Santé,NeurosciencesetVieillissement

•  Ageing:mechanisms–  UMRBiologicalAdapta=onandAgeing(B2A)

»  PrBertrandFriguet,UPMC

–  DHUFAST(FightagainstAgeingandSTress)»  PrJeanMariani,DrChris7anNeri,UPMC

•  Brainageing–  Normalandpathology

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Chronicdisorders

Interest/interac=onswithJapan

•  Mechanismsofageing:lifestyle/genes–  Predic=vemarkersoflongevity(100yrolds)

»  DrChris7anNeri–  Pa=entcohortsDHU+Keio&Kyushuuniversi=es

»  powerofstudy

•  Neuroscience:cogni=vedecline–  Whysovariable?–  Capacitytomodify

»  Delay/slow/reverse?–  Psychosocial/technical?

»  General/specificinput»  People,domo7cs,brains7mula7on

Precisely-phenotypedcohortsforthestudyofstressresilience

(IledeFranceandna=onal/interna=onalcohorts)

CogDisCo (Marc Verny) 1000 patients, +500 patients/year IADL + MRI 80%, PET 20%

UPOG (Jacques Boddaert) 900 patients, +600 patients/year 340 parameters

AGER (Eric Pautas) Standardized questionnaire 150 parameters; starting 1500-2000 Patients/yr

Cognitive decline, brain proteostasis neuroinflammation (imaging) Post surgery trauma and immune response survival distribution at 6 months and beyond

Acute geriatrics