Section2Section2

Clinical Approaches of MSCs

Tissue engineeringGene & Cell therapy

Encapsulated cell biodelivery

Cell based therapies:Regenerative therapy to treat Parkinson’s, Alzheimer’s, spinal cord injury, stroke, severe burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritisStem cells in gene therapyStem cells as vehicles after they have been genetically manipulated

Stem cells in cancer

Potential uses

according to the World Health Organization,

traumatic brain injury (TBI) will surpass many diseases

as the major cause of death and disability .It is estimated that 10 million people are affected

annually by TBI, with the highest incidence among persons 15 to 24 years of age and 75 years and older. Since TBI may result in lifelong impairment of an individual's physical, cognitive, and psychosocial functioning, and given the absence of a cure, TBI is a disorder of major public health significance.

Traumatic brain injury

Current therapies in neurotrauma aim particularly to prevent brain edema, raised intracranial pressure, ischemic damage and in bleedings.

most of the

mentioned therapies are associated with problems and

are thought as a complementation of the existing

therapies. Stem cell therapy aims not only for receiving

brain tissue and functions but also for restoring of both.

So, stem cell therapies may possess the most effective

potential for neuronal and functional recovery.

Inflammation

Repair

Remodeling

Stages of fracture healing

strategies for cell therapy in neurotrauma

“cell replacement” “mini – pumps"

pharmacologic manipulation and / or gene therapy

• release of trophic factors, enzymes and neurotransmitters • buffering toxic molecules • blocking of endogenous repair-inhibitory factors • expressing extracellular matrix molecules • stabilize brain tissue and promote remyelination • providing favorable cell-cell communication

neuronal and functional recovery

Phase 1:

-proof of safety

Phase 2:

-proof of efficacy

Phase 3:

-proof of clinical usability

Clinical trials

Thanks for your Thanks for your attentionattention

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