BrainRestorationCenter

OurMission

ToRestoreBrainFunction!

VisionofTheBrainRestorationCenter

� As a center, we direct, facilitate, and organize the cooperation of individual expertise to promote the improvement in patient care and therapeutic outcomes for neurology and neurosurgery patients.

StrategicFocus

Clinical Trials Discovery Research

Pre-clinical Research GLP Testing in Animal Models

Patient Care

• Clinical Trials focus on advancing patient care

• Pre-clinical research provides initial safety data and establishes protocol design

• Animal research validates clinical findings

• Discovery research identifies potential novel therapies

BrainRestorationCenter

CoreLeaders/Directors

FacultyandStaff

R&DDiscovery

Strategicplanningandfunding

AdvisoryBoard

Pre-operativeanalysisDBSReferral Surgery DBS

programmingCommunicationwithreferringphysicians

ServiceLine

GLPStudies

ExecutiveLeadership

o ExternalAdvisoryBoardo Dr. Lee Toddo Mr. Henry Evanso Mr. Thomas Dupree, Jr.

o Internal Advisory Panelo Phillip Tibbs, MD: Neurosurgeryo Larry Goldstein, MD: Neurologyo Jim Geddes, PhD: Spinal Cord and Brain Injury Center

o Directorso Craig van Horne, MD, PhD: DBSo John Slevin, MD: Clinical Neurologyo Greg Gerhardt, PhD: Basic and Translational Research

FacultyandStaff

AssociatedFaculty• CraigvanHorne• GregGerhardt• DonGash• PhilTibbs• JohnSlevin• SarahSalles• JulieGurwell• AmeliaAnderson• RichardGrondin• LukeBradley• ZhimingZhang

AssociatedStaff• DavidChapman• GeorgeQuintero•MikeHilvers• JoshPatton• FrancoisPomerleau•MarleneMcClure• RobinLindsay• AnnHanley

Trainees• AndrewWelleford,MD,PhDStudent• JustinPhillips,NeurologyFellow• WeifengLu,MDNeurosurgeryFellow

Deep Brain Stimulation volume: ranked #9 in the United States by Medtronic

Parkinson’s disease Essential TremorDystonia Huntington’s diseaseEpilepsyParkinson’s disease dementia

Translational Research

Peripheral Nerve GraftPhase I: complete in JulyPhase II: 3 subjects implanted

Asleep DBS SurgeryProject in progressFavorable outcomes

Nerve Graft for Cognitive Impairment

First patient implantedSecond patient enrolledApproved for 6 patients

Unique Destination Services

Reversed staged proceduresAsleep DBS surgeryCellular therapy

DBS Service Line:

CoreInitiatives:

� Parkinson’s disease¡ Deep Brain Stimulation¡ Cellular Therapies¡ Growth factor delivery¡ Drug discovery & development

� Cognitive impairment¡ Patient Identification¡ Data tracking and quantification¡ Diagnostic biomarkers ¡ treatment strategies – cell therapy

� Epilepsy¡ Responsive Neurostimulation (RNS)¡ Electrode development¡ FDA post approval study (NeuroPace)