red wine and breast cancer
DESCRIPTION
A research project and presentation I worked on in my Medical Nutrition Therapy class, which discusses the link between moderate consumption of red wine and its effect on breast cancerTRANSCRIPT
MODERATE CONSUMPTION OF
RED WINE REDUCES THE RISK OF
BREAST CANCERCristi Ambroso
Erin Ducker
Julia Simon
Lauren Walker
OUTLINE Hypothesis Introduction Body of Knowledge
Polyphenols Estrogen Phytoestrogens
Studies Conclusion Implications Recommendations Trials and Tribulations Quiz
HYPOTHESIS
Moderate Consumption of Red Wine Reduces the Risk of Breast Cancer
INTRODUCTION
1 in 8 women will get breast cancer during their lifetime
Based on this statistic, 10 people in HNF 320 will develop breast cancer in their lifetime
1/3 of cancers are linked to diet 3-4 million cancer cases can be prevented
each year by change in diet Grapes are most widely consumed fruit
worldwide Contain polyphenols
POLYPHENOLS
Antioxidants found in the seeds, skins, and stems of grapes
Beneficial health effects including inhibiting cancer growth
Resveratrol is a powerful polyphenol in red wine and prevents tumor growth
ROLE OF ESTROGEN
Estrogen: hormone that contributes to normal breast and sexual development
Estrogen stimulates cell division, meaning excessive amounts can lead to tumor development
Polyphenols decrease estrogen levels
Phytoestrogens are estrogens found in plants
PHYTOESTROGENS
Commonly found in tofu, soy beans, whole grains, fruits, and vegetables
Diet high in phytoestrogens can decrease one’s risk for breast cancer If phytoestrogens bind to the estrogen
receptor instead of the stronger human made estrogen less cell division will occur
STUDY #1: POTENT INHIBITORY ACTION OF RED WINE POLYPHENOLS ON HUMAN BREAST CANCER CELLS
Objective: To determine the anti-proliferative affect of red wine concentrate on the hormone sensitive breast cancer cells
Results: Low concentrations of polyphenols, and consecutively, consumptions of wine or other polyphenol rich foods and beverages could have a beneficial anti-proliferative affect on breast cancer cell growth
STUDY #2: RESVERATROL, A POLYPHENOLIC COMPOUND FOUND IN GRAPES AND WINE, IS AN AGONIST FOR THE ESTROGEN RECEPTOR
Objective: To determine whether Resveratrol may be considered a phytoestrogen
Researchers found resveratrol binds to the human estrogen competeing with human made estrogen
Results: Resveratrol is a phytoestrogen, meaning Resveratrol plays a role in reducing breast cancer risk
STUDY #3: CANCER CHEMOPREVENTIVE ACTIVITY OF RESVERATROL, A NATURAL PRODUCT DERIVED FROM GRAPES
Objective: To determine whether Resveratrol can be a cancer chemopreventive agent
Used a mouse mammory gland culture model of carcinogenesis to test activity resveratrol
Results: found to inhibit tumor initiation, promotion, and progression
CONCLUSION
Positive correlation between red wine consumption and decrease breast cancer risk Hypothesis is accepted
Polyphenols have been shown to be beneficial in decreasing breast cancer risk
More research is needed, especially clinical trials involving humans
IMPLICATIONS
Moderate consumption of red wine can be beneficial
Grapes contain the polyphenols, not alcohol
Eating grapes or drinking 100% natural grape juice can offer similar protection against breast cancer
OUR RECOMMENDATIONS
Both men and women should have a diet rich in polyphenols (antioxidants)
TRIALS AND TRIBULATIONS
Rewards: Became knowledgeable on importance of
diet with breast healthBecame more familiar with researching
Challenges:Difficult to compile all of our information Interpreting the research articles
QUIZ:
Polyphenols areA. GrapesB. AntioxidantsC. A type of wineD. Cancer causing substance
ANSWER: B. Antioxidant
QUIZ:
True or falseResveratrol is a human made estrogen
ANSWER: FALSE
CHEERS!