Research Opportunities

Claude Ervin Davis III, Ph.D.

East Carolina University November 14, 2005

Outline

• Health Psychology, Behavioral Medicine, & Cognitive Neuroscience

• Some Research History– Chronic Pain– Emotion with fMRI– Pain & Emotion with fMRI– Mental Illness & Cognitive Impairment

• Psychophysiology and EEG Lab

Some Research History

• Psychological Factors in Headache and Orofacial Pain

• Structural Equation Model to Predict Orofacial Pain

• Brain Mechanisms of Emotion Processing with fMRI

• Brain Mechanisms of Pain Processing with fMRI

Anger and Fear Affect Pain Related Brain Activity

• Patients with Chronic Pain Affected by Stress & Emotion

• Model for Face Pain• Brief Painful Heat

Stimulation• Functional Magnetic Resonance

Imaging fMRI – Blood Oxygen Level – Brain Activity

Brain Mechanisms of Pain Model

• Brief Repeated Trials of Painful Heat Stimulation

• Pain alone • Pain with Anger Recall• Pain with Fear Recall • Observe the effect of anger and fear on

pain• Start with healthy, pain-free individuals

fMRI Scanning

Thermal Stimulation-Apparatus

Photos courtesy of Reny de Leeuw, D.D.S, Ph.D.

Thermal Stimulation

25

30

35

40

45

50

48oC

39oC

Producing Fear and Anger• Personal Episodic Emotional Recall

• A time you felt very Angry, Fearful, or Neutral

Neutral

DeskSittingBedroomLamp

Anger

BrotherYellingTelephoneMoney

Fear

JulieExplorerCrashBlood

Brain Mechanisms of Emotion• Personal Episodic Emotional Recall

Anger Fear

L R L R

1.0

-1.0

0.0

p<.05

Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review).

(eta2)

Brain Mechanisms of Pain• Painful Stimulation and Anger Recall

Pain Pain and Anger

Note: Pain is (Pain – Warm Sensation)

p<.05

1.0

-1.0

L R

Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review).

L R0.0

1.0

(eta2)

Brain Mechanisms of Pain• Painful Stimulation and Fear Recall

Pain

L R

Pain and Fearp<.05

L R

1.0

0.0

-1.0

Note: Pain is (Pain – Warm Sensation) Davis, C. E., Blonder, L. X., Andersen, A. H. & Carlson, C. R. (Under Review).

(eta2)

Mental Illness & Cognitive Impairment

Real World Decision-Making, Complex Decision-Making/ Conjoint Analysis

Psychophysiology & EEG Lab

• Psychophysiology System– Heart Rate / Electrocardiogram (ECG)– Muscle Tension / Electromyogram (EMG)– Respiration– Finger Temperature– Skin Conductance (SCR)– Brain Activity /Electroencephalogram (EEG) (2 CH)

• EEG System (32 CH)

Psychophysiology System

I-330-C2+ 12 Channel

EEG System

Questions?

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