São Paulo, BRAZILNOVEMBER 9-10, 2018

Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment

MDS-0318-353

Course Program

International Parkinson and Movement Disorder Society

International Secretariat

555 East Wells Street, Suite 1100 Milwaukee, WI 53202 USA

Email: education@movementdisorders.org Tel: +1 (414) 276-2145 • Fax: +1 (414) 276-3349

The International Parkinson and Movement Disorder Society (MDS) is an international professional society of clinicians, scientists, and other healthcare professionals who are interested in Parkinson’s

disease, related neurodegenerative and neurodevelopmental disorders, hyperkinetic Movement Disorders, and abnormalities in muscle tone and motor control.

The Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment course has received corporate support from the following:

Quest Diagnostics Do Brasil Ltda – EPP

Diagnóstico da América S/A Beaufour Ipsen Farmaceutica Ltda

Creta - Centro Reumatologico de Terapia Avancada Ltda Centogene AG

Mendelics Análise Genômica S.A

The Ataxias and Spastic Paraplegias: From Molecular Biology to Bedside and Treatment is supported in

part due to a generous contribution from the following:

MDS Associate Membership

Non-Members now have the opportunity to become a member of MDS absolutely free for a year! Participants of this course (who are eligible for this offer) will be contacted one month following the activity. Contact will consist of an email providing a link to apply for and obtain the free Associate

Membership for one year. Once individuals apply online and receive acceptance to the Society, they will have immediate access to all online content and member benefits.

If you were registered for this course by someone else, please check with your MDS Secretariat liaison

onsite to ensure that your correct email address is on file for this offer to reach you.

Visit the MDS Website for eligibility and further information: www.movementdisorders.org/Associate-Membership.htm

TABLE OF CONTENTS

Course Venue Map…………………………………………………... Course Faculty……………..………………………………………… CME & Program Information………………………………………... Course Agenda ………………………………………………………. Notes…………………………………………………………………..

Course Venue

Associação Paulista de Medicina (APM) – 9th Floor Av. Brigadeiro Luís Antônio, 278 Bela Vista

São Paulo / SP - 01318-901 Brazil

Course Materials

To access the course presentations please visit the website listed below. Presentations are available for 60 days after the course.

www.movementdisorders.org/Private/2018-Pages/Ataxias-and-Spastic-Paraplegias-From-Molecular-Biology-to-Bedside-and-Treatment-So-Paulo-Brazil.htm

Please arrive via the main entrance on Av. Brigadeiro Luis Antonio

Signs will guide you to registration.

Course Venue Map Associação Paulista de Medicina (APM) – 9th Floor

Av. Brigadeiro Luís Antônio, 278 Bela Vista São Paulo / SP - 01318-901

Brazil

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COURSE DIRECTORS

Orlando G. P. Barsottini, MD, PhD Federal University of São Paulo São Paulo, Brazil

José Luiz Pedroso, MD, PhD Federal University of São Paulo São Paulo, Brazil

COURSE FACULTY

Pedro Braga-Neto, MD, PhD Universidade Federal do Ceará Fortaleza, Brazil

Francisco Cardoso, MD, PhD, FAAN The Federal University of Minas Gerais Belo Horizonte, Brazil

Giovana Diaféria, MS Centro de Estudos Da Voz & Associação Brasil Parkinson São Paulo, Brazil

Chien Hsin Fen, MD, PhD University of Sao Paulo São Paulo, Brazil

Henrique B. Ferraz, MD Federal University of São Paulo São Paulo, Brazil

Laura B. Jardim, MD, PhD Universidade Federal Do Rio Grande Do Sul Porto Alegre, Brazil

Marcondes C. França Junior, MD, PhD University of Campinas Campinas, Brazil

Fernando Kok, MD, PhD University of São Paulo São Paulo, Brazil

Antonio Orlacchio, MD, PhD Henry Paulson, MD, PhD IRCCS Santa Lucia Rome, Italy

University of Michigan Medical Center Ann Arbor, MI, USA

Hélio A. G. Teive, MD, PhD Federal University of Parana Curitiba, Brazil

INVITED GUESTS

Henrique B. Ferraz, MD Federal University of São Paulo São Paulo, Brazil

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COURSE PROGRAM INFORMATION

COURSE DESCRIPTION Hereditary ataxias and spastic paraplegias are complex genetic disorders. The knowledge, information and concepts have expanded and evolved substantially during the past few years. The advances have established a solid base to potential therapeutic approaches. This course will discuss clinical manifestations, physiopathology, rehabilitation, genetic aspects, management, as well as future directions in the field of ataxias and spastic paraplegias. This will be an interactive course with audience participation and patient videos on clinical cases.

LEARNING OBJECTIVES After participating in this activity, the learner will be able to:

• Recognize typical and less common forms of inherited ataxias and spastic paraplegias• Identify pathophysiology (pharmacologic, genetic and biochemical) of ataxias and spastic paraplegias• Acquire knowledge of pharmacological, rehabilitation and other treatment approaches on ataxias and

spastic paraplegias.

TARGET AUDIENCE Medical doctors, physiotherapists, speech therapists, physiatrists, medical students, and allied health professionals.

COURSE LANGUAGE All printed course materials are in English. Lectures will be presented in either Portuguese or English at the discretion of the presenting faculty. Simultaneous translations of the lectures from Portuguese to Spanish are available.

COURSE EVALUATION The course evaluation is available online. A link will be provided to you upon the conclusion of the course.

CERTIFICATE OF ATTENDANCE A certificate of attendance will be available at the conclusion of the course.

EDUCATION DISCLAIMER The primary purpose of MDS programming is to provide educational opportunities that enhance patient care. Information presented, as well as publications, technologies, products and/or services discussed are intended to inform attendees about the knowledge, techniques and experiences of physicians who are willing to share such information with colleagues. A diversity of opinions exists in the medical field, and the views of the workshop’s faculty are offered solely for educational purposes. Faculty members’ views do not represent those of the MDS and do not constitute endorsement by MDS.

RECORDINGS PROHIBITED Audio and videotaping are not allowed during the course. Photography of the presentations and slides is not allowed during the activity. This includes mobile phone photography.

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Friday, November 9, 2018 12:30 – 13:30 Registration 13:30 – 14:00 Opening Comments

Co-Chairs: Orlando G. P. Barsottini, José Luiz Pedroso, and Henrique B. Ferraz Section 1 – Anatomy, Function and Natural History of the Ataxias

Chair: Orlando G.P. Barsottini 14:00 – 14:30 Anatomy and Function of the Cerebellum, and Phenomenology of the Ataxias

Pedro Braga Neto 14:30 – 15:00 Experimental Models in Cerebellar Diseases

Henry Paulson 15:00 – 15:30 The Natural History and Epidemiology of the Spinocerebellar Ataxias (SCAs)

Pedro Braga Neto 15:30 – 15:40 Discussion with Question and Answer 15:40 – 16:00 Coffee Break

Section 2 – Genetics of Ataxias and Hereditary Spastic Paraplegias Chair: Henrique Ballalai Ferraz

16:00 – 16:30 New Genes in Ataxias Marcondes C. França Junior

16:30 – 17:00 Exome Sequencing and Genes for Undetermined Ataxias Fernando Kok

17:00 – 17:30 A New Group of Diseases: The Spastic Ataxias Marcondes C. França Junior

17:30 – 18:00 Update on the Genetics of Hereditary Spastic Paraplegia Jonas Saute

18:00 – 18:10 Discussion with Question and Answer

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Saturday, November 10, 2018 08:00 – 08:20 Opening Comments

Chair: Marcondes C. França Junior 08:20 – 09:00 Update in Spinocerebellar Ataxias (SCAs)

Orlando G. P. Barsottini 09:00 – 09:40 Clinical Trials in Ataxias

Jonas Saute 09:40 – 10:00 Coffee Break

Section 3 – Update on Ataxias Chair: Francisco Cardoso

10:00 – 10:30 Acquired and Secondary Ataxias Hélio Teive

10:30 – 11:00 Unusual Ataxias (With Video) José Luiz Pedroso

11:00 – 11:30 Multiple System Atrophy (Cerebellar Form) Henrique Balallai Ferraz

11:30 – 12:00 Movement Disorders Associated with Ataxias José Luiz Pedroso

12:00 – 12:10 Discussion with Question and Answer 12:10 – 13:30 Lunch

Section 4 – Rehabilitation and Therapeutics in Ataxias and Hereditary Spastic Paraplegia Chair: Pedro Braga Neto

13:30 – 14:00 Measuring Ataxia and Spastic Paraplegia Severity. A Critical Review. Chien Hsin Fen

14:00 – 14:30 Speech Therapy in Ataxias Speech Ther. Giovana Diaferia

14:30 – 15:00 Rehabilitation in Ataxias and Hereditary Spastic Paraplegia Chien Hsin Fen

15:00 – 15:30 Treatable Ataxias Orlando G. P. Barsottini

15:30 – 15:40 Discussion with Question and Answer 15:40 – 16:00 Coffee Break

Section 5 – New Frontiers in Ataxias Chair: Helio A. G. Teive

16:00 – 16:30 Moving toward therapy for the SCAs Henry Paulson

16:30 – 17:00 Ataxia and Chorea: Huntington`s disease and Other Conditions Francisco Cardoso

17:00 – 17:30 Discussion with Question and Answer 17:30 – 18:00 Cocktail – Espaco de Eventos (10th Floor) 18:00 – 19:00 Video Challenge: Ataxias

Chairs: Francisco Cardoso Orlando Barsottini José Luiz Pedroso

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