rna viruses of animals. viral classification taxonomy order (-viridae) family (-viridae) subfamily...
TRANSCRIPT
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RNA Viruses
of Animals
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Viral Classification
Taxonomy Order (-viridae) Family (-viridae) Subfamily (-virinae) Genus (-virus) Species
Group III (ds) IV (+ss) V (-ss)
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RNA Virions Cytoplasm:
Replication Biosynthesis
Helical capsid Most enveloped
with spikes NA
Double sense Single sense (+ / -) 2 single sense (+)
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Viral Entry into Cells
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Group III: dsRNA Reoviridae
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REOVIRIDAE
REO=Respiratory Enteric Orphan Virus
Non-enveloped Icosahedral RNA ds Segmented Human Diseases
Rotavirus Coltivirus
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Rotavirus World wide infection Fecal-oral spread Incubation: 1-3 days Diarrhea Children Diagnosis
ELISA Latex Agglutination
Prevention Hygiene Water sanitation
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Coltivirus Colorado Tick
Fever Disease
• Acute• Myalgia• Photophobia• Rash• Hemorrhage
Tick vector Rodent reservoir
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RNA ss (+); (-); & retro-
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Group IV: +ssRNA nonenveloped Picornavirus
Rhinovirus Enterovirus Hepatovirus
Calicivirus Astrovirus Hepevirus
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Hepevirus (formerly calcivirus)
+ss RNA nonenveloped Icosahedral Fecal-oral Domestic pig
reservoir Developing
countries/sanitation Hepatitis E
(enteric hepatitis)
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ASTROVIRIDAE Astro = Star Nonenveloped +ssRNA 7 Human Serotypes Diarrhea Treatment
Supportive
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CALICIVIRIDAE
Calicus Cup shaped Indentations
Non-enveloped Icosahedral Linear ss + RNA Human Diseases
Norwalk Virus(Norovirus)
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Calicivirus
Norwalk Virus Summer diarrhea Epidemic Gastroenteritis V/D Institutions ID virus in stool 90% of viral
diarrheas
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PICORNAVIRIDAE Pico = small Nonenveloped Icosahedral RNA + ss Human Diseases
Enterovirus• Polio• Coxsackie A , B• ECHO
Rhinovirus Hepatovirus
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Rhinovirus
Common cold virus: 50%
Transmission: inhalation Incubation: 1-3 days Symptoms
Sore throat Mucopurulent nasal
discharge Complications
predispose to secondary bacterial infections
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Hepatovirus: Hepatitis A Infectious Hepatitis Milder disease than
Hepatitis B No chronic form Fecal-oral Incubation: 2-5 weeks Virus excreted in stool Resistant to
disinfection Dx: IgM
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Enterovirus
Disease Groups Poliovirus Coxsackie A, B Echovirus
Fecal-oral Cytolytic
GI mucosa Lymphatic tissue
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Echovirus ECHO=
Enteric Cytopathic Human Orphan
Fecal-oral route Disease
Meningitis Paralysis URTI Myocarditis Fever Rashes Orchitis
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Coxsackie A and B Fecal-oral Disease
Coxsackie A• Skin Rashes• Herpangina
• Mouth• Pharynx
• Hand/Foot/Mouth• Conjunctivitis• +/- DM Type I cause
Coxsackie B• Myocarditis• Meningitis• URTI• Paralysis
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Poliomyelitis 3 serotypes (Type 1 disease) Transmission: fecal-oral Throat ->LN->Ileum->Blood-> CNS Phases
Asymptomatic: 90% Minor Polio Non-paralytic Paralytic: 2-3%, causes 75% of paralysis
Dx: virus in feces, secretions Prevention: Vaccine
Salk (IPV, killed) Sabin (OPV, modified live)
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Poliovirus
Post Polio syndrome
BulbarPoliomyelitis
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Group IV:+ssRNA enveloped
Togavirus Flavivirus Coronavirus
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CORONAVIRIDAE Corona = crown Enveloped Helical Linear RNA + ss Respiratory droplet Human Diseases
Common cold (20%)
SARS
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Severe Acute Respiratory Syndrome (SARS)
Respiratory Droplet Direct Indirect
2-10 day incubation Cough->Pneumonia Stable in environment
for days Dx: PCR Tx: supportive Prevention
avoid contact disinfect
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TOGAVIRIDAE Toga = coat Spiked envelope Icosahedral Linear ss+RNA ~Arthropod vector Human diseases
Encephalitis • (VEE, WEE, EEE)
Rubella
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Encephalitis: VEE, WEE, EEE
Rodent: VEE
all
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Togavirus: Rubella Rubella
German Measles Respiratory Droplet 2-3 week incubation Rash: 3 days
• Facial• Spreads to body• Changes hourly
Complications• Adults
• Arthritis• Encephalitis
• Congenital defects• Nervous• Heart• Blindness
Prevention: MMRRubivirus
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FLAVIVIRIDAE Flavus = yellow Enveloped Helical Linear RNA ss + Human Diseases
Hepatitis Encephalitis Hemorrhagic Fever
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Flavivirus Hepatitis C
• HCV• Non A non B
Endemic Parental
• Blood• Needles• Organs
6-8 week incubation Mild form Chronic
• Cancer• Liver failure
Dx:IgG, PCR Tx: Interferon
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Flaviviridae Hepatitis
Yellow Fever• Liver / GI• Kidneys• Heart
Hepatitis G• Acute• Persistent• Co-infection with
Hepatitis C• Parental: blood
Encephalitis Japanese Complex Russian
spring/summer St. Louis
• Acute• Inflammatory• Vector: mosquito• 4-21 days
incubation
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Flavivirus Encephalitis
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Flavivirus West Nile Virus
Acute Febrile Hemorrhagic Vector: mosquito 3-14 days
incubation Dx: IgM, ELISA Tx: Supportive
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Flavivirus: Dengue Fever Tropical Aedes mosquito Disease syndromes
Breakbone fever• Rash• Myalgia
Hemorrhagic fever• Reinfection• Hyperimmune
response
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Group V: -ssRNA enveloped, segmented
Bunyvirus Orthomyxovirus Arenavirus
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ARENAVIRIDAE Arenosus = sand (ribosomes) Enveloped Helical Segmented linear ss- RNA Rodent reservoir Human Disease
Hemorrhagic fever• Old world
• Lassa• Sabia• Junin
Lymphocytic choriomenigitis (LCM)
• New world arenavirus
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Arenavirus Hepatitis D
Delta Agent Defective Incomplete ss RNA
• Viroid• Co-infection with HepB• Satellite virus
Enveloped Body fluid spread
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BUNYAVIRIDAE Named after location
of first viral isolation Spiked, enveloped Helical Circular ss-RNA Human Disease
Arborvirus• Encephalitis• Respiratory• Hemorrhagic Fever
Rodent• Hanta Virus
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Bunyavirus Hanta virus
Adult Respiratory Disease
1-3 weeks incubation Transmission: deer
mice Symptoms
• SOB• N/V• pain
Tx: supportive Prevention: rodent
control, disinfect
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ORTHOMYXOVIRIDAE Myxo = mucus Spiked envelope
HA• hemaggluttinin• attach• Antigen number
NA• neuraminidase• through mucus• antigen number
Helical capsid 8 Segmented linear ss-
RNA Human Diseases
Influenza A Influenza B
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-ssRNA
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Orthomyxovirus Influenza
Range of symptoms from mild to severe
Droplet • Direct• Indirect
1-3 days incubation Reservoir: Humans Treatments
• Vaccination• Drugs
Complications• Recombinant due to
segmented RNA• Secondary bacterial
infections• Viral super infection with
Adenovirus
Influenza Treatments Inhibit Neuraminidase
Relenza (IN)Tamiflu (PO)
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Antigenic drift: HA/NA mutationsAntigenic shift: genetic reassortment
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Influenza Pandemics
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Group V: -ssRNA enveloped, nonsegmented Paramyxovirus
Morbillivirus Parainfluenza Rubella RSV Nipahavirus
Rhabdovirus Filovirus
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PARAMYXOVIRIDAE Similar to
Orthomyxoviruses Spiked Envelope
HA NA Fusion (F protein)
Helical Segmented linear ss –
RNA Human Diseases
Respiratory Epithelial
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Paramyxovirus : Respiratory Parainfluenza
4 types (HPIV) Pediatric infection Symptoms
• Fever• Coryza• Barking cough
(Croup)• Airway obstruction
Droplet Tx: supportive
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Paramyxovirus :Respiratory Respiratory
Syncytial Virus (RSV) Infants Pneumonia
• lower airways• Alveoli damaged
Symptoms• Cold like• Fever• Coryza• Cough• Wheeze• Dsypnea
Droplet Tx: supportive
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Paramyxovirus: Epithelial Mumps
Glandular (Parotiditis) Droplet transmission 21 day incubation Inflammation Complications
• Encephalitis• Orchitis• Nephritis• Pancreatitis• Arthritis
IgM Tx: symptomatic Prevention: MMR
Rubulavirus
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Mumps Pathogenesis
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Paramyxovirus: Epithelial Measles (Rubeola)
Epithelial mucosal linings
• Skin -> rash• Respiratory• GI
Complications• Panencephalitis• Conjunctivitis
Droplet transmission 10-12 days incubation Desquamation Highly infectious Tx: symptomatic Prevention: MMR
Morbillivirus
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RHABDOVIRIDAE Rhabdo = rod like Spiked, enveloped
Hemagglutin Helical -ssRNA Human Disease
Vesicular Stomatitis Rabies
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Rhabdovirus Lyssa virus
Rabies• Encephalitis• Direct• 3-8 weeks incubation• Replication
• Local• CNS• Salivary
• Reservoir• Bats• K-9 / coyotes / foxes• Racoons• Skunks
• Clinical• Furious• Dumb
Tx: IgGPrevention: vaccination
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FILOVIRIDAE Filo = filamentous Spiked, enveloped Helical Linear ss – RNA Pleomorphic shape
Filament, branched, U-shape, Circular
Gp epithelial receptors
Human Disease Acute Hemorrhagic
fevers• Marburg Virus• Ebola Virus
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Marburg Fruit bat/green monkey Africa (Germany isolated Body fluid spread 3-9 day incubation Course
Rash Gi inflammation Liver failure Pancreatitis Hemorrhageshock MODSDeath
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Ebola virus Africa Direct contact Acute hemorrhagic
fever 4-16 day incubation Symptoms
Fever V/D Rash Hemorrhage from all
open body cavities Death due to shock from
fluid and blood loss
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RETROVIRIDAE Retro = reverse RNA dependent DNA polymerase (RT) Spiked envelope polyhedral 2 linear +ssRNA (diploid virus) Enzymes
Reverse transcriptase Protease Integrase
Human Diseases Deltaretrovirus HTLV: leukemia Lentivirus HIV: AIDS
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Retroviridae Human T-Lymphocytic
Virus (HTLV-1) Adult T cell Leukemia Aggressive Tumor Latent Infiltrates
• Skin• brain
Transmission• Horizontal
• Blood• Sexual Intercourse
• Vertical• Breast milk
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Retroviridae Human T-Lymphocytic
Virus (HTLV-2) B-Lymphocytes Hairy cell leukemia
• Slow growing• Middle aged men• Type of CLL
Signs• Bruising/bleeding• Swollen LN• Fatigue• Fevers
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Human Immunodeficiency Virus
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Ecological Groups Arboviruses
Arthropod borne viruses
Transmitted by• Insects• Mites• Ticks• Lice
Viral Families• Togavirus• Bunyaviridae• Rhabdovirus (some)• Arenavirus (some)• Reovirus (some)
Oncoviruses Cancer causing DNA related Viral Families
• Papovirus• Adenovirus• Parvovirus• Herpesvirus• Retrovirus
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Zoonoses Disease that humans can acquire from
animals Viral examples
Marburg (monkeys) Pox (cow pox, pseudo-cowpox, monkey pox)
Rabies (warm blooded mammals)
Influenza A Lassa (rodents, bats) Hanta virus: pulmonary (rodents)
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Viral Vaccines Live / Attenuated
Measles Mumps Rubella Polio (oral) Yellow Fever VZV
Killed / Viral Protein Hepatitis A Hepatitis B Rabies Polio (Salk)
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Antiviral Chemotherapy Inhibits Viral DNA-dependent DNA polymerase
Herpes Inhibits DNA replication and transcription
Herpes Interferes with penetration or viral uncoating
Influenza A Inhibits translation of late mRNA
Smallpox Inhibits reverse transcriptase
Aids Inhibits Protein synthesis
Genital Warts
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Questions?