reduce your risk of breast cancer
DESCRIPTION
Reduce your risk of Breast Cancer. View these slides from DFH.TRANSCRIPT
Reduce Your Reduce Your Risk of Risk of
Breast Cancer Breast Cancer
www.designsforhealth.comwww.designsforhealth.com
Breast Cancer is Breast Cancer is
diagnosed every diagnosed every
3 minutes 3 minutes
in this country, in this country, ALONEALONE..
www.designsforhealth.comwww.designsforhealth.com
Incidence of Breast Incidence of Breast Cancer…Cancer…
• Second only to lung cancer in women
• BRCA1 and 2 gene account for about 5% of all breast cancers
• 20 to 30% of women who carry the BRCA gene mutation do not go on to develop breast cancer.
www.designsforhealth.comwww.designsforhealth.com
What is Cancer?What is Cancer?Proliferation of abnormal malignant cells that Proliferation of abnormal malignant cells that
grow uncontrolled & may eventually grow uncontrolled & may eventually metastasize and spread.metastasize and spread.
www.designsforhealth.comwww.designsforhealth.com
CancerCancer
• Carcinogenetic Process– Exposure to carcinogens,
initiation of tumor, tumorpromotion, progression, precancerous cells, malignant tumor, & metastasis.
• On average, this process can take 8 to10 years before breast cancer is detected from a one cell tumor.– Ex: Carcinogen (UV Radiation) & Promoter
(hormones).
www.designsforhealth.comwww.designsforhealth.com
Etiology of Risks for Cancer
• History of BRCA 1 or 2• Family History• Increasing age• Early menarche• Late menopause• HRT extended use• Obesity• Excessive alcohol
www.designsforhealth.comwww.designsforhealth.com
Etiology of Risks for Cancer
• First child over age 30• Total estrogen exposure and type of
estrogen exposure• Relationship to environmental
influences and genetic individuality that is not related to the BRCA 1 or 2 gene.
www.designsforhealth.comwww.designsforhealth.com
Contributing FactorsContributing Factors
SmokingObesity
Lack of Physical ActivityHormones
StressInherited Risk
www.designsforhealth.comwww.designsforhealth.com
SmokingSmoking
• Causes cancer by beingboth a carcinogen and a promoter.
• Suppresses the immune system by depleting the body of the anti-oxidants needed to fight cancer.
www.designsforhealth.comwww.designsforhealth.com
ObesityObesity
• 64.5% of U.S. adults areoverweight which is a BMI > 25
• 1/3 of those are obese, which is a BMI >30
• Hundreds of studies have shown that being overweight increases the risk of breast cancer and numerous other cancers
www.designsforhealth.comwww.designsforhealth.com
Physical Activity/ExercisePhysical Activity/Exercise
• Research shows that people who exercise are at a reduced risk of developing certain types of cancer including breast.
• Vigorous exercise increases immune function.
• Affects hormone levels.• Shortens stool transit time• Helps promote healthy body
composition.• Exercise releases toxins
through sweat
www.designsforhealth.comwww.designsforhealth.com
Physical Activity/ExercisePhysical Activity/Exercise
• Try to exercise on a regular basis
– Anything you can do to relieve your stress and to enhance your comfort, satisfaction, and joy will have a major effect on your quality of life.
www.designsforhealth.comwww.designsforhealth.com
Physical ActivityPhysical Activity
•Better sleep FOLLOWS regular exercise
•Increases immune system functioning
•Endorphin releasing which contributes to a feeling of well being & decreases stress
www.designsforhealth.comwww.designsforhealth.com
HormonesHormones
• Breast feeding decreases the risk of breast cancer
• If circumstances allow, consider having children sooner rather than later in life
• The balance of the different estrogens in your body matters
• Test your ratio to check your risk for breast cancer.
www.designsforhealth.comwww.designsforhealth.com
StressStress• Increased stress
depresses immune system function, which protects you from cancer
• Increased stress decreases survival in cancer patients
• Stress management improves quality of life
www.designsforhealth.comwww.designsforhealth.com
Self Breast ExamSelf Breast Exam
Self breast exams and mammograms should be done on days 7-14 of your menstrual cycle
Occasional self-breast exams should start at the age of 18Every other month at the age of 20Begin monthly at the age of 30
www.designsforhealth.comwww.designsforhealth.com
ScreeningScreening
If you have a family history of pre-menopausal breast cancer in a 1st degree relative: You should start screening 10 years
prior to the age of that relative when she was diagnosed
www.designsforhealth.comwww.designsforhealth.com
ScreeningScreeningMRI
Ultrasound
Mammogram
www.designsforhealth.comwww.designsforhealth.com
Breast Thermography• Thermography is a painless, non invasive, state of the art
clinical test without any exposure to radiation and is used as part of an early detection program which gives women of all ages the opportunity to increase their chances of detecting breast disease at an early stage. It is particularly useful for women under 50 where mammography is less effective.
• Thermography's role in breast cancer and other breast disorders is to help in early detection and monitoring of abnormal physiology and the establishment of risk factors for the development or existence of cancer. When used with other procedures the best possible evaluation of breast health is made.
• This test is designed to improve chances for detecting fast-growing, active tumors in the intervals between mammographic screenings or when mammography is not indicated by screening guidelines for women under 50 years of age.
www.designsforhealth.comwww.designsforhealth.com
Breast Thermography• Uses new ultra-sensitive, high
resolution digital infrared cameras.
• Thermography demonstrates heat patterns that are strongly indicative of breast abnormality. The test can detect subtle changes in breast temperature that indicate a variety of breast diseases and abnormalities. Once abnormal heat patterns are detected in the breast, follow-up procedures including mammography are necessary to rule out or properly diagnose cancer and a host of other breast diseases such as fibrocystic syndrome.Source: ACCT website
www.designsforhealth.comwww.designsforhealth.com
Breast ThermographyCanadian researchers recently found that infrared imaging of breast cancers could detect minute temperature variations related to blood flow and demonstrate abnormal patterns associated with the progression of tumors. These images or thermograms of the breast were positive for 83% of breast cancers compared to 61% for clinical breast examination alone and 84% for mammography.
http://www.thermologyonline.org/Breast/breast_thermography_what.htm
www.designsforhealth.comwww.designsforhealth.com
Nutrition, Lifestyle, & CancerNutrition, Lifestyle, & Cancer
• 35% of all cancers are linked to diet
• Estimates for women are as high as 50%
• Simple lifestyle and behavior changes could reduce the U.S death rate of cancer by 50%
• Breast cancer is the most common cancer in females, second only to lung cancer
www.designsforhealth.comwww.designsforhealth.com
ACS Nutrition & Lifestyle GuidelinesACS Nutrition & Lifestyle Guidelines
• Stop drinking alcohol or limit consumption to no more than two alcoholic drinks per week (cutting down on alcohol increases your liver's ability to regulate blood estrogen levels)
• Limit red meat and other sources of animal fat (this includes dairy fat in cheese, milk, and ice cream), as they may contain stored hormones or pesticides
• Eat 5 or more servings of a variety of fruits and vegetables each day
• Choose whole grains instead of processed (refined) grains and sugars
www.designsforhealth.comwww.designsforhealth.com
Dietary Approach
• Decrease consumption of “pro-inflammatory” foods.
• Restrict sugar and refined carbohydrates…optimize blood glucose regulation.
• Add protective foods - veggies and fruits loaded with phytonutrients and antioxidants.
• Reduce your total toxic load by buying organic foods and staying away from foods heavily sprayed with pesticides or injected with hormones
www.designsforhealth.comwww.designsforhealth.com
Inflammatory Cascade
Breast Cancer“The frontier of COX inhibition in breast cancer prevention and treatment is being probed by several lines of evidence. Epidemiologic research demonstrates a 40% to 50% decrease in the risk of breast cancer among women who are chronic users of NSAIDs.”
Nutritional and Botanical Modulation ofthe Inflammatory Cascade—Eicosanoids,Cyclooxygenases, and Lipoxygenases—
As an Adjunct in Cancer TherapyJeanne M. Wallace, PhD, CNC
www.designsforhealth.comwww.designsforhealth.com
Inflammatory Cascade
COX-2, and its byproduct PGE2, may contribute to tumor viability and progression by:
1. Promotion of cell proliferation2. Inhibition of apoptosis3. Increased angiogenesis4. Increased invasiveness (and metastases)5. Immunosuppression.
Nutritional and Botanical Modulation ofthe Inflammatory Cascade—Eicosanoids,Cyclooxygenases, and Lipoxygenases—
As an Adjunct in Cancer TherapyJeanne M. Wallace, PhD, CNC
www.designsforhealth.comwww.designsforhealth.com
Cell MembraneCell Membrane
Arachidonic AcidArachidonic Acid
cyclooxygenase lipooxygenase
Phospholipase A2
Synthetic Modulation of Arachidonic Acid Cascade
2 SeriesProstaglandins
ThromboxaneA2
LeukotrienesSRS-A
Cortisone
IndomethacinAspirinIbuprofenAcetaminophen (weak)Sulfasalazine (topically)
Colchicine
Sulfasalazine (topically)
www.designsforhealth.comwww.designsforhealth.com
Cell Membrane
Arachidonic Acid (AA)
cyclooxygenase lipooxygenase
Phospholipase A2Glycyrrhiza glabraQuercetin
QuercetinAllium cepaAllium sativumCurcuma longaBoswellia serrata(specific for 5-lipoxygenase)
Other Anti-Inflammatory Botanicals Ananas Comosus -- fibrinolysis, inhibits bradykinin, increases Series I Prostaglandins Tanacetum parthenium -- inhibits platelet aggregation Matricaria chamomilla -- unknown Scutellaria baicalensis -- stabilizes mast cell membranes Capsicum Minimum -- depletes substance PQuercetin -- stabilizes mast cell membranes Ammi Visnaga -- stabilizes mast cell membranes
:
Botanical Modulation of Arachidonic Acid Cascade
Potentiates cortisol: Glycyrrhiza glabraCurcuma longa
Zingiber officinaleCurcuma longaQuercetin (weak)Ananas Comosus(?)Salix nigraGaultheria procumbens
Prostaglandins Series 2 Thromboxane
A2
Leukotrienes
www.designsforhealth.comwww.designsforhealth.com
Changing fatty acid intake:omega-6: omega-3 ratios
0
5
10
15
20
25
30
35
40
45
Prehistoric Early 1900 Current
Om 6 FA
Om 3 FA
0
5
10
15
20
25
30
35
40
45
Prehistoric Early 1900 Current
Om 6 FA
Om 3 FA
1:1 4:1 25:1
www.designsforhealth.comwww.designsforhealth.com
Metabolic Pathways of Essential Fatty Acids
Series 1 Prostaglandins,
Leukotrienes, and Thromboxanes
Omega-6 Fatty Acids (N6)Omega-6 Fatty Acids (N6) (e.g., canola, corn, soybean, safflower, sunflower oils)
CIS Linoleic Acid (LA)CIS Linoleic Acid (LA)
elongase
-6 desaturase
Gamma Linolenic Acid (GLA)Gamma Linolenic Acid (GLA)Borage oilBlack currant seed oilEvening primrose oil
Mothers’ breast milk
Di-Homo-Gamma- Linolenic Acid Di-Homo-Gamma- Linolenic Acid
(DGLA)(DGLA)
Animal fats in diet Series 2 Prostaglandins,
Leukotrienes, and Thromboxanes
Omega-3 Fatty Acids (N3)Omega-3 Fatty Acids (N3)(e.g.,flax seed, hemp, canola, soybean, walnut)
Alpha-Linolenic Acid (LNA)Alpha-Linolenic Acid (LNA)
Eicosapentaenoic Acid (EPA)Eicosapentaenoic Acid (EPA)
Docasahexaenoic Acid (DHADocasahexaenoic Acid (DHA)
Arachidonic Acid (AA)Arachidonic Acid (AA)
-6 desaturase
elongase
Stearidonic Acid Stearidonic Acid
Eicosatetraenoic AcidEicosatetraenoic Acid
-5 desaturase
-4 desaturase
Black currant seed oil
Fish Oils
Fish OilsMarinealgae
-5 desaturase
elongase
-4 desaturase
Adrenic AcidAdrenic Acid
Docosapentaenoic AcidDocosapentaenoic Acid
elongase
Series 3 Prostaglandins, Leukotrienes, and
Thromboxanes
DocosapentaenoicDocosapentaenoic
Acid Acid
www.designsforhealth.comwww.designsforhealth.com
Cell MembraneCell Membrane
Arachidonic AcidArachidonic Acid
cyclooxygenase lipooxygenase
Phospholipase A2
Nutrient Modulation of Arachidonic Acid Cascade
EPA/DHA
EPA substrate competition
2 SeriesProstaglandins
ThromboxaneA2
EPA substrate competition
LeukotrienesSRS-A
EPA
dihomo-y-linolenic acid (DGLA)
Delta 5 desaturase
Vitamin E, C (stabilize membrane)
Nonenzymatic Oxidation
LeukotrienesSRS-A
EPAVitamin E
GS-Px
Vitamin EGS-Px
Vitamin E
www.designsforhealth.comwww.designsforhealth.com
FatsFats• Saturated• Hydrogenated Fats
– Chemically altered/processed
• Monounsaturated• Polyunsaturated• Molecular Structure
and effects on body• EPA/DHA
www.designsforhealth.comwww.designsforhealth.com
FatsFats
• Polyunsaturated – Omega 6 – Vegetable oils (except
monounsaturated above)– Nuts and seeds
• Polyunsaturated - Omega 3– Fish - salmon, albacore, tuna,
mackerel, sardines– Flaxseed, chia seed, hemp seed– walnuts
www.designsforhealth.comwww.designsforhealth.com
Healthy FatsHealthy Fats Eat at least two 4oz. servings
of preferably wild cold-water fish/week, Salmon, sardines, trout, herring,
halibut, anchovies Flaxseed, walnuts, spinach,
kale, broccoli, & leafy green veggies are also rich in Omega 3 fats.
Avoid processed foods, salad dressings, & cooking with Omega 6 oils. corn, soybean, safflower,
sunflower, & cottonseed oils
www.designsforhealth.comwww.designsforhealth.com
Omega 3’s Decrease Omega 3’s Decrease InflammationInflammation
• Balance out the affects of omega 6 fatty acid (linoleic acid). Omega 6 fats produce pro-inflammatory compounds which promote tumor growth, foster angiogenesis, and suppress immune function.
• Omega-3’s compete w/Omega-6’s for enzymes needed for cancer-promoting metabolites.
• Make cancer cells more vulnerable to free-radical attack by making membranes less saturated.
• Promote cancer cell self destruction, increasing their rate of die-off and slowing tumor growth.
www.designsforhealth.comwww.designsforhealth.com
Dietary Fish Oil and Breast Cancer Progression
• The growth of breast cancer cells in culture and in mice is inhibited by omega-3 fatty acids, scientists report in a fast track article in the November 10th International Journal of Cancer.
• According to Dr. Rafat A. Siddiqui from the Methodist Research Institute, Clarian Health Partners in Indianapolis, "Omega-3 fatty acids activate an enzyme called sphingomyelinase, which generates the release of ceramide, a compound that ultimately causes cancer cell death.“
• Int J Cancer 2005;117:340-343.
www.designsforhealth.comwww.designsforhealth.com
Optimize Blood Glucose Regulation
• Rises in blood glucose generate corresponding rises in insulin, which push prostaglandin production toward PGE-2.
• Cancer cells feed directly on blood glucose.
• Elevated blood glucose levels suppress the immune system.
Beating Cancer with Nutrition, Patrick Quillin, PHD, RD, CNS p 104
www.designsforhealth.comwww.designsforhealth.com
Fruits & Fruits & VegetablesVegetables
Serving = ½ cup cooked or 1 cup raw Dark green, yellow, & orange types are the richest in protective
phytonutrients Eat from the rainbow, variety covers your bases. Eat a salad for lunch or dinner… Get RAW Asparagus, mushrooms, flaxseed, fermented soy products &
tomato sauce, pomegranate seeds & juice, curry dishes, berries (especially blueberries), & rhubarb
The average American consumes
ONLY 3 servings/day
Get in a minimum of 5 servings (7 servings = good, 9 servings = great)
www.designsforhealth.comwww.designsforhealth.com
Cruciferous Veggies• Broccoli, cauliflower,
brussels sprouts, kale, turnip, arugula, mustard greens, rutabaga, cabbage
• Contain indoles, isothiocynates, sulforaphane, glucosinolates
• Shunt the metabolism of estrogen toward protective 2-OH estrogen and away from cancer promoting 16-OH estrogen.
www.designsforhealth.comwww.designsforhealth.com
Brassica Veggies and Breast Cancer
• 2,832 women 50-74 years with Breast Ca and 2,650 controls (Sweden)
• Women consuming 1.5 cups of Brassica vegetables daily have 25% decreased risk
www.designsforhealth.comwww.designsforhealth.com
Carotenoids• Beta carotene: yellow,
orange, and leafy green veggies and fruits
• Alpha carotene: pumpkin, carrots
• Cryptoxanthin: citrus, peaches, apricots
• Lutein: kale, spinach, collards, beet greens
• Lycopene: tomato products, watermelon, pink grapefruit
• Zeaxanthin: green veggies, citrus, corn.
www.designsforhealth.comwww.designsforhealth.com
More Protective Phytonutrients
• Allium Family (garlic, onion, leeks, shallots, chives) contain thiols, quercetin, alyll sulfides
• Rosemary contains carnosol. Interferes with ability of estrogens to fit onto estrogen receptors in breast tissue. (1)
• Berries! Raspberriess and blackberries contains ellagic acid, cherries contain glucaric acid, which helps clear estrogens out. (2)
• Citrus peel contains limonene. Add to teas.How Diet and Nutrition Can Help Control Cancer Jeanne Wallace, PhD, CNC
www.designsforhealth.comwww.designsforhealth.com
Reduce Your Total Toxic Load
• Avoid pesticides and herbicides by buying organic produce.
• Avoid hormone injected meats and poultry. Buy hormone-free, free-range poultry and meat.
• Avoid fried foods and hydrogenated oils including margarine.
• Drink 8 -10 glasses of purified water daily to help remove toxins.
www.designsforhealth.comwww.designsforhealth.com
PaleoFiber™PaleoFiber™
• Certified antioxidant capacity due to is polyphenol content
• Good balance of soluble and insoluble fibers, with an emphasis on soluble fiber (which is hard to achieve from common diets)
• Fiber binds toxins in the gut, improves insulin response and lowers blood glucose levels
DFH has a unique DFH has a unique combination of combination of
12 types of fibers12 types of fibers
www.designsforhealth.comwww.designsforhealth.com
Environmental Toxins• Breast tissue is very susceptible to fat soluble toxins. In a
National Government (EPA) human adipose study published in 1990 involving 1377 individuals, 100 % of adipose tissue samples contained dioxin, dichlorobenzene, styrene, xylene, and ethylphenol. 76% of samples had PCB’s, benzene and a host of other chemicals.
• Many chemicals act as xenoestrogens and many are just plain carcinogenic. DDT derivatives DDE, PCBs and organochlorenes have been found concentrated in cancer tissue.
• Detoxification needs to be a primary focal point in the prevention of cancer.
• Phase 2 liver detoxification is essential for removal of excess circulating estrogens and xenobiotics as well.
www.designsforhealth.comwww.designsforhealth.com
Tips for Self NourishingTips for Self Nourishing
Lifestyle Recommendations:• Avoid negativity and
worrying.• Reduce stress.• Pray and meditate daily.• Exercise regularly –
whatever you enjoy most.• Do what makes you happy –
kayak on a lake, hike in the mountains.
• Time in nature that inspires a sense of awe.
www.designsforhealth.comwww.designsforhealth.com
Tips for Self Nourishing
• Adequate sleep in a darkened bedroom• Physical Touch• Close personal relationships and social
support. • Humor and laughter. Laughter raises
endorphins!• Expression of your true emotions • Positive, optimistic outlook on life despite
its inevitable difficulties.
www.designsforhealth.comwww.designsforhealth.com
Optimal Food Choices
Note: consume organic foods whenever possible
• ProteinWild salmon, mackerel, herring, sardines, anchovies, grass-fed beef or buffalo, lamb, hormone free poultry, DHA enriched eggs, plain whole yogurt
• Vegetarian ProteinBeans (all – including chickpeas, black, red, kidney), lentils, nuts
• VegetablesAsparagus, beets, broccoli, kale, Brussels sprouts, cauliflower, collard greens, cabbage, fennel, horseradish, kale, leeks, onions, peppers, pumpkin, purslane, spinach, turnips
• FruitsBlueberries, cherries, strawberries cranberries, apricots, apples, bananas, grapes, kiwi, oranges, papaya, peaches, pineapple, watermelon
www.designsforhealth.comwww.designsforhealth.com
Optimal Foods Choices• Starches
Brown rice, quinoa, steel-cut oats, sweet potatoes, yams, beets
• FatsOlive oil, olives, walnut oil or walnuts, flax, hempseed oil, avocado, coconut oil
• Herbs/SpicesTurmeric, ginger, garlic, chives, rosemary, thyme, sage, oregano, parsley, cilantro, fennel, mint, dill, tarragonBeverages
• Green tea, Pomegranate juice, freshly made vegetable and fruit juicesGreen tea contains catechins and polyphenols.
www.designsforhealth.comwww.designsforhealth.com
Foods to Avoid
• Sugar in all forms, hormones in meat and dairy products, pesticides, non-organic foods, food additives and preservatives (nitrates, nitrites), white flour, iron-fortified cereals, safflower, sunflower, corn oils, margarine, fried foods, processed and refined foods, commercial cereals, soda, fruit juice, alcohol, isolated soy protein and other processed soy products, reduced fat and nonfat dairy products (plain full fat yogurt in small quantities okay).
www.designsforhealth.comwww.designsforhealth.com
Protocol for Breast CancerProtocol for Breast CancerNutritional SupportNutritional Support
Supplement Recommendations:Twice Daily Essential Packets
1 packet twice a day (both multi vitamins in the am)
EGCg Green Tea 1 capsule twice a day
CLA 1 soft gel three times a day
DIM 1 capsule daily with dinnerQ Avail (CoQ10) 100 mg 1 soft gel per dayBroccoProtect
1 capsule per dayVitamin D as indicated by testing.
www.designsforhealth.comwww.designsforhealth.com
Importance of Multi VitaminsImportance of Multi Vitamins
• A recent study reported that most Americans weren’t even getting the Recommended Daily Intake1 (RDI) of vitamins and minerals, much less the optimal levels of them and that this suboptimal intake of vitamins and minerals is a risk factor for many chronic diseases (breast cancer, osteoporosis, heart disease, diabetes, …).
www.designsforhealth.comwww.designsforhealth.com
Importance of Importance of Multi VitaminsMulti Vitamins
• A summary of current research clearly shows that those who don’t supplement with a high quality multivitamin/ mineral and antioxidant formula are at risk for deficiencies2.
– 1 RDI is the recommended amount to avoid diseases of deficiency like scurvy or pellagra, NOT the amount needed for optimal health and to avoid the major diseases of aging like heart disease, osteoporosis, cancer and diabetes.
– 2 Medical Professionals and Health Care Practitioners looking for more information on the research supporting the above program can contact Designs for Health support and technical department at 800-847-8302 x 105 or via the website, www.designsforhealth.com.
JAMA, Jun 2002
www.designsforhealth.comwww.designsforhealth.com
Twice DailyTwice DailyEssential PacketsEssential Packets
• Each Packet contains:– Twice Daily Multi™– Calcium Malate Chelate– Magnesium Malate Chelate– Omega Ultra Marine™ Softgel
www.designsforhealth.comwww.designsforhealth.com
Check Vitamin D Levels!• In a study of 166 women undergoing treatment for breast cancer,
nearly 70 percent had low levels of vitamin D in their blood, according to a study presented at the American Society of Clinical Oncology's Breast Cancer Symposium in San Francisco. The analysis showed women with late-stage disease and non-Caucasian women had even lower levels.
• "Vitamin D is essential to maintaining bone health, and women with breast cancer have accelerated bone loss due to the nature of hormone therapy and chemotherapy. It's important for women and their doctors to work together to boost their vitamin D intake," said Luke Peppone, Ph.D., research assistant professor of Radiation Oncology, at Rochester's James P. Wilmot Cancer Center. Scientists funded by the NCI analyzed vitamin D levels in each woman, and the average level was 27 nanograms per milliliter; more than two-thirds of the women had vitamin deficiency.
Women with breast cancer have low vitamin D levelsNewsRx.com
10-23-09 Life Extension News
www.designsforhealth.comwww.designsforhealth.com
EGCg EGCg (green tea extract)(green tea extract)
• Studies have identified several pathways through which substances in tea can fight cancer development
• Research with human cancer cells show that a natural phytochemical in tea, called EGCG, can block several enzymes necessary for these cells to reproduce and flourish
• Polyphenol substances in tea are strong antioxidants; prevent and repair DNA damage that could otherwise lead to cancer
www.designsforhealth.comwww.designsforhealth.com
CLACLA• Conjugated linoleic acid decreases
production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism.
Biochim Biophys Acta. 2002 Apr 15;1581(3):89-99
• Conjugated Linoleic Acid (CLA) is a dietary fatty acid that has received considerable attention due to its unique properties in rodent models including anti-cancer, anti-atherogenic and anti-diabetic effects.
Anti-Inflammatory Properties as well as Immune Enhancing
Properties
www.designsforhealth.comwww.designsforhealth.com
Q AvailQ Avail (Co-Q10)(Co-Q10)
• A POWERHOUSE antioxidant• Studies indicate that Co-Q10 may have a dramatic
immune-enhancing effect
•Levels of coenzyme Q10 decline with advancing age
•Optimal dosages cannot be achieved through common diets
•Supplementation is needed to achieve optimal Q10 levels
www.designsforhealth.comwww.designsforhealth.com
Dim Avail• Broccoli and other cruciferous
vegetables are well known for their phytochemicals including indole-3-carbinole and sulphoraphane.
• DIM (diindolmethane), the active form of indole-3-carbinole, has been well researched to increase metabolism of estrogen into its 2- hydroxy forms which have a protective effect on breast cancer.
• Excess 16- OH metabolites tend to promote cellular growth.
www.designsforhealth.comwww.designsforhealth.com
Estrone Metabolites
4/16-Hydroxyestrone• Strong Agonist• Promotes Cancer• Difficult to Change
Rate of Formation
Proc Natl Acad Sci 82(18): 6295, 1985
2-Hydroxyestrone• Weak Agonist• Kills cancer cells• Prevents spread of
cancer cells• Easy to raise this by
taking DIM and increasing veggie consumption
J Endocrinol 150 Suppl: S259, 1996
www.designsforhealth.comwww.designsforhealth.com
BroccoProtect
• Contains a specially cultivated form of broccoli seed.
• Naturally rich in glucoraphanin, the direct precursor to sulforaphane.
• Sulforaphane is able to upregulate phase II enzymes in the liver and other parts of of the body to allow for full and proper detoxification of unsafe chemicals.
• Can be used in combination with DIM Avail.
www.designsforhealth.comwww.designsforhealth.com
The Folic Acid Controversy
• Folic Acid supports the growth of normal cells. • Epidemiological studies demonstrate that too
much folic acid may promote the growth of precancerous cells.
• Folic acid (synthetic) and folate (natural) has a “U” shaped relationship to the incidence of cancer. Too little folate presents risk for cancer due to deficient methylation, genetic expression and cell differentiation. Too much folate can promote the growth of tumor lesions. The correctamount of natural folate is protective.
www.designsforhealth.comwww.designsforhealth.com
The Folic Acid Controversy
• Research is suggesting that the use of folic acid (synthetic) in fortified foods and most nutritional supplements may pose much higher risk than natural folate found in foods and some supplements.
• The synthetic folic acid must be converted (reduced) in the body. Many individuals cannot effectively convert the amount of folic acid they are now being exposed to since the introduction of food fortification in the US in 1998, and due to the increased use of nutritional supplements containing folic acid. This may result in a build-up of “unmetabolized” synthetic folic acid in many individuals.
www.designsforhealth.comwww.designsforhealth.com
The Folic Acid Controversy
• This synthetic “unmetabolized” folic acid may increase cellular proliferation, including tumors, much more than natural folates (Some studies suggest 100 times more!).
• While overall, folates are beneficial and protective to most individuals, there are some people at risk of high levels of folate intake, including those with pre-cancerous or cancerous lesions.
www.designsforhealth.comwww.designsforhealth.com
For further reference:For further reference:
www.breasthealthcenter.comwww.bcrfcure.orgwww.cancer.org
www.breastcancer.orgwww.pubmed.org
www.aicr.orgwww.strang.org
www.desertwomenshealth.com
www.designsforhealth.comwww.designsforhealth.com
Thank You