section 2: metabolism glucose catabolism and electron...
TRANSCRIPT
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Section 2: Metabolism
Glucose catabolism and electron transport
Section 2: Metabolism
Glucose catabolism and electron transport
So what is fermentation again?
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IT'S THIS!
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation -
Unifying concepts for all fermentations
Organic molecules serve asMolecule being metabolized doesn't have all its
NAD+ reduced toEnergy is derived fromEnergy yields are isn't involved
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Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Glycolysis (Embden-Meyerhof pathway)
Total ATP
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Glycolysis (Embden-Meyerhof pathway)
Total ATP
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Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Glycolysis (Embden-Meyerhof pathway)
Total ATP
Total NAD+
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Glycolysis (Embden-Meyerhof pathway)
Total ATP
Total NAD+
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Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Need to regenerate the NAD+, since it's limiting in cells
Recall
Total ATP
Total NAD+
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Total ATP
Total NAD+
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Total NAD+
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
End products
Total ATP
Section 2: Metabolism
Glucose catabolism and electron transport
A. Fermentation example
Total energy of glucose available by complete oxidation =
Total energy yield of 2 net ATP =
Fermentation through glycolysis is
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Section 2: Metabolism
Glucose catabolism and electron transport
B. Respiration - general concepts
Goal: extract as many e- as possible from the substrate & use thatenergy to create
Oxidation of a source of energy by removal of e- & donation to an inorganic
Substrate often has all available e- removed; is fullyInvolves a membrane bound system that creates a gradient
gradient can do work & is used to makeis generated by e- transport chain
Section 2: Metabolism
Glucose catabolism and electron transport
B. Respiration
Not this
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Section 2: Metabolism
Glucose catabolism and electron transport
B. Respiration
But this
Section 2: Metabolism
Glucose catabolism and electron transport
B. RespirationActually this
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Section 2: Metabolism
Glucose catabolism and electron transport
B. Respiration
A digression, sort of:
So, how does cyanide (CN-) kill you?
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A digression, sort of:
So, how does cyanide (CN-) kill you?
A digression, sort of:
How can you lose weight with pills containing 2,4-dinitrophenol (DNP)?
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A digression, sort of:
How can you lose weight with pills containing 2,4-dinitrophenol (DNP)?
DNP disrupts PMF by uncoupling the
DNP acts as aIt binds H+ on one side of amembrane, and being fat-solubleit drifts to the opposite side where itloses the H+
It is impossible to maintain a H+ gradientwith sufficient DNP in the system
e- continue to pass through the ETS andreduce , butATP is not synthesized in the process
Section 2: Metabolism
Glucose catabolism and electron transport
C. Citric acid cycle (Krebs, TCA)
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Section 2: Metabolism
Glucose catabolism and electron transport
C. Citric acid cycle (Krebs, TCA)
Section 2: Metabolism
Glucose catabolism and electron transport
D. Alternatives to aerobic respiration and fermentation
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Section 2: Metabolism
Glucose catabolism and electron transport
D. Alternatives to aerobic respiration and fermentation
Section 2: Metabolism
Glucose catabolism and electron transport
D. Alternatives to aerobic respiration and fermentation
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Section 2: Metabolism
Glucose catabolism and electron transport
D. Alternatives to aerobic respiration and fermentation
Section 2: Metabolism
When would it be beneficial for an organism to use fermentation if it is capable of aerobic respiration? Why?
What type(s) of metabolism would be resistant to cyanide poisoning?
What type(s) of metabolism would be resistant to DNP poisoning?
In what type of environment would you expect to find photoheterotrophs? Why?
Due the class after the exam.