LOOKING at the benefits of RBC depletion/exchangevs. RBC Exchange

One Centre Experience(Eduard Cojocari and Pamela Harmon, UHN)

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• Indication1. Chest crisis2. Pain3. Pain/PHTN4. Pain/Priapism5. Pain/Ulcer6. Stroke7. Stroke8. Stroke9. Stroke

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Demographics

Hct in Depletion/ExchangeHct in Depletion/ExchangeHct in Depletion/ExchangeHct in Depletion/Exchange

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Hct in RBC ExchangeHct in RBC Exchange Hct in RBC ExchangeHct in RBC Exchange

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The use of blood productsThe use of blood productsThe use of blood productsThe use of blood products

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Run ParametersRun ParametersRun ParametersRun Parameters

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Platelets DepletionPlatelets Depletion Platelets DepletionPlatelets Depletion

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Ferritin LevelFerritin LevelFerritin LevelFerritin Level

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Hemoglobin C LevelHemoglobin C Level

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Hemoglobin S LevelHemoglobin S Level

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Summary Summary

Inlet Rate Depletion/Exchange ≈ Exchange

Run Time Depletion/Exchange ≈ Exchange

Post-RBCX Plt Depletion/Exchange < Exchange

Post-RBCX Hct Depletion/Exchange ≈ Exchange

Post-RBCX HbC Depletion/Exchange ≈ Exchange

Post-RBCX HbS Depletion/Exchange ≈ Exchange

Ferritin Depletion/Exchange < Exchange

Use of PRBC Depletion/Exchange < Exchange

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ConclusionsConclusions

RBC Depletion/Exchange procedure:• efficiency is comparable with simple RBC Exchange• allows to decrease the use of PRBC product by

≈ 2 units/procedure or ≈ 24 units/patient/year

Acknowledgements to Dr. David Barth.

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