sample drug information questions. question 1 what medication is recommended for the initial...
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Sample Drug Information Questions
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Question 1
What medication is recommended for the initial
management of fibromyalgia syndrome?
Category of Question:
Therapeutic Management/Recommendation/Guidelines
Possible 3ry sources:
Uptodate, Evidence based Medicine Guidelines……………
Possible websites: Guidelines.gov, Tripdatabase.com
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Question 1
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Question 2
What topical medication is recommended for the initial management of uncomplicated catheter exit site infection in Haemodialysis patients?
Category of Question:
Therapeutic
Management/Recommendation/Guidelines
Possible 3ry sources:
Uptodate, Evidence based Medicine
Guidelines………
Possible websites: Guidelines.gov,
Tripdatabase.com
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Question 2
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Question 3
What is the dose of tiotropium bromide (Spiriva) for a
patient with chronic obstructive pulmonary disease??
Category of Question:
Dosing
Possible 3ry sources:
Drug information Handbook, AHFS, Handbook of
Clinical Drugs Data
Possible websites: Lexi-comp, Micromedex
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Question 3
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Question 4
• A 48 years old Patient is suffering from complicated UTI (Ht=175 cm, wt=100 kg), his SCr is stable around 3.5 mg/dl, after revising “Sanford guide for antimicrobial therapy” you selected ………… ………………
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Question 4 (cont.)
• A 48 years old White Male Patient is suffering from complicated UTI (Ht=175 cm, wt=100 kg), his SCr is stable around 3.5 mg/dl, after revising “Sanford guide for antimicrobial therapy” you selected Levofloxacin(750mg/24h) which needs renal dose adjustment! ... What will you do?:// . . / .http www globalrph com crcl htm
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Question 4 (cont.)
• Next day, His S.Cr. Jumped to 5 mg/dl ….modify the dose
:// . . / .http www globalrph com unstable htm
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Question 4 (cont.)
• If the Patient is on HD, What is the recommended dose of levofloxacin
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Question 5
• Based upon a blood culture, Tigecycline was selected to treat Community acquired pneumonia in a liver impaired patient, his total bilirubin is 4 mg/dl, albumin = 2, Prothrombin time = 23 sec, Severe Ascites and grade 3 hepatic encephalopathy.
Calculate Tigecycline dose for this patient.
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Hepatic Functions
• Mild hepatic impairment = < 6 points.
• Moderate hepatic impairment = 6 – 10 points.
• Severe hepatic impairment = > 10 points.
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Hepatic Functions
Child Pugh score ------- (8 – 9) needs (25 %) decrease in initial daily drug dosage for agents that are primarily (≥ 60%) hepatically metabolized.
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Hepatic Functions
Child Pugh score (≥ 10) needs (50 %) decrease in initial daily dose for agents primarily hepatically metabolized.
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Hepatic Functions
e.g. Rifampicin AND Propranolol
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Question 6
• A 25 years Old Pregnant Woman is complaining of Sinusitis, her physician wants to give her desloratadine tablet but has no idea about its safety in pregnancy, What is your recommendation??
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Drugs in Pregnancy and lactation
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Question 7
• A 23 yrs breastfeeding woman was diagnosed with depression her physician wants to give her paroxetine, she is worried about its safety in lactation….What is your recommendation?
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Question 7
http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT
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Question 8
• A patient is receiving a continuous infusion of sodium bicarbonate. Amikacin is prescribed. Is amikacin compatible with sodium bicarbonate?
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Question 9
• You were astonished when you found Doxazosin in a urology consultant prescription for a non HTN female patient, what would be the possible indications for Doxazosin??
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Question 10
• What is the risk of telithromycin (Ketek)– associated liver failure?
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Question 11
• What electrocardiogram changes are associated with amitriptyline toxicity?
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Question 11
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Question 12
• A Kidney posttransplant patient suffered from erectile dysfunction and topical candidiasis , his dermatologist wants to add sildenafil (viagra) and fluconazole (diflucan) to his medications. The patient is currently on ciclosporin, mycophenolate and prednisolone. What is your recommendation??
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Question 12
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Question 13
• A comatosed patient in the ICU is suffering from hypercholesterolemia, we want to add an HMGCo-A reductase inhibitor to his medications, which agent is more suitable??
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Question 13
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Take Away Case
• A patient with Pheochromocytoma, Candidate for unilateral adrenalectomy. What is the Pre-and Postoperative Drug Therapy Required?