Review of muscle cell structure and phenotype plasticity.

LEARNING OBJECTIVES

1. Review the structure of skeletal muscle.

BS277 Biology of Muscle

Review of muscle structure.Organism to cell.

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1. Brachium2. Tendon3. Skeletal muscle / biceps4. Epimysium5. Blood vessels and nerves6. Perimysium7. Muscle fascicle8. Muscle fibre / myocyte/muscle cell9. Blood vessels10. Endomysium11. Capillary12. Sarcolemma13. Sarcoplasm14. Nucleus15. Mitochondria16. Nerve17. Satellite cell

Overview of Muscle Development.

Review of muscle structure. Cell to organelle. 1

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1. Sarcolemma2. Sarcoplasm3. Nucleus4. Myofibril5. Sarcoplasmic reticulum6. Terminal cisterna7. Mitochondrion8. T-tubule9. Triad10.Thick myofilament11.Thin myofilament

Review of muscle structure. Cell to organelle.

Review of muscle structure. Myofibril banding pattern.

Sarcomere

A bandI band

H zone

M line

Z line

Zone of overlap

Thin myofilament

Thick myofilament

Titin

Review of muscle structure. Myofibril banding pattern.

The molecular basis of the sarcomere banding pattern

Sarcomere

Thin myofilamentThick

myofilamentα-actinin

Titin

Titin

The molecular basis of myofilament structure

The molecular basis of myofilament structure

Sliding filaments and muscle contraction

Overview of the regulation of muscle contraction

The active state. Initiation of cross bridge cycling.

The cross bridge cycle. Step 1.