November – December 2017ReseaRch Bulletin

hend alqaderi, DDs, DMsc, lecturer on Oral Health Policy and Epidemiology, received an award from the Karam Foundation for, “Oral Health for Syrian Refugees.” The goals of the project are: To describe the oral health delivery system for Syrian refugees during the fleeing period and before appealing for asylum. To evaluate the oral health status for a given sample of Syrian refugees in Lowell, MA.

To recommend efficient, cost effective oral health strategies as per the information collected and the needs of the population for the future. Alqaderi is working with Anubhuti Shukla, DMD student and Janice Cho, instructor in Oral Health Policy and Epidemiology, on this study.

Roland Baron, DDs, PhD, professor and chair of Oral Medicine, Infection and Immunity, received an award from Radius Health, Inc. for “Comparison of the Osteocytic Responses to Abaloparitide versus Teriparatide: First Phase.” In this study, Baron will determine whether the differential effects of osteoporosis medications, Abaloparatide and Teriparatide, on bone resorption

originate from different responses of the osteocytes to these two ligands.

shu-chi allison Yeh, PhD, research fellow in the Intini Lab, Oral Medicine, Infection and Immunity, received a 2017 Outstanding Postdoctoral Fellow Award from the HMS/HSDM Office for Postdoctoral Fellows. Yeh was one of eight recipients from HSDM and HMS celebrated for their achievements. Her research uses intravital imaging to study post-natal calvarial skeletal stem cells.

Floyd Dewhirst, DDs, PhD, senior member of the staff at the Forsyth Institute and professor of Oral Medicine, Infection and Immunity at HSDM, was nominated as a Fellow in the Dentistry and Oral Health Sciences from the American Association for the Advancement of Science. Dewhirst, who has become a leading force behind characterizing the oral microbiome, and helped identify the diverse, genetic capability and

pathogenic potential of organisms present in the human oral cavity. His efforts have identified approximately 700 species of phylotypes of human oral bacteria that are described in the Human Oral Microbiome Database which is hosted at the Forsyth Institute.

ReseaRch aWaRDs & RecognitionsZachary Peacock, DMD, MD, assistant professor of Oral and Maxillofacial Surgery

and co-director of the Cleft and Craniofacial Center at Shriners Hospitals for Children and Massachusetts General Hospital, along with Yisi (Daisy) Ji, DMD 2018 candidate, received the Best Paper in Oral Surgery Award for their publication, “Cost and lack of insurance coverage are prohibitive to having dental implants after resections for benign mandibular neoplasms” from Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. This was a retrospective cohort study of patients who underwent resection for benign mandibular neoplasms between 2005 and 2014. Demographic variables included age, sex, and race. Outcome variables include rates of implant placement, implant restoration, and reasons for not having implants. Fisher’s exact test and odds ratios were calculated. Peacock and Ji concluded that patients do not typically go on to dental reconstruction after mandibular resection, with cost as a major barrier.

Since matriculating into the DMD program at HSDM, Yisi (Daisy) Ji has produced ten publications in peer-reviewed journals.

2 Research Bulletin • November – December 2017 • Harvard School of Dental Medicine

neW PostDoc anD Visiting scholaRs

toshiki nojiri, DDs, joined the Nagai Lab as a visiting graduate student in the Department of Restorative Dentistry and Biomaterials Sciences. Nojiri comes from Tochigi, Japan and received his dental degree from Iwate Medical University. In the Nagai Lab, he is working on soft tissue integration around percutaneous/permucosal implants to combat infection.

Beiyu Wang, MD, joined the Yefu Li Lab as a visiting postgraduate research fellow in the Department of Developmental Biology. Wang comes from Chengdu, China, and received his MD from West China School of Medicine, Sichuan University, majoring in spine surgery. In the Li Lab, he will focus on the molecular investigation of biological effects of osteoarthritis and spine

degeneration related factors.

Miao Zhang, PhD, joined the Yang Lab as a postdoctoral research fellow in the Department of Developmental Biology. Zhang comes from TianJin, China, and received her PhD degree in cell biology from NanKai University School of Medicine, Tianjin, China. In the Yang Lab, she will focus on investigating Wnt5a regulated planar cell polarity (PCP) signaling.

hsDM collaBoRation With iWate MeDical uniVeRsitY

shigemi nagai, DDs, PhD, associate professor of Restorative Dentistry and Biomaterials Sciences, and director of clinical research at HSDM, has entered into a six-year memorandum of understanding with Iwate Medical University, in Japan.

Nagai along with colleagues, John Da Silva, DMD, MPH, vice dean and associate professor of Restorative Dentistry and Biomaterials Sciences, and David Kim, DDS, DMSc, associate professor of Oral Medicine, Infection and Immunity, work with Iwate Medical University on developing collaborations for mutual academic benefit and scholarship. Nagai has developed a robust externship program with thirty students rotating through each university. Furthermore, collaborations with Iwate Medical University have produced successful research projects including the following publications:

Sugawara S, Maeno M, Lee C, Nagai S, Kim D, Da Silva J, Nagai M, Kondo H. Establishment of epithelial attachment on titanium surface coated with platelet activating peptide. PLoS One 2016;11(10):e0164693.

Maeno M, Lee C, Kim D, Da Silva J, Nagai M, Sugawara S, Nara Y, Kihara H, Nagai M. Function of platelet-induced epithelial attachment at titanium surfaces inhibits microbial colonization. Journal of Dental Research 2017;96(6):633-639.

Kihara H, Kim D, Nagai M, Nagai S, Chen C, Lee C, Hatakeyama W, Kondo H, DaSilva J. Efficacy of novel peptide identified by panning on epithelial cell adhesion on the smooth titanium surface. International Journal of Oral Science (under review).

Photographed are Shigemi Nagai, DDS, PhD, John Da Silva, DMD, MPH, David Kim, DDS, DMSc, and students from HSDM and Iwate Medical University.

Research Bulletin • November – December 2017 • Harvard School of Dental Medicine 3

hsDM PuBlications Developmental BiologyBecker K, Wilmes B, Grandjean C, Vasudavan S, Drescher D. Skeletally anchored mesialization of molars using digitized casts and two surface-matching approaches: Analysis of treatment effects. Orofacial Orthopedics 2017; Nov 13.

Clarenbach T, Wilmes B, Ihssen B, Vasudavan S, Drescher D. Hybrid hyrax distalizer and mentoplate for rapid palatal expansion, class III treatment, and upper molar distalization. Journal of Clinical Orthodontics 2017;51(6):317-325.

Crystal Y, Marghalani A, Ureles S, Wright J, Sulyanto R, Divaris K, Fontana M, Graham L. Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs. Pediatric Dentistry 2017;39(5):135-145.

Khan S, Yadav P, Elliott G, Hu D, Xu R, Yang Y. Induced GnasR201H expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling. Proceedings of the National Academy of Sciences USA 2017; Nov 20.

Klein O, Duverger O, Shaw W, Lacruz R, Joester D, Moradian-Oldak J, Pugach M, Wright J, Millar S, Kulkarni A, Bartlett J, Diekwisch T, DenBesten P, Simmer J. Meeting report: A hard look at the state of enamel research. International Journal of Oral Science 2017;9(11):e3.

Nagao M, Hamilton J, Kc R, Berendsen A, Duan X, Cheong C, Li X, Im H, Olsen BR. Vascular endothelial growth factor in cartilage development and osteoarthritis. Scientific Reports 2017;7(1):13027.

Tsutsui S, Anada T, Shiwaku Y, Tsuchiya K, Yamazaki H, Suzuki O. Surface reactivity of octacalcium phosphate-derived fluoride-containing apatite in the presence of polyols and fluoride. Journal of Biomedical Materials Research Part B 2017; Oct 27.

Yang W, Garrett L, Feng D, Elliott G, Liu X, Wang N, Wong Y, Choi N, Yang Y, Gao B. Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Research 2017; Oct 20.

oral Medicine, infection and immunityBarker W, Martin S, Chandler C, Nguyen T, Harris T, Goodell C, Melander R, Doi Y, Ernst R, Melander C. Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. Bioorganic & Medicinal Chemistry 2017; Sep 9.

Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro A, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial I, Rosen C, Reagan M. Metformin affects cortical bone mass and marrow adiposity in diet-induced obesity in male mice. Endocrinology 2017;158(10):3369-3385.

Caetano-Lopes J, Lessard S, Hann S, Espinoza K, Kang K, Lim K, Horan D, Noonan H, Hu D, Baron R, Robling A, Warman M. Clcn7F318L/+ as a new mouse model of Albers-Schönberg disease. Bone 2017; Sep 20.

Chen L, Pan H, Zhang Y, Feng K, Kong X, Huang T, Cai Y. Network-based method for identifying co- regeneration genes in bone, dentin, nerve and vessel tissues. Genes (Basel) 2017;8(10).

Chen L, Long D, Huang S, Yang Q, Hao J, Wu N, Peng L. Evaluation of a novel poly(amidoamine) with pendant aminobutyl group on the cellular properties of transfected bone marrow mesenchymal stem cells. Journal of Biomedical Materials Research Part A 2017; Oct 7.

Gupta A, Sonis S, Schneider E, Villa A. Impact of the insurance type of head and neck cancer patients on their hospitalization utilization patterns. Cancer 2017; Nov 7.

Hanna G, Woo SB, Li Y, Barletta J, Hammerman P, Lorch J. Tumor PD-L1 expression is associated with improved survival and lower recurrence risk in young women with oral cavity squamous cell carcinoma. International Journal of Oral and Maxillofacial Surgery 2017; Sep 29.

Kim D, Bassir S. When is cone-beam computed tomography imaging appropriate for diagnostic inquiry in the management of inflammatory periodontitis? Journal of Periodontology 2017;88(10):978-998.

Li CC, Shen Z, Bavarian R, Yang F, Bhattacharya A. Oral cancer: Genetics and the role of precision medicine. Dental Clinics of North America 2018;62(1):29-46.

Lotinun S, Suwanwela J, Poolthong S, Baron R. Kit W-sh mutation prevents cancellous bone loss during calcium deprivation. Calcified Tissue International 2017; Oct 14.

Mandelaris G, Scheyer E, Evans M, Kim D, McAllister B, Nevins M, Rios H, Sarment D. American Academy of Periodontology best evidence consensus statement on selected oral applications for cone-beam computed tomography. Journal of Periodontology 2017;88(10):939-945.

Matsubara T, Kokabu S, Nakatomi C, Kinbara M, Maeda T, Yoshizawa M, Yasuda H, Takano-Yamamoto T, Baron R, Jimi E. The actin-binding protein PPP1r18 regulates maturation, actin organization, and bone resorption activity of osteoclasts. Molecular Cell Biology 2017; Nov 20.

Reinbolt R, Sonis S, Timmers C, Fernández-Martínez J, Cernea A, de Andrés-Galiana E, Hashemi S, Miller K, Pilarski R, Lustberg M. Genomic risk prediction of aromatase inhibitor-related arthralgia in patients with breast cancer using a novel machine-learning algorithm. Cancer Medicine 2017; Nov 23.

Sima C, Montero E, Nguyen D, Freire M, Norris P, Serhan C, Van Dyke T. ERV1 overexpression in myeloid cells protects against high fat diet induced obesity and glucose intolerance. Science Reports 2017;7(1):12848.

Villa A, Akintoye S. Dental management of patients who have undergone oral cancer therapy. Dental Clinics of North America 2018;62(1):131-142.

Zhang Y, Han K, Chandler C, Tjaden B, Ernst R, Lory S. Probing the sRNA regulatory landscape of P. aeruginosa: post-transcriptional control of determinants of pathogenicity and antibiotic susceptibility. Molecular Microbiology 2017; Oct 4.

Zhou C, Shi Z, Meng J, Hu B, Zhao C, Yang Y, Yu W, Chen Z, Heng B, Parkman V, Jiang S, Zhu H, Wu H, Shen W, Yan S. Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signaling pathway in a rat model. British Journal of Pharmacology 2017; Nov 11. oral health Policy and epidemiologyAldosari M, Tavares M, Matta-Machado A, Abreu M. Factors associated with patients’ satisfaction in Brazilian dental primary health care. PLoS One 2017;12(11):e0187993.

4 Research Bulletin • November – December 2017 • Harvard School of Dental Medicine

Burke S, Burgess A, Cadet T. Utilizing evidence-based assessment instruments to detect well-being and distress in English- and Spanish-speaking caregivers of individuals affected by dementia. Dementia (London) 2017; Jan 1.

Burke S, Cadet T, Alcide A, O’Driscoll J, Maramaldi P. Psychosocial risk factors and Alzheimer’s disease: the associative effect of depression, sleep disturbance, and anxiety. Aging & Mental Health 2017; Oct 27:1-8

Choy C, Isong I. Assessing preschoolers’ beverage consumption using the theory of planned behavior. Clinical Pediatrics 2017; Oct 1.

Simon L. Mr. Thomas does not have cancer. Family Medicine 2017;49(8):644-645.

Simon L. My real patients. New England Journal of Medicine 2017;377(22):2109-11.

Wright A, Ai A, Ash J, Wiesen J, Hickman T, Aaron S, McEvoy D, Borkowsky S, Dissanayake P, Embi P, Galanter W, Harper J, Kassakian S, Ramoni R, Schreiber R, Sirajuddin A, Bates D, Sittig D. Clinical decision support alert malfunctions: Analysis and empirically derived taxonomy. American Medical Informatics Association 2017; Oct 16.

oral and Maxillofacial surgery Caruso P, Buch K, Rincon S, Hakimelahi R, Peacock Z, Resnick C, Foster C, Guidoboni L, Donahue T, Macdonald R, Rothermel H, Curtin H, Kaban L. Optimization of quantitative dynamic postgadolinium MRI technique using normalized ratios for the evaluation of temporomandibular joint synovitis in patients with juvenile idiopathic arthritis. American Journal of Neuroradiology 2017; Nov 23.

Cillo J Jr, Aghaloo T, Basi D, Bouloux G, Campbell J, Chou J, Dodson T, Edwards S, Kademani D, Peacock Z. Proceedings of the American Association of Oral and Maxillofacial Surgeon’s 2017 Clinical and Scientific Innovations in Oral and Maxillofacial Surgery. Journal of Oral and Maxillofacial Surgery 2017; Oct 26.

Khawaja S, Scrivani S, Holland N, Keith D. Effectiveness, safety, and predictors of response to botulinum toxin type a in refractory masticatory myalgia: A retrospective study. Journal of Oral and Maxillofacial Surgery 2017;75(11):2307-2315.

Resnick C, Estroff J, Kooiman T, Calabrese C, Koudstaal M, Padwa B. Pathogenesis of cleft palate in Robin Sequence: Observations from prenatal magnetic resonance imaging. Journal of Oral and Maxillofacial Surgery 2017; Oct 16.

Multi-DepartmentalChutinan S, Riedy C, Park S. Student performance in a flipped classroom dental anatomy course. European Journal of Dental Education 2017; Nov 9.

Dolce M, Parker J, Marshall C, Riedy C, Simon L, Barrow J, Ramos C, Da Silva J. Expanding collaborative boundaries in nursing education and practice: The nurse practitioner-dentist model for primary care. Journal of Professional Nursing 2017;33(6):405-409.

Jumah F, Alkhdour S, Mansour S, He P, Hroub A, Adeeb N, Hanif R, Mortazavi M, Tubbs R, Nanda A. Os odontoideum: A comprehensive clinical and surgical review. Cureus 2017;9(8):e1551.

Kressirer C, Smith D, King W, Dobeck J, Starr J, Tanner A. Scardovia wiggsiae and its potential role as a caries pathogen. Journal of Oral Bioscience 2017;59(3):135-141.

a publication of the office of Research188 Longwood Avenue

Boston, MA 02115 www.hsdm.harvard.edu

Bjorn R. Olsen, MD, PhD, Dean for ResearchDawn M. DeCosta, Editor and Layout

Heather M. Denny, EditingLeanne Jacobellis, Editing

Lia Sgourakes, Editing

hsDM & FoRsYth chalk talks

DeceMBeR 15, 2017 12-1pm @ The Forsyth Institute

“Role of Prx1 expressing cells in calvarial bone regeneration and osteosarcoma”

Giuseppe Intini, DDS, PhDAssistant Professor of Oral Medicine, Infection and

Immunity, HSDM

JanuaRY 12, 2018 12-1pm, REB 109 @ HSDM

“Inside out: The enamel-microbiome interface”

Megan Pugach-Gordon, PhDAssistant Member of the Staff, Forsyth

Instructor in Developmental Biology, HSDM