rice bran neutraceuticals
TRANSCRIPT
by
International Trade and Marketing CEO Dr. Amr M. Helal
Rice Bran Nutraceuticals
from Waste material
to Products for Healthy aging
Dream or Reality
Before we starts
Numbers Never Lies
List of exporters for the selected product in 2013
Product : 1211 Medicinal plants
Value exported in 2013
(USD thousand) Trade balance in 2013 (USD thousand)
World 3,399,350
China 1,196,725
India 207,758
Canada 184,930
United States of
America 168,286
Germany 148,372
Egypt 109,845
Korea, Republic of 109,379
List of exporters for the selected product in 2013 Product : 30 Pharmaceutical products
Trade Indicators
Value exported in 2013 (USD
thousand) Trade balance in 2013 (USD thousand)
World 486,308,192
Germany 73,779,288
Israel 6,099,722
Best Investment !
On going Success Story Supported by EU- RDI
Egyptian Partners
German University in Cairo Faculty of Pharmacy Cairo U. National Research center Agriculture Research Center Health Tech Al Sonbolah Rice Mill International Trade and
marketing
EU Partners
Goethe University Muenster University VIVA cell Biotechnology FB- Food Germany Analyze and realize (a&r) Baspharma Holland Holland Food Trade Ainia (Spain)
Rice Bran
in Egypt
Total Rice cultivated area
>1.5 Million Acers
> 500,000 MT Rice bran
Rice Milling Processes
Husk removed Bran removed
is one of the most nutritive ingredients of the rice crop, where about 60% of the total nutritive value of rice itself resides
Rice Bran
PROTEIN
OIL DIETARY
FIBRE
VITAMINS &
MINERALS
GAMMA
ORYZANOL
ANTIOXIDANTS
TRACE
ELEMENTS
RICE BRAN
These components can be obtained from other sources in nature separately, but Rice Bran is unique in having them all
Rice Bran Nutraceutical / Functional Food Values
Potent
Antioxidant
High Nutritional Value
Blood
Pressure
Blood
Cholesterol
Potential benefits of RICE BRAN
Blood Sugar
However due to non stabilization of Rice Bran; it is still discarded or used as animal feed despite its high content of bioactive substances.
It all starts with IMC support for : RICE BRAN INNOVATIVE STABILIZATION
Project Name Funding Authority Budget
Rice Bran Stabilization Unit (5-7-1) Faculty of Agriculture, Mansoura University 2007-2008
Industrial Modernization Centre (IMC)
70,000 L.E.
Rice Bran Stabilization Industrial Unit (1-12-53) Faculty of Agriculture, Mansoura University 2009-2010
Industrial Modernization Centre (IMC)
700,000 L.E.
Rice Bran Phytochemical Study (3-7-4) National Research Centre 2008-2009
Industrial Modernization Centre (IMC)
100,000 L.E.
Rice Bran Industry Implementation (5-7-2) National Research Centre 2008-2010
Industrial Modernization Centre (IMC)
200,000 L.E.
Rice Bran Nutraceuticals
• Contract Number MED/2008/214-423
• Total cost of the action EURO 192000 (18 months)
• Project PI: Prof. Dr. M.T. Khyyal
• Project Partners: International trade and Marketing IT&M
(Coordinator), Faculty of Pharmacy; German University in
Cairo GUC; Faculty of Pharmacy; Johann Wolfgang Goethe
Unifersirty Frankfurt (GUF) ; VivaCell Biotechnology GmbH
VC (Germany)
• Egyptian rice bran was stabilized immediately after milling to preserve its active constituents.
• An extract (RBEX) was prepared, analyzed phytochemicaly and standardized to contain 2.05 % gamma-oryzanol.
• Other active constituents included tocotrienols, tocopherols and policosanol.
• The extract was used to study the pharmacological properties outlined below with a view of developing nutraceutical formulations.
• RBEX was found to have therapeutic potentials in rheumatic disorders, hypertension, Type 2 diabetes and Alzheimer & neurodegenerative disorders.
POSTER ABSTRACT
Conclusions
Based on present experimental evidence, Egyptian rice bran extract has therapeutic potentials in:
1. Rheumatic disorders: associated with its anti-inflammatory, antioxidant activity and effect on cytokines.
2. Hypertension: related to its antioxidant & hypocholesterolemic activity.
3. Type 2 Diabetes: effect on insulin release and blood glucose.
4. Alzheimer and neurodegenerative disorders: mitochondrial protection.
Rice Bran Extract Safety studies
No genotoxicity up to 200 ug
Normal karyotype. No numerical aberrations, gaps or breaks
Normal karyotype. No translocations
-No signs of acute or sub –chronic oral toxicity was observed over the range of studied doses (2.0, 1.0 and 0.5 g/kg Rice bran oil extract) - The doses selected are 20 , 10 and 5 times above the therapeutic dose. -Some significant histological and biochemical differences were observed at the 2.0g/kg rice bran oil extract -No signs of mutagenicity or genotoxicity was detected for the rice bran oil extract at gene, DNA or chromosomal level using the applied techniques in the present study
Conclusions
Rice Bran Formulations
• Contract Number: RDI2/S2/26
• Total cost of the action: EURO 104000 (15 months)
• Project PI: Dr. Amr M. Helal
• Project Partners and associates:
– Faculty of Pharmacy Cairo University
– Faculty of Pharmacy; Johann Wolfgang Goethe University Frankfurt
– Analyze & Realize, Germany
– BasPharma, The Netherlands
• The overall objective of the project is Innovative formulation for stabilized rice bran extract with maximum therapeutic usefulness for pharmaceutical, food, beverage and cosmetic applications
• And the specific objective(s); Stabilized rice bran prompt extraction at room temperature and spray drying into instant water - soluble formulation.
Products under registration
Stabilized Rice Bran Sachets
Products under registration (Cont.)
RICPLEX
20 Soft Gel capsules
PorridgePlus - a food against dementia
Aim to develop a food product for elderly with the objective to promote healthy brain aging
Aim of the Project: • to develop a food product for elderly with the
objective to promote healthy brain aging.
This project primarily based on the findings that Rice Bran Extract protects from mitochondrial dysfunction in the brain.
• to develop a rice bran extract as a potential food supplement to prevent neurodegeneration
“Together with partners from Egypt”
Nutraceutical Products; Rice Bran Planned products
Rice Bran Spray Dried Powder (Healthy Creamer)
Rice Bran / Ginkgo product range (Capsules – Soluble Powder)
Rice Bran/ Barley product range (Capsules – Soluble Powder)
Project Outputs Marketing
INNOVATION AWARDS
National and Int’l MEDIA COVERAGE
Nations’ s Wealth
Is not by what they have
Or what they know
But
By Knowing what to do
with what they have
Contact Data
• Address: 118 Mohy El Dein Abo El Ezz. Giza POC 12411- EGYPT
• Tel: 00202 33045736
• Fax: 00202 33477755
• Email: [email protected]
• Web site : www.healthtech-eg.com
Healthtech-eg.com