restorative medicine conference stowe, vt 2006 integrative natural hormonal modulation
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Restorative Medicine Conference Stowe, VT 2006 Integrative Natural Hormonal Modulation By Al Sears, MD. First Things First. What ’ s a Hormone? And… What ’ s not? New from: T he Department of Redundancy Department. Why?. Hormones involved in everything. Often most natural option. - PowerPoint PPT PresentationTRANSCRIPT
Restorative Medicine Conference Stowe, VT 2006
Integrative Natural Hormonal
ModulationBy Al Sears, MD
First Things First
What’s a Hormone? And… What’s not? New from: The Department of Redundancy Department
Why?1. Hormones involved in everything.2. Often most natural option.3. Disease = loss of homeostasis =
hormonal imbalance.4. Bridge gap between disease Rx and
health improvement.5. We are born into altered environs.6. Hormones are primary mediators of
aging.
How?In Preferred Order
1. Enlightenment2. Activity Guidance3. Food4. Exercise5. Nutritional Supplements6. Exogenous Hormones7. Herbal Supplements
5 Modern Hormonal Epidemics
1. Hyperinsulinemia2. Vitamin D Deficiency3. Adrenal Fatigue4. Estrogen Excess5. Abnormal Aging
Hyperinsulinemia
Cholesterolemia (with Iatrogenic Cascade)
Heart Disease Obesity Fatigue Accelerated Aging Environmental Diabetes
Heart Disease: # 1 Killer
Heart disease claims 950,000 lives each year.
More than half who die are women. Heart disease claims more women’s
lives than next 6 killers combined.
Each minute another woman dies from heart disease.
"Heart Disease and Stroke Statistics—2005 Update," American Heart Association.
Cholesterol Mistake
Cholesterol is the Most Fundamentally Important Hormone Precursor!
Cholesterol Provides the Basic Building Blocks for ALL Steroid Hormones
Cholesterol: The Red Herring
80% of people who have heart attacks have the same cholesterol profiles as those who don’t have heart attacks.
National Cholesterol Education Program
Cholesterol-lowering drugs are being prescribed to 13 million people.
The new NCEP guidelines include more people. Under new guidelines, the number may climb to 36 million
But Who Is the NCEP?
8 of the 9 NCEP doctors made money from cholesterol-lowering drugs.
2 own stock in statin drugs. 2 others worked for drug companies
after setting the guidelines. One was a consultant for 10 drug
companies.
Source: USA Today, October, 2004.
Cholesterol Drugs Lipitor made $8 billion for Pfizer
last year. Pfizer sponsors studies for
journals. Recent Pfizer study concluded that people with normal cholesterols benefit.
Statins block production of CoQ10.
Fatique and muscle soreness prevents exercise.
J-Lit (2002)
Japanese Lipid Intervention Trial 6-year study of 47,294 taking simvastatin No correlation between LDL reduction and
death rate LDL below 80 had death rate of 3.5 at 5
years LDL over 200 had death rate of 3.5 at 5
years
Statins and Plaque
American Journal of Cardiology, 2003 Examination of coronary plaque buildup in
182 people taking statins One group took over 80mg a day The other group took less than 80mg a
day No correlation between statins and plaque
reduction– at either dose At the end of 1 year, both groups showed
a 9.2 percent increase in plaque buildup
Statins and Women
ASCOT-LLA (2003) Lipitor vs. Placebo over 3 years No statistical difference in heart
attacks, strokes, or mortality.The University of British Columbia
Therapeutics Initiative Statins offer no benefit to women for
prevention of heart disease
Statins Side Effects, Pt. 1
Muscle Weakness: Most common problem is fatigue. Study found 98% taking Lipitor had muscle problems. Can be debilitating. Rhabdomyolysis, can kill.
Neuropathy: Permanent nerve damage. Starts as weakness, tingling in the hands and feet. Statins increase risk with duration. After one year, risk is 15 percent higher. After two years, 26 percent higher.
Statins Side Effects, Pt. 2 Heart Failure: Statins deplete
CoQ10, risk of heart failure climbs with dose and duration. In the first eight years statins were available, deaths from congestive heart failure more than doubled.
Memory Loss: Many have trouble recalling basic facts about lives – like how old they are or where they live. Some experience global transient amnesia, complete memory loss for a brief period.
Statin Side Effects, Pt. 3
Depression: Multiple studies link low cholesterol and cholesterol treatment with depression
39 percent of women with low cholesterol have depression
HDL More Important than LDL
Castiglioni A, Neuman R. HDL Cholesterol: What Is Its True Clinical Significance? Emergency Medicine. Jan 2003. p30-42.
The Best Predictor of CV Risk
Physician’s Health Study - 15,000 men High homocysteine = 3 times heart attack risk regardless of cholesterol
20 studies linked homocysteine and cardiac events
You can lower homocysteine with B vitamins at less than $10 per month
BIOLOGICAL MARKERS INSULIN plays a key role in aging…
• Increases with age• Tells body to build fat• Keep insulin level below 20• Below 10 even better
Case Study: CF's Body Composition
Weight 325 283 226 222 221% of Fat 55 42 15 8 7
Fat LBS 177 119 33 18 15
L.B.M 148 164 193 205 206
The Big Fat Lie
Pre-Agricultural Diet
Protein31%
Carbs31%
Fats38%
Typical American Diet
Carbs49%
Fats35%
Protein16%
Low Glycemic Load vs. Low Fat Diet
Low GL diet decreases clotting agent plasminogen by 39% vs. a 33% increase from a low fat diet.1
High GL consumption nearly doubles relative risk of heart disease in women.2
1. Ebbeling CB, et al. Effects of an ad libitum low-glycemic load diet on cardiovascular disease risk factors in obese young adults. Am J Clin Nutr 2005; 81(5): 976-82
2. Liu S, Willett WC, et al. A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 2000; 71(6): 1455-61
More Advantages to Low Glycemic Load Diet
Low GL diet decreases abdominal obesity better than low fat diet.
Low GL diet increases HDL cholesterol levels -- low fat diet has no effect on HDL levels.
Low GL diet lowers fasting blood glucose -- low fat diet increases it.
Lahaye SA, et al. Comparison between a low glycemic load diet and a Canada Food Guide diet in cardiac rehabilitation patients in Ontario. Can J Cariol 2005; 21(6): 489-94
High Glycemic Foods
Potato (white, boiled) 104
Rice Krispies 82
French Baguette 95 French Fries 76
Corn Flakes 92 Bagel (white) 71
Instant Rice 91 Mac & Cheese 64
Low Glycemic Foods
Grapes 43 Chicken 0
Grapefruit 25 Eggs 0
Cherries 22 Spinach 0
Beef 0 Walnuts 0
Vitamin D as a HormoneStrengthens immunityReduces inflammationPrevents cancerPrevents multiple sclerosisIncreases muscle strengthPrevents diabetesLowers blood sugarIncreases insulin
sensitivityReduces cavitiesImproves moodPrevents depressionStrengthens bonesPrevents arthritis
Reduces risk of heart attackLowers blood pressureReduces cholesterolBalances other hormonesEliminates PMSPrevents hearing lossImproves reaction timeIncreases balanceEliminates back painBoosts fertility both sexesRaises libidoBalances sleep cyclesOptimizes weight
Change in an Ancient Relationship
98% of time humans on this planet, we lived naked in the sun, near the equator
The shift to indoors sudden and recent change
If evolutionary period single day:
Last day we migrated away from equator
Last few hours we put on clothes
Last few minutes we started working inside
Last minute we started traveling in vehicles
Last second we covered ourselves in sunscreen
Sun Wrongly Blamed for Prevalence of Skin Cancer
Skin cancer rare before 1930 – when many worked outside
Rate of melanoma up 1,800% since our grandparents generation
Rate of melanoma up 400% since mid 1970s – start of public awareness regarding “sun protection”
Endemic of Vitamin D Deficiency
• 50,000-70,000 Cancer deaths in US every year from insufficient vitamin D
• 300,000 Deaths in US (all cause) every year from insufficient vitamin D
• 85% of the population is deficient to some degree
• Nearly 100% of African-Americans are vitamin D deficient
Vitamin D Reference Ranges
The ridiculously low Government’s RDA:• 200 IU of vit D for infants• 200 IU men & women 1-50 years • 400 IU for those 50 to 70 years• 600 IU for people over 70
Healthy adult uses 3,000 to 5,000 units per day (if it is available)
You need 3,000 to 5,000 IU cholecalciferol /day from all sources
Vitamin D Replacement
• Sunlight – 15 minutes a day
• Cod liver oil (400 IU / tsp)
• Wild Salmon
• Sardines
• Vitamin D supplements
Adrenal Fatigue
The most misdiagnosed in US today
Stuck in “fight or flight” mode
Bloodstream repeatedly flooded with adrenaline and cortisol with eventual chronic suppression of DHEA.
Adrenal Response
Natural “fight or flight” response evolved to deal with different world of ancient times
Today’s loud/stressful environment over stimulates adrenals and constantly triggers “fight or flight”
Signs of Deficiency
Muscle wasting Bone loss Increased body fat Anxiety, worry, irritability Tendonitis, fasciitis, bursitis Chronic fatigue Multiple chronic diseases Sequential cascade
DHEA: Reference Ranges
Men:Serum – 110 to 370 mcg/dLSaliva – 137 to 336 pg/ml
Women:Serum – 40 to 325 mcg/dLSaliva – 106 to 300 pg/ml
Rebalancing DHEA
Martial Arts Meditation Acupuncture Yoga Massage PACE exercise program
Boosting DHEA
DHEA Supplementation:
Start with 5 mg a day. No more than 10 mg a day without
testing blood levels.Course often only 1-3 mos.Adrenal recovery common.
Case Study: “DC”
Adrenal FatigueTreatment: DHEA
November,2002
64 mcg/dL
April,2004
377 mcg/dL
August,2006
505mcg/dL
PACE & DHEA
Training for Recovery
Periods of “exertion and recovery” retrain your body to recover from stress
Allows your body to exit “fight or flight” response
Estrogen Excess Syndrome
Adulterated Food Supply Endocrine Disruptors in thousands of
everyday products Precocious Puberty – Girls reaching
puberty by age 6 Men developing feminine features Growing rates of hormone based
cancers – breast, ovarian, endometrial, cervical & prostatic
Xenoestrogens Affects Fertility 15% of US couples are infertile
In 30% to 40% of these cases, male infertility is the problem
British researchers suspected estrogen-mimicking chemical HPTE, commonly found in pesticides
By experimenting on rats, they found that HPTE directly interferes with testosterone production in the testes
Estrogen and Men’s Health1.Tufts University found that crop dusters who
handled estrogen-impersonating pesticides: > Lost their sexual desire > Developed very low sperm counts
2.German researchers found that estrogen levels in prostatic tissue increase as men get older
3.The journal Prostate reported that estrogen increases your risk of benign prostatic hyperplasia (BPH)
4.Japanese researchers discovered link between estrogens and prostate size: “Estrogens are the key hormones for the induction and development of BPH”
Estrogen: Reference RangesMen:Serum - < 130 pg/mLSaliva - < 2.5 pg/mL
Women:Serum – Early Follicular Phase – 70 to 400 pm/mLLate Follicular Phase – 100 to 900 pm/mLLuteal Phase – 70 to 700 pm/mLPostmenopausal - < 130 pm/mL
Saliva –Pre-menopausal – 1 to 10.8Post-menopausal – 1 to 3.2
Symptoms of Estrogen in Men
• Feminization: Gynecomastia • Fat gain • Muscle loss • Cancer • Loss of sex drive • Moodiness & depression
Dangers of a Plastic World
Endocrine Disruptors:Chemicals in everyday products that
mimic estrogen
Vinyl flooring, Deodorants, Hair spray, Moisturizers, Pesticides, Detergents, Perfumes, Garden hoses, Fertilizers, Shampoo, Inflatable toys, Plastics
Estrogen Dangers: 2 Big Offenders
Bisphenol A and Phthalates: Chemicals have structures that look
strikingly similar to estrogen.
Perfluorooctanoic acids (PFOA): CDC results: Every person tested - without exception - had trace amounts of these chemicals in their bloodstream.
Jim Pirkle, deputy director at the CDC's Environmental Laboratory: "The big concern with phthalates is that they have anti-androgen activity."
Reduce Estrogens Daily: Drink only purified water. Trim excess fat from meat before
cooking. (Hormones only in fat.) Estrogen-fighting foods: Berries,
citrus, pineapples, pears, grapes, squash, onions, green beans, figs, melons and pumpkin seeds.
Cruciferous vegetables: Broccoli, cauliflower, Brussels’s sprouts, cabbage - excrete estrogen.
Vegetables high in fiber. Longer stool in bowel, more estrogen absorbed.
Free-range poultry and grass-fed beef whenever possible.
Case Study: B.C.
Estrogen Levels:
Treatment:
DIM 400 mg /day
PACE TIW
April, 2003
180pg/mL
July, 2003 178pg/mL
August, 2003
149pg/mL
October,2003
134pg/mL
BC: Before & After
Case Study: “KB”
Post-Menopausal;Estrogen Levels
Treatment: DIM
August,2005
543 pg/mL
October,2005
268pg/mL
December,2005
171pg/mL
Androgens
Testosterone Precursors
Treatment Dosages
Androstenedione ---- 10mg4-Androstendediol ---- 5mg19-Nor-4 Androstenedione ---- 5mg19-Nor- 4-Androstendediol ---- 5mg
BIOLOGICAL MARKERS Testosterone/Estrogen Ratio
Low Testosterone – loss of energy, mental clarity, bone density, muscle mass and sexual activity M & W.
High Estrogen – obesity, uterine and breast cancer for women, prostate disease for men
Men: 4 to 1 PM Women: from 1 to 2 to 1 to 4
Case Study: “VT” Body Composition
Weight 125 125 118 112 114 118
% of Fat 27 20 17 16 15 13
LBS of Fat 34 25 20 17 17 15
L.B.M 91 100 98 95 97 103
Testosterone Reference Ranges
Men:Serum – 241 to 827 ng/dLSaliva – 30.1 to 142.5 pg/mL
Women: Serum – 20 to 76 ng/dLSaliva – 4.5 to 49 pg/mL
Treatment Strategies
Boosting Testosterone: Increase protein and fat in diet Oral precursor androgens Testosterone shots, gels, patches PACE
Lowering Estrogen: DIM Indole-3 Carbinol Chrysin Durational exercise or PACE
Case Study: “DF”
Initial Meeting: 12/2004Testosterone: 42
Most Recent Follow Up:7/2006Testosterone: 410
Dangers of Testosterone ReplacementEstrogen Excess
Dihydrotestosterone
Converted from testosterone
Loss of free testosterone Loss of hair Prostate growth – BPH Rx = DHT blockers + progesterone
BIOLOGICAL MARKERS INSULIN plays a key role in aging…
(Even if you’re not diabetic.)
• Increases with age• Tells body to build fat• Keep insulin level below 20• Below 10 even better
Hyperinsulinemia
Treatment Options Low Glycemic Diet Non-Traditional Exercise (Periods of Exertion and Recovery) Chromium GTF Gymnema sylvestre
Changes that Occur with Aging
Lung capacity Cardiac output Muscle mass Bone density Excess fat
Age Related Loss of Lung Function
0
10
20
30
40
50
60
70
80
90
100
30 40 50 60 70 80
AGE
Pe
rce
nt
Re
ma
inin
g
Vital Capacity Maximal Breathing Capacity
PHYSICAL MARKERSMaximum Heart Rate
140
150
160
170
180
190
Hea
rt R
ate
30 35 40 757045 50 55 60 65
Resources
Websites:
www.AlSearsMD.com
www.WellnessResearch.org
Additional Information
12 Secrets to Virility (Download) http://www.AlSearsMD.com/stoweconf
Slideshow: http://www.AlSearsMD.com/Stowe/slideshow
Health Confidential Newsletter: http://www.AlSearsMD.com/healthconfidentials/HCE8.html