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    Kyle J. Kramer, DDS, MS

    2/24/11

    Sedation Protocols

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    Goals

    ! Rational for selecting sedation techniques! Enteral (oral)

    !

    Parenteral (IV)

    ! Dental procedures possible while utilizing sedation! Common concerns

    !

    Common sedation protocols! Enteral (oral)

    ! Parenteral (IV)

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    Goals

    ! Preoperative instructions for sedation patients

    ! NPO Guidelines

    ! Post-sedation protocol

    ! Discharge criteria

    ! Common postoperative instructions

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    Indications for Sedation

    ! Comfort and care

    ! Profound relaxation

    !

    Long procedures! Invasive procedures

    ! Behavioral Modification

    !

    Gagging! Uncooperative nature

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    Indications for Sedation

    ! Anxiety! Situational anxiety

    !

    Dental phobia

    ! Medically Compromised Patients! Cardiovascular disease

    ! Pulmonary disease

    !

    Cerebrovascular disease! Seizure disorders

    ! Etc

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    Indications for Sedation

    ! Goal: Adapt YOUR techniques to the patient

    ! Mix and match!

    Extraction = IV sedation!

    Implant = Oral + nitrous oxide

    ! Uncovery = Nitrous only

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    Selection Rationale

    ! Provider preference

    ! Comfort and familiarity

    !

    Appropriate licensure!

    Adequate training

    ! Appropriate resources

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    Selection Rationale

    ! Patient selection

    ! ASA Classification!

    How healthy is my patient?! Anticipated problems

    ! What are they and are you capable of managing the problems?

    ! Will they tolerate the sedation protocol I have selected?! Example: Conscious sedation on pediatric patients

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    Selection Rationale

    ! Surgical Plan

    ! How long is the procedure going to be?!

    BE REALISTIC!! Does your surgical plan compromise your sedation plan?

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    Selection Rationale

    ! IDEAL: Ability to titrate sedation! Depth of stimulation

    ! Duration of surgery

    ! What is expected amount of postoperative pain! Immediate postop

    ! Usually easily controlled with LA in dentistry

    !

    Once back home! OTCs

    ! Rx

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    Dental Procedures

    ! Almost all dental procedures are safe to performconcurrently with minimal or moderate sedation

    !

    Minor modifications may be needed!

    Rubber dam

    ! Isolite

    ! C-sponges

    ! Throat pack

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    Dental Procedures: General DentistryProcedures Concerns

    ! Evaluations

    !

    Radiographs! Routine treatment

    ! Drill & fill

    ! Crown & bridge

    !

    Implants! Extractions

    ! Placement

    ! Uncovering

    ! Irrigation

    !

    Loose restorative materials! Alloy

    ! Implant components

    ! Obstruction of airway

    !

    Radiograph holders! Impression trays

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    Dental Procedures:

    Periodontal TherapyProcedures Concerns

    ! Nonsurgical

    !

    Prophy! DSRP

    ! Surgical procedures

    ! Open flap debridement

    ! Soft tissue grafts

    ! Irrigation

    !

    Intraoperative bleeding

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    Dental Procedures:

    Endodontic TherapyProcedures Concerns

    ! RCT

    !

    Surgical/invasive therapy! Apicoectomy

    ! Irrigation

    !

    Intraoperative bleeding! Obstruction of airway

    ! Radiograph holders

    ! Microscope?

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    Dental Procedures:

    Oral SurgeryProcedures Concerns

    ! Extractions

    !

    Invasive procedures! Biopsies

    ! Tissue grafts

    ! Incision & drainage

    ! Irrigation

    !

    Intraoperative bleeding! Obstruction of airway

    ! Loose teeth

    ! Radiograph holders

    !

    Microscope?

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    Key to Success!

    ! Think through the surgical plan ahead of time and takenecessary precautions

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    Oral Sedation Rationale:

    Benzodiazepine

    ! Diazepam, Midazolam or Triazolam??

    ! Ideal for:

    !

    Anxious patients! Rest the night before the appointment

    ! Procedural sedation

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    Oral Sedation Rationale:

    Diazepam, Midazolam or Triazolam??

    ! All provide relatively similar levels of sedation at equipotentdoses

    !

    Anxiolysis! Amnesia possible

    ! Relatively safe

    ! Minimal cardiovascular or respiratory depression when usedalone

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    Oral Sedation Rationale:

    Diazepam, Midazolam or Triazolam??

    ! Worried about active metabolites (think renal dysfunction!)! Diazepam?

    ! Maybe not

    !

    Worried about prolonged recovery/resedation?! Diazepam?

    ! Maybe not

    ! Duration of surgical procedure! Diazepam > midazolam = triazolam

    !

    Diazepam produces slightly different type of sedation

    ! Patient age! Preoperative midazolam for children

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    Oral Sedation Rationale

    Diazepam, Midazolam or Triazolam??

    ! Can combine with nitrous oxide to achieve moderatesedation

    !

    Requires more monitoring/vigilance!

    Monitor for oversedation/hypopnea

    ! Recommend pulse oximeter

    ! Obtain baseline, then titrate in N2O!

    Able to titrate to level of stimulation

    !

    Rapid recovery?

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    Oral Sedation Rationale

    Diazepam, Midazolam or Triazolam??

    ! Medically compromised patients

    ! Contraindication?!

    Maybe, maybe not! Stress reduction protocol

    ! Remember: The wholetreatment plan doesnt need to be done at onceespeciallyif the patient isnt doing well

    ! Use with care!

    Go low and go slow

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    IV Sedation Rationale

    ! Benzodiazepine (Solo Agent)

    ! Diazepam

    !

    Midazolam

    ! May be sufficient for some patients depending on theprocedure/situation

    !

    Anxiety! Minor procedures

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    IV Sedation Rationale

    ! Match the plan to the procedure

    ! Shorter procedures = midazolam

    !

    Longer procedures = diazepam (+ midazolam)

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    IV Sedation Rationale:

    Diazepam verses Midazolam

    Diazepam Midazolam

    ! Dosing:

    !

    Initial 2.5 mg bolus! Typical dose: 5-15 mgs

    ! Max: 30 mgs

    ! Onset: ~1-2 minutes

    !

    Peak effect: 3-5 minutes

    ! Dosing:

    !

    Initial 1 mg bolus! 0.3 mg/kg

    ! Typical dose: 2-10 mgs

    ! Max: 20 mg

    ! Onset: ~1-2 minutes

    !

    Peak effect: 3-5 minutes

    Titrate to desired level of sedation. Give AMPLE time BEFORE redosing

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    IV Sedation Rationale:

    Combinations

    enzodiazepine Narcotic

    ! Diazepam

    !

    Midazolam

    ! Fentanyl

    !

    Meperidine! Hydromorphone

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    IV Sedation Rationale:

    Diazepam + Fentanyl

    ! Duration: Moderate procedures

    ! Quadrant dentistry

    !

    ~45 minutes

    ! Ideal for procedures with initial period of stimulationfollowed by mild/minimal stimulation

    !

    Periodontal surgery! Invasive oral surgery

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    IV Sedation Rationale:

    Diazepam + Fentanyl

    ! Intraoperative considerations

    ! Patients will begin wake up around 30-45 minutes!

    Possibly avoid redosing if patient is still comfortable

    ! Postoperative considerations

    ! Diazepam active metabolites! Hangover possible

    ! Resedation is possible as well

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    IV Sedation Rationale:

    Diazepam + Fentanyl

    Diazepam Fentanyl

    ! Dosing:

    !

    2-10 mgs! Max: 30 mgs

    ! Onset: 3-5 minutes

    !

    Titrate to desired level ofsedation. Give AMPLE

    time BEFORE redosing

    ! Dosing:

    !

    1-2 mcg/kg! Onset: ~60 seconds

    ! Start with 1 mcg/kg, add

    remaining dose if needed! Helps reduce risk of apnea,

    chest wall rigidity

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    IV Sedation Rationale:

    Diazepam + Hydromorphone (Dilaudid)

    ! Duration: Moderate-long procedures

    !

    Prolonged action of hydromorphone! Extended analgesic coverage

    ! Ideal for procedures where postoperative pain is likely

    !

    Invasive oral surgery! Periodontal surgery

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    IV Sedation Rationale:

    Diazepam + Hydromorphone (Dilaudid)

    ! Dosing:

    ! Diazepam!

    Start 2.5 mg, wait 3-5 minutes before redosing! Hydromorphone

    ! Start with 0.1-0.2 mg

    ! Wait ~5 minutes before redosing

    !

    Titrate to required level of sedation! Anxiolysis

    ! Analgesia

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    IV Sedation Rationale:

    Diazepam + Meperidine

    ! Historically used combination

    ! Not commonly used anymore

    ! Meperidine

    ! Unwanted side effects! Tachycardia

    ! Risk of serotonin toxicity

    !

    Risk of seizures (proconvulsant)

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    IV Sedation Rationale:

    Diazepam + Meperidine

    ! Phased out of most hospitals

    ! Still available at Wishard

    !

    Not available at Clarian/IU Health

    ! Replaced by cleaner alternatives

    ! Fentanyl

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    IV Sedation Rationale:

    Midazolam + Fentanyl

    ! Extremely common combination

    !

    Moderate duration! Matches well with typical dental procedures

    ! Initial dose: ~30-45 minutes of sedation

    !

    Rapid onset & peak effect! Titration is easily accomplished

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    IV Sedation Rationale:

    Midazolam + Fentanyl

    Midazolam Fentanyl

    ! Dosing:! Initial 1 mg bolus

    !

    0.3 mg/kg

    ! Onset: ~1-2 minutes

    ! Peak effect: 3-5 minutes

    !

    Titrate to desired level ofsedation. Give AMPLEtime BEFORE redosing

    ! Dosing:

    ! 1-2 mcg/kg

    ! Onset: ~60 seconds

    ! Start with 1 mcg/kg, add

    remaining dose if needed! Helps reduce risk of apnea,

    chest wall rigidity

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    IV Sedation Rationale:

    Midazolam + Fentanyl

    ! Minimal postoperative concerns

    ! No clinically significant active metabolites

    ! Minimal concerns of resedation

    !

    Minimal hangover

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    IV Sedation Rationale:

    Guidelines

    !

    Rule #1: Go low!!Rule #2: Go slow!

    ! You can ALWAYS give more

    !

    But you CANT take it away onceyouve given it..

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    Preoperative Instructions

    ! Review with patients during consult

    !

    Give patients a hard copy! Include any special instructions

    ! Hold your multivitamin that morning,

    ! Take half of your regular insulin

    ! Be sure to bring your inhaler

    !

    Bring your CPAP machine

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    NPO Guidelines and Oral Medications

    ! Is it a NPO violation if patients take their regular oralmedication?

    ! No, as long as.

    ! 30-60 minutes prior to the appointment

    ! Taken with a clear fluid

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    NPO Guidelines and Oral Medications

    ! What about patients require taking meds with applesauce?

    ! Common with mentally disabled patients

    ! Technically a violation, but we accept the risk

    ! Minimize risk

    ! Have patients take meds early as possible! 2-4 hours prior to appointment?

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    NPO Guidelines and Oral Medications

    ! What about oral premedications?

    ! Antibiotic premeds

    !

    Oral sedatives

    ! Not a violation

    ! Part of the anesthetic/surgical plan

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    Preoperative Instructions

    ! Review NPO guidelines verbally and in writing

    ! It really does mean NOTHING by mouth

    !

    Concept:! Reduction in stomach contents

    ! Volume

    ! Acidity

    ! Decreased risk of pulmonary complications if aspirated

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    Current NPO Guidelines

    ! 2 hours

    ! Clear liquids

    ! Examples

    ! Water

    ! Fruit juices WITHOUT pulp

    !

    Black coffee! Clear tea

    ! Carbonated beverages

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    Current NPO Guidelines

    ! 4 hours

    ! Breast milk ONLY

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    Current NPO Guidelines

    ! 6 hours

    ! Infant formula

    !

    Non-human milk! Light meal

    ! Dry toast and clear liquids

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    Current NPO Guidelines

    ! Meals that include fatty or fried foods or meat may prolonggastric emptying time

    !

    8+ hours?!

    Increased aspiration risk

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    Current NPO Guidelines:

    Delayed Gastric Emptying

    ! Concern with certain medical conditions

    ! Obesity

    !

    Diabetes mellitus

    ! Prolong NPO time

    ! Reduce aspiration risk

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    Preoperative Instructions:

    Patient Escort

    ! Escort is responsible for:

    ! Getting patient home safely

    !

    Ensuring the patient DOES NOT drive

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    Preoperative Instructions:

    Patient Escort

    ! Ideally:

    ! Arrives with the patient

    !

    Stays in the office! Is capable of caring for the patient once home

    ! Postop instructions

    ! Postop pain meds?

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    Preoperative Instructions

    ! Wear loose fitting clothes

    !

    No:! Makeup

    ! Mascara

    ! Contact lenses

    !Jewelry

    ! Perfume

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    Postoperative Instructions:

    Discharge Criteria

    ! Awake, responsive and oriented

    ! Adequately returned to baseline

    !

    Peak effect of sedatives

    ! Minimal/no PONV

    ! Controlled

    ! Postoperative pain under control

    ! Local anesthesia

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    Postoperative Instructions:

    Discharge Criteria

    ! Vital signs stable

    ! 20% of baseline! Blood pressure

    ! Pulse

    ! Adequate ventilation and oxygenation

    ! SpO2 > 90%

    !

    Should be back to baseline!

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    Postoperative Instructions:

    Discharge Criteria

    ! Written postoperative instructions given to patient/escort

    !

    Discuss any concerns/answer all questions

    ! Document who patient left the office in care of

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    Postoperative Instructions:

    Discharge Criteria

    ! Escort patients directly to their car, rather than dischargethem directly from the chair.

    !

    Helps prevent any falls, injuries

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    Postoperative Instructions

    ! http://www.youtube.com/watch?v=txqiwrbYGrs&feature=related

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    Postoperative Instructions:

    Common Directions

    ! Clear liquids, advance slowly as tolerated

    ! Avoid fatty or greasy meals

    ! Stay well hydrated and resume regular meds

    ! Go home and rest

    !

    Do NOT drive! Do NOT make any big decisions

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    Postoperative Instructions:

    Common Directions

    ! Contact the office if:! Irretractable PONV

    ! Oral ondansetron

    !

    Rectal promethazine! Any other concerns or questions

    ! Patients need to have a method to contact you after asedation/surgery with complications! It is NOT acceptable to tell patients to just go to the hospital

    ! 911 is ok if life threatening

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    Questions???

    ! Thanks!!