Sandoz Canada Inc.

145, Jules-Léger Boucherville (Québec) J4B 7K8 Canada Tel: (450) 641-4903 Fax: (866) 774-5654 www.sandoz.ca

October 30, 2008

Sandoz Canada Inc. is pleased to introduce:

Rocuronium Bromide Injection 10 mg/mL

(an alternative to Zemuron®)

For further information, please contact your Sandoz Regional Sales Manager or call our Customer Service Department at 1 800 361-3062.

Other Skeletal Muscle Relaxants available at Sandoz Canada Inc.:

- PRAtracurium Besylate Injection 10 mg/mL, 10 x 10 mL, code 1330, DIN 02236759 - PRPancuronium Bromide Injection 1 mg/mL, 5 x 5 mL, code 6500, DIN 02169622 - PRPancuronium Bromide Injection 2 mg/mL, 10 x 2 mL, code 6510, DIN 02169630 - PRPancuronium Bromide Injection 2 mg/mL, 5 x 5 mL, code 6520, DIN 02169630

® Registered trademark owned by N.V. Organon

UPC DIN PRODUCT CODE STRENGTH PACKAGING

0 57513 11250 8 02318415 11250 10 mg/mL Box of 10 x 5 mL

vials

NEW PRODUCT

PrRocuronium Brom

ide InjectionSkeletal M

uscle Relaxants

www.sandoz.caSandoz Canada Inc. 145 Jules-Léger, Boucherville (Québec) J4B 7K8Customer Service: Phone: 1-800-361-3062 or (514) 596-0000

PrRocuronium Bromide InjectionA generic alternative to PrZemuron®

Now available!

Latex-free stopper*Available in vialsOne format: 10 x 50 mg/5 mL

® Registered trademark owned by N.V. Organon* Stopper contains no dry natural rubber

PrRocuronium Bromide Injection 10 mg/mL AHFS 12:20.00 Skeletal Muscle Relaxants

Comparative Product Information

November 2008

The information listed above is accurate to the best of our knowledge on the specified date. ® Registered trademark owned by N.V. Organon* Trademark of West Pharmaceutical Services, Inc.

Feature Sandoz OrganonProduct Name PrRocuronium Bromide Injection PrZemuron®

DIN 02318415 02108208

Description Sterile non-pyrogenic solution Sterile non-pyrogenic solution

Formulation Each mL contains: Rocuronium bromide 10 mg Sodium chloride 3.3 mg Sodium acetate trihydrate 2.0 mgNaOH and/or glacial acetic acid to adjust pHWater for injection

Each mL contains: Rocuronium bromide 10 mg Sodium chloride approx. 3.3 mg Sodium acetate, trihydrate 2.0 mgNaOH and/or glacial acetic acid to adjust the pH to approximately 4.0Nitrogen presentWater for injection

Preservative None None

Administration IV injection only IV injection only

Storage Store between 2 and 8°C until ready to use.Unopened vials may be stored up to 90 days at room temperature between 15 and 30°C.Use punctured vials within 30 days.

Store under refrigeration (2–8°C) until ready to use. Unopened vials may be stored up to 90 days at room temperature (15–30°C).Use punctured vials within 30 days.

Packaging 5 mL clear, multidose vial with Flip-Off*closure formed by a red ferrule with ‘Paralyzing Agent‘ written in white and a transparent plastic cap.

5 mL clear, multidose vial with fliptop closure.

Package Size Box of 10 x 5 mL vials Box of 10 x 5 mL vials

Product Code 11250 41311