 0 0 0.5 8.4 0 0 0 0 0 0 0 0 1.1 3.5 0 0 0 0.1 0 0 0 0 0 0 0.3 0 0.9 0 0 0 0 0 0.2 0 0.5 0 2.1 0 0 0 2.4 0 0 0 0.2 1.2 0 0 0 5.8 0 4.2 0 0 5 0 0.3 0 0 1.2 0 5.7 3.7 1.9 0 0 0 25 0.3 0 0.3 0 0.6 0 4.8 0 0.1 0 0 0 0.4 6.4 0 0 0 0 0 0.3 0 0 0 1 0 7.1 0 0 0 0.5 2.1 0 0 0.7 3.9 0 0.1 0 0 0 0 0.7 0 0 0 1.5 0 0 0 0 0.7 0 0 2.5 0 0 0 0 0.7 9 0 1.8 1.5 0 2.3 1.6 0 0 0 2 0 2.2 2.7 0 0 0 0 1 0 0 4.9 0
S6K1 inhibitor 1 2.1 0 0.1 0 0 0 0 0 0 0 0 0 0 0 0 0 3.1 0 0 0 0 3.3 0.7 0.6 0 0 0 0 0 0 0 0.3 0 0 0 0 0 0 0 0 0 0 1.6 4.5 3.9 0 0 0 0 0 0 0 0 0 0.2 0 0 0 0 0 0 0 0 3.4 0 0 0 0 0 0 0.8 0 0 0.3 1.1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 6.2 7.2 6.7 0 0.8 1.4 0 0 0 0 0 0 0 0 0 4.6 0 0 0 3.9 8.6 0 0 0 0 0 0 0 0 0 0 0 1.6 0 15 0 0.1 4.8 0 0.7 1.1 0 0 2.6 1.2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0 1.9 21 0 0 3.6 0 0 0 0 0 2.6 0 0 0 0.3 0 0 2.4 0 0 0 0 0 2 2.5 0 4.2
SAR302503 1 44 27 0 0 2.7 9.3 10 59 23 37 0.7 5.5 0 0 0 3.6 12 0.1 4.9 0 0 0.7 0 0 0 0 0 0 0 9.7 0 4.9 1.2 32 2.3 0 0 0 0 25 2.2 2.5 0 0 0 0 0 0 0 0 0.5 5.2 0 5.6 0 13 18 48 8.8 0 13 2.4 85 32 5.7 57 0.3 0 0 8.5 1.1 14 12 9.6 18 0 0 25 62 29 47 12 38 42 12 0 0 0 0 0 0 0 0 0 0 0 1.9 1.3 0 0.4 5.8 16 11 25 5.7 2.8 5.3 0 3.5 16 47 1.9 47 4.8 5.8 0.5 0.4 7.9 1.2 9.2 2.1 70 2.6 1.1 0.4 0.8 0.8 0.5 47 64 4.6 32 2 0 12 26 0.3 1.6 2.3 0.9 1.9 3.2 7.4 11 12 0 0.3 7.2 1.2 8.9 0.3 24 12 1.6 39 0 0 0 1.9 5 4 1.3 1.6 1.2 3.1 0.3 0 0 23 58 36 0.2 0 0 0 0 0 0 0.9 18 2.4 42 33 2.4 8.7 21 40 3.5 53 0
SB-333612 1 4.4 4.8 1.1 1.7 2.5 3.6 2.8 5 3.1 0 2.7 0 6 3.7 2.9 0.3 0.8 4.4 4.2 0.7 0.2 0.7 1.8 0 3.9 3.7 2.1 0 9.4 8.4 5.5 0 2.7 5 3.4 4.4 4.5 2.8 4.5 11 1.5 3.2 3.1 0.1 3.3 0 1.3 3.8 8.3 5.7 7.4 3.9 1 8.9 2.9 4.1 5.3 6.8 8.1 0 2.4 1.8 2.1 1.6 2.6 4.6 0.7 3.8 2.4 8.8 0 2 5.1 3.8 6.1 2.2 3.1 1.5 1.1 1.5 0 12 6.6 1.6 3.9 2.8 6.8 5 1.9 4.3 3.1 5.1 4 1.1 4 5.3 3.5 4.6 10 1.1 3.9 0.1 6 3.1 4.8 4.1 0 5.1 2.3 1 0 0 2.1 3.2 6.5 0 6.9 5.7 4.4 3.7 3 4.4 8.7 2.3 5.1 2.3 0.6 0.1 13 0 1.6 3.4 4.7 0 4.2 3.6 0.9 0.6 0 3.9 4.5 1.8 0.9 0 5.5 3.7 4.6 5.5 3.3 2.1 1.9 8.3 4.8 1 2.4 1.9 2.7 11 1.9 2.5 2.2 1.7 9.9 2.1 1.8 2.1 2.1 3.2 5.8 1.3 5.9 0 0 1 7.5 6.3 6.4 0 3 6.1 5.6 3.2 3.7 1.4 7.7 5.4 0 3.4 0.1 3.1
SB-590885-AAD 1 6.4 4.6 0.7 1 1.3 2.2 1.3 1.6 1.7 0 2.1 2.1 63 0 0.6 0.8 0.3 2.8 1.3 0 0 0.5 1.6 1.9 3.8 2.9 2.4 7.4 2.5 1.9 6.6 0 2 0 6.3 3.4 2.5 2.3 3.1 4 0.7 1.4 4.2 2.9 2 2.9 1.5 2.4 7 5.2 3.8 1.9 2.5 10 1.9 2.2 6.1 4.7 5.9 0.2 2.2 2.4 2.7 1.9 2.2 0 3.1 5.1 4.7 3 6 4.6 0.9 9.2 5.6 6.1 0 0.8 3.4 1.8 0 3.5 4.2 2.1 2.6 2.5 6.3 4.4 0.7 9.6 4 2.4 1.5 1 3.9 2 0 1.7 2.6 1.4 2.5 1.3 2.6 0.4 1.6 0.9 3.8 8.7 1.3 1.4 0 0 3 0.8 2.7 3.8 1.6 4.1 2 1.8 1.5 1.2 4.6 2.7 3.9 0 7.4 0 8.1 4.8 0.8 1.2 3.7 0 3.1 1.6 1.1 0 0 2.1 0 1.5 0.6 1.3 1.9 3.3 2.6 3.6 2.2 2.7 1.2 5.8 4.9 12 6 0.5 3.2 3.6 2.1 1.9 1.1 2.4 3.4 0.9 1.4 2.2 2.4 2.9 2.5 6.2 0.3 0 0 1.1 22 4.6 4.7 0 1.7 4.8 2.3 1.2 1.9 3.3 6.9 2.3 0 3.4 3.1 0
SB-682330-A 1 2 2.4 0 0 0 0 0.1 0 0.7 1.3 0 0 49 0 0 0.4 0 0 0 0 0 0 0.5 0 0 0 0.7 0 0 0 0 0.7 0 0 0 0 0 0 0 0 0 0.3 0 0 0 4.9 0 0.5 0 0 0 0.1 3.7 1.7 0 0.2 0 0 0 2 1.5 0 0 0 0 1.3 0 0 0 0 0 0 0 0 3.2 0 0 0 1.5 0.4 0 0 0 2.7 1 0 0.9 1.4 2.2 0.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 0.6 1.1 0.2 0 0.6 0 0.3 0 0 0 0 0 0 0.9 0.8 0 0 0 2 0 1.5 3.1 2.4 0.5 1.8 0 3.7 0 2 0.6 0 1.1 1.7 0.7 2.8 0 0 0.6 0 0.9 0 0 0 0 0 1.8 0 3.5 0 0 0 0 0 0 0.1 0 0 0 1.3 0 1.7 0.1 0 1.1 3 0 0 17 0 0 0.9 0 0.4 0.8 0 0 0.2 1.3 0.7 0.9 0 2.2 0
SB-686709-A 1 0.5 1.1 0 0 0 0.2 2.4 0 0.9 1.6 0.6 0 0 0 1.7 0 0.7 0 0 0.3 0 0.8 3.9 3.9 2.4 5.9 3 5.6 0 0 0 0 1.3 0 2.5 0 1.7 0 0.2 0 0 1.1 14 13 0 1.2 0 0 0 0.4 0.7 0.5 1.2 0 0 0 0 0 0 1.8 1.7 0.8 1.7 1.1 0.3 1.4 0 85 81 0.3 0 0 0 0 0 0 0.3 0.5 1.7 0 0.1 1.7 1.8 0 2 0 0.1 2.2 2.5 3.5 0 0.1 0 0 0 0 0 0 0 0 0.9 0 0 0.4 0 0.6 4.1 2.4 1.6 0.5 0.5 0.5 1.9 0 0 1.3 0 4.8 2 0.5 2.1 3.7 0 0 0 0 0 1.4 0.9 3.1 0 2 0 0.1 0 0 0 0 0 0 1 0.2 0 0 0 0 0.3 0 0.2 0 0.8 0 0 0 2.5 0 0.7 0 0.2 0 1.1 0.4 0 0.8 0 0.6 2.3 0 0 0 0 1.4 0 0 0 0 0.2 1 0.5 0 1.8 0 0 0 0 0 3 0 2.4 0
SB-698596-AC 1 4 3.4 0.4 0 0 2.5 4 0.2 1.4 0.5 3.4 1.5 3.3 0 2.1 0.5 1.6 3.2 2.4 2.8 0 0.1 1.7 2.7 0.2 5.4 1.1 0 1.7 1.9 4.7 5.4 0 0 0 0.5 0.9 0 0 3.6 0 1.6 10 7.9 1.7 0 0.8 3.3 5.3 0 2 0 2.4 3.8 0 2.4 0.2 0.6 0 0.9 2.5 0.6 3.7 1 0.6 0 1.2 89 85 3.5 0 0.9 5.3 4.7 1.7 1.4 0.5 0 3.4 0.9 0 0.8 0 2 2.5 2.1 3.3 2.2 0.3 2.4 4 2.8 1.4 1.1 1.3 3.4 2 1.2 1.7 1.1 1.9 0 2.1 2.3 3.7 0 4.5 3.7 1.7 2 0 0.7 1.9 1.6 2.8 2 2.6 0.1 0 0.5 0.2 0 4 2.1 3.9 4.5 2 0.8 5.3 0 1.9 5 3.9 2.6 3.4 2.2 0.6 0.4 1.8 2.1 2.4 1.6 0.7 2.1 3.4 0.7 2.5 1.5 1.1 1.6 0.4 2 2.5 10 3 0.3 1.6 1.1 1.4 1.1 3.2 2.2 0.9 1.8 0.7 0.5 0 0.8 4.9 0 5.1 0 0 0 3.9 3.6 2.8 0 1.1 0.8 1.5 0.5 2.1 3.2 4.2 0 0.3 1.4 2.1 0
SB-734117 1 0 1.4 3.4 1.2 3.4 0 0 0.6 0 4.1 0 1.9 0 0 0.6 0 0.7 0 0 1.1 19 30 5.2 7.8 4.5 0.8 5 0 0 0 0 4 0 27 0 0 0 0 0 0 0 0.1 34 23 0 1.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4.1 0.3 2.1 0 66 62 0 0 0 0 0 0 0 2.1 0 0 0 0 7 0 0 4.7 0 0 0.1 3.9 6.3 0 0 0 0 0 0 0 0 0 0 2.9 3.7 4 2.8 10 0 0 2 0 0.2 13 0.8 0 0 0 0.5 0.1 0 0 0 0 0.8 0 0 0 0 0 1 3.7 4.6 0.3 0 0 4.2 0 0 30 5.2 11 0 0 20 2.5 31 8.5 0 0 0 14 41 3.7 0 0 2.2 3.6 31 42 5.3 52 70 41 60 76 6.8 73 1.2 5.9 7 0 0 1.2 1.5 1 0 0.4 0 0.5 3.5 4 0 1.8 0 0.2 0 0 0 4.5 0 1.7 0
SB-736302 1 0 0 0 0 0 0 0 0 0 0 0 0 3.8 4.6 4 0 0.4 0.6 2.6 1.4 5.9 9.3 0 1.1 1.9 0 0 0 0.6 1.5 3.8 3.2 0 1.3 3.5 4.1 0 0 0 0 0 1.3 20 11 3.2 0 0 0 5.8 2.9 1.1 0 0.4 2.2 1.3 1 2.3 0 1.5 0 3.5 2.5 0.3 0 1 0 3.6 21 18 2.7 0.4 0 2.2 3.8 4.7 0.4 2.4 0 0.6 1.1 0 14 2.6 0 0.1 1.1 1.6 3.6 3.4 7.8 2.4 1.6 2.6 4.5 3.5 3 0.4 1.4 2.5 1.1 4.7 0 5.9 2.4 13 1.3 2.5 8.4 1.6 1.6 3.7 0 1.5 1.5 2.8 0 4.5 3.4 0 3.1 1.9 1.6 4.5 1.1 2.8 3.5 4.2 0 5.5 3 2.4 3.9 2.7 1.3 6.8 8.2 14 0 4.2 2.8 3.9 2.1 0 48 3.3 0.3 0.3 1.3 15 40 4.7 11 2.9 2.7 4.2 46 54 4.4 64 69 47 49 72 12 69 2.6 8.5 22 2.7 5.7 0 0 0 0 3.1 2.6 2.3 0 2 0 1.3 0.5 4.4 1.1 5 0 0.1 1.6 1.1 0
SB-750140 1 4.8 4.9 3.8 3.5 1.7 6.3 3.6 3.6 3.8 0 3.2 5.9 7.2 4.8 4.1 0 2 4.9 6.4 0 43 60 3.1 5.1 6.9 5 4.8 0 8.3 2.9 7.3 6.2 2.1 12 3.1 3.6 5.7 3.5 2.1 7 0 2.8 8.5 5.7 3.4 1.7 0.5 7 9.5 6.6 7.6 2.2 2.4 16 3 13 4.1 6.5 9.6 0 1.7 1.1 1.2 6.1 1.8 1.2 5.5 26 18 6.3 1.5 5.7 8.9 5.5 8.5 3.8 0 1.7 5 2 0 10 5.8 3.8 17 5.2 6.2 8.1 3.6 10 6.5 5.1 3.5 2.2 4.7 4.4 8 1.8 4.3 1.5 6.4 4.1 5.8 4.5 34 1.5 5.2 11 4.4 1.1 3 1 6.4 3.2 6.2 3.5 7.3 2.3 1.8 3.1 3.1 4.9 12 3.2 5.9 0 0 0 10 9.1 2.6 7.7 6.8 0 4.8 3.7 34 8.2 16 3.8 6.1 10 4.7 29 4.2 8.2 8.6 8.6 6.1 16 5.9 11 5 8.4 5.7 81 83 15 56 56 43 20 55 10 21 5.3 5.2 3.7 5.7 5.9 9.8 0 0 0 8.2 10 9.9 0 4.4 4.7 2.7 1.9 9.7 3.1 19 1.8 0 1.9 0.3 0
SB-772077-B 1 4.3 5.3 3.3 3.7 5.4 4 3.1 2.8 1.6 0 2.7 2.2 6.4 1.4 0.9 0 1.8 3.7 4.1 1.7 15 23 0.4 2.1 5.3 3 0.5 0 4.6 1.1 14 5.1 1.3 1.3 5.9 3.7 3.6 3.1 2.5 5.7 0.2 1.4 13 7.9 15 0.8 0 5 9.5 5 6.6 6.2 4.2 13 1.2 2.6 0.3 2.5 3.7 0 3.4 0 1.6 5.9 3.2 3.5 6.8 3.3 2.4 6.4 1.4 4.6 7.2 14 4.3 0.8 2.9 0.6 0 0.6 0 7.1 5.4 2.2 4.6 4.3 8.6 6.9 0.4 5.4 4.9 3.4 0.1 2.3 0 3.5 8.2 1.8 3 1.8 4.7 1.6 3.8 2.2 15 0.5 5.7 7 3.7 2.1 2.9 0 4.2 1.9 5.3 0.6 6.2 12 0.4 4.4 2.6 0 10 1 5 0 0 0.3 7.7 4.1 9.4 6.1 6.7 0 5.4 3.2 74 9.7 52 4.3 4.7 49 5.7 44 6.8 4.6 6.7 4 57 73 32 11 4.5 13 5.6 65 75 7.5 45 18 31 45 68 6.1 33 7.3 6.5 20 5.7 4.3 0 0.4 0 0 4.4 4.3 3.7 0 3.1 4.4 11 1.1 7.4 3.6 16 3.1 0 4.1 1.8 0
VCC379989:02 1 77 41 0 0.1 0 0 15 32 7 27 0 0 0 6.9 7.2 3.6 0.3 0 16 0 2.4 3.4 4.6 0.7 7.8 7.7 5.8 63 0 4 0.4 26 4 58 4.2 3.2 1.5 0.4 0 0 1.6 8.4 39 21 55 0 2.7 0 0 10 0 6.9 0 0 0.1 0 13 26 9.2 0 15 55 95 46 5.7 30 0 0 0.5 14 11 0 2.1 2.5 4.8 0 0 30 0 0 0 51 37 38 8 0 4.3 0 79 67 0 0 0 0 0 0 0 5.7 0 2.1 32 39 42 52 30 5.4 1.7 54 53 57 2 0 47 1 0 0 0 2.3 1.1 2.3 0 51 0 0 0 0 0 0 47 70 0 40 23 11 25 40 0 0.4 1.3 0.1 9.3 1.1 0 0 1.1 0 0 0.8 2 11 11 0 19 0.2 19 0.4 0 3.8 1.4 1.6 0.2 0 2.1 1 3.2 16 3.9 2 11 57 23 0.5 0 6 23 0 0 0 3.5 0.4 0.3 0 0 0.6 7.3 22 1.8 8.7 47 3.8
VCC781016:01 1 1.5 1.1 0 0.4 0 0 0.3 0 0 0.5 0 0 1.1 0 0 0.3 0.1 0 1.9 0 0.4 0 1.6 0.3 0 0 0.8 0 0 1.4 0 17 0.2 0 1 0 0 0 0 0 0.9 0 0.3 6.4 0.8 0 0 0 0 0 0 0 1.4 0 0 0 0 2.2 0 0 0 0 0 0 0.8 0 2.1 0 0 0 0.6 0 2.2 1.5 1.1 0 1.3 0 0 0 3.1 0.1 0 0 0.2 0.5 0 0 0 2.4 0 0 0 0 0 1.2 0.4 0.7 0 0.7 0 5.9 8.4 5.3 0 0 0 18 0 0 1.4 0 0.3 0 6.1 0 0 0.2 0 0 0.2 8.2 0 0 0 0 0 0 0 0 0 7.4 1.7 7.5 0 12 0 0.4 2.2 0 0 0.3 0 0.3 4.3 0.2 0 0 0.2 1.2 0 0 1.8 7.1 0 0 0 0 0 0 0 0 0 0 0 0 1.9 6.9 0 1.5 0 1 0 1.6 0 0 0 0.9 0 1.1 0.3 0 0 0 10 0.9 0 0 2.4 5.1
VX-11E 1 0 0 0 1.9 0 0 0 4.2 0 0 0 0 0 0 3.7 0.1 3.3 0.1 0 0 1.1 0 3.1 1.1 2.8 0 2.8 6.6 0.3 5.9 1.9 1.2 4.8 5.2 0 3.1 3.9 0 2.1 0 0 0 0.6 4.4 3.9 2.4 0 0.2 1.5 0 2.3 0 0 0 0 2.8 0 0 8.9 0 0 0 4.7 5.1 5.2 0.5 4.6 0.4 0 3.9 0 1.8 0 1.1 0 0.7 0 6.6 2.6 4.5