respon imun wb
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Respon imun WB akut dan kronisTRANSCRIPT
DAFTAR ISIDAFTAR ISI..................................................................................................................iDAFTAR GAMBAR......................................................................................................iiDAFTAR TABEL..................................................................
......................................iiiABSTRAK...................................................................................................................ivPENDAHULUAN........................................................................................................1TINJAUAN PUSTAKA................................................................................................3
1. Target Pengembangan Imunokontrasepsi ........................................................41.1............................................................................................ Produksi Gamet .....................................................................................................................4
1.2.................................................................................................. Hasil Gamet.....................................................................................................................51.3........................ Fungsi gamet ........................................................................
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...7a. Zona Pellusida (ZP)..............................................................................7b.Pprotein Sperma (SP)............................................................................142. Protein sperma Catsper
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...13 PENUTUP...................................................................................................................17DAFTAR PUSTAKA..................................................................................................1DAFTAR ISIDAFTAR ISI..................................
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....iDAFTAR GAMBAR......................................................................................................iiDAFTAR TABEL........................................................................................................iii
ABSTRAK...................................................................................................................ivPENDAHULUAN........................................................................................................1TINJAUAN PUSTAKA................................................................................................31. Target Pengembangan
Imunokontrasepsi ........................................................41.1............................................................................................ Produksi Gamet .....................................................................................................................41.2.......................................................................
........................... Hasil Gamet.....................................................................................................................51.3........................ Fungsi gamet ....................................................................................................................................................
......................................
...7a. Zona Pellusida (ZP)..............................................................................7b.Pprotein Sperma (SP)............................................................................142. Protein sperma Catsper ......................................
......................................
...13 PENUTUP...................................................................................................................17DAFTAR PUSTAKA..................................................................................................1
DAFTAR ISI
Daftar Isi......................................................................................................................... i
Daftar Singkatan............................................................................................................. ii
Daftar Gambar................................................................................................................ iii
Abstrak............................................................................................................................ iv
Pendahuluan.................................................................................................................... 1
Tinjauan Pustaka............................................................................................................. 2
2.1.................................................... Gambaran Filariasis Global dan Nasional 2
2.2............................................................................... Daur Hidup W. bancrofti 32.3.................................... Prinsip Dasar Respon Imun terhadap Infeksi Filaria 52.4............................................................. Respon Imun Selama Fase Entry L3 82.5............................................................ Respon Innate terhadap W. bancrofti 92.6................................................................... Respon Imun pada Infeksi Akut
...................................................................................................................102.7................................................................. Respon Imun pada Infeksi Kronis
...................................................................................................................122.8...................................... Peran Wolbachia Bacteria dalam Induksi Imunitas
...................................................................................................................13
Kesimpulan..................................................................................................................... 15
Daftar Pustaka................................................................................................................. 16
DAFTAR SINGKATAN
AAM Alternatively Activated Macrophages
ADCC Antibody Dependent Cell Cytotoxicity
CCL Chemocin (C-C motif) Ligand
CD Cluster of Differentiaton
CTL Cytotoxic Limphocyte
DC Dendritic Cell
GTLR Glucocorticoid-induced TNFR family related
IL Interleukin
ILC Innate Lymphoid Cells
IFN Interferon
L3 Larva Stadium III
MHC Major Histocompatibility Complex
NK Natural Killer
Th Sel T helper
TLR Toll-liked Receptor
TNF Tumor Necrosis Factor
WSP Wolbachia Surface Protein
DAFTAR GAMBAR
Gambar 1. Peta persebaran filariasis.............................................................................2
Gambar 2. Jumlah kasus klinis filariasis 2010-2014....................................................3
Gambar 3. Daur Hidup W. bancrofti.............................................................................4
Gambar 4. Respon imun klasik yang diinduksi oleh antigen helmin...........................6
Gambar 5. Respon Protektif pada infeksi L3 ..............................................................9
Gambar 6. Regulasi Respon imun pada infeksi filaria...............................................12
Gambar 7. Mekanisme inhibisi respon sel T CD4+ ....................................................13
ABSTRAK
Sampai saat ini infeksi filariasis masih menjadi masalah di dunia. Salah satu penyebabnya
adalah cacing Wuchereria bancrofti yang menyebabkan 90 % dari seluruh kasus limfatik
filariasis limfatik. Di dalam tubuh pejamu parasit mengalami perkembangan-
perkembangan yang bertujuan untuk memperlama infeksi dan menghasilkan keturunan
yang infektif. Sampai saat ini, regulasi respon imun pada setiap tahapan perkembangan
parasit ini belum dimengerti secara menyeluruh. Namun demikian penggunaan hewan
model telah memberikan gambaran mekanisme respon imun dalam preventif dan eliminasi
infeksi. Meskipun jalur utama respon imun terhadap filariasis dimainkan oleh T helper 2,
W.bancrofti mampu bertahan dan menyebabkan infeksi kronis yang ditandai dengan
meningkatnya aktivitas respon imun regulatorik/supresi. Dengan adanya pemahaman peran
endosimbion bakteri Wolbachia memberikan penjelasan-penjelasan yang lebih baik dalam
memahami respon imun pejamu terhadap infeksi ini
Kata Kunci : Filariasis, Respon imun, W. bancrofti, Th2
REGULASI RESPON IMUN PADA INFEKSI AKUT DAN KRONIK WUCHERERIA BANCROFTI
Seminar I
12 April 2016
Penulis : dr. RM. Agung Pranata K A (Imunologi)
Pembimbing : Dr. Drs. Heri Wibowo, M.S.
Pembahas 1 : Rendi Hosea, S.Si (Onkologi)
Pembahas 2 : Rizkyana Avissa, S.Si (Mikrobiologi)
PROGRAM MAGISTER ILMU BIOMEDIKFAKULTAS KEDOKTERANUNIVERSITAS INDONESIA
2016