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Jack R. Reifert Page 1 of 2 2528 Orella St. Unit B Santa Barbara, CA 93105 Phone: (858) 922-5923 Email: [email protected] EDUCATION 2005-2011 Doctor of Philosophy (Ph.D.) - Molecular, Cellular, and Developmental Biology (MCDB) University of California, Santa Barbara 1996-2000 Bachelor of Science (B.S.) - Pharmacological Chemistry University of California, San Diego INDUSTRY RESEARCH EXPERIENCE 2014-Present Serimmune INC., Santa Barbara, CA Scientist • Utilize peptide display screening, deep sequencing, and antigen discovery for patient antibody profiling • Lead scientist on project to identify therapeutic candidates to block autoantibodies in Graves Disease • Discovered motif panels specific to two autoimmune diseases for biomarker development • Developed improved screening and deep sequencing techniques to map patient specific antibody recognition repertoires 2002-2005 Salmedix INC., La Jolla, CA Research Associate • Investigated mechanism of action, evaluated combination potential, and tested second-generation analogs on small-molecule cancer therapeutics • Bendamustine (Treanda) research supported clinical trials for B-Cell NHL (FDA approval in 2008) • Published results indicating Treanda’s mechanism of action is divergent from other chemotherapies • Designed a functional assay to support IHC scoring when typing patients for inclusion in clinical trials 2001-2002 BD Pharmingen, La Jolla, CA Quality Control Associate I • Tested antibodies in immunoblotting, ELISA, and flow-cytometry assays for product release ACADEMIC RESEARCH EXPERIENCE 2011-2014 Chemical Engineering (UCSB), Santa Barbara, CA Postdoctoral Fellow (CIRM) Advisor: Professor Patrick Daugherty, Ph.D. Projects: Discovery and engineering stable peptide inhibitors targeting proteases involved in metastasis. Screening bacterial display libraries to identify antigen motifs specific to autoimmune disease. • Awarded a CIRM fellowship to use protease inhibitor peptides to target and image cancer stem cells • Published results implementing a proof-of-principal study using deep sequencing technology on peptide libraries screened for serum antibody binding in celiac disease 2005-2011 Neuroscience Research Institute (UCSB), Santa Barbara, CA Graduate Researcher Advisor: Professor Stuart Feinstein, Ph.D. Thesis Topic: Involvement of tau in the mechanism of amyloid beta induced neurodegeneration. 2000-2001 Stein Institute for Research on Aging (UCSD), La Jolla, CA Research Associate Advisors: Dr. Dennis Carson, M.D. and Dr. Malini Sen, Ph.D. Research: Wnt / β-catenin signaling pathway involvement in the progression of rheumatoid arthritis.

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Page 1: Reifert CV

Jack R. Reifert

Page 1 of 2

2528 Orella St. Unit B Santa Barbara, CA 93105

Phone: (858) 922-5923 Email: [email protected] EDUCATION 2005-2011 Doctor of Philosophy (Ph.D.) - Molecular, Cellular, and Developmental Biology (MCDB)

University of California, Santa Barbara

1996-2000 Bachelor of Science (B.S.) - Pharmacological Chemistry University of California, San Diego

INDUSTRY RESEARCH EXPERIENCE 2014-Present Serimmune INC., Santa Barbara, CA Scientist • Utilize peptide display screening, deep sequencing, and antigen discovery for patient antibody profiling • Lead scientist on project to identify therapeutic candidates to block autoantibodies in Graves Disease • Discovered motif panels specific to two autoimmune diseases for biomarker development • Developed improved screening and deep sequencing techniques to map patient specific antibody recognition repertoires 2002-2005 Salmedix INC., La Jolla, CA Research Associate

• Investigated mechanism of action, evaluated combination potential, and tested second-generation analogs on small-molecule cancer therapeutics • Bendamustine (Treanda) research supported clinical trials for B-Cell NHL (FDA approval in 2008) • Published results indicating Treanda’s mechanism of action is divergent from other chemotherapies • Designed a functional assay to support IHC scoring when typing patients for inclusion in clinical trials

2001-2002 BD Pharmingen, La Jolla, CA Quality Control Associate I

• Tested antibodies in immunoblotting, ELISA, and flow-cytometry assays for product release

ACADEMIC RESEARCH EXPERIENCE 2011-2014 Chemical Engineering (UCSB), Santa Barbara, CA Postdoctoral Fellow (CIRM) Advisor: Professor Patrick Daugherty, Ph.D. Projects: Discovery and engineering stable peptide inhibitors targeting proteases involved in metastasis. Screening bacterial display libraries to identify antigen motifs specific to autoimmune disease. • Awarded a CIRM fellowship to use protease inhibitor peptides to target and image cancer stem cells • Published results implementing a proof-of-principal study using deep sequencing technology on peptide libraries screened for serum antibody binding in celiac disease 2005-2011 Neuroscience Research Institute (UCSB), Santa Barbara, CA Graduate Researcher Advisor: Professor Stuart Feinstein, Ph.D. Thesis Topic: Involvement of tau in the mechanism of amyloid beta induced neurodegeneration. 2000-2001 Stein Institute for Research on Aging (UCSD), La Jolla, CA Research Associate Advisors: Dr. Dennis Carson, M.D. and Dr. Malini Sen, Ph.D. Research: Wnt / β-catenin signaling pathway involvement in the progression of rheumatoid arthritis.

Page 2: Reifert CV

Jack R. Reifert

Page 2 of 2

SELECTED PUBLICATIONS Pantazes RJ, Reifert J, Isben KN, Guzman E, Zhou HJ, Kosik KS, Daugherty PS. “Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing.” Submitted Feb. 2016 to Scientific Reports Benbow SJ, Cook BM, Reifert J, Wozniak KM, Slusher BS, Littlefield BA, Wilson L, Jordan MA, Feinstein SC. “Effects of Paclitaxel and Eribulin in mouse sciatic nerve: a microtubule-based rationale for the differential induction of chemotherapy-induced peripheral neuropathy.” Neurotox Res. 29(2): 299-313. Feb. 2016 Shropshire TD, Reifert J, Rajagopalan S, Baker D, Feinstein SC, Daugherty PS. “Amyloid β peptide cleavage by kallikrein 7 attenuates fibril growth and rescues neurons from Aβ-mediated toxicity in vitro.” Biol Chem. 395(1): 109-18. Jan. 2014 Reifert J, Hartung-Cranston D, Feinstein S.C. “Amyloid β-mediated cell death of cultured hippocampal neurons reveals extensive tau fragmentation without increased full-length tau phosphorylation.” J Biol Chem. 286(23): 20797-811. Jun. 2011 Sun CJ, Srivastava A, Reifert JR, Waite JH. “Halogenated DOPA in a marine adhesive protein.” J. Adhesion 85(2-3): 126-138. Feb. 2009 Leoni LM, Bailey B, Reifert J, Bendall HH, Zeller RW, Corbeil J, Elliott G, Neimeyer CC. “Bendamustine (Treanda) displays distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents.” Clin Cancer Res. 14(1): 309-17. Jan. 2008

HONORS / AWARDS / SKILL DEVELOPMENT 2012-2014 California Institute for Regenerative Medicine (CIRM) Postdoctoral Fellowship 2010 Nominated and appointed Associate Faculty Member of Faculty of 1000 (F1000) 2008 Shing and Shang-Yung Chang Award for best 4th year graduate research talk 2005 Storke Award for highest achievement in first year graduate coursework CONFERENCES AND MEETINGS 2010 Attended the 40th Society for Neuroscience Annual Meeting, San Diego 2009 Poster Presenter, 49th Meeting for The American Association for Cell Biology (ASCB), San Diego 2008 Poster Presenter, 47th Meeting for The American Association for Cell Biology (ASCB), San Francisco 2007 Attended the 37th Society for Neuroscience Annual Meeting, San Diego 2005 Poster Presenter, 7 Abstracts at the 96th American Association for Cancer Research (AACR), Anaheim 2004 Poster Presenter, 46th American Association of Hematology (ASH), San Diego 2004 Poster Presenter, 5 Abstracts at the 95th American Association for Cancer Research (AACR), Orlando 2003 Poster Presenter, 3 Abstracts at the 94th American Association for Cancer Research (AACR), DC

SELECTED RESEARCH SKILLS Culture of primary and transformed cells FACS analysis and sorting (Aria, FACSCalibur) 3D culture of primary cells Tissue embedding and sectioning (cryo, agarose) In-vivo drug delivery and toxicity analysis Peptide display library design / construction / screening In-vitro enzyme inhibition and activity assays Protein purification and characterization (HPLC) Cell based assays: transfection, growth, toxicity, colony forming, invasion, migration Deep sequencing amplicon library preparation – Ion Proton, HiSeq, NextSeq DNA manipulation: cloning, site-directed mutagenesis, primer design, plasmid construction Protein detection: ELISA, Western blot, Immunofluorescence microscopy (IFM), Immunohistochemistry (IHC) Trained on multiple microscopy systems including fluorescent, confocal, and DSU Computer skills: Microscopy analysis software (Slidebook, Metamorph, Image J, Fluoview), graphing programs (Prism, Excel), MS Office, SAP, Filemaker, FlowJo, Calcusyn. REFERENCES AVAILABLE UPON REQUEST


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