Research in theSchool of Dentistry

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School of Dentistry

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1888First class enrolled

3 year program

22 students

4 faculty

Dr. Edith White followed the gold rush to the Yukon

School Statistics• Student body

– 98 DDS students/class– 10 PASS students/2 classes– 24 BS dental hygiene students/class– 10 MS dental hygiene students/class– 9 dental therapy students/class– 92 residents in 8 advanced education programs

• Faculty– 116 full-time– 181 adjunct

• Professional and support staff– 232 total

Clinical services

Moos Tower – open to the public377 clinical operatories95,514 patient visits per year

Outreach sites: 15,000 patient visits Northpoint Health & Wellness Cntr Center (N. Mpls) CUHCC (S. Mpls) Walker Dental Clinic (S. Mpls) Hibbing Willmar Howard, South Dakota Mobile Dental Unit

Continuing Dental Education: 154 courses per year 7,349 practitioners

Research Training

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Graduate Program in Oral Biology

MinnCResT (NIDCR T32)

Positions: 11 post-doc 7 pre-doc

Ph.D. students advised by SOD faculty: 18Ph.D. oral biology - 13Other Ph.D. – 5

Summer Research Opportunities

Graduate Program in Oral Biology

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40th Anniversary in 2009

14 grad students32 Faculty

School of Dentistry

Department of Veterinary Biosciences, College of Veterinary Medicine

Department of Medicine, Medical School.

Department of Microbiology

Department of Neuroscience, School of Medicine

Department of Pediatrics and Department of Genetics, Cell Biology and Development

Department of Pharmaceutics, College of Pharmacy

Director: Mark Herzberg T32DE007288-14 Neuroscience Microbiology and Immunology Cancer Biology Developmental Biology, Molecular Genetics, and Stem Cells Clinical Research Translational Genetics and Communications Disorders Genomics, Proteomics, Structural Biology, and Computational Biology Nanotechnology, Materials Sciences, and Tissue Engineering

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Summer Research

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Director: Joel Rudney, Asst. Dean Res.

DDS (DH) students20 students / year

10 week full-time program

Presentations at national and regional meetings

$600,000 fundraising campaign to stabilize funding

Research Funding

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NIH institutes:

NIDCRNIDANCINIAIDNIGMSNINDSORWH

ARRA funding:

R01 subcontr (2)R21R01 supplementNSF subcontr.GO grant IHI/SON

NSFHRSA/MN

Corporate:3MORMCODentscareAmgen

Funding Sources FY09

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Total: $ 4,574,143

32%

9%

17%

42%

NIDCR

Other NIH Institutes

Subcontracts

Non-federal

Total: $ 6,278,002

Funding Increase Jun-Nov 2009

$0

$500,000

$1,000,000

$1,500,000

$2,000,000

$2,500,000

$3,000,000

NIDCR Other NIH Inst Subcontracts Non-federal

June $ 4.5M

November $ 6.3M

ARRA: $862,265

21 Funded SOD investigators

Research Areas

Bone Biology Neuroscience, PainMicrobiology, Virology Salivary Proteins Cell BiologyBiomaterials Dental MaterialsImagingImmunologyPeriodontal and Systemic Disease Temporomandibular joint disease Orthodontics Endodontics Dental ImplantsOral SurgeryOral CancerDevelopmental BiologyPublic Health, Preventive Care

Investigators:

School of Dentistry - 5School of Medicine - 15College of Pharmacy - 3School of Public Health - 2College of Veterinary Science - 5Mayo Clinic - 13

Director: Louis Mansky

Bacteriophage phi29

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1966: Bacteriophage phi29 is identified by Bernard Reilly and Dwight Anderson from soil sample obtained on St. Paul Campus

2009: R01DE003606-39 Morphogenesis of bacteriophage phi29Shelley Grimes

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Director: Alex Siu-Lun Fok

Works closely with manufacturers to develop and test new dental products and materials in the areas of biomaterials, biomechanics and nano-technology. 3M support since 1991

Virtual Dental Patient: interactive 3D computer rendition of a dental patient.

Artificial Mouth: replicates the effects of a year of chewing in one day (“chews” 300,000 per day)Exhibited in Smithsonian Inst.

Shape Optimization of Dental Restorations

An interdisciplinary project involving engineers and dental scientists.

92% of fractured teeth have been previously restored

Shape optimization based on finite element analysis and biological adaptive growth process led to significant reduction in the stress levels at the tooth–restoration interface.

Conventional

Optimized

Oral Health Clinical Research Center

Director: Bryan Michalowicz

Founded 1990, $2.5 M NIH grant

Multi-purpose research clinic consisting of 10 dental operatories

Translate advances in the basic and applied sciences to the clinical setting

Test new technologies in dental care or delivery

Periodontitis and systemic disease

1UO1 DE018902, Engebretson (PI)

DIABETES AND PERIODONTICS TRIAL

Determine if periodontal treatment improves glycemic control in type II diabetics with moderate to advanced periodontitis

5U01DE014338-06, Michalowicz (PI)

EFFECTS OF PERIODONTAL THERAPY ON PRETERM BIRTH

Treatment of periodontitis in pregnant women improves periodontal disease and is safe but does not significantly alter rates of preterm birth, low birth weight, or fetal growth restriction.

Launched 2002

NIDCR contract $ 5.9 M

Jim Fricton (PI)

Sandra Myers (Repository)

Lois Kehl (Neuroscience)

John Look (Registry)

• A variety of therapeutic approaches have evolved for the relief of TMJD symptoms. Implants have been used primarily to replace the articular disc of the joint and the condylar head of the mandible. Long-term success and functioning of these implants remains a major problem.

A neural pathway for itch

Steve Davidson, Xijing Zhang, Sergey G Khasabov, Donald A Simone & Glenn J Giesler Jr

Department of Neuroscience, Department of Diagnostic and Biological Sciences.

Nature Neuroscience 12, 544 - 546 (2009)

“scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.”

News stories carried by NYT, BBC, Reuters, MPR

A look ahead

A diverse research program

Stabilize funding:Review of Summary StatementsGrant Writers ClubResearch Incentive Plan

Organize research themesMeet the Program Director

Increased collaboration to reach critical mass