Tissue Repair, IsASL Annual ConferenceJune 16th – 18th 2016

The Dan Hotel Eilat (Red Sea)

Scientific Program

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Thursday 16/6/2016

10:00-10:30 Light breakfast & exhibition

10:30-13:10 SESSION 1: THE JUNE LIVER FORUM Moderator: Yoav Lurie & Rifaat Safadi 10:30-11:00 Case Presentation & Discussion 1, Rambam, Haifa11:00-11:10 Case Presentation & Discussion 2, Bnei Zion, Haifa11:10-11:40 Case Presentation & Discussion 3, Kaplan, Rehovot11:40-12:10 Case Presentation & Discussion 4, Hadassah, Jerusalem12:10-12:40 Case Presentation & Discussion 5, Barzilay, Ashkelon12:40-13:10 Case Presentation & Discussion 6, Rambam, Haifa Sponsored by 13:10-13:45 Light Lunch & Exhibition PARALLEL SESSION

13:45-14:00 TISSUE REPAIR OPENING IsASL Chairman: Rifaat Safadi 14:00-15:14 SESSION 2: THE 2016 CHALLENGES IN VIRAL HEPATITIS Chairs: Amir Shlomai & Michal Carmiel14:00-14:20 Translating molecular virology into novel antiviral therapies Jeffrey Glenn, Associate Professor of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Director, Center for Hepatitis and Liver Tissue Engineering, Stanford University School of Medicine14:22-14:30 Hepatitis B virus antagonizes sorafenib in hepatoma cells through indirect induction of the Raf-Mek-Erk pathway Amir Shlomai1,2 , Dvora Witt-Kehati2, Romy Zemel2

1 Department of Medicine D, Beilinson hospital, 2 Felsenstein Medical Research Center, The Faculty of Medicine, Tel-Aviv University

14:32-14:36 Regression of Liver Fibrosis assessed by non-invasive methods in Patients with Chronic Hepatitis C who Achieved Sustained Virologic Response after DAAs Treatment Davidov Yana1, Klienboum Yoram2, Cohen-Ezra Oranit1,3, Veitsman Ella1, Berdichevsky Tanya1, Weiss Perez1, Katerginsky Sima2, Hassid Avishag1, Tzaraf Keren1, Ben-Ari Ziv1,3

1Liver Disease Center, 2Department of Radiology Sheba Medical Center, Tel Hashomer, Ramat Gan, 3Sackler School of Medicine, Tel Aviv University14:37-14:41 Beneficial outcomes of DAA’s on post SVR liver stiffness Saleh Daher1, Nadav Ilani1, Tawfik Khouri1, Mina Rowe1, Rifaat Safadi1

1 The Liver Unit, Institute of Gastroenterology and hepatology, Hadassah-Hebrew University Medical Center, Jerusalem 14:42-14:46 Hepatitis C virus induces oncogenic signatures that are not fully reverted following treatment with DAAs Shira Perez1,2, Antony Kaspi3, Ateret Davidovich1, Assy Nimer4, Izhak Haviv2, Meital Gal-Tanamy1

1 Molecular Virology Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Cancer Personalized Medicine and Diagnostic Genomics Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 3 Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, 4 Galilee, Medical Centre, Nahariya 14:47-14:51 The Efficacy and Safety of Different Direct-Acting Antiviral Agents in Liver Transplant Recipients with Recurrent Hepatitis C: A Single Center Study Ella Weitzman1, Lichter Maria1, Keren Tsaraf1, Ardita Jonuzi1, Peretz Weiss1, Orna Mor2,3, Ziv Ben-Ari1,3

1 Center for liver diseases, Sheba Medical Center, 2 Central Virology Laboratory, Ministry of Health, Ramat Gan, 3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, 14:52-15:12 Harvoni Real Life German Data Peter Buggisch, Head of Liver Center Hamburg, IFI at the Asklepiosklinik St. Georg Haus L

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SESSION 3: NURSES WORKSHOP I, DAA’S ADHERENCE Chairman: Matthias Carlebach & Rimma Kramsky

פתיחת שירותי כבד בבי”ח העמק 13:45-14:00אלכס שטרקמן,בי”חהעמק

מהכנה להשתלה, מנקודות המבט של המטופל והצוות 14:00-14:15רימה קראמסק,רמב”ם

חוליו בורמן עמותת חץ - עמותת חץ, הווה ועתיד בפעילויות בארץ 14:15-14:30

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15:14-16:30 SESSION 4: ABSTRACTS PRESENTATION & DEBATE: ANTICOAGULATION AND CHIROSSIS Chairman: Assy Nimmer & Tarek Saadi15:14-15:24 Debate: Pro - Amir Shlomai Con - Michal Carmiel15:25-15:33 Genomic signatures of Hepatitis viruses in liver cancer Shira Perez1,2, Anat Lavi-Izkovitz3, Gur Yaari3, Ana Tover4, Salomon M Stemmer4, Izhak Haviv2, Meital Gal-Tanamy1

1 Molecular Virology Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Cancer Personalized Medicine and Diagnostic Genomics Lab, Faculty of Medicine in the Galilee, Bar- Ilan University, Safed, 3 Systems computational biology, Faculty of Engineering, Bar-Ilan University, Ramat-Gan 4 Davidoff Center, Tel-Aviv University, Rabin Medical Center, Beilinson Campus, Petach Tikva15:34-15:42 Sortilin deficiency reduces ductular reaction, hepatocyte apoptosis and liver fibrosis in cholestatic-induced liver injury Isabel Zvibel 1* Einav Hubel1, Ashish Saroha2, Woo-Jae Park3, Yael Pewzner-Jung2, Elise G Lavoie 4, Anthony H Futerman2, Rafael Bruck1, Sigal Fishman1, Jonathan A Dranoff 4, Oren Shibolet 1# 1The Research Center for Digestive Tract and Liver Diseases, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 2 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 3 Department of Biochemistry, School of Medicine, Gachon University, 4 Division of Gastroenterology & Hepatology, University of Arkansas for Medical Sciences

15:43-15:55 NK cells from homozygous NLG4-/- (KO) mice inhibit liver fibrosis through PI3K/AKT/mTOR pathway and decreased interleukin-4 Rifaat Safadi, Johnny Amer, Ahmad Salhab, Liver Unit, Gastroenterology and Liver Diseases, Hadassah- Hebrew University Medical Center,Jerusalem15:56-16:04 Improvement in Non-Invasive Hepatic Parameters of Nonalcoholic Fatty Liver Disease in Obese Uncontrolled T2DM Patients who underwent Endoscopic Duodenal–Jejunal Bypass Liner (Endobarrier) Implantation Oranit Cohen-Ezra1, G Segal-Liberman2, A Lang3, M Lahav3, Y Kleinbaum4, Y Inbar4, S Katscherginsky4, E Veitsman1, T Bradichevsky1, P Weiss1, K Tsaraf1, Z Ben-Ari1

1 liver disease center, sheba medical center, Ramat Gan 2 Endocrine institute, sheba medical center, Ramat Gan 3 Gastroenterology institute, sheba medical center, Ramat Gan16:04-16:08 Effects of anti-hypertensive and triglyceride lowering agents on hepatic copper concentrations in rats with fatty liver disease Zvi Ackerman1, Galina Skarzinski2, Maria Grozovski3 , Mor Oron- Herman4, Ben-Ami Sela4

1 Department of Medicine, Hadassah-Hebrew University Medical Center, 2 Department of Pathology, Hadassah-Hebrew University Medical Center, 3 Department of Human Nutrition and Metabolism, Hebrew University- Hadassah Medical School, 4 Biotechnology, Ort Braude College of Engineering, Karmiel16:09-16:13 The effects of iron overload on acetaminophen hepatotoxicity in rats Zvi Ackerman1, Galina Skarzinski2, Gabriela Link3, Maya Glazer1, Orit Pappo2, Maria Grozovski4

1 Department of Medicine, Hadassah-Hebrew University Medical Center, 2 Department of Pathology, Hadassah-Hebrew University Medical Center, 3 Department of Human Nutrition and Metabolism, Hebrew University- Hadassah Medical School, 4 Biotechnology, Ort Braude College of Engineering, Karmiel

16:14-16:22 Batf3 Dependent Dendritic cells are crutial for Primary Bilary Cholangitis Ehud Zigmond1, Debby Reuveni1, Yael Gore1, Patrick Leung2, Eli Brazowski1, Zamir Halpern1, Oren Shibolet1, Eric Gershwin2 1 Research Center for Digestive Diseases, Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv, 2 Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis16:23-16:31 Detected HCV RNA at the end of treatment with DAAs deos not reduce the possibility to achieve SVR Tarek Saadi1, Rawi Hazzan2, Yelena Yermenko2, Michal Carmiel3, Matthias Carlebach4, Rimma Kramskay1, Vered Ben-Hakoon1, Bella Smolen1, Hisham Sholy1, Johad Khoury1, Yaacov Baruch1

1 Liver Units, Rambam-Health Care Campus, Haifa; 2 Liver Unit, HaEmek Medical Center, Afula; 3 Liver Unit, Western Galilee Hospital, Nahariya; 4 Bnai-Zion, Medical Center, Haifa.

16:32-17:00 Coffee Break & Exhibition

17:00-18:10 SESSION 5: ACUTE AND / ON CHRONIC LIVER FAILURE Chairman: Yoram Menachem & Marius Braun 17:00-17:18 Hepatic decompensation during DAAs therapy in advanced HCV cirrhosis Ziv Ben Ari, Director Liver Disease Center, Sheba Medical Center, Tel Hashomer17:20-17:24 Acute Coronary Syndromes in patients with Non-alcoholic Fatty Liver Disease (NAFLD) Yaakov Maor1, Dan Haberman2, Ehud Melzer1, Jacob George2

1 Institute of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, 2 Heart Center, Kaplan Medical Center, Affiliated to the Hebrew university, Jerusalem, Rehovot 17:25-17:29 Non-alcoholic Fatty Liver Disease in Young Adults-Epidemiologic Data from a Large Cohort Yaakov Maor1, Salah Daher2,3, Eran Israeli3, Lior Katz2,4

1 Institute of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, 2 Israeli Defense Force,Israeli Defense Force, 3 Department of Gastroenterology and Hepatology, Hadassah Medical Center, Jerusalem, 4 Department of Gastroenterology, Sheba Medical Center, Tel-Hashomer

17:30-17:34 Unexpected diagnosis of Hepatocellular Carcinoma(HCC) soon after all oral (DAA) therapy for hepatitis C virus (HCV) Marius Braun 1,2, Michal Cohen Naftali 1,2, Yfaat Snir1,2, Orly Sneh Arbib 1,2, Amir Shlomai 1,2, Ofer Beniaminov2,3, Salomon Stemer2,4, Ran Tur Kaspa1,5 1 Liver Institute, Beilinson Hospital , Petah Tikva, Israel 2 Sackler School of Medicine, Tel Aviv University, Israel 3 Imaging department, Beilinson Hospital , Petah Tikva, Israel 4 Oncology department, Beilinson Hospital , Petah Tikva, Israel 5 Faculty of Medicine of Bar-Ilan University in the Galilee, Safed17:35-17:39 The role of hepatic microenvironment in growth and metastasis of hepatitis c virus - induced hepatocellular carcinoma Abraham Nissani1, Liat Ninio1, Ateret Davidovich1, Mark Shlapobersky2, Anastasia Malek3, Izhak Haviv2, Hava Gil- Henn3, Meital Gal-Tanamy1

1 Laboratory of molecular virology, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Laboratory of cancer research, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 3 Laboratory of cell migration and invasion, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed17:40-17:44 The interplay between Hepatitis C virus infection, changes in higher chromatin organization and cancer Meital Gal-Tanamy1, Michael Gevor1, Shira Perez1, Antony Kaspi2, Ateret Davidovich1, Izhak Haviv1, Itay Onn1, 1 Faculty of Medicine in the Galilee, Bar-Ilan University, 2 Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart & Diabetes Institute17:45-18:10 Acute Liver Failure: Causes and Consequences Adrian Reuben, Medical University of South Carolina (MUSC), Charleston SC, USA

19:30 Dinner

Friday 17/6/2016

07:30 Breakfast with Visitors, F:F meeting

08:00-09:00 SESSION 6: NURSES WORKSHOP II, DAA'S ADHERENCE Chairman: Alice Herskovic & Orly Azulay

NASH אפקטים סיעודיים בטיפול בחולי 08:00-08:15מרינה ליבשיץ איכילוב

חווית המטפל בחולים קשים והשפעתה על תפקודו 08:15-08:30יעל חריף בלינסון

תוצאות סקר מטופלי HCV בישראל בהשוואה לאוכלוסיה באירופה 08:30-08:45קרן צארף, המרכזלמחלותכבדתלהשומר

C תפקיד האחות בעידן הטיפולים החדשים בהפטיטיס 08:45-09:00ד”ר גל ניצן גיליאד

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08:00-10:00 SESSION 7: PEDIATRIC HEPATOLOGY: METABOLIC DISORDERS Chairman: Tania Berdichevski & Rifaat Safadi 08:00-08:18 Pediatric liver transplantations – Indications and outcome Dr. Yael Mozer, Schneider Children's Hospital 08:20-08:28 Challenging the current normal range of serum alanine aminotransferase in the elderly - a need for reevaluation Schmilovitz-Weiss Hemda1,2, Rachel Gingold-Belfer1,2, Yichayaou Beloossesky1,2, Joseph Meirovitch2, Nira Koren- Morag2, Avraham Weiss1,2

1 Gastroenterology, Rabin Medical Center, Petach-Tiqwa 2 Sackler faculty of medicine, Tel Aviv University, Tel Aviv08:30-08:38 The association of ALT levels with myocardial perfusion imaging and cardiovascular morbidity. David Yardeni1, Ohad Etzion1,4, Ronen Toledano2, Victor Novack2, Aryeh Shalev3, Arik Wolak3, Yaron Rotman4

1 Gastroenterology and Liver Disease Institute, Soroka University Medical Center, 2 Clinical Research Center, Soroka University Medical Center, 3 Cardiology Section, Soroka University Medical Center, 4 Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, USA

08:40-08:58 The role of Whole Exome Sequencing in diagnosis of liver diseases Orli El Peleg, Hadassah Medical Center 09:00-09:04 Thiopurine Metabolite Assessment in children with Autoimmune Hepatitis Eyal Shteyer1, Jahjah Elias1, Orit Pappo2, Ledder Oren1, Raffi Lev-Tzion1 1 Pediatric Gastroenterology institute, Shaare Zedek Medical Center, Jerusalem, 2 Departement of Pathology, Hebrew University-Hadassah Medical Center, Jerusalem09:05-09:09 New ultrasonographic protocol for early diagnosis of cystic fibrosis liver disease Eyal Shteyer5, Or Steg Saban1, Michael Wilschanski1 , Moti Menachem1, Natasha Simanovski2, Eitan Kerem1, Deirdre Kelly4, Louis Stewart4 1 Pediatric Gastroenterology Unit, 2 Radiology Department, 3 Department of Pediatrics, Hebrew University-Hadassah Medical Center, Jerusalem, 4 Liver Unit, Birmingham Children’s Hospital, Birmingham, 5 Pediatric Gastroenterology institute, Shaare Zedek Medical Center, Jerusalem 09:10-09:28 MiRNA tools in diagnosis and treatment of liver diseases Shimon Reif, Hadassah Medical Center 09:30-09:34 ADAR1 knockdown HepG2 cells directly affect the activation of primary HSCs via the up-regulation of IL-6 Michal Safran1, Polina Kagan1,4, Shirley Oren2,4, Maya Sultan1, Ziv Ben-Ari1,3,4

1 Liver Research Laboratory, Chaim Sheba Medical Center, Ramat Gan, 2 Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, 3 Liver Disease Center, Chaim Sheba Medical Center, Ramat Gan, 4 The Sackler School of Medicine, Tel Aviv University, Tel-Aviv09:35-09:39 CD49a- CD49b+ NK1.1 cells in C57/BL fibrotic livers are distinct from peripheral NK cells in their neurologin4/CD107a activatory marker Johnny Amer, Ahmad Salhab, Rifaat Safadi Liver Unit, Gastroenterology and Liver Diseases, Hadassah- Hebrew University Medical Center,Jerusalem

09:40-09:58 Characteristics of Cholestatic liver disease in Pediatrics. Efrat Broide, Assaf Harofe Medical Center

10:00-10:30 Coffee Break & Exhibition

10:30-11:45 SESSION 8: NUTRITION AND LIVER DISEASE Chairman: Eli Zuckerman & Rafi Bruck10:30-10:48 Nutrition in Cirrhosis Shibolet Oren, Director of the Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center and Tel-Aviv University10:50-11:08 Nutrition & Acute Liver States Rifaat Safadi, Liver & Gastroenterology Units, Hadassah-Hebrew University Hospital11:10-11:18 Baseline and treatment failure resistance analysis in HCV GT1 patients treated with first and second generation direct acting antivirals Yael Gozlan1, Ziv Ben Ari2,3, Rachel Shirazi1, Roy Moscona1, Avia Rakovsky1, Ella Weitzman2,3, Tania Bradichevsky2,3, Peretz Weiss2,3, Avishag Hassid2, Keren Tsaraf2, Yoav Luria4, Oren Shibolet3,5, Eli Zuckerman6,7, Marius Brown3,8, Michal Cohen- Naftali3,8, Ofer Peleg9, Ella Mendelson1,10, Orna Mor1

1 Central Virology Laboratory, Ministry of Health, 2 Liver Disease Center, Sheba Medical Center, 3 Faculty of Medicine, Sackler faculty of Medicine, Tel Aviv University, 4 Liver unit, Shaare Zedek Medical Center, 5 Department of Gastroenterology, Tel- Aviv Medical Center, 6 Liver Unit, Carmel Medical Center, 7 Rappaport Faculty of Medicine, The Technion, 8 Liver Institute, Rabin Medical Center, 9 Genaphora, Genaphora, 10 School of Public Health, Tel Aviv University11:20-11:24 Unique clinical features of Non Alcoholic Steato Hepatitiis (NASH)-related hepatocellular carcinoma (HCC) Yoram Menachem 1, Oren Shibolet 1, Izhar Levy 2, Rifaat Safadi2, Eli Zuckerman3

1 Tel Aviv Sourasky Medical Center, 2 Hadassah University Hospital Jerusalem, 3 Carmel Hospital, Haifa

11:25-11:29 HBV down regulates the expression levels of vitamin d receptor in hepatocellular carcinoma transfected cells thereby preventing inhibition of viral replication by Vitamin D Michal Safran1 , Neta Gotlieb1, Irina Tachlytski1, Lena Lapidot1,3, Maya Sultan1, Ziv Ben Ari1,2,3

1 Liver Research Laboratory, Sheba Medical Center, Ramat Gan, 2 Liver Disease Center, Sheba Medical Center, Ramat Gan 3 The Sackler School of Medicine, Tel Aviv University11:30-11:34 Enhancing patients` knowledge and accessibility to healthcare services increase implementation of hepatitis C virus therapy in methadone maintenance treatment patients Einat Peles1, Miriam Adelson1, Anat Sason1, Helena Katchman2, Stella Levit2, Shaul Schreiber1, Oren Shibolet2 and Rafael Bruck2

1 Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse Treatment & Research, 2Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center & Sackler Faculty of Medicine, Tel Aviv University11:35-11:39 Israeli’s and global lessions extracted from the HCV Quest Global Patient Survey Ziv Ben-Ari1,3,4, Hulio Burman2, Keren Tsaraf1, Charles Gore3

11:40-11:44 Autoimmune hepatitis: a single center experience with a long follow-up Eli Zuckerman1, Yulia Kovalev1, Eyal Ashkenasie1

11:45-14:00 SESSION 9: THE 2016 CHALLENGES IN VIRAL HEPATITIS Chairman: Dani Shoval & Yaacov Maor 11:45-12:10 HCV treatment in special populations Didier Samuel, Professor of Hepatology and Gastroenterology at Université Paris-Sud, Villejuif, France Sponsored by 12:12-12:32 The HCV real life in Israel Prof. Eli Zuckerman

12:34-12:42 Hepatitis E in Israel Orna Mor1, Daniela Ram1, Yossi Manor1, Yael Gozlan1, Eli Schwartz2, Ziv Ben-Ari3, Ella Mendelson1, Shaul Possi4

1 Central Virology Laboratory, Ministry of Health, 2 Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, 3 Liver Diseases Center, Chaim Sheba Medical Center12:43-12:51 Hepatitis E in haematological patients in Israel Rasha Daniel1,4,5, Tsila Zuckerman2, Shira Zelber-Sagi3,5, Mira Barak4, Orly Azulay1, Eli Zuckerman1

1 Liver Unit, Carmel Medical Center, Haifa, Haifa and Western Galilee District, 2 BMT Unit, Department of Hematology, Rambam Medical Center, Haifa, 3 Department Gastroenterology, Tel-Aviv Medical Center, 4 Nesher Central Laboratories, CHS, Haifa and Western Galilee District, 5 Faculty of Public Health, Haifa University 12:52-12:56 The Prevalence Of Hepatitis E Virus Antibodies In Israel Rasha Daniel1,3,4, Shira Zelber-Sagi2,4, Mira Barak3, Orly Azulay1, Eli Zuckerman1

1 Liver Unit, Carmel Medical Center, 2 Department Gastroenterology, Tel-Aviv Medical Center, 3 Nesher Central Laboratories, CHS, Haifa and Western Galilee District, 4 Faculty of Public Health, Haifa University12:57-13:01 Patients’ age rather than their Model of End-stage Liver Disease (MELD) score predicts long-term survival after liver transplantation Yaara Leibovici-Weissman1,2, Moshe Leshno3, Amir Shlomi1,2,4

1 Sackler Faculty of Medicine, Tel-Aviv University, 2 Department of Medicine D, Beilinson hospital, 3 School of Management, Tel-Aviv University, 4 The Liver Institute, Beilinson hospital 13:02-13:22 Prenylation inhibitors for treating delta hepatitis Jeffrey Glenn, Associate Professor of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Director, Center for Hepatitis and Liver Tissue Engineering, Stanford University School of Medicine13:30-13:40 IsASL Business Meeting: IsASL Governing Board Rifaat Safadi, Chairman Tania Berdichevski, Treasurer Matthias Carlebach, Observer 13:40 Closing Remarks: Rifaat Safadi, IsASL Chairman

14:00 Lunch