report of the president 2014/2015 - conway institute · many hosts of mycobacteria: tuberculosis,...

47
Report of the President 2014/2015 - Conway Institute >> Book Chapters >> Peer Reviewed Journals >> Other Journals >> Conference Publications >> Other Publications Book Chapters Professor Mohamed Al-Rubeai Shirsat, N., English, N., Glennon B., and Al-Rubeai M. (2015) 'Modelling of mammalian cell cultures. In: Al-Rubeai M. (ed.), 'Animal Cell Culture'' In: Al-Rubeai M (eds). Animal Cell Culture. Dordrecht: Springer. Professor Michael Duffy Duffy (2015) 'Use of Biomarkers in Screening for Cancer' In: Scatena R (eds). Advances in Experimental Medicine and Biology. Netherlands: Springer. , pp.27-39 Professor Stephen Gordon Stephen V. Gordon and Marcel A. Behr (2015) 'Comparative Mycobacteriology of the Mycobacterium tuberculosis complex' In: Mark Chambers, Harshini Mukundan, Michelle Larsen, W. Ray Waters (eds). Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB International. Professor Michael Keane Butler, M McLoughlin, P Keane, M (2015) 'Chemokines, Adipokines, and Growth Factors in the Lung' In: Grippi, M Elias, J Fishman, J Pack, A Senior, R Kotloff, R (eds). Fishman's Pulmonary Diseases and Disorders. Philadelphia: McGraw-Hill. Professor Paul McLoughlin Butler MW, McLoughlin P, Keane MP (2015) 'Chemokines, Adipokines, and Growth Factors in the Lung' In: Michael A. Grippi; co-editors,Jack A. Elias, Jay A. Fishman, Robert M. Kotloff, Allan I. Pack, Robert M. Senior (eds). Fishman's Pulmonary Diseases and Disorders, Fifth Edition. USA: McGraw-Hill Education. Professor Ron Pinhasi Arimura M; Gasparyan B; Nahapetyan S; Pinhasi R (2014) 'Forest Exploitation during the Holocene in the Aghstev valley, Northeast Armenia' In: Gasparyan B; Arimura M (eds). Stone Age of Armenia. Kanazawa, Japan: Center for Cultural Resource Studies, Kanazawa University. , pp.261-282 Smith A; Bagoyan T; Gabrielyan I; Pinhasi R; Gasparyan B (2014) 'Late Chalcolithic and Medieval Archaeobotanical Remains from Areni-1 (Birds¿ Cave), Armenia' In: Gasparyan B; Arimura M (eds). Stone Age of Armenia. Kanazawa, Japan: Center for

Upload: others

Post on 22-May-2020

2 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Report of the President 2014/2015 -

Conway Institute

>> Book Chapters

>> Peer Reviewed Journals

>> Other Journals

>> Conference Publications

>> Other Publications

Book Chapters

Professor Mohamed Al-Rubeai

Shirsat, N., English, N., Glennon B., and Al-Rubeai M. (2015) 'Modelling of

mammalian cell cultures. In: Al-Rubeai M. (ed.), 'Animal Cell Culture'' In: Al-Rubeai M

(eds). Animal Cell Culture. Dordrecht: Springer.

Professor Michael Duffy

Duffy (2015) 'Use of Biomarkers in Screening for Cancer' In: Scatena R (eds). Advances

in Experimental Medicine and Biology. Netherlands: Springer. , pp.27-39

Professor Stephen Gordon

Stephen V. Gordon and Marcel A. Behr (2015) 'Comparative Mycobacteriology of the

Mycobacterium tuberculosis complex' In: Mark Chambers, Harshini Mukundan,

Michelle Larsen, W. Ray Waters (eds). Many Hosts of Mycobacteria: Tuberculosis,

Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK:

CAB International.

Professor Michael Keane

Butler, M McLoughlin, P Keane, M (2015) 'Chemokines, Adipokines, and Growth

Factors in the Lung' In: Grippi, M Elias, J Fishman, J Pack, A Senior, R Kotloff, R

(eds). Fishman's Pulmonary Diseases and Disorders. Philadelphia: McGraw-Hill.

Professor Paul McLoughlin

Butler MW, McLoughlin P, Keane MP (2015) 'Chemokines, Adipokines, and Growth

Factors in the Lung' In: Michael A. Grippi; co-editors,Jack A. Elias, Jay A. Fishman,

Robert M. Kotloff, Allan I. Pack, Robert M. Senior (eds). Fishman's Pulmonary

Diseases and Disorders, Fifth Edition. USA: McGraw-Hill Education.

Professor Ron Pinhasi

Arimura M; Gasparyan B; Nahapetyan S; Pinhasi R (2014) 'Forest Exploitation during

the Holocene in the Aghstev valley, Northeast Armenia' In: Gasparyan B; Arimura M

(eds). Stone Age of Armenia. Kanazawa, Japan: Center for Cultural Resource Studies,

Kanazawa University. , pp.261-282

Smith A; Bagoyan T; Gabrielyan I; Pinhasi R; Gasparyan B (2014) 'Late Chalcolithic

and Medieval Archaeobotanical Remains from Areni-1 (Birds¿ Cave), Armenia' In:

Gasparyan B; Arimura M (eds). Stone Age of Armenia. Kanazawa, Japan: Center for

Page 2: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Cultural Resource Studies, Kanazawa University. , pp.233-260

Stapleton L; Margaryan L; Areshyan GE; Pinhasi R; Gasparyan B (2014) 'Weaving the

Ancient Past: Chalcolithic Basket and Textile Technology at the Areni-1 Cave, Armenia'

In: Gasparyan B; Arimura M (eds). Stone Age of Armenia. Kanazawa, Japan: Center for

Cultural Resource Studies, Kanazawa University. , pp.219-232

Gasparyan B; Egeland CP; Adler DS; Pinhasi R; Glauberman P; Haydosyan H. (2014)

'The Middle Paleolithic Occupation of Armenia: Summarizing Old and New Data' In:

Gasparyan B; Arimura M (eds). Stone Age of Armenia. Kanazawa, Japan: Center for

Cultural Resource Studies, Kanazawa University. , pp.65-106

Back to Top

Peer Reviewed Journals

Professor Mohamed Al-Rubeai

Shirsat N., Avesh M., Whelan J., English N., Glennon B., Al-Rubeai M. (2015)

'Revisiting Verhulst and Monod models: analysis of batch and fed-batch culture'.

Cytotechnology, 67 (3):515-530.

Professor Alan Baird

Medani M, Collins D;Mohan HM;Walsh E;Winter DC;Baird AW (2015) 'Prostaglandin

D2 regulates human colonic ion transport via the DP1 receptor'. Life Sciences, 122 :87-

91.

Dr John Andrew Baugh

Glezeva, N. and Voon, V. and Watson, C. and Horgan, S. and McDonald, K. and

Ledwidge, M. and Baugh, J. (2015) 'Exaggerated inflammation and monocytosis

associate with diastolic dysfunction in heart failure with preserved ejection fraction:

Evidence of M2 macrophage activation in disease pathogenesis'. Journal of Cardiac

Failure, 21 (2):167-177.

Glezeva N, Voon V, Watson C, Horgan S, McDonald K, Ledwidge M, Baugh J. (2014)

'Exaggerated inflammation and monocytosis associate with diastolic dysfunction in

Heart Failure with Preserved Ejection Fraction: evidence of M2 macrophage activation

in disease pathogenesis'. Journal of cardiac failure .

Finucane OM, Reynolds CM, McGillicuddy FC, Harford KA, Morrison M, Baugh

J,Roche HM (2014) 'Macrophage migration inhibitory factor deficiency ameliorates

high-fat diet induced insulin resistance in mice with reduced adipose inflammation and

hepatic steatosis'. PLoS ONE .

Murtagh G, O Connell J, O Connell E, Tallon E, Watson C, Gallagher J, Baugh J, Patle

A, O Connell L, Griffin J, O' Hanlon R, Voon V, Ledwidge M, O Shea D, McDonald K

(2014) 'Importance of Risk Factor Management in Diabetic Patients & Reduction in

Stage B Heart Failure'. Quarterly Journal of Medicine .

Horgan S, Watson C, Glezeva N, Baugh J (2014) 'Murine models of diastolic

dysfunction and heart failure with preserved ejection fraction'. Journal of cardiac failure

.

Dr Orina Belton

Di Francesco L, Dovizio M, Trenti A, Marcantoni E, Moore A, O Gaora P, McCarthy C,

Tacconelli S, Bruno A, Alberti S, Gizzo S, Nardelli GB, Orso G, Belton O, Trevisi L,

Dixon DA, Patrignani P (2015) 'Dysregulated post-transcriptional control of COX-2

Page 3: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

gene expression in gestational diabetic endothelial cells'. British Journal of

Pharmacology .

Marcantoni E, Dovizio M, O Gaora P, Di Francesco L, Bendaya I, Schiavone S, Trenti

A, Guillem-Llobat P, Zambon A, Nardelli GB, Trevisi L, Patrignani P, Belton O (2015)

'Dysregulation of gene expression in human fetal endothelial cells from gestational

diabetes in response to TGF-β1'. Prostaglandins and Other Lipid Mediators .

Marcone S, Haughton K, Simpson PJ, Belton O, Fitzgerald DJ (2015) 'Milk-derived

bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ

dependent regulation of NF-κB'. Journal of inflammation (London, England), 12 (1).

de Gaetano M, Alghamdi K, Marcone S, Belton O (2015) 'Conjugated linoleic acid

induces an atheroprotective macrophage MΦ2 phenotype and limits foam cell formation'.

Journal of inflammation (London, England), 12 .

Dr Oliver Blacque

Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TM, Racher H, Phelps IG,

Toedt G, Kennedy J, 60 other authors, Blacque OE, Gleeson JG, Wolfrum U, Beales PL,

Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA. (2015) 'An siRNA-

based functional genomics screen for the identification of regulators of ciliogenesis and

ciliopathy genes'. Nature Cell Biology .

Sanders AA, Kennedy J;Blacque OE (2015) 'Image analysis of Caenorhabditis elegans

ciliary transition zone structure, ultrastructure, molecular composition, and function'.

Methods in Cell Biology, 127 :323-347.

Lambacher NJ, Bruel A-L, van Dam JPT, Szymańska K, Slaats GG, Kuhns S, McManus

GJ, Kennedy JK, Gaff K, Man Wu K, van der Lee R, Burglen L, Doummar D, Rivière J-

B, Faivre L, Attié-Bitach T, Saunier S, Curd A, Peckham M, Giles RH, Johnson CA,

Huynen MA, Thauvin-Robinet C, Blacque OE. (2015) 'TMEM107 recruits ciliopathy

proteins to subdomains of the ciliary transition zone membrane and causes Joubert

syndrome'. Nature Cell Biology .

Professor David Brayden

Bhattacharjee S. & Brayden D. J (2015) 'Development of nanotoxicology: implications

for drug delivery and medical devices'. Nanomedicine, 10 (14):2289-2305.

Brayden DJ, Maher S, Bahar B, Walsh E (2015) 'Sodium caprate-induced increases in

intestinal permeability and epithelial damage are prevented by misoprostol'. European

journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft

fur Pharmazeutische Verfahrenstechnik e.V .

Brayden DJ, Cryan SA, Dawson KA, O'Brien PJ, Simpson JC (2015) 'High-content

analysis for drug delivery and nanoparticle applications'. Drug Discovery Today .

Aguirre TA, Rosa M, Guterres SS, Pohlmann AR, Coulter I, Brayden DJ (2014)

'Investigation of coco-glucoside as a novel intestinal permeation enhancer in rat models'.

European journal of pharmaceutics and biopharmaceutics : official journal of

Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88 (3):856-865.

Brayden DJ, Gleeson J, Walsh EG (2014) 'A head-to-head multi-parametric high content

analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-

2 cells'. European journal of pharmaceutics and biopharmaceutics : official journal of

Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88 (3):830-839.

Ryan, SM & Brayden DJ (2014) 'Progress in the delivery of nanoparticle constructs:

towards clinical translation'. Current Opinion in Pharmacology, 18 :120-128.

Page 4: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

O'Connor A, Marsat JN, Mitrugno A, Flahive T, Moran N, Brayden D, Devocelle M

(2014) 'Poly(Ethylene glycol)-based backbones with high Peptide loading capacities'.

Molecules, 19 (11):17559-17577.

Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy EP,

Brayden D, Veale DJ, Fearon U. (2014) 'Redox mediated angiogenesis in the hypoxic

joint of inflammatory arthritis'. Arthritis and Rheumatism .

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL,

Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M,

Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J,

O'Boyle KM, Williams CH, Hardiman O (2014) 'First-in-class thyrotropin-releasing

hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor

subtype in human brain and is effective in neurodegenerative models'.

Neuropharmacology, 89C :193-203.

Brayden DJ, Walsh E (2014) 'Efficacious intestinal permeation enhancement induced by

the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative'. AAPS

Journal, 16 (5):1064-1076.

Professor Lorraine Brennan

Marsaux, C. F., Celis-Morales, C., Fallaize, R., Macready, A. L., Kolossa, S.,

Woolhead, C., O'Donovan, C. B., Forster, H., Navas-Carretero, S., San-Cristobal, R.,

Lambrinou, C. P., Moschonis, G., Surwillo, A., Godlewska, M., Goris, A., Hoonhout, J.,

Drevon, C. A., Manios, Y., Traczyk, I., Walsh, M. C., Gibney, E. R., Brennan, L.,

Martinez, J. A., Lovegrove, J. A., Gibney, M. J., Daniel, H., Mathers, J. C., Saris, W. H.

(2015) 'Effects of a Web-Based Personalized Intervention on Physical Activity in

European Adults: A Randomized Controlled Trial'. J Med Internet Res, 17 (10).

Morris, C., O'Grada, C. M., Ryan, M. F., Gibney, M. J., Roche, H. M., Gibney, E. R.,

Brennan, L. (2015) 'Modulation of the lipidomic profile due to a lipid challenge and

fitness level: a postprandial study'. Lipids Health Dis, 14 .

Livingstone, K. M., Celis-Morales, C., Lara, J., Ashor, A. W., Lovegrove, J. A.,

Martinez, J. A., Saris, W. H., Gibney, M., Manios, Y., Traczyk, I., Drevon, C. A.,

Daniel, H., Gibney, E. R., Brennan, L., Bouwman, J., Grimaldi, K. A., Mathers, J. C.,

Food4Me, (2015) 'Associations between FTO genotype and total energy and

macronutrient intake in adults: a systematic review and meta-analysis'. Obes Rev, 16

(8):666-78.

Matone, A., O'Grada, C. M., Dillon, E. T., Morris, C., Ryan, M. F., Walsh, M., Gibney,

E. R., Brennan, L., Gibney, M. J., Morine, M. J., Roche, H. M. (2015) 'Body mass index

mediates inflammatory response to acute dietary challenges'. Mol Nutr Food Res .

O'Donovan, C. B., Walsh, M. C., Gibney, M. J., Gibney, E. R., Brennan, L. (2015) 'Can

metabotyping help deliver the promise of personalised nutrition?'. Proc Nutr Soc, :1-9.

Woolhead, C., Gibney, M. J., Walsh, M. C., Brennan, L., Gibney, E. R. (2015) 'A

generic coding approach for the examination of meal patterns'. American Journal of

Clinical Nutrition, 102 (2):316-23.

Morris C, O'Grada CM, Ryan MF, Gibney MJ, Roche HM, Gibney ER, Brennan L

(2015) 'Modulation of the lipidomic profile due to a lipid challenge and fitness level: a

postprandial study'. Lipids in Health and Disease, 14 (1).

Forster, H., Walsh, M. C., Gibney, M. J., Brennan, L., Gibney, E. R. (2015)

'Personalised nutrition: the role of new dietary assessment methods'. Proc Nutr Soc, :1-

Page 5: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

10.

Leite, J. C., Forte, R., de Vito, G., Boreham, C. A., Gibney, M. J., Brennan, L., Gibney,

E. R. (2015) 'Comparison of the effect of multicomponent and resistance training

programs on metabolic health parameters in the elderly'. Arch Gerontol Geriatr, 60

(3):412-7.

Leite JC, Forte R, de Vito G, Boreham CA, Gibney MJ, Brennan L, Gibney ER (2015)

'Comparison of the effect of multicomponent and resistance training programs on

metabolic health parameters in the elderly'. Archives Of Gerontology And Geriatrics, 60

(3):412-417.

Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R.,

O'Donovan, C. B., Forster, H., Woolhead, C., Marsaux, C. F., Macready, A. L., Fallaize,

R., Kolossa, S., Tsirigoti, L., Lambrinou, C. P., Moschonis, G., Godlewska, M.,

Surwillo, A., Drevon, C. A., Manios, Y., Traczyk, I., Gibney, E. R., Brennan, L., Walsh,

M. C., Lovegrove, J. A., Alfredo Martinez, J., Saris, W. H., Daniel, H., Gibney, M.,

Mathers, J. C. (2015) 'Profile of European adults interested in internet-based

personalised nutrition: the Food4Me study'. Eur J Nutr .

Lindsay KL, Brennan L;Kennelly MA;Maguire OC;Smith T;Curran S;Coffey M;Foley

ME;Hatunic M;Shanahan F;McAuliffe FM (2015) 'Impact of probiotics in women with

gestational diabetes mellitus on metabolic health: a randomized controlled trial'.

American Journal of Obstetrics and Gynecology, 212 (4):4960-4911.

Gibbons H, McNulty BA;Nugent AP;Walton J;Flynn A;Gibney MJ;Brennan L (2015)

'A metabolomics approach to the identification of biomarkers of sugar-sweetened

beverage intake'. The American journal of clinical nutrition, 101 (3):471-477.

O'Donovan, C. B., Walsh, M. C., Nugent, A. P., McNulty, B., Walton, J., Flynn, A.,

Gibney, M. J., Gibney, E. R., Brennan, L. (2015) 'Use of metabotyping for the delivery

of personalised nutrition'. Mol Nutr Food Res, 59 (3):377-85.

Lindsay KL, Brennan L, Kennelly MA, Maguire OC, Smith T, Curran S, Coffey M,

Foley ME, Hatunic M, Shanahan F, McAuliffe FM (2015) 'Impact of probiotics in

women with gestational diabetes mellitus on metabolic health: A randomized controlled

trial'. American Journal of Obstetrics and Gynecology .

Celis-Morales, C., Livingstone, K. M., Marsaux, C. F., Forster, H., O'Donovan, C. B.,

Woolhead, C., Macready, A. L., Fallaize, R., Navas-Carretero, S., San-Cristobal, R.,

Kolossa, S., Hartwig, K., Tsirigoti, L., Lambrinou, C. P., Moschonis, G., Godlewska,

M., Surwillo, A., Grimaldi, K., Bouwman, J., Daly, E. J., Akujobi, V., O'Riordan, R.,

Hoonhout, J., Claassen, A., Hoeller, U., Gundersen, T. E., Kaland, S. E., Matthews, J.

N., Manios, Y., Traczyk, I., Drevon, C. A., Gibney, E. R., Brennan, L., Walsh, M. C.,

Lovegrove, J. A., Alfredo Martinez, J., Saris, W. H., Daniel, H., Gibney, M., Mathers, J.

C. (2015) 'Design and baseline characteristics of the Food4Me study: a web-based

randomised controlled trial of personalised nutrition in seven European countries'. Genes

Nutr, 10 (1).

Livingstone, K.M. and Celis-Morales, C. and Navas-Carretero, S. and San-Cristobal, R.

and Oâ¿¿Donovan, C.B. and Forster, H. and Woolhead, C. and Marsaux, C.F.M. and

Macready, A.L. and Fallaize, R. and Kolossa, S. and Tsirigoti, L. and Lambrinou, C.P.

and Moschonis, G. and Godlewska, M. and Surwiſſo, A. and Drevon, C.A. and

Manios, Y. and Traczyk, I. and Gibney, E.R. and Brennan, L. and Walsh, M.C. and

Lovegrove, J.A. and Alfredo Martinez, J. and Saris, W.H. and Daniel, H. and Gibney,

M. and Mathers, J.C. (2015) 'Profile of European adults interested in internet-based

personalised nutrition: the Food4Me study'. European Journal of Nutrition .

Page 6: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

O'Donovan, C.B. and Walsh, M.C. and Nugent, A.P. and Mcnulty, B. and Walton, J. and

Flynn, A. and Gibney, M.J. and Gibney, E.R. and Brennan, L. (2015) 'Use of

metabotyping for the delivery of personalised nutrition'. Molecular Nutrition and Food

Research .

González-Guardia, L. and Yubero-Serrano, E.M. and Delgado-Lista, J. and Perez-

Martinez, P. and Garcia-Rios, A. and Marin, C. and Camargo, A. and Delgado-Casado,

N. and Roche, H.M. and Perez-Jimenez, F. and Brennan, L. and López-Miranda, J.

(2015) 'Effects of the mediterranean diet supplemented with coenzyme Q10 on

metabolomic profiles in elderly men and women'. Journals of Gerontology - Series A

Biological Sciences and Medical Sciences, 70 (1):78-84.

Gibbons, H. and O'Gorman, A. and Brennan, L. (2015) 'Metabolomics as a tool in

nutritional research'. Current Opinion in Lipidology, 26 (1):30-34.

Lindsay KL, Heneghan C, McNulty B, Brennan L, McAuliffe FM (2015) 'Lifestyle and

dietary habits of an obese pregnant cohort'. Maternal and Child Health Journal, 19

(1):25-32.

Lindsay, K.L. and Heneghan, C. and McNulty, B. and Brennan, L. and McAuliffe, F.M.

(2015) 'Lifestyle and Dietary Habits of an Obese Pregnant Cohort'. Maternal and child

health journal, 19 (1):25-32.

Nyamundanda, G., Gormley, I.C. and Brennan, L. (2014) 'A dynamic probabilistic

principal components model for the analysis of longitudinal metabolomics data'. Journal

of the Royal Statistical Society: Series C (Applied Statistics) .

Walsh JM, Wallace M, Brennan L, McAuliffe FM (2014) 'Early pregnancy maternal

urinary metabolomic profile and later insulin resistance and fetal adiposity'. Journal of

Maternal-Fetal and Neonatal Medicine, :1-4.

Lindsay KL, Brennan L, McAuliffe FM (2014) 'Reply to C Griffin'. The Journal of

clinical nutrition, 100 (4):1209-1210.

O'Gorman A, Morris C, Ryan M, O'Grada CM, Roche HM, Gibney ER, Gibney MJ,

Brennan L (2014) 'Habitual dietary intake impacts on the lipidomic profile'. Journal of

Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 966

:140-146.

O'Gorman, A., Morris, C., Ryan, M., O'Grada, C. M., Roche, H. M., Gibney, E. R.,

Gibney, M. J., Brennan, L. (2014) 'Habitual dietary intake impacts on the lipidomic

profile'. J Chromatogr B Analyt Technol Biomed Life Sci, 966 :140-6.

O'Doherty AM, O'Gorman A, al Naib A, Brennan L, Daly E, Duffy P, Fair T (2014)

'Negative energy balance affects imprint stability in oocytes recovered from postpartum

dairy cows'. Genomics, 104 (3):177-185.

Professor Geraldine Butler

Branco J, Silva AP, Silva RM, Silva-Dias A, Pina-Vaz C, Butler G, Rodrigues AG,

Miranda IM. (2015) 'Fluconazole and Voriconazole Resistance in Candida parapsilosis

Is Conferred by Gain-of-Function Mutations in MRR1 Transcription Factor Gene'.

Antimicrobial Agents and Chemotherapy, 59 :6629-6633.

Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A, Ames L,

Haynes K, Higgins DG, Butler G. (2014) 'Comparative Phenotypic Analysis of the

Major Fungal Pathogens Candida parapsilosis and Candida albicans'. PLoS Pathogens,

10 .

Turner SA, Butler G (2014) 'The Candida Pathogenic Species Complex'. Cold Spring

Page 7: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Harbor Perspectives in Medicine, 4 .

Dr Gerard Cagney

Munawar N, Olivero G;Jerman E;Doyle B;Streubel G;Wynne K;Bracken A;Cagney G

(2015) 'Native gel analysis of macromolecular protein complexes in cultured

mammalian cells'. Proteomics .

Farrelly L, Föcking M; Piontkewitz Y; Dicker P; English J; Wynne K; Cannon M;

Cagney G; Cotter DR (2015) 'Maternal immune activation induces changes in myelin

and metabolic proteins, some of which can be prevented with risperidone in

adolescence'. Developmental Neuroscience, 37 (1):43-55.

Föcking M, Lopez LM, English JA, Dicker P, Wolff A, Brindley E, Wynne K, Cotter

DR, Cagney G (2015) 'Proteomic and genomic evidence implicates the postsynaptic

density in schizophrenia'. Molecular Psychiatry .

Professor Dolores Cahill

Christianson DR, Dobroff AS;Proneth B;Zurita AJ;Salameh A;Dondossola E;Makino

J;Bologa CG;Smith TL;Yao VJ;Calderone TL;O'Connell DJ;Oprea TI;Kataoka K;Cahill

DJ;Gershenwald JE;Sidman RL;Arap W;Pasqualini R (2015) 'Ligand-directed targeting

of lymphatic vessels uncovers mechanistic insights in melanoma metastasis'.

Proceedings of the National Academy of Sciences of the United States of America, 112

(8):2521-2526.

Dr Marguerite Clyne

Ryan, A. and Smith, A. and Moore, P. and McNally, S. and Carrington, S.D. and Reid,

C.J. and Clyne, M. (2015) 'Expression and characterization of a novel recombinant

version of the secreted human mucin MUC5AC in airway cell lines'. Biochemistry, 54

(4):1089-1099.

Professor Mark Crowe

Parr, M. H. and Crowe, M. A. and Lonergan, P. and Evans, A. C. O. and Fair, T. and

Diskin, M. G. (2015) 'The concurrent and carry over effects of long term changes in

energy intake before insemination on pregnancy per artificial insemination in heifers'.

Animal Reproduction Science, 157 :87-94.

Aungier SP, Roche JF;Duffy P;Scully S;Crowe MA (2015) 'The relationship between

activity clusters detected by an automatic activity monitor and endocrine changes during

the periestrous period in lactating dairy cows'. Journal of Dairy Science, 98 (3):1666-

1684.

Crowe MA, Williams EJ, Mulligan FJ (2015) 'Physiological and health factors affecting

fertility in beef and dairy cows'. Cattle Practice, 23 (1):47-61.

Scully, S. and Evans, A.C.O. and Carter, F. and Duffy, P. and Lonergan, P. and Crowe,

M.A. (2015) 'Ultrasound monitoring of blood flow and echotexture of the corpus luteum

and uterus during early pregnancy of beef heifers'. Theriogenology, 83 (3):449-458.

Beltman ME, Walsh SW;Canty MJ;Duffy P;Crowe MA (2014) 'Hormonal composition

of follicular fluid from abnormal follicular structures in mares'. Research in Veterinary

Science, 97 (3):488-490.

McNally JC, Crowe MA, Roche JF, Beltman ME (2014) 'Effects of physiological and/or

disease status on the response of postpartum dairy cows to synchronization of estrus

using an intravaginal progesterone device'. Theriogenology, 82 (9):1263-1272.

Page 8: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Parr MH, Crowe MA, Lonergan P, Evans AC, Rizos D, Diskin MG (2014) 'Effect of

exogenous progesterone supplementation in the early luteal phase post-insemination on

pregnancy per artificial insemination in Holstein-Friesian cows'. Animal Reproduction

Science, 150 (1-2):7-14.

Professor Michael Duffy

Caiazza F, McGowan PM;Mullooly M;Murray A;Synnott N;O'Donovan N;Flanagan

L;Tape CJ;Murphy G;Crown J;Duffy MJ (2015) 'Targeting ADAM-17 with an

inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer

cells'. British Journal of Cancer, 112 (12):1895-1903.

Duffy MJ, Walsh S, McDermott EW, Crown J. (2015) 'Biomarkers in Breast Cancer:

Where Are We and Where Are We Going?'. Advances in Clinical Chemistry, 71 :1-23.

Duffy MJ, Sturgeon CM;Sölétormos G;Barak V;Molina R;Hayes DF;Diamandis

EP;Bossuyt PM (2015) 'Validation of new cancer biomarkers: a position statement from

the European group on tumor markers'. Clinical Chemistry, 61 (6):809-820.

Duffy MJ (2015) 'Personalized treatment for patients with colorectal cancer: role of

biomarkers'. Biomarkers in Medicine, 9 :337-347.

Duffy MJ, Synnott NC, McGowan PM, Crown J, O'Connor D, Gallagher WM. (2014)

'p53 as a target for the treatment of cancer'. Cancer Treatment Reviews, 40 :1153-1160.

Duffy MJ, Crown J, Mullooly M. (2014) 'ADAM10 and ADAM17: New players in

trastuzumab tesistance'. Oncotarget, 30 :10963-10964.

Duffy MJ (2014) 'PSA in screening for prostate cancer: more good than harm or more

harm than good?'. Advances in Clinical Chemistry, 66 :1-23.

Duffy MJ, Crown J (2014) 'Monitoring response to therapy in patients with cancer: is

circulating DNA the answer?'. Annals of Translational Medicine, 1 (3).

Professor Jim Egan

Egan J (2015) 'Challenges in IPF diagnosis, current management and future

perspectives: Patient case 1'. Sarcoidosis, vasculitis, and diffuse lung diseases : official

journal of WASOG / World Association of Sarcoidosis and Other Granulomatous

Disorders, 32 (1 Suppl):36-37.

Professor Alexander Evans

Zhao S, Liu ZX;Gao H;Wu Y;Fang Y;Wu SS;Li MJ;Bai JH;Liu Y;Evans A;Zeng SM

(2015) 'A three-dimensional culture system using alginate hydrogel prolongs hatched

cattle embryo development in vitro'. Theriogenology, 84 (2):184-192.

Murphy BA, Blake CM;Brown JA;Martin AM;Forde N;Sweeney LM;Evans AC (2015)

'Evidence of a molecular clock in the ovine ovary and the influence of photoperiod'.

Theriogenology, 84 (2):208-216.

Parr, M. H. and Crowe, M. A. and Lonergan, P. and Evans, A. C. O. and Fair, T. and

Diskin, M. G. (2015) 'The concurrent and carry over effects of long term changes in

energy intake before insemination on pregnancy per artificial insemination in heifers'.

Animal Reproduction Science, 157 :87-94.

Jimenez-Krassel F, Scheetz DM;Neuder LM;Ireland JL;Pursley JR;Smith

GW;Tempelman RJ;Ferris T;Roudebush WE;Mossa F;Lonergan P;Evans AC;Ireland JJ

(2015) 'Concentration of anti-Mullerian hormone in dairy heifers is positively associated

with productive herd life'. Journal of Dairy Science, 98 (5):3036-3045.

Page 9: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Scully, S. and Evans, A.C.O. and Carter, F. and Duffy, P. and Lonergan, P. and Crowe,

M.A. (2015) 'Ultrasound monitoring of blood flow and echotexture of the corpus luteum

and uterus during early pregnancy of beef heifers'. Theriogenology, 83 (3):449-458.

Parr MH, Crowe MA, Lonergan P, Evans AC, Rizos D, Diskin MG (2014) 'Effect of

exogenous progesterone supplementation in the early luteal phase post-insemination on

pregnancy per artificial insemination in Holstein-Friesian cows'. Animal Reproduction

Science, 150 (1-2):7-14.

Zielak-Steciwko AE, Browne JA, McGettigan PA, Gajewska M, DziĿcioſ M, Szulc

T, Evans AC (2014) 'Expression of microRNAs and their target genes and pathways

associated with ovarian follicle development in cattle'. Genomics, 46 (19):735-745.

Tharmalingam-Jaikaran T, Walsh SW, McGettigan PA, Potter O, Struwe WB, Evans

AC, Rudd PM, Carrington S (2014) 'N-glycan profiling of bovine follicular fluid at key

dominant follicle developmental stages'. Reproduction .

Dr Paul Evans

Read Zaidan, Shaun Smullen and Paul Evans (2015) 'Asymmetric synthesis of (+)- and

(-)-deoxyfebrifugine and deoxyhalofuginone'. Tetrahedron Letters, 56 :6433-6435.

Cleary JA, Doherty W, Evans P, Malthouse JP. (2015) 'Quantifying tetrahedral adduct

formation and stabilization in the cysteine and the serine proteases'. Biochimica et

Biophysica Acta - Proteins and Proteomics, 1854 :1382-1391.

Dr Aurelie Fabre

Barnes JC, Lumsden RV;Worrell J;Counihan IP;O'Beirne SL;Belperio JA;Fabre

A;Donnelly SC;Boylan D;Kane R;Keane MP (2015) 'CXCR3 Requirement for the

Interleukin-13-Mediated Up-Regulation of Interleukin-13R¿¿2 in Pulmonary

Fibroblasts'. American Journal of Respiratory Cell and Molecular Biology, 53 (2):217-

225.

Roy AK, Fabre A;Cunningham M;Buckley U;Crotty T;Keane D (2015) 'Post mortem

study of the depth and circumferential location of sympathetic nerves in human renal

arteries--implications for renal denervation catheter design'. Catheterization and

cardiovascular interventions : official journal of the Society for Cardiac Angiography &

Interventions, 86 (2):1-7.

Lumsden RV, Worrell JC;Boylan D;Walsh SM;Cramton J;Counihan I;O'Beirne

S;Medina MF;Gauldie J;Fabre A;Donnelly SC;Kane R;Keane MP (2015) 'Modulation of

pulmonary fibrosis by IL-13R¿¿2'. American Journal of Physiology - Lung Cellular and

Molecular Physiology, 308 (7):1-8.

Dodd JD, Lavelle LP;Fabre A;Brady D (2015) 'Imaging in cystic fibrosis and non-cystic

fibrosis bronchiectasis'. Seminars in Respiratory and Critical Care Medicine, 36

(2):194-206.

Foley RW, Maweni RM;Fabre A;Healy DG (2015) 'Aggressive behaviour of metastatic

melanoma in a patient with neurofibromatosis type 1'. Case reports in surgery, 2015 .

Cramton JL, Counihan IP, Kane R, Belperio JA, Lumsden RV, O'Beirne SL, Boylan D,

Reviriego C, Fabre A, Xue YY, Grusby M, Strieter RM, Keane MP (2014) 'CXCR3 is

required for the IL-13 mediated upregulation of IL-13Rα2 in pulmonary fibroblasts'.

American Journal of Respiratory Cell and Molecular Biology .

Professor Oliver Fitzgerald

Collins ES, Butt AQ;Gibson DS;Dunn MJ;Fearon U;van Kuijk AW;Gerlag

Page 10: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

DM;Pontifex E;Veale DJ;Tak PP;FitzGerald O;Pennington SR (2015) 'A clinically

based protein discovery strategy to identify potential biomarkers of response to anti-

TNF-¿¿ treatment of psoriatic arthritis'. Proteomics - Clinical Applications .

Mc Ardle A, Flatley B;Pennington SR;FitzGerald O (2015) 'Early biomarkers of joint

damage in rheumatoid and psoriatic arthritis'. Arthritis Research and Therapy, 17 .

Humby F, Kelly S;Bugatti S;Manzo A;Filer A;Mahto A;Fonseca JE;Lauwerys

B;D'Agostino MA;Naredo E;Lories R;Montecucco C;Tak PP;Fitzgerald O;Smith

MD;Veale DJ;Choy EH;Strand V;Pitzalis C (2015) 'Evaluation of Minimally Invasive,

Ultrasound-guided Synovial Biopsy Techniques by the OMERACT Filter-determining

Validation Requirements'. Rheumatology .

Haroon M, Gallagher P;FitzGerald O (2015) 'Diagnostic delay of more than 6¿¿¿months

contributes to poor radiographic and functional outcome in psoriatic arthritis'. Annals of

the Rheumatic Diseases, 74 (6):1045-1050.

FitzGerald O, Haroon M;Giles JT;Winchester R (2015) 'Concepts of pathogenesis in

psoriatic arthritis: genotype determines clinical phenotype'. Arthritis Research and

Therapy, 17 .

Butt AQ, McArdle A;Gibson DS;FitzGerald O;Pennington SR (2015) 'Psoriatic arthritis

under a proteomic spotlight: application of novel technologies to advance diagnosis and

management'. Current Rheumatology Reports, 17 (5).

Harty L, O'Toole G;FitzGerald O (2015) 'Profound reduction in hospital admissions and

musculoskeletal surgical procedures for rheumatoid arthritis with concurrent changes in

clinical practice (1995-2010)'. Rheumatology [formerly the British journal of

rheumatology], 54 (4):666-671.

Bowes J, Budu-Aggrey A;Huffmeier U;Uebe S;Steel K;Hebert HL;Wallace C;Massey

J;Bruce IN;Bluett J;Feletar M;Morgan AW;Marzo-Ortega H;Donohoe G;Morris

DW;Helliwell P;Ryan AW;Kane D;Warren RB;Korendowych E;Alenius GM;Giardina

E;Packham J;McManus R;FitzGerald O;McHugh N;Brown MA;Ho P;Behrens

F;Burkhardt H;Reis A;Barton A (2015) 'Dense genotyping of immune-related

susceptibility loci reveals new insights into the genetics of psoriatic arthritis'. Nature

Communications, 6 .

Butt, A.Q. and McArdle, A. and Gibson, D.S. and FitzGerald, O. and Pennington, S.R.

(2015) 'Psoriatic Arthritis Under a Proteomic Spotlight: Application of Novel

Technologies to Advance Diagnosis and Management'. Current Rheumatology Reports,

17 (5):1-12.

Mc Ardle, A. and Flatley, B. and Pennington, S.R. and FitzGerald, O. (2015) 'Early

biomarkers of joint damage in rheumatoid and psoriatic arthritis'. Arthritis Research and

Therapy .

Emery P, Hammoudeh M;FitzGerald O;Combe B;Martin-Mola E;Buch MH;Krogulec

M;Williams T;Gaylord S;Pedersen R;Bukowski J;Vlahos B (2014) 'Sustained remission

with etanercept tapering in early rheumatoid arthritis'. New England Journal of

Medicine, 371 (19):1781-1792.

Acosta Felquer ML, Coates LC;Soriano ER;Ranza R;Espinoza LR;Helliwell

PS;FitzGerald O;McHugh N;Roussou E;Mease PJ (2014) 'Drug therapies for peripheral

joint disease in psoriatic arthritis: a systematic review'. Rheumatology, 41 (11):2277-

2285.

Minnock P, McKee G;Bresnihan B;FitzGerald O;Veale DJ (2014) 'How much is fatigue

explained by standard clinical characteristics of disease activity in patients with

Page 11: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

inflammatory arthritis? A longitudinal study'. Arthritis Care and Research, 66

(11):1597-1603.

Haroon M, Winchester R;Giles JT;Heffernan E;FitzGerald O (2014) 'Certain class I

HLA alleles and haplotypes implicated in susceptibility play a role in determining

specific features of the psoriatic arthritis phenotype'. Annals of the Rheumatic Diseases .

Professor William Gallagher

O'Hurley G, Busch C, Fagerberg L, Hallström BM, Stadler C, Tolf A, Lundberg

E,Schwenk JM, Jirström K, Bjartell A, Gallagher WM, Uhlén M, Pontén F (2015)

'Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and

Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic

Markers in Prostate Cancer'. PLoS ONE, 10 (8).

Vizoso M, Ferreira HJ, Lopez-Serra P, Carmona FJ, Martínez-Cardús A, Girotti MR,

Villanueva A, Guil S, Moutinho C, Liz J, Portela A, Heyn H, Moran S, Vidal

A,Martinez-Iniesta M, Manzano JL,Fernandez-Figueras MT, Elez E, Muñoz-Couselo

E,Botella-Estrada R, Berrocal A, Pontén F, Oord Jv, Gallagher WM, Frederick

DT,Flaherty KT, McDermott U, Lorigan P, Marais R, Esteller M (2015) 'Epigenetic

activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting

EGFR'. Nature Medicine, 21 (7):741-750.

van den Hurk K, Balint B, Toomey S, O'Leary PC, Unwin L, Sheahan K, McDermott

EW, Murphy I, van den Oord JJ, Rafferty M, FitzGerald DM, Moran J, Cummins

R,MacEneaney O, Kay EW, O'Brien CP, Finn SP, Heffron CC, Murphy M, Yela R,

Power DG, Regan PJ, McDermott CM, O'Keeffe A, Orosz Z, Donnellan PP, Crown JP,

Hennessy BT, Gallagher WM. (2015) 'High-throughput oncogene mutation profiling

shows demographic differences in BRAF mutation rates among melanoma patients'.

Melanoma Research, 25 (3):189-199.

Mischak H, Critselis E, Hanash S, Gallagher WM, Vlahou A, Ioannidis JP. (2015)

'Epidemiologic design and analysis for proteomic studies: a primer on -omic

technologies'. American Journal of Epidemiology, 181 (9):635-647.

Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F,

Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR,

Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirström K,Yakkundi A,

McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O'Connor D, Robson T

(2015) 'FKBPL: a marker of good prognosis in breast cancer'. Oncotarget, 6 (14):12209-

12223.

Murphy L, Prencipe M, Gallagher WM, Watson RW (2015) 'Commercialized

biomarkers: new horizons in prostate cancer diagnostics'. Expert Review of Molecular

Diagnostics, 15 (4):491-503.

Szwej, E. and Devocelle, M. and Kenny, S. and Guzik, M. and O'Connor, S. and

Nikodinovic-Runic, J. and Radivojevic, J. and Maslak, V. and Byrne, A.T. and

Gallagher, W.M. and Zulian, Q.R. and Zinn, M. and O'Connor, K.E. (2015) 'The chain

length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity

and structure of anti-cancer peptides'. Journal of Biotechnology, 204 :7-12.

Jarzabek MA, Amberger-Murphy V, Callanan JJ, Gao C, Zagozdzon AM, Shiels L,

Wang J, Ligon KL, Rich BE, Dicker P, Gallagher WM, Prehn JH, Byrne AT. (2014)

'Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-

derived tumour models'. British Journal of Cancer, 111 (12):2275-2286.

Duffy MJ, Synnott NC, McGowan PM, Crown J, O'Connor D, Gallagher WM. (2014)

Page 12: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

'p53 as a target for the treatment of cancer'. Cancer Treatment Reviews, 40 (10):1153-

1160.

Mulrane L, Gallagher WM, O'Connor DP (2014) 'A novel mechanism of regulation of

the anti-metastatic miR-31 by EMSY in breast cancer'. Breast Cancer Research, 16 (6).

Stephen F Madden, Colin Clarke, Britta Stordal, Mark S Carey, Russell Broaddus,

William M Gallagher, John Crown, Gordon B Mills and Bryan T Hennessy. (2014)

'OvMark: a user-friendly system for the identification of prognostic biomarkers in

publically available ovarian cancer gene expression datasets'. Molecular Cancer, 13

(241).

Professor Declan Gerard Gilheany

Processes. K. V. Rajendran, K. Nikitin and D. G. Gilheany (2015) 'Hammond Postulate

Mirroring Enables Enantiomeric Enrichment of Phosphorus Compounds via Two

Thermodynamically Interconnected Sequential Stereoselective Processes'. Journal of the

American Chemical Society, 137 (29):9375-9381.

P.A. Byrne, and Y Ortin, and D.G. Gilheany (2015) 'First ever observation of the

intermediate of phosphonium salt and ylide hydrolysis: P-

hydroxytetraorganophosphorane'. Chemical Communications, 51 (6):1147-1150.

Professor Catherine Godson

Todd JN, Dahlstr¿¿m EH;Salem RM;Sandholm N;Forsblom C; ;McKnight AJ;Maxwell

AP;Brennan E;Sadlier D;Godson C;Groop PH;Hirschhorn JN;Florez JC (2015) 'Genetic

Evidence for a Causal Role of Obesity in Diabetic Kidney Disease'. Journal of Diabetes

.

Emma Börgesoncorrespondenceemail, Andrew M.F. Johnson, Yun Sok Lee, Andreas

Till, Gulam Hussain Syed, Syed Tasadaque Ali-Shah,Patrick J. Guiry, Jesmond Dalli,

Romain A. Colas, Charles N. Serhan, Kumar Sharma10, Catherine Godson (2015)

'Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver

and Kidney Disease'. Cell metabolism .

Professor Stephen Gordon

Farrell D, Gordon SV (2015) 'Epitopemap: a web application for integrated whole

proteome epitope prediction'. BMC Bioinformatics, 16 .

Farrell D, Shaughnessy RG;Britton L;MacHugh DE;Markey B;Gordon SV (2015) 'The

Identification of Circulating MiRNA in Bovine Serum and Their Potential as Novel

Biomarkers of Early Mycobacterium avium subsp paratuberculosis Infection'. PLoS

ONE, 10 (7).

Berg S, Schelling E;Hailu E;Firdessa R;Gumi B;Erenso G;Gadisa E;Mengistu

A;Habtamu M;Hussein J;Kiros T;Bekele S;Mekonnen W;Derese Y;Zinsstag J;Ameni

G;Gagneux S;Robertson BD;Tschopp R;Hewinson G;Yamuah L;Gordon SV;Aseffa A

(2015) 'Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals

no single driving factor and minimal evidence for zoonotic transmission of

Mycobacterium bovis infection'. BMC Infectious Diseases, 15 .

Rue-Albrecht K, Magee DA;Killick KE;Nalpas NC;Gordon SV;MacHugh DE (2014)

'Comparative functional genomics and the bovine macrophage response to strains of the

mycobacterium genus'. Frontiers in Immunology, 5 .

Killick KE, Magee DA, Park SD, Taraktsoglou M, Browne JA, Conlon KM, Nalpas NC,

Gormley E, Gordon SV, MacHugh DE, Hokamp K (2014) 'Key Hub and Bottleneck

Page 13: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Genes Differentiate the Macrophage Response to Virulent and Attenuated

Mycobacterium bovis'. Frontiers in immunology, 5 .

Professor Andrew Green

Aloraifi F, McCartan D;McDevitt T;Green AJ;Bracken A;Geraghty J (2015) 'Protein-

truncating variants in moderate-risk breast cancer susceptibility genes: A meta-analysis

of high-risk case-control screening studies'. Cancer genetics, 208 (9):455-463.

Aloraifi F, Boland MR;Green AJ;Geraghty JG (2015) 'Gene analysis techniques and

susceptibility gene discovery in¿¿non-BRCA1/BRCA2 familial breast cancer'. Surgical

Oncology, 24 (2):100-109.

Aloraifi F, Alshehhi M;McDevitt T;Cody N;Meany M;O'Doherty A;Quinn CM;Green

AJ;Bracken A;Geraghty JG (2015) 'Phenotypic analysis of familial breast cancer:

comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast

cancer'. European journal of surgical oncology : the journal of the European Society of

Surgical Oncology and the British Association of Surgical Oncology, 41 (5):641-646.

Beygo J, Elbracht M;de Groot K;Begemann M;Kanber D;Platzer K;Gillessen-Kaesbach

G;Vierzig A;Green A;Heller R;Buiting K;Eggermann T (2015) 'Novel deletions

affecting the MEG3-DMR provide further evidence for a hierarchical regulation of

imprinting in 14q32'. European journal of human genetics : EJHG, 23 (2):180-188.

Professor Patrick Guiry

Emma Börgesoncorrespondenceemail, Andrew M.F. Johnson, Yun Sok Lee, Andreas

Till, Gulam Hussain Syed, Syed Tasadaque Ali-Shah,Patrick J. Guiry, Jesmond Dalli,

Romain A. Colas, Charles N. Serhan, Kumar Sharma10, Catherine Godson (2015)

'Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver

and Kidney Disease'. Cell metabolism .

Ä¿wiek, P. and Leni, Z. and Salm, F. and Dimitrova, V. and Styp-Rekowska, B. and

Chiriano, G. and Carroll, M. and Höland, K. and Djonov, V. and Scapozza, L. and

Guiry, P. and Arcaro, A. (2015) 'RNA interference screening identifies a novel role for

PCTK1/CDK16 in medulloblastoma with c-Myc amplification'. Oncotarget, 6 (1):116-

129.

Doran, Robert; Carroll, Michael P.;Akula, Ramulu; Hogan, Bryan F.; Martins, Marta;

Fanning, Seamus; Guiry, Patrick J. (2014) 'A Stereoselective Switch: Enantiodivergent

Approach to the Synthesis of Isoflavanones'. Chemistry - A European Journal, 20

(47):15354-15359.

Robert Doran and Patrick J. Guiry (2014) 'Catalytic Asymmetric Synthesis of Sterically

Hindered Tertiary alpha-Aryl Ketones'. Journal of Organic Chemistry, 79 (19):9112-

9124.

Dr Jana Haase

Haase, J. and Brown, E. (2015) 'Integrating the monoamine, neurotrophin and cytokine

hypotheses of depression - A central role for the serotonin transporter?'. Pharmacology

and Therapeutics, 147 :1-11.

Dr Chandralal Hewage

Kenny, O., Brunton, N. P., Walsh, D., Hewage, C. M., McLoughlin, P., Smyth, T. J.

(2015) 'Characterisation of Antimicrobial Extracts from Dandelion Root (Taraxacum

officinale) Using LC-SPE-NMR'. Phytotherapy Research .

Page 14: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Kenny, O. and Brunton, N.P. and Walsh, D. and Hewage, C.M. and McLoughlin, P. and

Smyth, T.J. (2015) 'Characterisation of antimicrobial extracts from dandelion root

(Taraxacum officinale) using LC-SPE-NMR'. Phytotherapy Research, 29 (4):526-532.

Kenny, O. and Brunton, N.P. and Walsh, D. and Hewage, C.M. and Mcloughlin, P. and

Smyth, T.J. (2015) 'Characterisation of Antimicrobial Extracts from Dandelion Root

(Taraxacum officinale) Using LC-SPE-NMR'. Phytotherapy Research .

Kenny, O. and Smyth, T.J. and Hewage, C.M. and Brunton, N.P. (2015) 'Quantitative

UPLC-MS/MS analysis of chlorogenic acid derivatives in antioxidant fractionates from

dandelion (Taraxacum officinale) root'. International Journal of Food Science and

Technology, 50 (3):766-773.

Professor Desmond Gerard Higgins

Jehl P, Sievers F;Higgins DG (2015) 'OD-seq: outlier detection in multiple sequence

alignments'. BMC Bioinformatics, 16 .

Boyce, K. and Sievers, F. and Higgins, D.G. (2015) 'Reply to Tan et al.: Differences

between real and simulated proteins in multiple sequence alignments'. Proceedings of

the National Academy of Sciences of the United States of America, 112 (2).

Sievers F, Hughes GM, Higgins DG. (2014) 'Systematic exploration of guide-tree

topology effects for small protein alignments'. BMC Bioinformatics .

Yin J, Morrissey ME, Shine L, Kennedy C, Higgins DG, Kennedy BN (2014) 'Genes

and signaling networks regulated during zebrafish optic vesicle morphogenesis'.

Genomics, 15 (1).

Holland LM, Schröder MS, Turner SA, Taff H, Andes D, Grózer Z, Gácser A,

Ames L, Haynes K, Higgins DG, Butler G (2014) 'Comparative phenotypic analysis of

the major fungal pathogens Candida parapsilosis and Candida albicans'. PLoS

Pathogens, 10 (9).

Professor Michael Keane

Minnis P, Henry K;Keane MP (2015) 'Reflux in idiopathic pulmonary fibrosis'. QJM -

Monthly Journal of the Association of Physicians .

Barnes JC, Lumsden RV;Worrell J;Counihan IP;O'Beirne SL;Belperio JA;Fabre

A;Donnelly SC;Boylan D;Kane R;Keane MP (2015) 'CXCR3 Requirement for the

Interleukin-13-Mediated Up-Regulation of Interleukin-13R¿¿2 in Pulmonary

Fibroblasts'. American Journal of Respiratory Cell and Molecular Biology, 53 (2):217-

225.

Lumsden RV, Worrell JC;Boylan D;Walsh SM;Cramton J;Counihan I;O'Beirne

S;Medina MF;Gauldie J;Fabre A;Donnelly SC;Kane R;Keane MP (2015) 'Modulation of

pulmonary fibrosis by IL-13R¿¿2'. American Journal of Physiology - Lung Cellular and

Molecular Physiology, 308 (7):1-8.

Mawhinney, L; Armstrong, M.E; O'Reilly, C; Bucala, R; Leng, L; Fingerle-Rowson, G;

Fayne, D; Keane, M.P; Tynan, A; Maher, L; Cooke, G; Lloyd, D; Conroy, H; Donnelly,

S.C; (2015) 'Macrophage Migration Inhibitory Factor (MIF) Enzymatic Activity & Lung

Cancer'. Molecular Medicine, 20 (1):729-735.

Lee RN, Kelly E;Nolan G;Eigenheer S;Boylan D;Murphy D;Dodd J;Keane

MP;McNicholas WT (2015) 'Disordered breathing during sleep and exercise in

idiopathic pulmonary fibrosis and the role of biomarkers'. QJM - Monthly Journal of the

Association of Physicians, 108 (4):315-323.

Page 15: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Mitchell PD, Das JP;Murphy DJ;Keane MP;Donnelly SC;Dodd JD;Butler MW (2015)

'Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among

emphysema and idiopathic pulmonary fibrosis in smokers'. Respiratory Care, 60

(2):259-268.

Dr Breandán Kennedy

Casey, J.P. and McGettigan, P.A. and Healy, F. and Hogg, C. and Reynolds, A. and

Kennedy, B.N. and Ennis, S. and Slattery, D. and Lynch, S.A. (2015) 'Unexpected

genetic heterogeneity for primary ciliary dyskinesia in the Irish Traveller population'.

European Journal of Human Genetics, 23 (2):210-217.

Yin J, Morrissey ME, Shine L, Kennedy C, Higgins DG, Kennedy BN (2014) 'Genes

and signaling networks regulated during zebrafish optic vesicle morphogenesis'.

Genomics, 15 (1).

Professor Boris Kholodenko

Kolch, W; Halasz, M; Granovskaya, M; Kholodenko, BN. (2015) 'The dynamic control

of signal transduction networks in cancer cells'. Nature Reviews Cancer, 15 (9):515-527.

Nguyen LK, Degasperi A, Cotter P, Kholodenko BN. (2015) 'DYVIPAC: an integrated

analysis and visualisation framework to probe multi-dimensional biological networks'.

Scientific Reports .

Nguyen LK, Cavadas MA, Kholodenko BN, Frank TD, Cheong A. (2015) 'Species

differential regulation of COX2 can be described by an NFκB-dependent logic AND

gate'. Cellular and Molecular Life Sciences .

Milewska M, Romano D;Herrero A;Guerriero ML;Birtwistle M;Quehenberger F;Hatzl

S;Kholodenko BN;Segatto O;Kolch W;Zebisch A (2015) 'Mitogen-Inducible Gene-6

Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth

Factor Receptor and Thereby Limits Malignant Transformation'. PLoS ONE, 10 (6).

Kim TH, Monsefi N;Song JH;von Kriegsheim A;Vandamme D;Pertz O;Kholodenko

BN;Kolch W;Cho KH (2015) 'Network-based identification of feedback modules that

control RhoA activity and cell migration'. Journal of molecular cell biology, 7 (3):242-

252.

Volinsky N, McCarthy CJ;von Kriegsheim A;Saban N;Okada-Hatakeyama M;Kolch

W;Kholodenko BN (2015) 'Signalling mechanisms regulating phenotypic changes in

breast cancer cells'. Bioscience Reports, 35 (2).

Tortolina L, Duffy DJ;Maffei M;Castagnino N;Carmody AM;Kolch W;Kholodenko

BN;De Ambrosi C;Barla A;Biganzoli EM;Nencioni A;Patrone F;Ballestrero A;Zoppoli

G;Verri A;Parodi S (2015) 'Advances in dynamic modeling of colorectal cancer

signaling-network regions, a path toward targeted therapies'. Oncotarget, 6 (7):5041-

5058.

Nagashima T1, Inoue N, Yumoto N, Saeki Y, Magi S, Volinsky N, Sorkin A,

Kholodenko BN, Okada-Hatakeyama M. (2015) 'Feedforward regulation of mRNA

stability by prolonged extracellular signal-regulated kinase activity'. FEBS Journal .

Nguyen LK, Cavadas MA, Scholz CC, Fitzpatrick SF, Bruning U, Cummins EP,

Tambuwala MM, Manresa MC, Kholodenko BN, Taylor CT, Cheong A. (2015) 'A

dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network'. Journal of Cell

Science .

Nguyen LK, Matallanas DG;Romano D;Kholodenko BN;Kolch W (2015) 'Competing to

Page 16: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

coordinate cell fate decisions: the MST2-Raf-1 signaling device'. Cell Cycle, 14 (2):189-

199.

Bastiaens, P. and Birtwistle, M.R. and Blüthgen, N. and Bruggeman, F.J. and Cho,

K.-H. and Cosentino, C. and De La Fuente, A. and Hoek, J.B. and Kiyatkin, A. and

Klamt, S. and Kolch, W. and Legewie, S. and Mendes, P. and Naka, T. and Santra, T.

and Sontag, E. and Westerhoff, H.V. and Kholodenko, B.N. (2015) 'Silence on the

relevant literature and errors in implementation'. Nature Biotechnology, 33 (4):336-339.

Sanchez-Sanz, G; Matallanas, D; Nguyen, LK; Kholodenko, BN; Rosta, E; Kolch, W;

Buchete, NV (2015) 'MST2-RASSF protein-protein interactions through SARAH

domains'. Briefings in bioinformatics .

Dobrzyński M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A,

Cheong A, Kolch W, Kholodenko BN (2014) 'Nonlinear signalling networks and cell-to-

cell variability transform external signals into broadly distributed or bimodal responses'.

Journal of the Royal Society Interface, 11 (98).

Dobrzyſski M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A,

Cheong A, Kolch W, Kholodenko BN (2014) 'Nonlinear signalling networks and cell-to-

cell variability transform external signals into broadly distributed or bimodal responses'.

Journal of the Royal Society, Interface / the Royal Society, 11 (98).

Professor Therese Kinsella

O'Sullivan AG, Mulvaney EP, Hyland PB and Kinsella BT. (2015) 'Protein kinase C-

related Kinase 1 and 2 play an essential role in Thromboxane-mediated Neoplastic

Responses in Prostate Cancer'. Oncotarget, 6 (28):26437-26456.

Reid HM and Kinsella BT. (2015) 'Prostacyclin Receptors: Transcriptional Regulation

and Novel Signalling Mechanisms'. Prostaglandins & other lipid mediators, S1098-

8823 (15):1-13.

Eivers SB & Kinsella BT. (2015) 'Regulated Expression of the I Prostanoid Receptor

(IP) Gene by Androgens: Combined role for Serum Cholesterol'. FASEB Journal, 29

:619.7-619.7.

Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) 'Members of the

Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms

of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-

related Responses'. FASEB Journal, 29 :934.4-934.4.

Professor Ulla Knaus

O'Neill S, Brault J, Stasia MJ, Knaus UG (2015) 'Genetic disorders coupled to ROS

deficiency'. Redox Biology, 6 :135-156.

Mikhed Y, Gorlach A, Knaus UG, Daiber A (2015) 'Redox regulation of genome

stability by effects on gene expression, epigenetic pathways and DNA damage/repair'.

Redox Biology, 5 :275-289.

Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ (2015) 'Ubiquitin C-terminal

hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated

via NADPH oxidase 4'. Oncogene, 6 (18):16287-16303.

Koenigs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K,

Brakebusch C, Schwab A, Baehler M, Knaus UG, Hanley PJ (2014) 'Mouse

macrophages completely lacking Rho (RhoA, RhoB and RhoC) have severe

lamellipodial retraction defects, but robust chemotactic navigation and increased

Page 17: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

motility'. J BIOL CHEM .

Professor Sabine Koelle

Kölle S (2015) 'Transport, distribution and elimination of mammalian sperm following

natural mating and insemination'. Reproduction in Domestic Animals, (Suppl 3):2-6.

Kölle S (2015) 'Bovine sperm-oviduct interaction ¿new insights by the use of novel

imaging techniques'. Tierarztliche Umschau, 70 :351-355.

Trottmann, M; Kölle, S; Leeb, R; Doering, D; Reese, S; Stief, CG; Dulohery, K; Leavy,

M; Kuznetsova, J; Homann, C; Sroka, R. (2015) 'Ex vivo investigations on the potential

of optical coherence tomography (OCT) as a diagnostic tool for reproductive medicine

in a bovine model'. Journal of Biophotonics .

Trottmann. M; Sroka. R; Stepp. H; Heide. M; Liedl. B; Reese. S; Becker. A; Stief. CG;

Kölle. S. (2015) 'Probe-based confocal laser endomicroscopy (pCLE) - a new imaging

technique for in situ localization of spermatozoa'. Journal of Biophotonics, 8 :415-421.

Trottmann M, Sroka R, Stepp H, Heide M, Liedl B, Reese S, Becker A, Stief CG, Kölle

S (2014) 'Probe-based confocal laser endomicroscopy (pCLE) - a new imaging

technique for in situ localization of spermatozoa'. Journal Of Biophotonics .

Professor Walter Kolch

Kolch W, Halasz M;Granovskaya M;Kholodenko BN (2015) 'The dynamic control of

signal transduction networks in cancer cells'. Nature Reviews Cancer, 15 (9):515-527.

Milewska M, Romano D;Herrero A;Guerriero ML;Birtwistle M;Quehenberger F;Hatzl

S;Kholodenko BN;Segatto O;Kolch W;Zebisch A (2015) 'Mitogen-Inducible Gene-6

Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth

Factor Receptor and Thereby Limits Malignant Transformation'. PLoS ONE, 10 (6).

Kim TH, Monsefi N;Song JH;von Kriegsheim A;Vandamme D;Pertz O;Kholodenko

BN;Kolch W;Cho KH (2015) 'Network-based identification of feedback modules that

control RhoA activity and cell migration'. Journal of molecular cell biology, 7 (3):242-

252.

Volinsky N, McCarthy CJ;von Kriegsheim A;Saban N;Okada-Hatakeyama M;Kolch

W;Kholodenko BN (2015) 'Signalling mechanisms regulating phenotypic changes in

breast cancer cells'. Bioscience Reports, 35 (2).

Tortolina L, Duffy DJ;Maffei M;Castagnino N;Carmody AM;Kolch W;Kholodenko

BN;De Ambrosi C;Barla A;Biganzoli EM;Nencioni A;Patrone F;Ballestrero A;Zoppoli

G;Verri A;Parodi S (2015) 'Advances in dynamic modeling of colorectal cancer

signaling-network regions, a path toward targeted therapies'. Oncotarget, 6 (7):5041-

5058.

Volinsky, N., McCarthy, C. J., Von Kriegsheim, A., Saban, N., Okada-Hatakeyama, M.,

Kolch, W., Kholodenko, B. N. (2015) 'Signalling mechanisms regulating phenotypic

changes in breast cancer cells'. Biosci Rep .

Kilinc D, Lesniak A;Rashdan SA;Gandhi D;Blasiak A;Fannin PC;von Kriegsheim

A;Kolch W;Lee GU (2015) 'Mechanochemical stimulation of MCF7 cells with rod-

shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of

ERK'. Advanced healthcare materials, 4 (3):395-404.

Lesniak A, Kilinc D;Rashdan SA;von Kriegsheim A;Ashall B;Zerulla D;Kolch W;Lee

GU (2015) 'In vitro study of the interaction of heregulin-functionalized magnetic-optical

nanorods with MCF7 and MDA-MB-231 cells'. Faraday Discussions, 175 :189-201.

Page 18: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Nguyen LK, Matallanas DG;Romano D;Kholodenko BN;Kolch W (2015) 'Competing to

coordinate cell fate decisions: the MST2-Raf-1 signaling device'. Cell Cycle, 14 (2):189-

199.

Vandamme D, Herrero A;Al-Mulla F;Kolch W (2015) 'Regulation of the MAPK

pathway by raf kinase inhibitory protein'. Critical reviews in oncogenesis, 19 (6):405-

415.

Dr Arun Kumar

Ali MT, Martin K, Arun HS Kumar, Cavallin E, Pierrou S, Gleeson BM, McPheat WL,

Turner EC, Huang CL, Khider W, Vaughan C, Caplice NM. (2015) 'A novel CX3CR1

antagonist eluting stent reduces stenosis by targeting inflammation'. Biomaterials, 3

(69):22-29.

Clover AJ, Arun HS Kumar, Isakson M, Whelan D, Stocca A, Gleeson BM, Caplice

NM. (2015) 'Allogeneic mesenchymal stem cells, but not culture modified monocytes,

improve burn wound healing'. Burns, 41 (3):548-557.

Jegatheeswaran AG, Arun HS Kumar (2015) 'Advancement in biochemical diagnostics

and regenerative medicine leading to integration of dentistry into 360° health program'.

Journal of Natural Science, Biology and Medicine, 6 :283-285.

Leblond AL, Klinkert K, Martin K, Turner EC, Arun HS Kumar, Brown T, Caplice NM.

(2015) 'Systemic and cardiac depletion of M2 macrophage through CSF-1R signaling

inhibition alters cardiac function post myocardial infarction'. PLoS ONE, PONE-D-15-

19506R1 .

Gleeson BM, Martin K, Ali MT, Arun HS Kumar, Pillai MG, Kumar SP, O'Sullivan JF,

Whelan D, Stocca A, Khider W, Barry FP, O'Brien T, Caplice NM. (2015) 'Bone

marrow-derived mesenchymal stem cells have innate procoagulant activity and cause

microvascular obstruction following intracoronary delivery: Amelioration by anti-

thrombin therapy'. Stem cells (Dayton, Ohio) .

Kumar G, Arun HS Kumar (2015) 'Need for evidence-based practice at grass root level

to improve child health and development'. Journal of Natural Science, Biology and

Medicine, 6 :1-2.

David Kilroy and Arun HS Kumar (2015) 'Dilemma in the diversity of foramen magnum

dimensions'. BEMS Reports, 1 (1):3-6.

Huang CL, Leblond AL, Turner EC, Arun HS Kumar, Martin K, Whelan D, O'Sullivan

DM and Caplice NM (2015) 'Synthetic chemically modified mRNA-based delivery of

cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial

infarction'. Molecular Pharmacology .

Arun HS Kumar (2015) 'Letter by kumar regarding article, contribution of intimal

smooth muscle cells to cholesterol accumulation and macrophage-like cells in human

atherosclerosis'. Circulation .

Professor Carel Le Roux

Docherty, N. G., Canney, A. L., le Roux, C. W. (2015) 'Weight Loss Interventions and

Progression of Diabetic Kidney Disease'. Current Diabetes Reports, 15 (8).

Tremaroli V, Karlsson F;Werling M;St¿¿hlman M;Kovatcheva-Datchary P;Olbers

T;F¿¿ndriks L;le Roux CW;Nielsen J;B¿¿ckhed F (2015) 'Roux-en-Y Gastric Bypass

and Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut

Microbiome Contributing to Fat Mass Regulation'. Cell Metabolism, 22 (2):228-238.

Page 19: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Tremaroli V, Karlsson F, Werling M, Ståhlman M, Kovatcheva-Datchary P, Olbers T,

Fändriks L, le Roux CW, Nielsen J, Bäckhed F. (2015) 'Roux-en-Y Gastric Bypass and

Vertical Banded Gastroplasty Induce Long-Term Changes on the Human Gut

Microbiome Contributing to Fat Mass Regulation'. Cell metabolism .

Mathes CM, Bohnenkamp RA, le Roux CW, Spector AC (2015) 'Reduced Sweet and

Fatty Fluid Intake after Roux-en-Y Gastric Bypass in Rats is Dependent on Experience

without Change in Stimulus Motivational Potency'. American Journal Of Physiology-

Regulatory Integrative And Comparative Physiology .

Boxwell AJ, Chen Z;Mathes CM;Spector AC;Le Roux CW;Travers SP;Travers JB

(2015) 'Effects of high-fat diet and gastric bypass on neurons in the caudal solitary

nucleus'. Physiology and Behavior .

Boxwell AJ, Chen Z, Mathes CM, Spector AC, Le Roux CW, Travers SP, Travers JB

(2015) 'Effects of high-fat diet and gastric bypass on neurons in the caudal solitary

nucleus'. Physiology & Behavior .

Xavier Pi-Sunyer, M.D., Arne Astrup, M.D., D.M.Sc., Ken Fujioka, M.D., Frank

Greenway, M.D., Alfredo Halpern, M.D., Michel Krempf, M.D., Ph.D., David C.W.

Lau, M.D., Ph.D., Carel W. le Roux, F.R.C.P., Ph.D., Rafael Violante Ortiz, M.D.,

Christine Bjørn Jensen, M.D., Ph.D., and John P.H. Wilding, D.M. (2015) 'A

Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management'. New

England Journal of Medicine, 373 :11-22.

Werling M, F¿¿ndriks L;Olbers T;Bueter M;Sj¿¿str¿¿m L;L¿¿nroth H;Wallenius

V;Stenl¿¿f K;le Roux CW (2015) 'Roux-en-Y Gastric Bypass Surgery Increases

Respiratory Quotient and Energy Expenditure during Food Intake'. PLoS ONE, 10 (6).

Alsters SI, Goldstone AP;Buxton JL;Zekavati A;Sosinsky A;Yiorkas AM;Holder

S;Klaber RE;Bridges N;van Haelst MM;le Roux CW;Walley AJ;Walters RG;Mueller

M;Blakemore AI (2015) 'Truncating Homozygous Mutation of Carboxypeptidase E

(CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual

Disability and Hypogonadotrophic Hypogonadism'. PLoS ONE, 10 (6).

Dutia R, Embrey M;O'Brien S;Haeusler RA;Ag¿¿nor KK;Homel P;McGinty J;Vincent

RP;Alaghband-Zadeh J;Staels B;le Roux CW;Yu J;Laferr¿¿re B (2015) 'Temporal

changes in bile acid levels and 12¿¿-hydroxylation after Roux-en-Y gastric bypass

surgery in type 2 diabetes'. International journal of obesity (2005), 39 (5):806-813.

Tham, J. C., le Roux, C. W., Docherty, N. G. (2015) 'Cardiovascular, renal and overall

health outcomes after bariatric surgery'. Current Cardiology Reports, 17 (5).

Abegg, K., Corteville, C., Docherty, N. G., Boza, C., Lutz, T. A., Munoz, R., le Roux,

C. W. (2015) 'Effect of bariatric surgery combined with medical therapy versus

intensive medical therapy or calorie restriction and weight loss on glycemic control in

Zucker diabetic fatty rats'. American Journal of Physiology - Regulatory Integrative and

Comparative Physiology, 308 (4).

Goyale, A., Ashley, S.L., Taylor, D.R., Elnenaei, M.O., Alaghband-Zadeh, J.,

Sherwood, R.A., le Roux, C.W., Vincent, R.P. (2015) 'Predicting refeeding

hypophosphataemia: insulin growth factor 1 (IGF-1) as a diagnostic biochemical marker

for clinical practice'. Annals of Clinical Biochemistry, 52 (1):82-87.

Sam, A.H., Sleeth, M.L., Thomas, E.L., Ismail, N.A., Daud, N.M., Chambers, E.,

Shojaee-Moradie, F., Umpleby, M., Goldstone, A.P., Le Roux, C.W., Bech, P.,

Busbridge, M., Laurie, R., Cuthbertson, D.J., Buckley, A., Ghatei, M.A., Bloom, S.R.,

Frost, G.S., Bell, J.D., Murphy, K.G. (2015) 'Circulating pancreatic polypeptide

Page 20: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

concentrations predict visceral and liver fat content'. Journal of Clinical Endocrinology

and Metabolism, 100 (3):1048-1052.

Chuah, L.L., Miras, A.D., Papamargaritis, D., Jackson, S.N., Olbers, T., le Roux, C.W.

(2015) 'Impact of perioperative management of glycemia in severely obese diabetic

patients undergoing gastric bypass surgery'. Surgery for Obesity and Related Diseases .

Risstad, H., Søvik, T.T., Engström, M., Aasheim, E.T., Fagerland, M.W., Olsén,

M.F., Kristinsson, J.A., Le Roux, C.W., Bøhmer, T., Birkeland, K.I., Mala, T., Olbers,

T. (2015) 'Five-year outcomes after laparoscopic gastric bypass and laparoscopic

duodenal switch in patients with body mass index of 50 to 60: A randomized clinical

trial'. JAMA Surgery, 150 (4):352-361.

Papamargaritis, D., Aasheim, E.T., Sampson, B., le Roux, C.W. (2015) 'Copper,

selenium and zinc levels after bariatric surgery in patients recommended to take

multivitamin-mineral supplementation'. Journal of Trace Elements in Medicine and

Biology, 31 :167-172.

Lho, Y., Le Roux, C.W., Park, H.S., Kim, G.S., Jung, J., Hwang, G.-S., Seo, Y.K., Ha,

T.K., Ha, E. (2015) 'Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy'.

Obesity Surgery .

Wu, Q., Li, J.V., Seyfried, F., le Roux, C.W., Ashrafian, H., Athanasiou, T., Fenske, W.,

Darzi, A., Nicholson, J.K., Holmes, E., Gooderham, N.J. (2015) 'Metabolic phenotype-

microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric

bypass surgery'. International Journal of Obesity .

Miras, A.D., Chuah, L.L., Khalil, N., Nicotra, A., Vusirikala, A., Baqai, N., Graham, C.,

Ravindra, S., Lascaratos, G., Oliver, N., Le Roux, C.W. (2015) 'Type 2 diabetes mellitus

and microvascular complications 1 year after Roux-en-Y gastric bypass: a

caseâ¿¿control study'. Diabetologia .

Tham, J.C., le Roux, C.W., Docherty, N.G. (2015) 'Cardiovascular, Renal and Overall

Health Outcomes After Bariatric Surgery'. Current Cardiology Reports, 17 (5).

Arora, T., Velagapudi, V., Pournaras, D.J., Welbourn, R., Le Roux, C.W., Orešiĕ,

M., Bäckhed, F. (2015) 'Roux-en-Y gastric bypass surgery induces early plasma

metabolomic and lipidomic alterations in humans associated with diabetes remission'.

PLoS ONE, 10 (5).

Sathyapalan, Thozhukat and Thatcher, Natalie J. and Hammersley, Richard and Rigby,

Alan S. and Pechlivanis, Alexandros and Gooderham, Nigel J. and Holmes, Elaine and

le Roux, Carel W. and Atkin, Stephen L. and Courts, Fraser (2015) 'Aspartame

Sensitivity? A Double Blind Randomised Crossover Study'. PLoS ONE, 10 (3).

Mathes, Clare M. and Bohnenkamp, Ryan A. and Blonde, Ginger D. and Letourneau,

Chanel and Corteville, Caroline and Bueter, Marco and Lutz, Thomas A. and le Roux,

Carel W. and Spector, Alan C. (2015) 'Gastric bypass in rats does not decrease

appetitive behavior towards sweet or fatty fluids despite blunting preferential intake of

sugar and fat'. Physiology & Behavior, 142 :179-188.

Wilding, J. and Astrup, A. and Fujioka, K. and Greenway, F. and Krempf, M. and Lau,

D. and Le Roux, C. W. and Lilleore, S. K. and Jensen, T. and Violante Ortiz, R. (2015)

'In overweight and obese adults, liraglutide 3.0mg reduces the prevalence of prediabetes

and delays the onset of Type 2 diabetes: SCALE obesity and pre-diabetes trial'. Diabetic

Medicine, 32 (1, SI).

Wilding, J. and Lau, D. and Astrup, A. and Fujioka, K. and Greenway, F. and Krempf,

Page 21: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

M. and Le Roux, C. W. and Violante Ortiz, R. and Lilleore, S. K. and Jensen, T. and Pi-

Sunyer, X. (2015) 'Safety and tolerability of liraglutide 3.0mg following 56 weeks of

randomised treatment in overweight and obese adults: SCALE obesity and pre-diabetes

trial'. Diabetic Medicine, 32 (1, SI).

Miras, A. D. and Al-Najim, W. and Jackson, S. N. and McGirr, J. and Cotter, L. and

Tharakan, G. and Vusirikala, A. and le Roux, C. W. and Prechtl, C. G. and Scholtz, S.

(2015) 'PSYCHOLOGICAL CHARACTERISTICS, EATING BEHAVIOR, AND

QUALITY OF LIFE ASSESSMENT OF OBESE PATIENTS UNDERGOING

WEIGHT LOSS INTERVENTIONS'. Scandinavian Journal of Surgery, 104 (1, SI):10-

17.

Werling M, F¿¿ndriks L;Royce VP;Cross GF;le Roux CW;Olbers T (2014)

'Preoperative assessment of gut hormones does not correlate to weight loss after Roux-

en-Y gastric bypass surgery'. Surgery for Obesity and Related Diseases, 10 (5):822-828.

Laurenius A, Werling M;Le Roux CW;F¿¿ndriks L;Olbers T (2014) 'More symptoms

but similar blood glucose curve after oral carbohydrate provocation in patients with a

history of hypoglycemia-like symptoms compared to asymptomatic patients after Roux-

en-Y gastric bypass'. Surgery for Obesity and Related Diseases, 10 (6):1047-1054.

Jackson, S., le Roux, C. W., Docherty, N. G. (2014) 'Bariatric surgery and microvascular

complications of type 2 diabetes mellitus'. Current Atherosclerosis Reports, 16 (11).

Docherty, N. G., le Roux, C. W. (2014) 'Improvements in the metabolic milieu

following Roux-en-Y gastric bypass and the arrest of diabetic kidney disease'.

Experimental Physiology, 99 (9):1146-53.

Docherty, N. G., le Roux, C. W. (2014) 'Physiological and pathophysiological signalling

between the gut and the kidney: role in diabetic kidney disease'. Experimental

Physiology, 99 (9):1138-9.

le Roux CW, Bueter M (2014) 'The physiology of altered eating behaviour after Roux-

en-Y gastric bypass'. Experimental Physiology, 99 (9):1128-1132.

Buhmann H, le Roux CW;Bueter M (2014) 'The gut-brain axis in obesity'. Best practice

& research. Clinical gastroenterology, 28 (4):559-571.

Professor Gil Lee

Devrim Kilinc, Agata Blasiak, Gil U Lee (2015) 'Microtechnologies for studying the

role of mechanics in axon growth and guidance'. Frontiers in Cellular Neuroscience, 9 .

Conor Fields, Peng Li, James J O'Mahony, Gil Lee (2015) 'Advances in affinity ligand‐functionalized nanomaterials for biomagnetic separation'. Biotechnology and

Bioengineering .

Kilinc D, Lesniak A;Rashdan SA;Gandhi D;Blasiak A;Fannin PC;von Kriegsheim

A;Kolch W;Lee GU (2015) 'Mechanochemical stimulation of MCF7 cells with rod-

shaped Fe-Au Janus particles induces cell death through paradoxical hyperactivation of

ERK'. Advanced healthcare materials, 4 (3):395-404.

Lesniak A, Kilinc D;Rashdan SA;von Kriegsheim A;Ashall B;Zerulla D;Kolch W;Lee

GU (2015) 'In vitro study of the interaction of heregulin-functionalized magnetic-optical

nanorods with MCF7 and MDA-MB-231 cells'. Faraday Discussions, 175 :189-201.

Kelly, CM; Muzard, J; Brooks, BR; Lee, GU; Buchete, NV (2015) 'Structure and

dynamics of the fibronectin-III domains of Aplysia californica cell adhesion molecules'.

Physical Chemistry Chemical Physics, 17 :9634-9643.

Devrim Kilinc, Agata Blasiak, James J O'Mahony, and Gil U Lee (2014) 'Low

Page 22: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Piconewton Towing of CNS Axons against Diffusing and Surface-Bound Repellents

Requires the Inhibition of Motor Protein-Associated Pathways'. Scientific Reports .

Professor Patrick Lonergan

Maillo V, Ó Gaora P, Forde N, Besenfelder U, Havlicek V, Burns GW, Spencer TE,

Gutierrez-Adan A, Lonergan P, Rizos D (2015) 'Oviduct-Embryo Interactions in Cattle:

Two-Way Traffic or a One-Way Street?'. Biology of Reproduction, 92 (6).

Parr MH, Crowe MA;Lonergan P;Evans AC;Fair T;Diskin MG (2015) 'The concurrent

and carry over effects of long term changes in energy intake before insemination on

pregnancy per artificial insemination in heifers'. Animal Reproduction Science, 157 :87-

94.

Jimenez-Krassel F, Scheetz DM;Neuder LM;Ireland JL;Pursley JR;Smith

GW;Tempelman RJ;Ferris T;Roudebush WE;Mossa F;Lonergan P;Evans AC;Ireland JJ

(2015) 'Concentration of anti-Mullerian hormone in dairy heifers is positively associated

with productive herd life'. Journal of Dairy Science, 98 (5):3036-3045.

Scully, S. and Evans, A.C.O. and Carter, F. and Duffy, P. and Lonergan, P. and Crowe,

M.A. (2015) 'Ultrasound monitoring of blood flow and echotexture of the corpus luteum

and uterus during early pregnancy of beef heifers'. Theriogenology, 83 (3):449-458.

Professor David MacHugh

Moran, B., Butler, S. T., Moore, S. G., MacHugh, D. E., Creevey, C. J. (2015)

'Differential gene expression in the endometrium reveals cytoskeletal and

immunological genes in lactating dairy cows genetically divergent for fertility traits'.

Reproduction, Fertility and Development, [Online early] .

Farrell, D., Shaughnessy, R. G., Britton, L., MacHugh, D. E., Markey, B., Gordon, S. V.

(2015) 'The identification of circulating miRNA in bovine serum and their potential as

novel biomarkers of early Mycobacterium avium subsp paratuberculosis infection'.

PLoS ONE, 10 (7).

O'Doherty, A. M., MacHugh, D. E., Spillane, C., Magee, D. A. (2015) 'Genomic

imprinting effects on complex traits in domesticated animal species'. Frontiers in

Genetics, 6:156 .

Casey, M. E., Meade, K. G., Nalpas, N. C., Taraktsoglou, M., Browne, J. A., Killick, K.

E., Park, S. D. E., Gormley, E., Hokamp, K., Magee, D. A., MacHugh, D. E. (2015)

'Analysis of the bovine monocyte-derived macrophage response to Mycobacterium

avium subspecies paratuberculosis infection using RNA-seq'. Frontiers in Immunology,

6:23 .

Vegh, P., Magee, D. A., Nalpas, N. C., Bryan, K., McCabe, M. S., Browne, J. A.,

Conlon, K. M., Gordon, S. V., Bradley, D. G., MacHugh, D. E., Lynn, D. J. (2015)

'MicroRNA profiling of the bovine alveolar macrophage response to Mycobacterium

bovis infection suggests pathogen survival is enhanced by microRNA regulation of

endocytosis and lysosome trafficking'. Tuberculosis, 95 (1):60-67.

Schubert, M., Jonsson, H., Chang, D., Der Sarkissian, C., Ermini, L., Ginolhac, A.,

Albrechtsen, A., Dupanloup, I., Foucal, A., Petersen, B., Fumagalli, M., Raghavan, M.,

Seguin-Orlando, A., Korneliussen, T. S., Velazquez, A. M., Stenderup, J., Hoover, C.

A., Rubin, C. J., Alfarhan, A. H., Alquraishi, S. A., Al-Rasheid, K. A., MacHugh, D. E.,

Kalbfleisch, T., MacLeod, J. N., Rubin, E. M., Sicheritz-Ponten, T., Andersson, L.,

Hofreiter, M., Marques-Bonet, T., Gilbert, M. T., Nielsen, R., Excoffier, L., Willerslev,

E., Shapiro, B., Orlando, L. (2014) 'Prehistoric genomes reveal the genetic foundation

Page 23: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

and cost of horse domestication'. Proceedings of the National Academy of Sciences USA,

111 (52):5661-9.

Sanderson, N. D., Norman, P. J., Guethlein, L. A., Ellis, S. A., Williams, C., Breen, M.,

Park, S. D., Magee, D. A., Babrzadeh, F., Warry, A., Watson, M., Bradley, D. G.,

MacHugh, D. E., Parham, P., Hammond, J. A. (2014) 'Definition of the cattle killer cell

Ig-like receptor gene family: comparison with aurochs and human counterparts'. Journal

of Immunology, 193 (12):6016-6030.

Rue-Albrecht, K., Magee, D. A., Killick, K. E., Nalpas, N. C., Gordon, S. V., MacHugh,

D. E. (2014) 'Comparative functional genomics and the bovine macrophage response to

strains of the Mycobacterium genus'. Frontiers in Immunology, 5:536 .

Killick, K. E., Magee, D. A., Park, S. D., Taraktsoglou, M., Browne, J. A., Conlon, K.

M., Nalpas, N. C., Gormley, E., Gordon, S. V., MacHugh, D. E., Hokamp, K. (2014)

'Key hub and bottleneck genes differentiate the macrophage response to virulent and

attenuated Mycobacterium bovis'. Frontiers in Immunology, 5:422 .

Professor Kevin Malone

Murphy OC, Kelleher C;Malone KM (2015) 'Demographic trends in suicide in the UK

and Ireland 1980-2010'. Irish Journal of Medical Science, 184 (1):227-235.

Mulcahy HE, McDermott E, Mullen G, Moloney J, Keegan D, Byrne K, Doherty GA,

Cullen G, Malone K (2015) 'Body image dissatisfaction: clinical features, and

psychosocial disability in inflammatory bowel disease'. Inflammatory Bowel Diseases,

21 (2):353-360.

Sweeney, L. and Owens, C. and Malone, K. (2015) 'Communication and interpretation

of emotional distress within the friendships of young Irish men prior to suicide: A

qualitative study'. Health and Social Care in the Community, 23 (2):150-158.

Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2014)

'Anxiety is associated with higher levels of global DNA methylation and altered

expression of epigenetic and interleukin-6 genes'. Psychiatric Genetics .

Professor Jonathan Malthouse

Cleary JA, Doherty W, Evans P, Malthouse JP. (2015) 'Quantifying tetrahedral adduct

formation and stabilization in the cysteine and the serine proteases'. Biochimica et

Biophysica Acta - Proteins and Proteomics, 1854 :1382-1391.

Bergner T, Tabib CR, Winkler A, Stipsits S, Kayer H, Lee J, Malthouse JP, Mayhew S,

Müller F, Gruber K, Macheroux P. (2015) 'Structural and biochemical properties of

LuxF from Photobacterium leiognathi'. Biochimica Et Biophysica Acta-Proteins and

Proteomics, 1854 :1466-1475.

Professor Fionnuala McAuliffe

Horan, M. K., McGowan, C. A., Gibney, E. R., Donnelly, J. M., McAuliffe, F. M.

(2015) 'The association between maternal dietary micronutrient intake and neonatal

anthropometry - secondary analysis from the ROLO study'. Nutr J, 14 (1).

Mone F, Quigley J, Doyle B, Lambert M, Woolfson M, Downey P, Carroll S, Higgins S,

Mahony R, McAuliffe FM, Fitzgerald J, McParland P (2015) 'Clinical disparity of

haemolytic disease of the fetus and newborn in twin pregnancy'. Transfusion Medicine .

Corcoran S, Breathnach F, Burke G, McAuliffe F, Geary M, Daly S, Higgins J, Hunter

A, Morrison JJ, Higgins S, Mahony R, Dicker P, Tully EC, Malone FD (2015)

'Dichorionic twin ultrasound surveillance: sonography every 4 weeks significantly

Page 24: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

underperforms sonography every 2 weeks: results of teh Prospective Multicenter

ESPRiT Study'. American Journal of Obstetrics and Gynecology .

Cody F, Unterscheider J;Daly S;Geary MP;Kennelly MM;McAuliffe FM;O'Donoghue

K;Hunter A;Morrison JJ;Burke G;Dicker P;Tully EC;Malone FD (2015) 'The effect of

maternal obesity on sonographic fetal weight estimation and perinatal outcome in

pregnancies complicated by fetal growth restriction'. Journal of Clinical Ultrasound .

Cody F, Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM,

O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD

(2015) 'The effect of maternal obesity on sonographic fetal weight estimation and

perinatal outcome in pregnancies complicated by fetal growth restriction'. Journal Of

Clinical Ultrasound .

M¿¿llers SM, McAuliffe FM;Kent E;Carroll S;Mone F;Breslin N;Dalrymple J;Mulcahy

C;O'Donoghue K;Martin A;Malone FD (2015) 'Outcome following selective fetoscopic

laser ablation for twin to twin transfusion syndrome: an 8 year national collaborative

experience'. European Journal of Obstetrics, Gynecology and Reproductive Biology,

191 :125-129.

Mone F, Walsh C;Mulcahy C;McMahon CJ;Farrell S;MacTiernan A;Segurado

R;Mahony R;Higgins S;Carroll S;McParland P;McAuliffe FM (2015) 'Prenatal detection

of structural cardiac defects and presence of associated anomalies: a retrospective

observational study of 1262 fetal echocardiograms'. Prenatal Diagnosis, 35 (6):577-582.

Mone F; Walsh C; Mulcahy C; McMahon CJ; Farrell S; MacTiernan A; Segurado R;

Mahony R; Higgins S; Carroll S; McParland P; McAuliffe FM (2015) 'Prenatal

detection of structural cardiac defects and presence of associated anomalies: a

retrospective observational study of 1262 fetal echocardiograms'. Prenatal diagnosis, 35

(6):577-582.

Lindsay KL, Brennan L;Kennelly MA;Maguire OC;Smith T;Curran S;Coffey M;Foley

ME;Hatunic M;Shanahan F;McAuliffe FM (2015) 'Impact of probiotics in women with

gestational diabetes mellitus on metabolic health: a randomized controlled trial'.

American Journal of Obstetrics and Gynecology, 212 (4):4960-4911.

Horan, M., Gibney, E., Molloy, E., McAuliffe, F. (2015) 'Methodologies to assess

paediatric adiposity'. Irish Journal of Medical Science, 184 (1):53-68.

Lindsay KL, Brennan L, Kennelly MA, Maguire OC, Smith T, Curran S, Coffey M,

Foley ME, Hatunic M, Shanahan F, McAuliffe FM (2015) 'Impact of probiotics in

women with gestational diabetes mellitus on metabolic health: A randomized controlled

trial'. American Journal of Obstetrics and Gynecology .

Lindsay, K.L. and Heneghan, C. and McNulty, B. and Brennan, L. and McAuliffe, F.M.

(2015) 'Lifestyle and Dietary Habits of an Obese Pregnant Cohort'. Maternal and child

health journal, 19 (1):25-32.

Walsh JM, McAuliffe FM (2015) 'Impact of maternal nutrition on pregnancy outcome -

Does it matter what pregnant women eat?'. Best Practice and Research: Clinical

Obstetrics and Gynaecology .

Lindsay KL, Heneghan C, McNulty B, Brennan L, McAuliffe FM (2015) 'Lifestyle and

dietary habits of an obese pregnant cohort'. Maternal and Child Health Journal, 19

(1):25-32.

Barry SC, Walsh CA, Burke AL, McParland P, McAuliffe FM, Morrison JJ (2015)

'Natural history of fetal trisomy 13 after prenatal diagnosis'. American Journal of

Medical Genetics, Part A, 167 (1):147-150.

Page 25: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Walsh JM, McAuliffe FM (2015) 'Impact of maternal nutrition on pregnancy outcome -

Does it matter what pregnant women eat?'. Best Practice and Research in Clinical

Obstetrics and Gynaecology, 29 (1):63-78.

Levine TA, Grunau RE, McAuliffe FM, Pinnamaneni R, Foran A, Alderdice FA (2015)

'Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A

Systematic Review'. Pediatrics, 135 (1):126-141.

Moran M, Mulcahy C, Zombori G, Ryan J, Downey P, McAuliffe FM (2015) 'Placental

Volume, Vascalature and Calcification in pregnancies complicated by pre-eclampsia and

intra-uterine growth restriction'. European Journal of Obstetrics Gynecology and

Reproductive Biology .

Walsh, C.A. and MacTiernan, A. and Farrell, S. and Mulcahy, C. and McMahon, C.J.

and Franklin, O. and Coleman, D. and Mahony, R. and Higgins, S. and Carroll, S. and

McParland, P. and McAuliffe, F.M. (2014) 'Mode of delivery in pregnancies

complicated by major fetal congenital heart disease: a retrospective cohort study'.

Journal of Perinatology, 34 (12):901-905.

Walsh CA, Doyle B, Quigley J, McAuliffe FM, Fitzgerald J, Mahony R, Higgins S,

Carroll S, McParland P (2014) 'Reassessing critical maternal antibody threshold in RhD

alloimmunization: a 16-year retrospective cohort study'. Obstetrics and Gynecology, 44

(6):669-673.

Walsh CA, MacTiernan A, Farrell S, Mulcahy C, McMahon CJ, Franklin O, Coleman

D, Mahony R, Higgins S, Carroll S, McParland P, McAuliffe FM (2014) 'Mode of

delivery in pregnancies complicated by major fetal congenital heart disease: a

retrospective cohort study'. Journal of perinatology : official journal of the California

Perinatal Association, 34 (12):901-905.

Martyn FM, McAuliffe FM, Beggan C, Downey P, Flannelly G, Wingfield MB (2014)

'Excisional treatments of the cervix and effect on subsequent fertility: a retrospective

cohort study'. Obstetrics and Gynecology, 185C :114-120.

Walsh JM, Mahony RM, Canty G, Foley ME, McAuliffe FM (2014) 'Impact of low

glycemic index diet in pregnancy on markers of maternal and fetal metabolism and

inflammation'. Reproductive Sciences .

Walsh JM, Mahony RM, Culliton M, Foley ME, McAuliffe FM (2014) 'Impact of a low

glycemic index diet in pregnancy on markers of maternal and fetal metabolism and

inflammation'. Reproductive sciences (Thousand Oaks, Calif.), 21 (11):1378-1381.

Ruifrok AE, Rogozinska E, van Poppel MN, Rayanagoudar G, Kerry S, de Groot CJ,

Yeo S, Molyneaux E, McAuliffe FM, Poston L, Roberts T, Riley RD, Coomarasamy A,

Khan K, Mol BW, Thangaratinam S (2014) 'Study protocol: differential effects of diet

and physical activity based interventions in pregnancy on maternal and fetal outcomes--

individual patient data (IPD) meta-analysis and health economic evaluation'. Systematic

Reviews, 3 .

Mulcahy C, McAuliffe FM, Breathnach F, Geary M, Daly S, Higgins J, Hunter A,

Morrison J, Burke G, Higgins S, Dicker P, Mahony R, tully E, Malone F (2014) 'Blood

Flow Velocity Waveforms of the umbilical artery and middle cerebral artery in a twin

population: Longitudinal reference ranges from 24 to 38 weeks' gestation'. Ultrasound

In Obstetrics & Gynecology, (44(4)):461-467.

O'Dwyer V, Burke G, Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe

FM, O'Donoghue K, Hunter A, Morrison JJ, Dicker P, Tully EC, Malone FD (2014)

'Defining the residual risk of adverse perinatal outcome in growth-restricted fetuses with

Page 26: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

normal umbilical artery blood flow'. American Journal of Obstetrics and Gynecology,

211 (4):4200-4205.

Martyn F, McAuliffe FM, Wingfield M (2014) 'The role of the cervix in fertility: is it

time for a reappraisal?'. Human reproduction (Oxford, England), 29 (10):2092-2098.

Walsh JM, Wallace M, Brennan L, McAuliffe FM (2014) 'Early pregnancy maternal

urinary metabolomic profile and later insulin resistance and fetal adiposity'. Journal of

Maternal-Fetal and Neonatal Medicine, :1-4.

Doyle, O. and McGlanaghy, E. and Palamaro-Munsell, E. and McAuliffe, F. (2014)

'Home based educational intervention to improve perinatal outcomes for a

disadvantaged community: A randomised control trial'. European Journal of Obstetrics

Gynecology and Reproductive Biology, 180 :162-167.

Flood, K. and Unterscheider, J. and Daly, S. and Geary, M.P. and Kennelly, M.M. and

McAuliffe, F.M. and O'Donoghue, K. and Hunter, A. and Morrison, J.J. and Burke, G.

and Dicker, P. and Tully, E.C. and Malone, F.D. (2014) 'The role of brain sparing in the

prediction of adverse outcomes in intrauterine growth restriction: Results of

themulticenter PORTO Study'. American Journal of Obstetrics and Gynecology, 211

(3).

Mone F, Adams B, Manderson JG, McAuliffe FM (2014) 'The East Timorese: a high-

risk ethnic minority in UK obstetrics: a cohort study'. Journal of Maternal-Fetal and

Neonatal Medicine, :1-4.

Flood K, Unterscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM,

O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD

(2014) 'The role of brain sparing in the prediction of adverse outcomes in intrauterine

growth restriction: results of the multicenter PORTO Study'. American Journal of

Obstetrics and Gynecology, 211 (3):2880-2885.

Downey A, Hore K, McAuliffe FM, Mooney EE (2014) 'Umbilical cord shortening:

quantification postdelivery and postfixation'. Pediatric and developmental pathology :

the official journal of the Society for Pediatric Pathology and the Paediatric Pathology

Society, 17 (5):327-329.

Neff KJ, Forde R, Gavin C, Byrne MM, Firth RG, Daly S, McAuliffe FM, Foley M,

Coffey M, Coulter-Smith S, Kinsley BT (2014) 'Pre-pregnancy care and pregnancy

outcomes in type 1 diabetes mellitus: a comparison of continuous subcutaneous insulin

infusion and multiple daily injection therapy'. Medicine, 183 (3):397-403.

Doyle, O., McGlanaghy, E., Palamaro Munsell, E., McAuliffe, F. (2014) 'Home based

educational intervention to improve perinatal outcomes for a disadvantaged community:

a randomised control trial'. European Journal of Obstetrics & Gynecology and

Reproductive Biology, 180 :162-167.

Flood K, Underscheider J, Daly S, Geary MP, Kennelly MM, McAuliffe FM,

O'Donoghue K, Hunter A, Morrison JJ, Burke G, Dicker P, Tully EC, Malone FD

(2014) 'The role of brain sparing in the prediction of adverse outcomes in intrauterine

growth restriction: results of the multicenter PORTO Study'. American Journal of

Obstetrics and Gynecology .

Dr Gethin McBean

McBean, G.J., Aslan, M., Griffiths, H.R., Torrão, R.C. (2015) 'Thiol redox homeostasis

in neurodegenerative disease'. Redox Biology, 5 :186-194.

Dr Amanda McCann

Page 27: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Elma A. O¿Reilly, E. A.; Gubbins, L.; Sharmaa, S.; Tully, R.; Zhing Guang, M. H.;

Weiner-Gorzel, K.; McCaffrey, J.; Harrison, M.; Furlong, F.; Malcolm Kell, M.; and

McCann, A. (2015) 'The fate of chemoresistance in triple negative breast cancer

(TNBC)'. BBA Clinical, 3 :257-275.

Joyce H, McCann A;Clynes M;Larkin A (2015) 'Influence of multidrug resistance and

drug transport proteins on chemotherapy drug metabolism'. Expert Opinion on Drug

Metabolism and Toxicology, 11 (5):795-809.

Weiner-Gorzel K, Dempsey E, Milewska M, McGoldrick A, Toh V, Walsh A, Lindsay

S, Gubbins L, Cannon A, Sharpe D, O'Sullivan J, Murphy M, Madden SF, Kell M,

McCann A, Furlong F (2015) 'Overexpression of the microRNA miR-433 promotes

resistance to paclitaxel through the induction of cellular senescence in ovarian cancer

cells'. Cancer medicine, 4 (5):745-758.

Murphy TM, O'Donovan A, Mullins N, O'Farrelly C, McCann A, Malone K (2014)

'Anxiety is associated with higher levels of global DNA methylation and altered

expression of epigenetic and interleukin-6 genes'. Psychiatric Genetics .

Dr Margaret McGee

Mc Gee MM (2015) 'Targeting the Mitotic Catastrophe Signaling Pathway in Cancer'.

Mediators of Inflammation .

Lavin, Paul T; Mc Gee MM (2015) 'Cyclophilin function in Cancer; lessons from virus

replication'. Current Molecular Pharmacology .

Dr Fiona McGillicuddy

Finucane, O.M.a and Lyons, C.L.b and Murphy, A.M.c and Reynolds, C.M.d and

Klinger, R.e and Healy, N.P.f and Cooke, A.A.g and Coll, R.C.h and McAllan, L.i and

Nilaweera, K.N.j and O'Reilly, M.E.k and Tierney, A.C.l and Morine, M.J.m and

Alcala-Diaz, J.F.n and Lopez-Miranda, J.o and O'Connor, D.P.p and O'Neill, L.A.q and

McGillicuddy, F.C.r and Roche, H.M.s (2015) 'Monounsaturated fatty acid-enriched

high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and

insulin resistance despite obesity'. Diabetes, 64 (6):2116-2128.

Finucane OM, Reynolds CM;McGillicuddy FC;Harford KA;Morrison M;Baugh

J;Roche HM (2014) 'Macrophage migration inhibitory factor deficiency ameliorates

high-fat diet induced insulin resistance in mice with reduced adipose inflammation and

hepatic steatosis'. PLoS ONE, 9 (11).

Dr Edward McKone

Wainwright CE, Elborn JS;Ramsey BW;Marigowda G;Huang X;Cipolli M;Colombo

C;Davies JC;De Boeck K;Flume PA;Konstan MW;McColley SA;McCoy K;McKone

EF;Munck A;Ratjen F;Rowe SM;Waltz D;Boyle MP; ; (2015) 'Lumacaftor-Ivacaftor in

Patients with Cystic Fibrosis Homozygous for Phe508del CFTR'. New England Journal

of Medicine, 373 (3):220-231.

Carter S, Kelly S;Caples E;Grogan B;Doyle J;Gallagher CG;McKone EF (2015)

'Ivacaftor as salvage therapy in a patient with cystic fibrosis genotype

F508del/R117H/IVS8-5T'. Journal of cystic fibrosis : official journal of the European

Cystic Fibrosis Society, 14 (4):1-5.

Ierodiakonou D, Zanobetti A;Coull BA;Melly S;Postma DS;Boezen HM;Vonk

JM;Williams PV;Shapiro GG;McKone EF;Hallstrand TS;Koenig JQ;Schildcrout

JS;Lumley T;Fuhlbrigge AN;Koutrakis P;Schwartz J;Weiss ST;Gold DR; (2015)

Page 28: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

'Ambient air pollution, lung function, and airway responsiveness in asthmatic children'.

Journal of Allergy and Clinical Immunology .

McKone EF, Borowitz D;Drevinek P;Griese M;Konstan MW;Wainwright C;Ratjen

F;Sermet-Gaudelus I;Plant B;Munck A;Jiang Y;Gilmartin G;Davies JC; (2014) 'Long-

term safety and efficacy of ivacaftor in patients with cystic fibrosis who have the

Gly551Asp-CFTR mutation: a phase 3, open-label extension study (PERSIST)'. The

Lancet Respiratory Medicine, 2 (11):902-910.

Keating D, Crowe MJ;Kennedy B;Salmon A;Britton D;Gallagher CG;McKone

EF;Schaffer K (2014) 'Molecular detection of an atypical, highly resistant, clonal

Pseudomonas aeruginosa isolate in cystic fibrosis patients'. Journal of cystic fibrosis :

official journal of the European Cystic Fibrosis Society, 12 (2):141-146.

Professor Paul McLoughlin

McCullagh, BN; Costello, CM; Li, L; O'Connell, C; Codd, M; Lawrie, A; Morton, A;

Kiely, DG; Condliffe, R; Elliot, C; McLoughlin, P; Gaine, S. (2015) 'Elevated plasma

CXCL12α is associated with a poorer prognosis in pulmonary arterial hypertension'.

PLoS ONE, 10 (4).

P McLoughlin (2015) 'Obesity and lung disease: a toxic mix'. Acta Physiologica

Scandinavica, 213 (4):756-757.

Lynch C, Grant T, McLoughlin P, Last J (2015) 'The relevance of basic sciences in

undergraduate medical education'. Irish Journal of Medical Science .

Dr Hilary McMahon

O'Sullivan J, Comerford E, Rachidi W, Scott M, Hooper N, McMahon H (2015) 'The

effects of the cellular and infectious prion protein on the neuronal adaptor protein X11a'.

Biochimica et biophysica acta, 1850 (11):2213-2221.

Dr Tara McMorrow

Slyne J, Slattery C;McMorrow T;Ryan MP (2015) 'New developments concerning the

proximal tubule in diabetic nephropathy: in vitro models and mechanisms'. Nephrology,

dialysis, transplantation : official publication of the European Dialysis and Transplant

Association - European Renal Association, 30 Suppl 4 :1-7.

Cassidy H, Slyne J, O'Kelly P, Traynor C, Conlon PJ, Johnston O, Slattery C, Ryan MP,

McMorrow T (2015) 'Urinary biomarkers of chronic allograft nephropathy'. Proteomics

- Clinical Applications, 9 (5-6):574-585.

Professor Walter McNicholas

Mitchell S, Simonds A;Andreas S;Bonsignore MR;Cooper B;Donic V;McNicholas

WT;Morrell M;Palange P;Prest G;Riha R;Trang H;Randerath W;van der Grinten

C;Verbraecken J;de Backer W (2015) 'Introducing a core curriculum for respiratory

sleep practitioners'. Breathe (Sheffield, England), 11 (1):50-56.

Lee RN, Kelly E;Nolan G;Eigenheer S;Boylan D;Murphy D;Dodd J;Keane

MP;McNicholas WT (2015) 'Disordered breathing during sleep and exercise in

idiopathic pulmonary fibrosis and the role of biomarkers'. QJM - Monthly Journal of the

Association of Physicians, 108 (4):315-323.

Ryan S, Crinion SJ;McNicholas WT (2014) 'Obesity and sleep-disordered breathing--

when two 'bad guys' meet'. QJM - Monthly Journal of the Association of Physicians, 107

(12):949-954.

Page 29: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Tkacova R, McNicholas WT;Javorsky M;Fietze I;Sliwinski P;Parati G;Grote L;Hedner

J; (2014) 'Nocturnal intermittent hypoxia predicts prevalent hypertension in the

European Sleep Apnoea Database cohort study'. European Respiratory Journal, 44

(4):931-941.

Professor Wim Meijer

Babatunde, AO; Miranda-CasoLuengo, R; Imtiaz, M; Zhao, YQ; Meijer, WG (2015)

'Performance assessment and microbial diversity of two pilot scale multi-stage sub-

surface flow constructed wetland systems'. Journal of Environmental Sciences .

Bedri, Z; Corkery, A; O'Sullivan, JJ; Deering, LA; Demeter, K; Meijer, WG; O'Hare, G;

Masterson, B; (2015) 'Evaluating a microbial water quality prediction model for beach

management under the revised EU Bathing Water Directive'. Journal of Environmental

Management .

Coulson, GB; Miranda-CasoLuengo, AA; Miranda-CasoLuengo, R; Wang, X; Oliver, J;

Willingham-Lane JM; Meijer, WG; Hondalus, MK (2015) 'Transcriptome

reprogramming by plasmid encoded transcriptional regulators is required for host-niche

adaptation of a macrophage pathogen'. Infection and Immunity, 83 (8):3137-3145.

Valero-Rello, A; Hapeshi, A; Anastasi, E; Alvarez, S; Scortti, M; Meijer, WG;

MacArthur, I; Vazquez-Boland, J (2015) 'An invertron-like linear plasmid mediates

intracellular survival and virulence in bovine isolates of Rhodococcus equi'. Infection

and Immunity, 83 (7):2725-2737.

Bedri, Z; O'Sullivan, JJ; Deering, LA; Demeter, K; Masterson, B; Meijer, WG; &

O'Hare, G.M.P (2015) 'Assessing the water quality response to an alternative sewage

disposal strategy at bathing sites on the east coast of Ireland'. Marine Pollution Bulletin,

91 (1):330-346.

Bedri, Z; Corkery, A; O'Sullivan, JJ; Alvarez, MX; Erichsen, AChr, Deering, LA;

Demeter, K; O'Hare GMP; Meijer WG; Masterson, B (2014) 'An integrated catchment-

coastal modelling system for real-time water quality forecasts'. Environmental

Modelling and Software, 61 :458-476.

Professor Grace V T Mulcahy

Zintl A, Talavera S, Sacchi-Nestor C, Ryan M, Chryssafidis A, Mulcahy G (2015)

'Comparison of Fasciola hepatica genotypes in relation to their ability to establish patent

infections in the final host'. Veterinary Parasitology, 210 (3-4):145-150.

Chryssafidis, A. L., Fu, Y., De Waal, T., Mulcahy, G. (2015) 'Standardisation of egg-

viability assays for Fasciola hepatica and Calicophoron daubneyi: A tool for evaluating

new technologies of parasite control'. Veterinary Parasitology, 210 (1-2):25-31.

Ezzaty Mirhashemi, M. and Zintl, A. and Grant, T. and Lucy, F.E. and Mulcahy, G. and

De Waal, T. (2015) 'Comparison of diagnostic techniques for the detection of

Cryptosporidium oocysts in animal samples'. Experimental Parasitology, 151-152 :14-

20.

Professor Evelyn Murphy

Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP (2015)

'Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate

Hyperinflammatory Responses in Monocytic Cells'. Immunology, 195 (4):1436-1448.

Murphy EP, Crean D (2015) 'Molecular Interactions between NR4A Orphan Nuclear

Receptors and NF-kB Are Required for Appropriate Inflammatory Responses and

Page 30: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Immune Cell Homeostasis'. Biomolecules, 5 (3):1302-1318.

Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy EP,

Brayden D, Veale DJ, Fearon U. (2014) 'Redox mediated angiogenesis in the hypoxic

joint of inflammatory arthritis'. Arthritis and Rheumatism .

Dr Keith Murphy

Power, B.J. and O'reilly, G. and Murphy, R. and Murphy, K.J. and Pickering, M. and

Jones, J.F.X. (2015) 'Normal nerve striations are altered in the trembler-J mouse, a

model of charcot-marie-tooth disease'. Muscle and Nerve, 51 (2):246-252.

Dr Peter O'Brien

ZS Polizopoulou, CK Koutinas, JJ Cerón, A Tvarijonaviciute, S Martínez-Subiela, A

Dasopoulou, MJ York, IF Roman, M Gandhi, S Patel, PJ O'Brien (2015) 'Correlation of

serum cardiac troponin I and acute phase protein concentrations with clinical staging in

dogs with degenerative mitral valve disease'. Veterinary clinical pathology / American

Society for Veterinary Clinical Pathology, 44 (3):397-404.

DJ Brayden, SA Cryan, KA Dawson, PJ O¿Brien, JC Simpson (2015) 'High-content

analysis for drug delivery and nanoparticle applications'. Drug Discovery Today, 20 (8).

Professor Eoin O'Brien

Draman MS, Dolan E;van der Poel L;Tun TK;McDermott JH;Sreenan S;O'Brien E

(2015) 'The importance of night-time systolic blood pressure in diabetic patients: Dublin

Outcome Study'. Journal of Hypertension, 33 (7):1373-1377.

O'Brien E, Dolan E;Atkins N (2015) 'Failure to Provide ABPM to All Hypertensive

Patients Amounts to Medical Ineptitude'. Journal of clinical hypertension (Greenwich,

Conn.), 17 (6):462-465.

McCarthy NS, Vangjeli C;Cavalleri GL;Delanty N;Shianna KV;Surendran P;O'Brien

E;Munroe PB;Masca N;Tomaszewski M;Samani NJ;Stanton AV (2014) 'Two further

blood pressure loci identified in ion channel genes with a gene-centric approach'.

Circulation. Cardiovascular genetics, 7 (6):873-879.

Dr Eoin O'Cearbhaill

Zhang, Hong and Zhao, Tianyu and Duffy, Patrick and Dong, Yixiao and Annaidh,

Aisling N\'\i and O'Cearbhaill, Eoin and Wang, Wenxin (2015) 'Hydrolytically

Degradable Hyperbranched PEG-Polyester Adhesive with Low Swelling and Robust

Mechanical Properties'. Advanced healthcare materials, 4 (15):2260-2268.

Zhang, Hong and Zhao, Tianyu and Newland, Ben and Duffy, Patrick and Annaidh,

Aisling N\'\i and O'Cearbhaill, Eoin D and Wang, Wenxin (2015) 'On-demand and

negative-thermo-swelling tissue adhesive based on highly branched ambivalent PEG--

catechol copolymers'. Journal of Materials Chemistry B, 3 (31):6420-6428.

Cahill, Ellen Mary and O'Cearbhaill, Eoin D (2015) 'Towards Biofunctional

Microneedles for Stimulus Responsive Drug Delivery'. Bioconjugate chemistry .

Roche, Ellen T,Fabozzo, Assunta,Lee, Yuhan,Polygerinos, Panagiotis,Friehs,

Ingeborg,Schuster, Lucia,Whyte, William,Berazaluce, Alejandra Maria Casar,Bueno,

Alejandra,Lang, Nora (2015) 'A light-reflecting balloon catheter for atraumatic tissue

defect repair'. Science Translational Medicine, 7 (306).

Dr David O'Connell

Page 31: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

David J O'Connell, Francesca Baldelli Bombelli, Andrzej Pitek, Marco Monopoli,

Dolores Cahill and Kenneth A Dawson (2015) 'Characterization of the bionano interface

and mapping extrinsic interactions of the corona of nanomaterials'. Nanoscale .

Jan Rosier and David O'Connell (2015) 'Nuances in the Entrepreneurship Training

Toolbox'. Nature Biotechnology, 33 :133-135.

Duffy FJ, O'Donovan D, Devocelle M, Moran N, O'Connell DJ, Shields DC (2015)

'Virtual Screening Using Combinatorial Cyclic Peptide Libraries Reveals Protein

Interfaces Readily Targetable by Cyclic Peptides'. J CHEM INF MODEL .

Dawn R. Christiansona, Andrey S. Dobroffb, Bettina Pronetha, Amado J. Zuritad,

Ahmad Salameha, Eleonora Dondossolaa, Jun Makinoe, Cristian G. Bologaf, Tracey L.

Smith, Virginia J. Yaob, Tiffany L. Calderoneg, David J. O'Connell, Tudor I. Opreaf,

Kazunori Kataokai, Dolores J. Cahill, Jeffrey E. Gershenwald, Richard L. Sidmanj,

Wadih Arap, and Renata Pasqualini (2015) 'Ligand-directed targeting of lymphatic

vessels uncovers mechanistic insights in melanoma metastasis'. PNAS, :1-6.

Duffy, F.J. and O'Donovan, D. and Devocelle, M. and Moran, N. and O'Connell, D.J.

and Shields, D.C. (2015) 'Virtual screening using combinatorial cyclic peptide libraries

reveals protein interfaces readily targetable by cyclic peptides'. Journal of Chemical

Information and Modeling, 55 (3):600-613.

Professor Ronan O'Connell

Knowles CH, Horrocks EJ;Bremner SA;Stevens N;Norton C;O'Connell PR;Eldridge S;

(2015) 'Percutaneous tibial nerve stimulation versus sham electrical stimulation for the

treatment of faecal incontinence in adults (CONFIDeNT): a double-blind, multicentre,

pragmatic, parallel-group, randomised controlled trial'. Lancet .

Tevlin R, Larkin JO;Hyland JM;O'Connell PR;Winter DC (2015) 'Brain metastasis from

colorectal carcinoma: a single cancer centre experience'. Irish Journal of Medical

Science, 184 (3):673-675.

Devane L, Evers J, Jones JFX, O¿Connell PR (2015) 'A review of sacral nerve

stimulation parameters used in the treatment of faecal incontinence'. Surgeon, 13

(3):156-162.

Devane L, Evers J, Jones JFX, O¿Connell PR (2015) 'A review of sacral nerve

stimulation parameters used in the treatment of faecal incontinence'. Surgeon, 13

(3):156-162.

Tevlin R, Larkin JO;Hyland JM;O'Connell PR;Winter DC (2015) 'Primary colorectal

lymphoma - A single centre experience'. Surgeon, 13 (3):151-155.

Maeda Y, O'Connell PR;Lehur PA;Matzel KE;Laurberg S; (2015) 'Sacral nerve

stimulation for faecal incontinence and constipation: a European consensus statement'.

Colorectal Disease, 17 (4):1-87.

Clancy C, Burke JP;Albert MR;O'Connell PR;Winter DC (2015) 'Transanal endoscopic

microsurgery versus standard transanal excision for the removal of rectal neoplasms: a

systematic review and meta-analysis'. Diseases of the Colon and Rectum, 58 (2):254-

261.

Lavelle, A., Lennon, G., O'Sullivan, O., Docherty, N., Balfe, A., Maguire, A., Mulcahy,

H. E., Doherty, G., O'Donoghue, D., Hyland, J., Ross, R. P., Coffey, J. C., Sheahan, K.,

Cotter, P. D., Shanahan, F., Winter, D. C., O'Connell, P. R. (2015) 'Spatial variation of

the colonic microbiota in patients with ulcerative colitis and control volunteers'. Gut .

Page 32: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Lavelle A, Lennon G, O'Sullivan O, Docherty N, Balfe A, Maguire A, Mulcahy HE,

Doherty G, O'Donoghue D, Hyland J, Ross RP, Coffey JC, Sheahan K, Cotter PD,

Shanahan F, Winter DC, O'Connell PR (2015) 'Spatial variation of the colonic

microbiota in patients with ulcerative colitis and control volunteers'. Gut .

Cotter MB, Kelly ME, O'Connell PR, Hyland J, Winter DC, Sheahan K, Gibbons D

(2014) 'Anal intraepithelial neoplasia: a single centre 19 year review'. Colorectal

Disease, 16 (10):777-782.

Evers J, Devane L, Carrington EV, Scott SM, Knowles CH, O'Connell PR, Jones JF

(2014) 'Effects of stimulation frequency and intensity in sacral neuromodulation on

anorectal inputs to the somatosensory cortex in an experimental model'. British Journal

of Surgery, 101 (10):1317-1328.

Carrington EV, Evers J, Grossi U, Dinning PG, Scott SM, O'Connell PR, Jones JF,

Knowles CH (2014) 'A systematic review of sacral nerve stimulation mechanisms in the

treatment of fecal incontinence and constipation'. Neurogastroenterology and Motility,

26 (9):1222-1237.

Dr Darran O'Connor

Nelson L, McKeen HD, Marshall A, Mulrane L, Starczynski J, Storr SJ, Lanigan F,

Byrne C, Arthur K, Hegarty S, Ali AA, Furlong F, McCarthy HO, Ellis IO, Green AR,

Rakha E, Young L, Kunkler I, Thomas J, Jack W, Cameron D, Jirstr�m K,Yakkundi A,

McClements L, Martin SG, Gallagher WM, Dunn J, Bartlett J, O'Connor D, Robson T

(2015) ''FKBPL: a marker of good prognosis in breast cancer'. Oncotarget, 6

(14):12209-12223.

Finucane, O.M.a and Lyons, C.L.b and Murphy, A.M.c and Reynolds, C.M.d and

Klinger, R.e and Healy, N.P.f and Cooke, A.A.g and Coll, R.C.h and McAllan, L.i and

Nilaweera, K.N.j and O'Reilly, M.E.k and Tierney, A.C.l and Morine, M.J.m and

Alcala-Diaz, J.F.n and Lopez-Miranda, J.o and O'Connor, D.P.p and O'Neill, L.A.q and

McGillicuddy, F.C.r and Roche, H.M.s (2015) 'Monounsaturated fatty acid-enriched

high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and

insulin resistance despite obesity'. Diabetes, 64 (6):2116-2128.

Duffy MJ, Synnott NC, McGowan PM, Crown J, O'Connor D, Gallagher WM. (2014)

'p53 as a target for the treatment of cancer'. Cancer Treatment Reviews, 40 :1153-1160.

Mulrane L, Gallagher WM, O'Connor DP (2014) 'A novel mechanism of regulation of

the anti-metastatic miR-31 by EMSY in breast cancer'. Breast Cancer Research, 16 (6).

Ivers LP, Cummings B, Owolabi F, Welzel K, Klinger R, Saitoh S, O'Connor D, Fujita

Y, Scholz D, Itasaki N (2014) 'Dynamic and influential interaction of cancer cells with

normal epithelial cells in 3D culture'. Cancer Cell International, 14 (1).

Ivers LP, Cummings B, Owolabi F, Welzel K, Klinger R, Saitoh S, O'Connor D, Fujita

Y, Scholz D, Itasaka N (2014) 'Dynamic and influential interaction of cancer cells with

normal epithelial cells in 3D culture'. Cancer Cell International, 14 (1).

Dr John O'Connor

O'Connor JJ (2015) 'Neuroimmunology and synaptic function'. Neuropharmacology, 96

(A):1-3.

Goutier W, O'Connor JJ. Lowry, JP, McCreary AC (2015) 'The effect of nicotine

induced behavioral sensitization on dopamine D1 receptor pharmacology: An in vivo

and ex vivo study in the rat'. European Neuropsychopharmacology, 25 (6):933-943.

Page 33: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Audrey M. Wall, Gatambwa Mukandala, Nigel H. Greig, John J. O'Connor (2015)

'Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after

acute hypoxia'. Neuroscience Research, 93 (5):815-829.

Professor Kevin O'Connor

Jelena Radivojevic, Sanja Skaro, Lidija Senerovic, Branka Vasiljevic, Maciej Guzik,

Shane T Kenny, Veselin Maslak, Jasmina Nikodinovic-Runic, Kevin E O¿Connor

(2015) 'Polyhydroxyalkanoate-based 3-hydroxyoctanoic acid and its derivatives as a

platform of bioactive compounds'. Applied Microbiology and Biotechnology, :1-12.

T Narancic, R Davis, J Nikodinovic-Runic, KE O¿Connor. (2015) 'Recent developments

in biocatalysis beyond the laboratory'. Fems Microbiology Letters, 37 (5):943-954.

Davis R, Duane G, Kenny ST, Cerrone F, Guzik MW, Babu RP, Casey E, O'Connor KE.

(2015) 'High cell density cultivation of Pseudomonas putida KT2440 using glucose

without the need for oxygen enriched air supply'. Biotechnology and Bioengineering,

112 (4):725-733.

Santosh K. Choudhari, Federico Cerrone, Trevor Woods, Kieran Joyce, Vincent O

Flaherty, Kevin O Connor, Ramesh Babu. (2015) 'Pervaporation separation of butyric

acid from aqueous and anaerobic digestion (AD) solutions using PEBA based composite

membranes'. Journal of Industrial and Engineering Chemistry, 191 :45-52.

Szwej, E. and Devocelle, M. and Kenny, S. and Guzik, M. and O'Connor, S. and

Nikodinovic-Runic, J. and Radivojevic, J. and Maslak, V. and Byrne, A.T. and

Gallagher, W.M. and Zulian, Q.R. and Zinn, M. and O'Connor, K.E. (2015) 'The chain

length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity

and structure of anti-cancer peptides'. Journal of Biotechnology, 204 :7-12.

Cerrone, F. and Davis, R. and Kenny, S.T. and Woods, T. and O'Donovan, A. and

Gupta, V.K. and Tuohy, M. and Babu, R.P. and O'Kiely, P. and O'Connor, K. (2015)

'Use of a mannitol rich ensiled grass press juice (EGPJ) as a sole carbon source for

polyhydroxyalkanoates (PHAs) production through high cell density cultivation'.

Bioresource Technology, 191 :45-52.

Professor Donal O'Shea

Breen C, Ryan M;Gibney MJ;O'Shea D (2015) 'Diabetes-related nutrition knowledge

and dietary intake among adults with type 2 diabetes'. British Journal of Nutrition, 114

(3):439-447.

Mitchell PD, King TJ;O'Shea DB (2015) 'Subcutaneous Emphysema in Acute Asthma:

A Cause for Concern?'. Respiratory Care, 60 (8):1-3.

Mohan H, Nicholson P;Winter DC;O'Shea D;O'Toole D;Geoghegan J;Maguire D;Hoti

E;Traynor O;Cantwell CP (2015) 'Radiofrequency ablation for neuroendocrine liver

metastases: a systematic review'. Journal of vascular and interventional radiology :

JVIR, 26 (7):935-9420.

Carolan E, Tobin LM;Mangan BA;Corrigan M;Gaoatswe G;Byrne G;Geoghegan

J;Cody D;O'Connell J;Winter DC;Doherty DG;Lynch L;O'Shea D;Hogan AE (2015)

'Altered distribution and increased IL-17 production by mucosal-associated invariant T

cells in adult and childhood obesity'. Journal of Immunology, 194 (12):5775-5780.

O'Connor E, Green S;Kiely C;O'Shea D;Ega¿¿a M (2015) 'Differential effects of age

and type 2 diabetes on dynamic vs. peak response of pulmonary oxygen uptake during

exercise'. Journal of applied physiology (Bethesda, Md. : 1985), 118 (8):1031-1039.

Woods CP, Corrigan M;Gathercole L;Taylor A;Hughes B;Gaoatswe G;Manolopoulos

Page 34: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

K;Hogan AE;O'Connell J;Stewart PM;Tomlinson JW;O'Shea D;Sherlock M (2015)

'Tissue specific regulation of glucocorticoids in severe obesity and the response to

significant weight loss following bariatric surgery (BARICORT)'. Journal of Clinical

Endocrinology and Metabolism, 100 (4):1434-1444.

Murtagh G, O Connell J;O Connell E;Tallon E;Watson C;Gallagher J;Baugh J;Patle

A;O Connell L;Griffin J;O'Hanlon R;Voon V;Ledwidge M;O Shea D;McDonald K

(2015) 'Importance of risk factor management in diabetic patients and reduction in Stage

B heart failure'. QJM - Monthly Journal of the Association of Physicians, 108 (4):307-

314.

O'Malley E, Ahern T;Dunlevy C;Lehane C;Kirby B;O'Shea D (2015) 'Obesity-related

chronic lymphoedema-like swelling and physical function'. QJM - Monthly Journal of

the Association of Physicians, 108 (3):183-187.

Somerville R, McKenzie K;Eslami S;Breen C;O'Shea D;Wall P (2015) 'Poor mental

health in severely obese patients is not explained by the presence of comorbidities'.

Clinical Obesity, 5 (1):12-21.

Breen, C. and Mckenzie, K. and Yoder, R. and Ryan, M. and Gibney, M.J. and O'Shea,

D. (2015) 'A qualitative investigation of patients' understanding of carbohydrate in the

clinical management of type 2 diabetes'. Journal of Human Nutrition and Dietetics .

Yang S, Wang B;Humphries F;Hogan AE;O'Shea D;Moynagh PN (2014) 'The E3

ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin

resistance'. Immunity, 41 (6):973-987.

Exley MA, Hand L;O'Shea D;Lynch L (2014) 'Interplay between the immune system

and adipose tissue in obesity'. Journal of Endocrinology, 223 (2):1-8.

Kiely C, O'Connor E;O'Shea D;Green S;Ega¿¿a M (2014) 'Hemodynamic responses

during graded and constant-load plantar flexion exercise in middle-aged men and

women with type 2 diabetes'. Journal of applied physiology (Bethesda, Md. : 1985), 117

(7):755-764.

Murtagh G, O Connell J, O Connell E, Tallon E, Watson C, Gallagher J, Baugh J, Patle

A, O Connell L, Griffin J, O' Hanlon R, Voon V, Ledwidge M, O Shea D, McDonald K

(2014) 'Importance of Risk Factor Management in Diabetic Patients & Reduction in

Stage B Heart Failure'. Quarterly Journal of Medicine .

Professor Stefan Oscarson

Yuan S, Hollinger M, Lachowicz-Scroggins ME, Kerr SC, Dunican EM, Daniel BM,

Ghosh S, Erzurum SC, Willard B, Hazen SL, Huang X, Carrington SD, Oscarson S,

Fahy JV (2015) 'Oxidation increases mucin polymer cross-links to stiffen airway mucus

gels'. Science Translational Medicine, 7 (276).

McCabe O, Spinelli S, Farenc C, Labbé M, Tremblay D, Blangy S, Oscarson S,

Moineau S, Cambillau C (2015) 'The targeted recognition of Lactococcus lactis phages

to their polysaccharide receptors'. Molecular Microbiology .

Christensen, H.M. and Oscarson, S. and Jensen, H.H. (2015) 'Common side reactions of

the glycosyl donor in chemical glycosylation'. Carbohydrate Research, 408 :51-95.

L. Guazzelli, R. Ulc, L. Rydner, S.Oscarson (2015) 'A synthetic strategy to xylose-

containing thioglycoside tri- and tetrasaccharide building blocks corresponding to

Cryptococcus neoformans capsular polysaccharide structures'. Organic and

Biomolecular Chemistry .

Dr Francesca Paradisi

Page 35: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Takahashi, H; Kutasy, B; Pes, L; Paradisi, F; Puri, P (2015) 'Decidual b-carotene-

15,15¿-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of

congenital diaphragmatic hernia'. Pediatric Surgery International, 31 :37-43.

Kutasy, B; Pes, L; Friedmacher, F.; Paradisi, F; Puri, P (2014) 'Nitrofen increases total

retinol levels in placenta during lung morphogenesis in the nitrofen model of congenital

diaphragmatic hernia'. Pediatric Surgery International, 30 :1017-1022.

Pandurangan, K; Kitchen, J.A; Blasco, S; Paradisi, F; Gunnlaugsson, T (2014)

'Supramolecular pyridyl urea gels as soft matter with antibacterial properties against

MRSA and/or E. coli'. Chemical Communications, 50 :10819-10822.

Professor Ron Pinhasi

Pinhasi, R; et al. (2015) 'Optimal ancient DNA yields from the inner ear part of the

human petrous bone'. PLoS ONE .

Moncel M-H; Pleurdeau D; Pinhasi R; Yeshurun R; Agapishvili T; Chevalier T;

LeBourdonnec F-X; Poupeau G; Nomade S; Jennings R; Higham T; Tushubramisvili T;

Lordkipanidze D (2015) 'The Middle Palaeolithic record of Georgia: a synthesis of the

technological, economic and paleoanthropological aspects'. Anthropologie:

International Journal of Human Diversity and Evolution, 53 :93-125.

Pinhasi, R. and Eshed, V. and Von Cramon-Taubadel, N. (2015) 'Incongruity between

affinity patterns based on mandibular and lower dental dimensions following the

transition to agriculture in the Near East, Anatolia and Europe'. PLoS ONE, 10 (2).

Donoghue, H.D. and Michael Taylor, G. and Marcsik, A. and Molnár, E. and Pálfi,

G. and Pap, I. and Teschler-Nicola, M. and Pinhasi, R. and Erdal, Y.S. and VelemÃ-

nsky, P. and Likovsky, J. and Belcastro, M.G. and Mariotti, V. and Riga, A. and Rubini,

M. and Zaio, P. and Besra, G.S. and Lee, O.Y.-C. and Wu, H.H.T. and Minnikin, D.E.

and Bull, I.D. and O'Grady, J. and Spigelman, M. (2015) 'A migration-driven model for

the historical spread of leprosy in medieval Eastern and Central Europe'. Infection,

Genetics and Evolution, 31 :250-256.

Hlavenková, L. and Teasdale, M.D. and Gábor, O. and Nagy, G. and Beſuš, R.

and Marcsik, A. and Pinhasi, R. and Hajdu, T. (2015) 'Childhood bone tuberculosis from

Roman Pécs, Hungary'. HOMO- Journal of Comparative Human Biology, 66 (1):27-

37.

Macintosh, A.A. and Davies, T.G. and Pinhasi, R. and Stock, J.T. (2015) 'Declining

tibial curvature parallels ⿼6150 years of decreasing mobility in central european

agriculturalists'. American Journal of Physical Anthropology .

Macintosh1, AA; Pinhasi,R;Stock JT (2014) 'Divergence in Male and Female

Manipulative Behaviors with the Intensification of Metallurgy in Central Europe'. PLoS

ONE, 9 (11).

Gamba C, Jones ER, Teasdale MD, McLaughlin Rl, Gonzalez-Fortes G, Mattiangeli V,

Domboróczki L, Kővári I, Pap I, Anders A, Whittle A, Dani J, Raczky P, Higham TFG,

Hofreiter M, Bradley DG, Pinhasi R. (2014) 'Genomic flux and stasis during five

millennia of Hungarian prehistory'. Nature Communications .

Hlavenková, L; Teasdale, M; Gábor, O; Nagy, G; Beňu¿, R; Marcsik, A; Pinhasi, R;

Hajdu, T. (2014) 'Childhood bone tuberculosis from Roman Pécs, Hungary'. HOMO -

Journal of Comparative Human Biology .

Adler, DS; Wilkinson, KN; Blockley, S; Mark, D; Pinhasi, R; Schmidt-Magee, BA;

Yeritsyan, B; Nahapetyan, S; Mallol, C; Berna, F; Glauberman, PJ; Raczynski-Henk, Y;

Page 36: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Cullen, V; Frahm, E; Jöris, O; Macloud, A; Smith, V; Gasparian, B. (2014) 'Early

Levallois Technology and the Transition from the Lower to Middle Palaeolithic in the

Southern Caucasus'. Science, 345 :1609-1613.

Pinhasi, R; Meshveliani, T; Matskevich, Z; Bar-Oz, G; Weissbrod, L; Miller, CE;

Wilkinson, K; Lordkipanidze, D; Jakeli, N; Kvavadze, E; Higham TFG; Belfer-Cohen

A. (2014) '2014. Satsurblia: new insights about human response and survival across the

Last Glacial Maximum in the southern Caucasus'. PLoS ONE, 9 .

Professor Helen Roche

Rangel-Zúñiga OA, Camargo A, Marin C, Peña-Orihuela P, Pérez-Martínez P, Delgado-

Lista J, González-Guardia L, Yubero-Serrano EM, Tinahones FJ, Malagón MM, Pérez-

Jiménez F, Roche HM, López-Miranda J. (2015) 'Proteome from patients with metabolic

syndrome is regulated by quantity and quality of dietary lipids'. BMC Genomics, 8 (16).

Minihane AM, Vinoy S, Russell WR, Baka A, Roche HM, Tuohy KM, Teeling JL,

Blaak EE, Fenech M, Vauzour D, McArdle HJ, Kremer BH, Sterkman L, Vafeiadou K,

Benedetti MM, Williams CM, Calder PC. (2015) 'Low-grade inflammation, diet

composition and health: current research evidence and its translation'. British Journal of

Nutrition, 114 (7):999-1012.

Matone, A., O'Grada, C. M., Dillon, E. T., Morris, C., Ryan, M. F., Walsh, M., Gibney,

E. R., Brennan, L., Gibney, M. J., Morine, M. J., Roche, H. M. (2015) 'Body mass index

mediates inflammatory response to acute dietary challenges'. Mol Nutr Food Res .

Morris C, O'Grada CM, Ryan MF, Gibney MJ, Roche HM, Gibney ER, Brennan L

(2015) 'Modulation of the lipidomic profile due to a lipid challenge and fitness level: a

postprandial study'. Lipids in Health and Disease, 14 (1).

Finucane, O.M.a and Lyons, C.L.b and Murphy, A.M.c and Reynolds, C.M.d and

Klinger, R.e and Healy, N.P.f and Cooke, A.A.g and Coll, R.C.h and McAllan, L.i and

Nilaweera, K.N.j and O'Reilly, M.E.k and Tierney, A.C.l and Morine, M.J.m and

Alcala-Diaz, J.F.n and Lopez-Miranda, J.o and O'Connor, D.P.p and O'Neill, L.A.q and

McGillicuddy, F.C.r and Roche, H.M.s (2015) 'Monounsaturated fatty acid-enriched

high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and

insulin resistance despite obesity'. Diabetes, 64 (6):2116-2128.

González-Guardia, L. and Yubero-Serrano, E.M. and Delgado-Lista, J. and Perez-

Martinez, P. and Garcia-Rios, A. and Marin, C. and Camargo, A. and Delgado-Casado,

N. and Roche, H.M. and Perez-Jimenez, F. and Brennan, L. and López-Miranda, J.

(2015) 'Effects of the mediterranean diet supplemented with coenzyme Q10 on

metabolomic profiles in elderly men and women'. Journals of Gerontology - Series A

Biological Sciences and Medical Sciences, 70 (1):78-84.

Murphy, A.M. and Lyons, C.L. and Finucane, O.M. and Roche, H.M. (2015)

'Interactions between differential fatty acids and inflammatory stressors-impact on

metabolic health'. Prostaglandins Leukotrienes and Essential Fatty Acids, 92 :49-55.

McMorrow, A.M. and Connaughton, R.M. and Lithander, F.E. and Roche, H.M. (2015)

'Adipose tissue dysregulation and metabolic consequences in childhood and adolescent

obesity: Potential impact of dietary fat quality'. Proceedings of the Nutrition Society, 74

(1):67-82.

Finucane OM, Reynolds CM;McGillicuddy FC;Harford KA;Morrison M;Baugh

J;Roche HM (2014) 'Macrophage migration inhibitory factor deficiency ameliorates

high-fat diet induced insulin resistance in mice with reduced adipose inflammation and

Page 37: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

hepatic steatosis'. PLoS ONE, 9 (11).

O'Gorman, A., Morris, C., Ryan, M., O'Grada, C. M., Roche, H. M., Gibney, E. R.,

Gibney, M. J., Brennan, L. (2014) 'Habitual dietary intake impacts on the lipidomic

profile'. J Chromatogr B Analyt Technol Biomed Life Sci, 966 :140-6.

Dr Brian Rodriguez

I. Bdikin, A. Heredia, S. M. Neumayer, V. S. Bystrov, J. Gracio, Brian J. Rodriguez, A.

L. Kholkin (2015) 'Local piezoresponse and polarization switching in nucleobase

thymine microcrystals'. Journal of Applied Physics, 118 (7).

E. Seyedhosseini, I. Bdikin, M. Ivanov, D. Vasileva, A. Kudryavtsev, Brian J.

Rodriguez, A. L. Kholkin (2015) 'Tip-induced domain structures and polarization

switching in ferroelectric amino acid glycine'. Journal of Applied Physics, 118 (7).

J. I. Kilpatrick, I. Revenko, Brian J. Rodriguez (2015) 'Nanomechanics of Cells and

Biomaterials Studied by Atomic Force Microscopy'. Advanced healthcare materials .

P. Kumar, A. Satyam, X. Fan, Y. Rochev, Brian J. Rodriguez, A. Gorelov, L. Joshi, M.

Raghunath, A. Pandit, and D. I. Zeugolis (2015) 'Accelerated development of

supramolecular corneal stromal-like assemblies from corneal fibroblasts in the presence

of macromolecular crowders'. Tissue Engineering Part C: Methods, 21 .

Carville NC, Collins L;Manzo M;Gallo K;Lukasz BI;McKayed KK;Simpson

JC;Rodriguez BJ (2015) 'Biocompatibility of ferroelectric lithium niobate and the

influence of polarization charge on osteoblast proliferation and function'. Journal of

Biomedical Materials Research - Part A, 103 (8):2540-2548.

Ryan, K., Beirne, J.G., Redmond, G., Kilpatrick, J.I., Guyonnet, J., Buchete, N-V.,

Kholkin, A.L., and Rodriguez, B.J. (2015) 'Nanoscale piezoelectric properties of self-

assembled Fmoc-FF peptide fibrous networks'. ACS Applied Materials & Interfaces, 7

(23):12702-12707.

Liam Collins, Stephen Jesse, Nina Balke, Brian J. Rodriguez, Sergei Kalinin, and Qian

Li (2015) 'Band excitation Kelvin probe force microscopy utilizing photothermal

excitation'. Applied Physics Letters, 106 .

Pramod Kumar, Abhigyan Satyam, Xingliang Fan, Estelle Collin, Yury Rochev, Brian J.

Rodriguez, Alexander Gorelov, Simon Dillon, Lokesh Joshi, Michael Raghunath, Abhay

Pandit, and Dimitrios I. Zeugolis (2015) 'Macromolecularly crowded in vitro

microenvironments accelerate the production of extracellular matrix-rich supramolecular

assemblies'. Scientific Reports, 5 .

Collins, L. and Okatan, M.B. and Li, Q. and Kravenchenko, I.I. and Lavrik, N.V. and

Kalinin, S.V. and Rodriguez, B.J. and Jesse, S. (2015) 'Quantitative 3D-KPFM imaging

with simultaneous electrostatic force and force'. Nanotechnology, 26 (17):1-11.

Castro, A. and Ferreira, P. and Rodriguez, B.J. and Vilarinho, P.M. (2015) 'The role of

nanoporosity on the local piezo and ferroelectric properties of lead titanate thin films'.

Journal of Materials Chemistry C, 3 (5):1035-1043.

Carville, N.C. and Collins, L. and Manzo, M. and Gallo, K. and Lukasz, B.I. and

Mckayed, K.K. and Simpson, J.C. and Rodriguez, B.J. (2015) 'Biocompatibility of

ferroelectric lithium niobate and the influence of polarization charge on osteoblast

proliferation and function'. Journal of Biomedical Materials Research - Part A .

Mahajan, A. and Rodriguez, B.J. and Saravanan, K.V. and Ramana, E.V. and Costa,

P.M.F.J. and Vilarinho, P.M. (2015) 'Covering vertically aligned carbon nanotubes with

Page 38: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

a multiferroic compound'. Carbon, 82 (1):408-416.

Liam Collins, Stephen Jesse, Jason I. Kilpatrick, Alexander Tselev, M. Baris Okatan,

Sergei V. Kalinin, and Brian J. Rodriguez (2015) 'Kelvin Probe Force Microscopy in

liquid using Electrochemical Force Microscopy'. Beilstein Journal of Nanotechnology, 6

:201-214.

Kelly, CM; Northey, T; Ryan. K; Brooks, BR; Kholkin, AL; Rodriguez, BJ; Buchete,

NV; (2015) 'Conformational dynamics and aggregation behavior of piezoelectric

diphenylalanine peptides in an external electric field'. Biophysical Chemistry, 196 :16-

24.

L. Collins, A. Tselev, S. Jesse, M. B Okatan, R. Proksch, J. Mathews, G. Mitchell, B.J.

Rodriguez, S. V. Kalinin, and I. N. Ivanov (2014) 'Breaking the limits of structural and

mechanical imaging of the heterogeneous structure of coal macerals'. Nanotechnology,

25 .

Dr Noreen Sheehy

Miyatake, Y. and Sheehy, N. and Ikeshita, S. and Hall, W.W. and Kasahara, M. (2015)

'Anchorage-dependent multicellular aggregate formation induces CD44 high cancer

stem cell-like ATL cells in an NF-κB- and vimentin-dependent manner'. Cancer Letters,

357 (1):355-363.

Professor Denis Shields

Lombardi, F. Golla, K. Fitzpatrick, D. J. Casey, F. P. Moran, N. Shields, D. C. (2015)

'Discovering anti-platelet drug combinations with an integrated model of activator-

inhibitor relationships, activator-activator synergies and inhibitor-inhibitor synergies'.

PLoS Computational Biology, 11 (4).

Duffy, F.J. and O'Donovan, D. and Devocelle, M. and Moran, N. and O'Connell, D.J.

and Shields, D.C. (2015) 'Virtual screening using combinatorial cyclic peptide libraries

reveals protein interfaces readily targetable by cyclic peptides'. Journal of Chemical

Information and Modeling, 55 (3):600-613.

Duffy, F. J. Devocelle, M. Shields, D. C. (2015) 'Computational approaches to

developing short cyclic peptide modulators of protein-protein interactions'. Methods in

Molecular Biology, 1268 :241-271.

Bianchin, A. Bell, A. Chubb, A. J. Doolan, N. Leneghan, D. Stavropoulos, I. Shields, D.

C. Mooney, C. (2015) 'Design and evaluation of antimalarial peptides derived from

prediction of short linear motifs in proteins related to erythrocyte invasion'. PLoS ONE,

10 (6).

Fitzpatrick, D. J. Ryan, C. J. Shah, N. Greene, D. Molony, C. Shields, D. C. (2015)

'Genome-wide epistatic expression quantitative trait loci discovery in four human tissues

reveals the importance of local chromosomal interactions governing gene expression'.

BMC Genomics, 16 .

Therese Anne Holton , Vaishnavi Vijaykumar , David C. Dallas , Andrés Guerrero ,

Robyn C Borghese , Carlito B. Lebrilla , J. Bruce German , Daniela Barile , Mark A

Underwood , Denis C Shields , and Nora Khaldi , Accepted DOI: 10.1021/pr5006907

(Web): Oct 23, 2014 (2014) 'Following the digestion of milk proteins from mother to

baby'. Journal of Proteome Research .

Postmus et al (2014) 'Pharmacogenetic meta-analysis of genome-wide association

studies of LDL cholesterol response to statins'. Nature Communications, 5 .

Duffy FJ, Devocelle M, Croucher DR, Shields DC (2014) 'Computational survey of

Page 39: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

peptides derived from disulphide-bonded protein loops that may serve as mediators of

protein-protein interactions'. BMC Bioinformatics, 15 .

Professor Jeremy Simpson

Galea G, Bexiga MG;Panarella A;O'Neill ED;Simpson JC (2015) 'A high-content

screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER

retrograde trafficking'. Journal of Cell Science, 128 (13):2339-2349.

Carville NC, Collins L;Manzo M;Gallo K;Lukasz BI;McKayed KK;Simpson

JC;Rodriguez BJ (2015) 'Biocompatibility of ferroelectric lithium niobate and the

influence of polarization charge on osteoblast proliferation and function'. Journal of

Biomedical Materials Research - Part A, 103 (8):2540-2548.

Lecat S, Matthes HW;Pepperkok R;Simpson JC;Galzi JL (2015) 'A Fluorescent Live

Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic

Proteins Implicated in G Protein-coupled Receptor Signaling Pathways'. Molecular &

cellular proteomics : MCP, 14 (5):1385-1399.

Varela JA, Aberg C, Simpson JC, Dawson KA (2015) 'Trajectory-based co-localization

measures for nanoparticle-cell interaction studies'. Small, 11 (17):2026-2031.

Brayden DJ, Cryan SA, Dawson KA, O'Brien PJ, Simpson JC (2015) 'High-content

analysis for drug delivery and nanoparticle applications'. Drug Discovery Today .

Dunne CF, Twomey B;Kelly C;Simpson JC;Stanton KT (2015) 'Hydroxyapatite and

fluorapatite coatings on dental screws: effects of blast coating process and biological

response'. Journal of Materials Science: Materials in Medicine, 26 (1).

Heffernan LF, Simpson JC (2014) 'The trials and tubule-ations of Rab6 involvement in

Golgi-to-ER retrograde transport'. Biochemical Society Transactions, 42 (5):1453-1459.

Professor Cormac Taylor

Schaffer, K. and Taylor, C.T., (2015) 'The impact of hypoxia on bacterial infection'.

FEBS Journal, 282 (12):2260-2266.

Crifo B, Taylor CT (2015) 'Crosstalk Between Toll-Like Receptors and Hypoxia-

Dependent Pathways in Health and Disease'. Journal of investigative medicine : the

official publication of the American Federation for Clinical Research .

Kelly CJ, Zheng L;Campbell EL;Saeedi B;Scholz CC;Bayless AJ;Wilson KE;Glover

LE;Kominsky DJ;Magnuson A;Weir TL;Ehrentraut SF;Pickel C;Kuhn KA;Lanis

JM;Nguyen V;Taylor CT;Colgan SP (2015) 'Crosstalk between Microbiota-Derived

Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier

Function'. Cell Host and Microbe, 17 (5):662-671.

Nolan KA, Brennan EP;Scholz CC;Cullen C;Ryan A;Taylor CT;Godson C (2015)

'Paricalcitol protects against TGF-¿¿1-induced fibrotic responses in hypoxia and

stabilises HIF-¿¿ in renal epithelia'. Experimental Cell Research, 330 (2):371-381.

Manresa MC, Godson C;Taylor CT (2014) 'Hypoxia-sensitive pathways in

inflammation-driven fibrosis'. American Journal of Physiology - Regulatory Integrative

and Comparative Physiology, 307 (12):1-80.

Professor Emma C Teeling

Zixia Huang, Aurore Gallot, Nga T. Lao, Sébastien J. Puechmaille, Nicole M. Foley,

David Jebb, Michaël Bekaert and Emma C. Teeling (2015) 'A nonlethal sampling

method to obtain, generate and assemble whole blood transcriptomes from small, wild

Page 40: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

mammals'. Molecular Ecology Resources .

N. M. Foley, V. D. Thong, P. Soisook, S. M. Goodman, K. Armstrong, D. Jacobs, S. J.

Puechmaille & E. C. Teeling (2015) 'How and why overcome the impediments to

resolution: lessons from rhinolophid and hipposiderid bats'. Molecular Biology and

Evolution .

Emma SM Boston, Sébastien J Puechmaille, Fionn Clissmann, Emma C Teeling (2014)

'Further evidence for cryptic north-western refugia in Europe? Mitochondrial

phylogeography of the sibling species Pipistrellus pipistrellus and Pipistrellus

pygmaeus'. Acta Chiropterologica, 16 (2):263-277.

McMahon, B.J., Teeling, E.C. & Höglund, J. (2014) 'How and why should we

implement genomics into conservation?'. Evolutionary Applications, 7 :999-1007.

Sara Hayden and Emma C. Teeling (2014) 'The Molecular Biology of Vertebrate

Olfaction'. Anatomical Record, Volume 297 (Issue 11):2216-2226.

Professor Bill Watson

Wekesa A, Harrison M;Watson RW (2015) 'Physical activity and its mechanistic effects

on prostate cancer'. Prostate Cancer and Prostatic Diseases, 18 (3):197-207.

O'Hare FM, Watson RW;O'Neill A;Blanco A;Donoghue V;Molloy EJ (2015) 'Persistent

systemic monocyte and neutrophil activation in neonatal encephalopathy'. Journal of

Maternal-Fetal and Neonatal Medicine, :1-8.

O'Hare FM, Watson W;O'Neill A;Grant T;Onwuneme C;Donoghue V;Mooney

E;Downey P;Murphy J;Twomey A;Molloy EJ (2015) 'Neutrophil and monocyte toll-like

receptor 4, CD11b and reactive oxygen intermediates, and neuroimaging outcomes in

preterm infants'. Pediatric Research, 78 (1):82-90.

Gallagher MF, Salley Y, Spillane CD, Ffrench B, El Baruni S, Blacksheilds G, Smyth P,

Martin C, Sheils O, Watson W, O'Leary JJ. (2015) 'Enhanced regulation of cell cycle

and suppression of osteoblast differentiation molecular signatures by prostate cancer

stem-like holoclones'. J Clin Pathol .

Lundon, D. J. and Kelly, B. D. and Foley, R. and Loeb, S. and Fitzpatrick, J. M. and

Watson, R. W. G. and Rogers, E. and Durkan, G. C. and Walsh, K. (2015) 'Prostate

cancer risk assessment tools in an unscreened population'. WORLD JOURNAL OF

UROLOGY, 33 (6):827-832.

Evans JC, McCarthy J, Torres-Fuentes C, Cryan JF, Ogier J, Darcy R, Watson RW,

O'Driscoll CM. (2015) 'Cyclodextrin mediated delivery of NF-κB and SRF siRNA

reduces the invasion potential of prostate cancer cells in vitro'. Gene Therapy .

Foley, R.W., Gorman, L.V., Sharifi, N., Lundon, D.J., Murphy, K., Moore, H., Tuzova,

A., Perry, A., Murphy, T.B. and Watson, R.W.G. (2015) 'Improving Multivariable

Prostate Cancer Risk Assessment Using The Prostate Health Index'. BJU international .

Murphy L, Prencipe M;Gallagher WM;Watson RW (2015) 'Commercialized

biomarkers: new horizons in prostate cancer diagnostics'. Expert Review of Molecular

Diagnostics, 15 (4):491-503.

Eliwan HO, Watson RW;Aslam S;Regan I;Philbin B;O'Hare FM;O'Neill A;Preston

R;Blanco A;Grant T;Nolan B;Smith O;Molloy EJ (2015) 'Neonatal brain injury and

systemic inflammation: modulation by activated protein C ex vivo'. Clinical and

Experimental Immunology, 179 (3):477-484.

Foley, R.W. and Lundon, D.J. and Murphy, K. and Murphy, T.B. and Galvin, D.J. and

Watson, R.W.G. (2015) 'Predicting prostate cancer: analysing the clinical efficacy of

Page 41: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

prostate cancer risk calculators in a referral population'. Irish Journal of Medical Science

.

Professor Gerry Wilson

Montes, A. and Perez-Pampin, E. and Navarro-Sarabia, F. and Moreira, V. and de la

Serna, A.R. and Magallares, B. and Vasilopoulos, Y. and Sarafidou, T. and Fernández-

Nebro, A. and Ordóñez, M.C. and Narváez, J. and Cañete, J.D. and Marquez, A.

and Pascual-Salcedo, D. and Joven, B. and Carreira, P. and Moreno-Ramos, M.J. and

Caliz, R. and Ferrer, M.A. and Garcia-Portales, R. and Blanco, F.J. and Magro, C. and

Raya, E. and Valor, L. and Alegre-Sancho, J.J. and Balsa, A. and Martin, J. and Plant,

D. and Isaacs, J. and Morgan, A.W. and Barton, A. and Wilson, A.G. and Gómez-

Reino, J.J. and Gonzalez, A. (2015) 'Rheumatoid arthritis response to treatment across

IgG1 allotype - anti-TNF incompatibility: A case-only study'. Arthritis Research &

Therapy, 17 (1).

Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G,

Wright F, Akil M, Fearon U, Veale D, Ciani B, Wilson AG (2015) 'C5orf30 is a

negative regulator of tissue damage in rheumatoid arthritis'. PNAS, 112 (37):11618-

11623.

Hawtree S, Muthana M, Wilkinson JM, Akil M, Wilson AG (2015) 'Histone

Deacetylase 1 Regulates Tissue Destruction In Rheumatoid Arthritis'. Human Molecular

Genetics, 24 (19):5367-5377.

Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DPM, Worthington

J, Young A, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Raychaudhuri S, Barton A

(2015) 'Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity,

mortality, and treatment response'. JAMA-Journal of the American Medical Association,

313 (16):1645-1656.

Jani M, Chinoy H, Warren RB, Griffiths C E, Morgan AW, Wilson AG, Hyrich KL,

Isaacs J, Plant D, Barton A (2015) 'Clinical utility of random anti-TNF drug level testing

and measurement of anti-drug antibodies on long-term treatment response in rheumatoid

arthritis'. Arthritis Rheumatology, 67 (8):2011-2019.

Montes A, Perez-Pampin E, Navarro-Sarabia F, Moreira V, de la Serna AR, Magallares

B, Vasilopoulos Y, Sarafidou T, Fernández-Nebro A, del Carmen Ordóñez M, Narváez

J, Cañete JD, Marquez A, Pascual-Salcedo D, Joven B, Carreira P, Moreno-Ramos MJ,

Caliz R, Ferrer MA, Garcia-Portales R, Blanco FJ, Magro C, Raya E, Valor L, Alegre-

Sancho JJ, Balsa A, Martin J, Plant D, Isaacs J, Morgan AW, Barton A, Wilson AG,

(BRAGGSS), Gómez-Reino JJ, Gonzalez A (2015) 'Rheumatoid arthritis response to

treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study'. Arthritis

Research & Therapy, 17 (1).

Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs

JD, Cordingley L, Barton A (2015) 'Impact of inadequate adherence on response to

subcutaneously administered anti-tumour necrosis factor drugs: results from the

Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'.

Journal of Rheumatology, 54 (3):494-499.

Yarwood A, Viatte S, Plant D, Morgan AW, Isaacs J, Wilson AG, Hyrich K, Eyre S,

Barton A. (2014) 'Testing the role of vitamin D in response to antitumour necrosis factor

α therapy in a UK cohort: a Mendelian randomisation approach'. Annals of Rheumatic

Diseases, 73 (5):938-940.

Orozco G, Viatte S, Bowes J, Martin P, Wilson AG, Morgan AW, Steer S, Wordsworth

Page 42: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

P, Hocking LJ; Barton A, Worthington J, Eyre S. (2014) 'Novel Rheumatoid Arthritis

susceptibility locus at 22q12 identified in an extended UK genome wide association

study'. Arthritis Rheumatology, 66 (1):24-30.

Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG, Isaacs

JD, Cordingley L, Barton A. (2014) 'Impact of inadequate adherence on response to

subcutaneously administered anti-tumour necrosis factor drugs: results from the

Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort'.

Rheumatology (Oxford, England) .

Professor Kenneth Wolfe

Wolfe KH (2015) 'Origin of the Yeast Whole-Genome Duplication'. PLoS Biology, 13

(8).

Kobayashi N, Suzuki Y;Schoenfeld LW;M¿¿ller CA;Nieduszynski C;Wolfe KH;Tanaka

TU (2015) 'Discovery of an unconventional centromere in budding yeast redefines

evolution of point centromeres'. Current biology : CB, 25 (15):2026-2033.

Wolfe KH, Armis¿¿n D;Proux-Wera E;¿¿h¿¿igeartaigh SS;Azam H;Gordon JL;Byrne

KP (2015) 'Clade- and species-specific features of genome evolution in the

Saccharomycetaceae'. FEMS Yeast Research, 15 (5).

Monerawela C, James TC;Wolfe KH;Bond U (2015) 'Loss of lager specific genes and

subtelomeric regions define two different Saccharomyces cerevisiae lineages for

Saccharomyces pastorianus Group I and II strains'. FEMS Yeast Research, 15 (2).

Pitoniak A, Chavel CA;Chow J;Smith J;Camara D;Karunanithi S;Li B;Wolfe

KH;Cullen PJ (2014) 'Cdc42p-interacting protein Bem4p regulates the filamentous-

growth mitogen-activated protein kinase pathway'. Molecular and Cellular Biology, 35

(2):417-436.

Hanson SJ, Byrne KP;Wolfe KH (2014) 'Mating-type switching by chromosomal

inversion in methylotrophic yeasts suggests an origin for the three-locus Saccharomyces

cerevisiae system'. Proceedings of the National Academy of Sciences of the United

States of America, 111 (45):1-8.

Back to Top

Other Journals

Dr Arun Kumar

David Kilroy, and Arun HS Kumar (2015) 'Dilemma in the diversity of foramen

magnum dimensions' BEMS Reports .

Kumar G, Arun HS Kumar. (2015) 'Need for evidence-based practice at grass root level

to improve child health and development' J Nat Sc Biol Med, 6 (1).

Professor Eoin O'Brien

Turner, JR; O'Brien, E (2015) 'Inferences Beyond a Study Design's Grasp: A cautionary

case study from the recent renal sympathetic denervation literature' Therapeutic

Innovation and Regulatory Science, 49 (1):86-92.

Professor Kevin O'Connor

Margaret Walsh, Kevin O¿Connor, Ramesh Babu, Trevoe Woods, and Shane Kenny

(2015) 'Plant Oils and Products of Their Hydrolysis as Substrates for

Polyhydroxyalkanoate Synthesis' Chemical and Biochemical engineering quarterly, 29

Page 43: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

(2):123-133. Back to Top

Conference Publications

Professor David Brayden

Rooney, P., Srivastava, A., Gleeson, J., McCartney, F., Pandit, A. & Brayden, D. J.

(2015) Synthesis of hyaluronic acid-based nanoparticles for oral insulin delivery Proc.

Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh, 42: Abstract 379

Gleeson, J, P., Ryan, S. M. & Brayden, D. J. (2015) Intestinal permeation enhancers

improve flux of food-derived tripeptides across rat intestinal mucosae in vitro Proc.

Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh, 42: Abstract 340

McCartney, F., Garcia, J., Teixido, M., Heade, J., Giralt, E. & Brayden, D. J. (2015) A

cell penetrating peptide-medium chain fatty acid conjugate increases paracellular

permeability across isolated rat intestinal mucosae Controlled Release Society,

Edinburgh, 42: Abstract 268

McCartney, F., Rosa, M. & Brayden, D. J. (2015) Investigation of the cytotoxicity of a

sucrose ester, a novel intestinal permeation enhancer Controlled Release Society,

Edinburgh, 42: Abstract 344

Waters, S., McCartney, F., Brayden, D. J., Maher, S. (2015) Design of a histology score

card to standardize the assessment of intestinal toxicity of novel candidate

pharmaceutical excipients Proc. Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh,

Vol 42, absract

Bhattacharjee, S., Hristov, D., Mahon, E., Dawson K. A., & Brayden, D.J. (2015)

Microscopic-enabled microfluidic device to study the passage of nanoparticles in mucus

Proc. Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh, Abstract 59

Sladek, S., Eskander, M., Tajber, L. & Brayden, D. J. (2015) Size exclusion

chromatography: a useful method to determine peptide loading of nanoparticles

Controlled Release Society, Edinburgh, 42: Abstract 785

Aguirre, T., Rosa, M., Guterres, S., Pohlmann, A., Coulter, I., & Brayden, D. J. (2015)

Intestinal regional localisation of coated SmPill® beads in rats: proof of principle using

X-ray imaging Proc. Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh, 42: Abstract

115

McCartney, F., Heade, J. & Brayden, D. J. (2015) Investigation of dimethyl palmitoyl

ammonio propanesulfonate as an intestinal permeation enhancer using the Ussing

chamber technique. Investigation of the cytotoxicity of a sucrose ester, a novel intestinal

permeation enhancer Proc. Intern. Symp. Control. Rel. Bioact. Mater, Edinburgh, 42:

Abstract 343

Brayden, D.J. & Walsh, E. W. (2014) A medium chain fatty acid derivative, the sodium

salt of 10-undecylenic acid is an efficacious non-toxic intestinal permeation enhancer

AAPS, San Diego, Abstract AM-14-0

Professor Mark Crowe

Mc Nally, J, Crowe, MA, Beltman, ME (2014) Synchrony responses of cows in

different physiological states 18th Annual Conference for the European Society for

Domestic Animal Reproduction,

Professor Alexander Evans

Page 44: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Hobbs,LHC, Stockmann,H, Adamczyk,V, Rudd,PM , Evans,ACO, Carrington,

SD,Williams, EJ. (2014) Postpartum uterine disease in cattle is associated with increased

fucosylation of Immunoglobulin G European Society for Domestic Animal Reproduction

Annual Conference,

Dr Aurelie Fabre

A Szentpetery, J McCormack, L Mellerick, E Heffernan, A Fabre, ... (2015) Abatacept

Reduces CD4 Positive T-Cells in Psoriatic Arthritis Synovial Tissue; Preliminary

Analysis from a Single Centre, Placebo-Controlled, Crossover Study EULAR- European

leage Againt Rheumatism/ Annals of the Rheumatic Diseases, 74 (Suppl 2), 83

Dr Jana Haase

Eric Brown, Robert Schwamborn, Leilani Santos, Martina Gogarty, David Brayden, and

Jana Haase (2015) Regulation of serotonin transporter activity in animal models of

peripheral inflammation - relevance to inflammation-induced depression 40th Congress

of The Federation of European Biochemical Societies (FEBS),

Jana Haase, Eric Brown, Joanna Grudzinska, Elysian Chow, Sandra Malynn, Heidi

Kaastrup Müller, Julia Patzig, Hauke Werner, Zohreh Farsi, Reinhard Jahn, Johannes

Zander, Gudrun Ahnert-Hilger (2015) Serotonin transporter associated protein

complexes - new insight into transporter activity regulation and trafficking 40th

Congress of The Federation of European Biochemical Societies (FEBS),

Dr Breandán Kennedy

Clare T Butler, Adrian Murphy, William M Gallagher, Jacintha O'Sullivan, Breandán

Kennedy (2015) Phenotype-based development of novel therapies for the treatment of

colorectal cancer Cancer Research,

Conor Daly, Lisa Shine, Eugene Dillon, Theresa Heffernan, Alison Reynolds, David

Duffy, Gerard Cagney, Breandan N Kennedy (2015) PHARMACOLOGICAL

RESTORATION OF VISUAL FUNCTION IN A BLIND ZEBRAFISH MUTANT

FOLLOWING HDAC INHIBITOR (HDACi) TREATMENT Investigative

Ophthalmology & Visual Science,

Claire Kilty, Adolfo Lopez-Noriega, Camille Hurley, Neil O'Conner, Alison Reynolds,

Cormac Murphy, Fergal O'Brien, Breandan N Kennedy (2015) Sustained Release from

Biodegradable Microparticles of Bioactive Cysteinyl Leukotriene Receptor Antagonists

for the Treatment of Ocular Neovascularisation Investigative Ophthalmology & Visual

Science,

Temitope Sasore, Roisin Dunne, Breandan N Kennedy (2015) Can drug combinations

targeting PI3K/Akt/mTOR pathway inhibit angiogenesis, inflammation or permeability

in human RPE and endothelial cell lines? Investigative Ophthalmology & Visual

Science,

Breandan N Kennedy, Yolanda Alvarez, Claire Kilty, Orla Galvin, Clare Butler,

Stephanie Merrigan, Temitope Sasore, Carmel McVicar, Alan W Stitt, Alison Reynolds

(2015) Phenotype-Based Discovery of Cysteinyl Leukotriene Receptor Antagonists as

Novel Inhibitors of Developmental and Pathological Ocular Angiogenesis Investigative

Ophthalmology & Visual Science, 5848 - 5848

Stephanie Merrigan, Orla Galvin, Alison Reynolds, Breandan N Kennedy (2015)

Vitamin D Receptor Agonists Significantly Attenuate Ocular Developmental

Angiogenesis Investigative Ophthalmology & Visual Science,

Page 45: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Professor Therese Kinsella

Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) Members of the

Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms

of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-

related Responses American Association for Cancer Research, Philadelphia, PA, USA,

Presented at American Association for Cancer Research, Philadelphia, PA, USA. April

18 - April 22nd, 2015. Abstract: Proceedings of the 106th Annual Meeting of the

American Association for Cancer Research; 2015, Abstract #49,

Mulvaney EP, O'Sullivan AG, Hyland PB & Kinsella BT. (2015) Members of the

Protein Kinase C-related Kinase (PRK) Family Interact with the TPα and TPβ isoforms

of the Human Thromboxane A2 Receptor and Regulate Thromboxane-induced Cancer-

related Responses Experimental Biology 2015, Boston, MA, USA, Presented at

Experimental Biology 2015, Boston, MA, USA. March 28 - April 1, 2015. Published in

FASEB J. (2015) 29:934.4,

Kinsella BT. (2014) Platelets and vascular cells, prostacyclin and thromboxane receptors

5th European Workshop on Lipid Mediators, Presented at the 5th European Workshop

on Lipid Mediators. October 23-24th, 2014, University of Istanbul, Congress and

Cultural Center, Istanbul, Turkey,

Professor Sabine Koelle

Leavy M, Trottmann M, Liedl B, Reese S, Stief C, Kölle S (2014) How does estrogen

affect the functional integrity of the testis? European Congress of Andrology,

Trottmann M, Stepp H, Liedl B, Reese S, Leeb R, Becker A, Stief CG, Kölle S (2014)

Probe-based confocal laser endomicroscopy (pCLE) - a new imaging technique in

andrology 66th Conference of the German Society of Urology (DGU),

Freitag B, Sroka R, Kölle S, Reese S, Becker Aj, Khoder W, Pongratz T, Stief CG,

Trottmann M. (2014) Non-invasive alternatives for vasectomy: Intraluminal closure of

the vas deferens using laser and Histoacryl 66th Conference of the German Society of

Urology (DGU),

Kölle S, Leeb R, Trottmann M (2014) Probe-based confocal laser endomicroscopy

(pCLE) as a new diagnostic tool in the bovine female genital tract Conference of the

European Society for Animal Reproduction (ESDAR),

Professor Jonathan Malthouse

Cleary, J. and Malthouse, J.P.G. (2014) Using 1D 1H-NMR to investigate the

mechanism of chymotrypsin UCD Conway Institute Festival of Research, University

College Dublin,

Dr Edward McKone

Hisert, K.B; Shoenfelt, K.Q; Cooke, G; Grogan, B; Launspach, J.L; Gallagher, C.G.;

Donnelly, S.C; Welsh, M.J; Singh, P; McKone, E.F; Becker, L; (2014) Effects of CFTR

dysfunction on myeloid cell protein expression The 28th Annual North American Cystic

Fibrosis Conference, Georgia, USA, 269 - 270

Professor Ronan O'Connell

Lennon G, Lavelle A, Balfe A, Docherty NG, Coffey JC, Winter D, O'Connell PR

(2014) The gut microbiota: spatial ecology and community organization in health and

ulcerative colitis European Society of Coloproctology,

Page 46: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

Balfe A, Lennon G, Lavelle A, Docherty NG, Coffey JC, Winter D, O'Connell PR

(2014) Isolation of homogenous population of epithelial cells from mucosal biopsies

European Society of Coloproctology,

Back to Top

Other Publications

Professor Michael Duffy

Duffy MJ, Crown J;Mullooly M (2014) ADAM10 and ADAM17: New players in

trastuzumab tesistance. Comment.

Professor Stephen Gordon

Behr MA, Gordon SV (2014) Why doesn't Mycobacterium tuberculosis spread in

animals?. Comment.

Professor Walter Kolch

Bastiaens P, Birtwistle MR;Bl¿¿thgen N;Bruggeman FJ;Cho KH;Cosentino C;de la

Fuente A;Hoek JB;Kiyatkin A;Klamt S;Kolch W;Legewie S;Mendes P;Naka T;Santra

T;Sontag E;Westerhoff HV;Kholodenko BN (2015) Silence on the relevant literature

and errors in implementation. Comment.

Professor Carel Le Roux

Elliott JA, le Roux CW;Ph D FR (2015) How long should we make the biliopancreatic

limb during Roux-en-Y gastric bypass?. Editorial.

Professor Fionnuala McAuliffe

Mone F, Quigley J;Doyle B;Lambert M;Woolfson M;Downey P;Carroll S;Higgins

S;Mahony R;Mcauliffe FM;Fitzgerald J;Mcparland P (2015) Clinical disparity of

haemolytic disease of the fetus and newborn in twin pregnancy. LETTER.

Donnelly JM, Segurado R;McAuliffe FM (2015) Response to 'Inconsistencies and

inaccuracies in reporting on choice of endpoints and of statistical results in RCT of

maternal diet by Lewis et¿¿¿al.'. LETTER.

Dr Edward McKone

Cunningham L, Moran M;Keating C;McKone E;Gallagher C;Lally A (2015) Recall of

provision of sun protection measures to patients with cystic fibrosis being prescribed

voriconazole. LETTER.

Professor Paul McLoughlin

McLoughlin P (2015) Obesity and lung disease: a toxic mix. Comment.

Professor Eoin O'Brien

O'Brien, E (2015) Freedoms at the heart of medical education. Newspaper Articles.

O'Brien E (2014) In response: ambulatory blood pressure measurement in pharmacies.

Comment.

Dr John O'Connor

O'Connor (2015) Neuroimmunology and Synaptic function. Invited Review Articles.

Audrey Wall, Gatambwa Mukandala, John J. O'Connor. (2014) Hypoxic pre-

Page 47: Report of the President 2014/2015 - Conway Institute · Many Hosts of Mycobacteria: Tuberculosis, Leprosy, and other Mycobacterial Diseases of Man and Animals. Wallingford, UK: CAB

conditioning improves the recovery of synaptic transmission in the hippocampus.

Published abstracts.

Professor Stefan Oscarson

Guazzelli, Lorenzo; Ulc, Rebecca; Oscarson, Stefan (2015) Synthesis of a Glucuronic

Acid-Containing Thioglycoside Trisaccharide Building Block and Its Use in the

Assembly of Cryptococcus Neoformans Capsular Polysaccharide Fragments.

ChemistryOpen: Research Papers.

Professor Cormac Taylor

Taylor CT, Scholz CC (2014) Editorial: a PHD in macrophage survival. Comment. Back to Top