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ROBOX 240ROBOX 240Automation PlatformAutomation Platformfor Sample Oxidation and for Sample Oxidation and Scintillation CountingScintillation Counting

© 2010 ZINSSER ANALYTIC

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The Robox WorkcellThe Robox Workcell

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Automatic Sample Preparation with Automatic Sample Preparation with Robox 240Robox 240

Compact workcell 180 x 100 x 190 in cmCatalytic sample oxidizerOxygen regulator for enhanced combustionStorage racks for 240 sample boatsOriginal LSC-counter racksCapping/decapping station for LSC-vials2D-Barcode reader for the LSC-vials2D-Barcode reader for the sample boatsTriathler® scintillation counter (option)5-axes robot on 1m track with controllerPC with WinLissy® softwareUPS power supply

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Robot Work ...Robot Work ...

6-Axis Denso RobotOX-500 Oxidizer24 Vial racks for 10 vials

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TheThe Workbench Workbench ……

Robot transfers up to 240 samples to the oxidizerRobot handles scintillation vials and transports traysAutomatic capping and decapping of vialsControls combustion efficiency with integrated LSC-counterBarcode readingIntegrated into mobile safety cabinet

Capping Stationwith Barcode Reading

CRS Robot on Track

Sample Boats

Oxidizer

Vials in/out

LSC Counter

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The Oxidizer is the Heart ...Ox 700The Oxidizer is the Heart ...Ox 700

Combusts up to 300mg of wet or dry sampleSingle or dual labelled samples (H-3, C-14)High combustion temperature 900°CRecovery 98%, reproducibility ± 1%Low memory (less than 50 d.p.m. for 100.000 d.p.m. samples)Catalyst removes quenchers as SO2, NO2Automatic feeding of 12 samples

The Oxidizer is the Heart ... OX 500 ...The Oxidizer is the Heart ... OX 500 ...

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Catalytic combustion

High combustion temperature (900°C)

High recovery (C-14: 97%)

Small footprint

Easy to operate

Minimum maintenance

Very low service costLabor intensive

Less ConsumablesCatalyst 1 & 2Oxygen, Nitrogen

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Spare Parts & Consumables...Spare Parts & Consumables...

Combustion tube

Quartz ladles

Catalyst 1 (Copper dioxide)

Catalyst 2 (Special Catalyst)

Catalyst 3 (Platinum mesh)

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Samples in & samples out...Samples in & samples out...

Storage racks for 240 barcoded sample boatsOriginal counter racks with barcoded vials

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Capping and Decapping of Vials ...Capping and Decapping of Vials ...

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2D2D--Barcode Reading of LSCBarcode Reading of LSC--Vials...Vials...

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2D2D--Barcode Reading of Sample Boats...Barcode Reading of Sample Boats...

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Recovery Control ...Recovery Control ...

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Triathler Features ...Triathler Features ...

1000 channel Multi Channel Analyzers2keV –2000 keV energy rangeUp to 95% counting efficiency for C-14Luminescence interference in beta counting typically < 0.1 % Preset nuclides:H-3, C-14, P-32, S-35, P-33, I-125, Cr-5120 ml LSC vials

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Robot on 1m Track ...Robot on 1m Track ...

Smooth movementsFastPrecision positioningReliable (24h, 7 days...)

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Easy to Operate with WinLISSY ...Easy to Operate with WinLISSY ...

Graphic user interfaceControlled restart optionSchedulingUser level administration

Complete audit trail21 CFR Ch. 11 compliant

Download & upload of Excel®-filesCommunication with Oracle® etc.Easy to operate

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Result File...Result File...

Sample number

Source rack position

Sample I.D.

LSC rack number

LSC rack position

Vial I.D.

CPM of counted samples

Error messages

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Run File ...Run File ...

Action

Start of action

End of action

Flag

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Step 1: Prepare the Sample...Step 1: Prepare the Sample...

Weigh sample material onto sample boat

Prepare standards for recovery control

Place sample boats on carriers

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Step 2: Fill Counter Racks with VialsStep 2: Fill Counter Racks with Vials

Barcoded 20ml vials (Polyvials®) with caps on

LSC-Counter racks

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Step 3: Get the Cocktail ...Step 3: Get the Cocktail ...Oxysolve C-400 for C-14

A complete scintillator for counting C-14. It contains a specially sourced CO2 absorber for quick uptake

of CO2. The high CO2 capacity ensures complete

absorption of 1.8g CO2 per 15ml Oxysolve C-400.

It is recommended for use with the Harvey Oxidisers (OX-300, OX-400, OX-500) and can also be used for any type of 14CO2 measurement.

It is packaged under nitrogen in 2.5 litre amber glass bottles.

Flashpoint (PMCC)34oC

Pack Size 4 x 2.5 litres

Irgasafe for H-3

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The better Way of Sample Preparation...The better Way of Sample Preparation...

Achieve quench free counting samplesCompletely inhoused system, protecting workers from benzene fumes*!Takes the stress away from the staffCan handle extreme sample materials (motor oil, paint, soil, concrete (!))Highly reproducibleSeparation of H-3 and C-14 for better results for dual label samples

* 2 former emloyees against ABC-Lab

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ConclusionConclusion

Robox 240 is an ideal solution for sample combustionOnline quality control for the sampling processHigh throughput (240 to 320 samples per day)Barcode labelled sample boats and scintillation vialsIntegrated scintillation counterGLP data managementEasy to operateProven & reliable software WinLISSY®Easy to integrate into existing infrastructureWith its enclosure it is a remote enclosed workstation providing a safe environment for the user