Seascape/Indira Ghosh, JNU

Introduction

Seascape Intro

Indo-US company with a mission to foster international collaborative research, education and software knowledge development/dissemination in the areas of Drug Discovery and Nanotechnology. Operates from New Delhi and California and has been in operation for over ten years

Seascape Role

 Scientific Community Development & Integration in India and USA

 Scientific & Technical Support for Software & Collaborative R&D Projects

New project searching, identification and matching with scientific

skills in India and USA

Scientific Support, co-ordination and project management

Software support, co-ordination and management

 

Education and Training

Seascape - Key People

Sunil Chawla, Founder:• B.Tech from IIT Kharagpur, India

• M.Engg. from McGill-Montreal (Cancer Research Thesis

• MBA from UC Berkeley

• Experience: Apple, GE and Oracle in USA

Dr. Steve Bowlus, Comp Chemist• Postdoctoral studies in toxicology and nutrition, University of Illinois

• MS, Ph.D, Organic Chemistry, University of Illinois, Urbana

Dr. Indira Ghosh, JNU, Sci Advisor• Dean, School of info Technology, JNU, New Delhi

Dr. Indira Ghosh, JNU Introduction

Dr. Indira Ghosh, currently Dean of School of Information Technology, JNU, New Delhi is the Chief Investigator and Scientific Advisor working with

Seascape on the OpenTox collaborative project

Dr. Indira Ghosh - Background

• More than a decade of experience working in leading pharmaceutical industry (Astra Zeneca, R&D Bangalore, India)

• Ph.D from prestigious Indian Institute of Science, Bangalore in the field of molecular biophysics. Ph.D work on the enzyme specificity with respect to the stereochemical aspects of ligands

• Ph.D thesis could be taken as initial scientific study towards the development of field known as ‘docking’

• Post-doctoral appointment at University of Huston, Texas with Prof. J. A. McCammon (currently at University of California San Diego, USA)

• Worked on implementation of many complex algorithms in the filed of Molecular Dynamics, has contributed in development of free energy calculation using perturbation method

Recent/Relevant Research

• Research related to designing inhibitors for acting on H+ K+ ATPase, drug design (QSAR and toxicity prediction) for the lead series related to disease like tuberculosis and malaria, for more than a decade during her association with AstraZeneca.

• Currently, she is supervising major project related to force field development of Metalloprotease, excited state treatment of proton pumping phenomena of the ATPase funded by Ministry of Communication and Information Technology and Department of Biotechnology, Government of India.

Recent/Relevant Publications• An Information–Theoretical Measure of Similarity and a Topological Shape and Size Descriptor for Molecular Similarity Analysis (IEJMD,3,350- 360, 2004)

•Developing an Antituberculosis Compounds Database and Data Mining in the Search of a Motif Responsible (minimum common bioactive substructure-MCBS) for the Activity of a Diverse Class of Antituberculosis Agents (J. Chem. Info. Model, 46, 17-23, 2006)

•Mapping Selectivity and Specificity of Active Site of Plasmepsins from Plasmodium falciparum Using Molecular Interaction Field Approach (Protein & Peptide Letters, 14, 569-574, 2007)