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research article open access dysregulated phosphorylation of rab gtpases by lrrk2 induces neurodegeneration ga ram jeong1†, eun-hae jang2,3,4†, jae ryul bae1, soyoung…
lrrk2 and its substrate rab gtpases are sequentially targeted onto stressed lysosomes and maintain their homeostasis tomoya eguchia1 tomoki kuwaharaa1 maria sakuraia1 tadayuki…
1. 1new model to studyparkinsons diseaseelise villerslaurent magnies 2. introduction2an estimated 4 million the number of people affected by parkinsons diseaseparkinsons…
1 lrrk2 exonic variants associated with parkinson’s disease augment phosphorylation levels for lrrk2- ser1292 and rab10-thr73 kenneth v christensen1† morten hentzer1…
review the lrrk2 signalling system alice price1 & claudia manzoni1,2 & mark r. cookson3 & patrick a. lewis1,2 received: 2 august 2017 /accepted: 27 november 2017…
by the requirements for the degree of doctor of philosophy (medical genetics) (vancouver) ii abstract genetic studies have been extremely informative to the pathophysiology
infection and immunity, oct. 2003, p. 5855–5870 vol. 71, no. 10 0019-9567/03/$08.00�0 doi: 10.1128/iai.71.10.5855–5870.2003 copyright © 2003, american society for…
a drosophila model for lrrk2-linked parkinsonism zhaohui liu, xiaoyue wang, yi yu, xueping li, tao wang, haibing jiang, qiuting ren, yuchen jiao, akira sawa, timothy moran,…
section i: biological importance of gtpase-driven switches chapter 1 a. introduction 3 c. structure of the gtpase switch 4 d. primary structures identify gtpases with related
___________________________________ involvement of rhou in disease initiation and progression direttore della scuola supervisore : dipartimento di scienze chirurgiche, oncologiche…
research article open access lrrk2 phosphorylates pre-synaptic n-ethylmaleimide sensitive fusion (nsf) protein enhancing its atpase activity and snare complex disassembling…
inhibition of ral gtpases using stapled peptides 1 inhibition of ral gtpases using a stapled peptide approach jemima c thomas124 jonathan m cooper3 natasha s clayton1 chensu…
r d m j y c g p s k a b c d e f g h i j k l m n o p q r s t u a a r r 3 a a k c m w h c h 1 seminars in cancer biology 35 (2015) s129–s150 contents lists available at sciencedirect…
7/27/2019 cancer as a dysregulated epigenome 1/14even before the discovery of epigenetic mod-ifications in cancer, classical tumour biologysuggested that generalized disruption…
cell stem cell, volume 8 supplemental information lrrk2 mutant ipsc-derived da neurons demonstrate increased susceptibility to oxidative stress ha nam nguyen, blake byers,…
neurobiology of disease phosphorylation of ezrin/radixin/moesin proteins by lrrk2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis loukia parisiadou,1…
doi:10.1006/jmbi.2001.5378 available online at http://www.idealibrary.com on j. mol. biol. (2002) 317, 41±72 classification and evolution of p-loop gtpases and related atpases…
who cares about rho gtpases? http://www.geocities.com/capecanaveral/3504/gallery.htm bordetella spp. neisseria spp. clostridium spp. salmonella spp. historical gtpase events…
rab gtpases in vesicular transport introduction marino zerial and harald stenmark european molecular biology laboratory, heidelberg, germany specificity and directionality…
review rho gtpases and signaling networks linda van aelst1,3 and crislyn d’souza-schorey2 1cold spring harbor laboratory, cold spring harbor, new york 11724 usa; 2department…