rcts are the basis of good clinical practice - pro
TRANSCRIPT
RCTs ARE the basis of good clinical practice
www.tylervigen.com
Patient
Study designBelieveable RESULTS
RESULTS Generalisable
Population
ISIS 2: aspirin and streptokinase
-2.8% -2.4% -5.2%
ISIS-2: Lancet 1988
Thirty years and millions of unnecessary deaths between the
first trial and the eventual proof of worthwhile treatment benefit
Lancet 2005; 365:1957–59
CRASH-1: steroids in TBIRoberts: Lancet 2005
Thirty years and many thousands of unnecessary deaths between the
first trial and eventual proof of significant harm
This actually happened …..
A decade of uncertainty and between the first trial and eventual
proof of harm
Emphasises the importance in determining longer-term patient-
centred outcomes.
Kavanagh: AJRCCM 2015
Hammond: ESICM 2015
Fifty years of uncertainty about the safety and efficacy of one of the most common
interventions in acute medicine and unequivocal proof of harm.
Thousands of lives saved, millions of dollars saved.
We cannot solve our problems with the same thinking we used when we created them.