seer cancer statistics review 1975-2017...the apc is the annual percent change based on rates...

24
SEER Cancer Statistics Review 1975-2017 National Cancer Institute Joinpoint Regression Program Version 4.8, April 2020, National Cancer Institute. (https://surveillance.cancer.gov/joinpoint/). The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends are from the SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta). b Trends are from the SEER 21 areas (SEER 9 areas, Los Angeles, Alaska Native Registry, Rural Georgia, California excluding SF/SJM/LA, Kentucky, Louisiana, New Jersey, Georgia excluding ATL/RG, Idaho, New York and Massachusetts). c Trends are from US Mortality Files, National Center for Health Statistics, Centers for Disease Control and Prevention. d The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpoint. e API - Asian/Pacific Islander, AI/AN - American Indian/Alaska Native, NH - Non-Hispanic f Hispanic and Non-Hispanic are not mutually exclusive from whites, blacks, Asian/Pacific Islanders, and American Indians/Alaska Natives. Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registry. g Data for American Indian/Alaska Native are based on the Purchased/Referred Care Delivery Area (PRCDA) counties. * The APC/AAPC is significantly different from zero (p<.05). - Joinpoint regression line analysis could not be performed on data series. JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPC d Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17 SEER 9 Delay-Adjusted Incidence a , 1975-2017 All Races 1975-87 1.5* 1987-17 -0.2* -0.2* -0.2* White 1975-87 1.6* 1987-17 0.0 0.0 0.0 Black 1975-17 0.1 0.1 0.1 SEER 21 Delay-Adjusted Incidence b , 2000-2017 All Races 2000-17 -0.3* -0.3* -0.3* White 2000-17 -0.2* -0.2* -0.2* White NH ef 2000-17 0.0 0.0 0.0 Black 2000-17 -0.4 -0.4 -0.4 Black NH ef 2000-17 -0.4 -0.4 -0.4 API e 2000-17 0.5* 0.5* 0.5* AI/AN eg 2000-17 0.7 0.7 0.7 Hispanic f 2000-17 -0.6* -0.6* -0.6* U.S. Cancer Mortality c , 1975-2017 All Races 1975-83 0.4 1983-91 1.3* 1991-07 -1.0* 2007-17 0.5* 0.5* 0.5* White 1975-92 1.0* 1992-07 -0.8* 2007-17 0.6* 0.6* 0.6* Black 1975-92 0.9* 1992-07 -1.1* 2007-17 0.9* 0.9* 0.9* U.S. Cancer Mortality c , 2000-2017 All Races 2000-06 -1.2* 2006-17 0.5* 0.5* 0.5* White 2000-06 -1.0* 2006-17 0.6* 0.6* 0.6* White NH ef 2000-06 -0.9* 2006-17 0.7* 0.7* 0.7* Black 2000-17 0.1 0.1 0.1 Black NH ef 2000-17 0.2 0.2 0.2 API e 2000-17 1.1* 1.1* 1.1* AI/AN eg 2000-17 1.0 1.0 1.0 Hispanic f 2000-10 -0.4 2010-17 1.5* 1.1* 1.5* Table 3.1 Cancer of the Brain and Other Nervous System (Invasive) Trends in SEER Incidence ab and U.S. Mortality c Using the Joinpoint Regression Program, 1975-2017 With up to Five Joinpoints, 2000-2017 With up to Three Joinpoints, Both Sexes by Race/Ethnicity

Upload: others

Post on 18-Aug-2021

1 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-87 15 1987-17 -02 -02 -02

White 1975-87 16 1987-17 00 00 00

Black 1975-17 01 01 01

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -03 -03 -03

White 2000-17 -02 -02 -02

White NHef 2000-17 00 00 00

Black 2000-17 -04 -04 -04

Black NHef 2000-17 -04 -04 -04

APIe 2000-17 05 05 05

AIANeg 2000-17 07 07 07

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-83 04 1983-91 13 1991-07 -10 2007-17 05 05 05

White 1975-92 10 1992-07 -08 2007-17 06 06 06

Black 1975-92 09 1992-07 -11 2007-17 09 09 09

US Cancer Mortalityc 2000-2017

All Races 2000-06 -12 2006-17 05 05 05

White 2000-06 -10 2006-17 06 06 06

White NHef 2000-06 -09 2006-17 07 07 07

Black 2000-17 01 01 01

Black NHef 2000-17 02 02 02

APIe 2000-17 11 11 11

AIANeg 2000-17 10 10 10

Hispanicf 2000-10 -04 2010-17 15 11 15

Table 31

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Both Sexes by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-89 12 1989-17 -03 -03 -03

White 1975-89 13 1989-17 -02 -02 -02

Black 1975-17 -01 -01 -01

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -03 -03 -03

White 2000-17 -03 -03 -03

White NHef 2000-17 -01 -01 -01

Black 2000-17 -02 -02 -02

Black NHef 2000-17 -01 -01 -01

APIe 2000-17 07 07 07

AIANeg 2000-17 12 12 12

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-77 44 1977-82 -03 1982-91 13 1991-07 -09 2007-17 05 05 05

White 1975-77 47 1977-82 -03 1982-91 14 1991-06 -09 2006-17 05 05 05

Black 1975-90 08 1990-07 -09 2007-17 07 07 07

US Cancer Mortalityc 2000-2017

All Races 2000-06 -13 2006-17 05 05 05

White 2000-06 -11 2006-17 06 06 06

White NHef 2000-06 -10 2006-17 07 07 07

Black 2000-17 01 01 01

Black NHef 2000-17 02 02 02

APIe 2000-17 04 04 04

AIANeg 2000-17 08 08 08

Hispanicf 2000-17 03 03 03

Table 32

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Males by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-87 16 1987-17 -02 -02 -02

White 1975-87 17 1987-17 00 00 00

Black 1975-17 03 03 03

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -04 -04 -04

White 2000-17 -03 -03 -03

White NHef 2000-17 00 00 00

Black 2000-17 -07 -07 -07

Black NHef 2000-17 -07 -07 -07

APIe 2000-03 50 2003-09 -20 2009-14 36 2014-17 -76 -09 -49

AIANeg 2000-17 -05 -05 -05

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-92 09 1992-07 -11 2007-17 06 06 06

White 1975-92 10 1992-07 -09 2007-17 06 06 06

Black 1975-97 09 1997-05 -23 2005-17 09 09 09

US Cancer Mortalityc 2000-2017

All Races 2000-06 -11 2006-17 05 05 05

White 2000-07 -08 2007-17 06 06 06

White NHef 2000-07 -06 2007-17 07 07 07

Black 2000-17 02 02 02

Black NHef 2000-17 03 03 03

APIe 2000-17 18 18 18

AIANeg 2000-17 13 13 13

Hispanicf 2000-17 05 05 05

Table 33

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Females by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 686 802 585 761 899 638 468 431 4872010 661 759 573 734 832 643 428 458 4032011 672 791 567 755 874 647 444 488 4082012 658 776 556 734 859 623 454 596 3552013 658 760 568 731 834 639 411 506 3292014 639 774 519 723 872 587 359 409 3102015 670 802 556 758 902 628 376 421 3422016 631 762 517 710 849 586 388 456 3392017 644 758 548 724 833 630 406 528 323

Table 34Cancer of the Brain and Other Nervous System (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 659 787 551 723 860 605 408 481 3501975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 685 801 584 760 897 636 467 430 4862010 659 757 572 731 830 641 426 456 4012011 669 787 565 751 870 644 441 485 4052012 655 772 553 729 853 618 450 591 3522013 653 755 564 725 827 633 406 500 3262014 634 768 515 716 863 581 354 403 3062015 662 792 549 747 889 619 369 413 3372016 621 750 508 697 833 574 380 447 3322017 627 738 532 701 808 610 393 511 311

Table 35Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 2: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-89 12 1989-17 -03 -03 -03

White 1975-89 13 1989-17 -02 -02 -02

Black 1975-17 -01 -01 -01

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -03 -03 -03

White 2000-17 -03 -03 -03

White NHef 2000-17 -01 -01 -01

Black 2000-17 -02 -02 -02

Black NHef 2000-17 -01 -01 -01

APIe 2000-17 07 07 07

AIANeg 2000-17 12 12 12

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-77 44 1977-82 -03 1982-91 13 1991-07 -09 2007-17 05 05 05

White 1975-77 47 1977-82 -03 1982-91 14 1991-06 -09 2006-17 05 05 05

Black 1975-90 08 1990-07 -09 2007-17 07 07 07

US Cancer Mortalityc 2000-2017

All Races 2000-06 -13 2006-17 05 05 05

White 2000-06 -11 2006-17 06 06 06

White NHef 2000-06 -10 2006-17 07 07 07

Black 2000-17 01 01 01

Black NHef 2000-17 02 02 02

APIe 2000-17 04 04 04

AIANeg 2000-17 08 08 08

Hispanicf 2000-17 03 03 03

Table 32

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Males by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-87 16 1987-17 -02 -02 -02

White 1975-87 17 1987-17 00 00 00

Black 1975-17 03 03 03

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -04 -04 -04

White 2000-17 -03 -03 -03

White NHef 2000-17 00 00 00

Black 2000-17 -07 -07 -07

Black NHef 2000-17 -07 -07 -07

APIe 2000-03 50 2003-09 -20 2009-14 36 2014-17 -76 -09 -49

AIANeg 2000-17 -05 -05 -05

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-92 09 1992-07 -11 2007-17 06 06 06

White 1975-92 10 1992-07 -09 2007-17 06 06 06

Black 1975-97 09 1997-05 -23 2005-17 09 09 09

US Cancer Mortalityc 2000-2017

All Races 2000-06 -11 2006-17 05 05 05

White 2000-07 -08 2007-17 06 06 06

White NHef 2000-07 -06 2007-17 07 07 07

Black 2000-17 02 02 02

Black NHef 2000-17 03 03 03

APIe 2000-17 18 18 18

AIANeg 2000-17 13 13 13

Hispanicf 2000-17 05 05 05

Table 33

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Females by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 686 802 585 761 899 638 468 431 4872010 661 759 573 734 832 643 428 458 4032011 672 791 567 755 874 647 444 488 4082012 658 776 556 734 859 623 454 596 3552013 658 760 568 731 834 639 411 506 3292014 639 774 519 723 872 587 359 409 3102015 670 802 556 758 902 628 376 421 3422016 631 762 517 710 849 586 388 456 3392017 644 758 548 724 833 630 406 528 323

Table 34Cancer of the Brain and Other Nervous System (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 659 787 551 723 860 605 408 481 3501975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 685 801 584 760 897 636 467 430 4862010 659 757 572 731 830 641 426 456 4012011 669 787 565 751 870 644 441 485 4052012 655 772 553 729 853 618 450 591 3522013 653 755 564 725 827 633 406 500 3262014 634 768 515 716 863 581 354 403 3062015 662 792 549 747 889 619 369 413 3372016 621 750 508 697 833 574 380 447 3322017 627 738 532 701 808 610 393 511 311

Table 35Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 3: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Regression Program Version 48 April 2020 National Cancer Institute (httpssurveillancecancergovjoinpoint)The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

a Trends are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)b Trends are from the SEER 21 areas (SEER 9 areas Los Angeles Alaska Native Registry Rural Georgia California excluding

SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York and Massachusetts)c Trends are from US Mortality Files National Center for Health Statistics Centers for Disease Control and Preventiond The AAPC is the Average Annual Percent Change and is based on the APCs calculated by Joinpointe API - AsianPacific Islander AIAN - American IndianAlaska Native NH - Non-Hispanicf Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska

Natives Incidence data for Hispanics and Non-Hispanics are based on NHIA and exclude cases from the Alaska Native Registryg Data for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) counties The APCAAPC is significantly different from zero (plt05)- Joinpoint regression line analysis could not be performed on data series

JP Trend 1 JP Trend 2 JP Trend 3 JP Trend 4 JP Trend 5 JP Trend 6 AAPCd

Years APC Years APC Years APC Years APC Years APC Years APC 2008-17 2013-17

SEER 9 Delay-Adjusted Incidencea 1975-2017

All Races 1975-87 16 1987-17 -02 -02 -02

White 1975-87 17 1987-17 00 00 00

Black 1975-17 03 03 03

SEER 21 Delay-Adjusted Incidenceb 2000-2017

All Races 2000-17 -04 -04 -04

White 2000-17 -03 -03 -03

White NHef 2000-17 00 00 00

Black 2000-17 -07 -07 -07

Black NHef 2000-17 -07 -07 -07

APIe 2000-03 50 2003-09 -20 2009-14 36 2014-17 -76 -09 -49

AIANeg 2000-17 -05 -05 -05

Hispanicf 2000-17 -06 -06 -06

US Cancer Mortalityc 1975-2017

All Races 1975-92 09 1992-07 -11 2007-17 06 06 06

White 1975-92 10 1992-07 -09 2007-17 06 06 06

Black 1975-97 09 1997-05 -23 2005-17 09 09 09

US Cancer Mortalityc 2000-2017

All Races 2000-06 -11 2006-17 05 05 05

White 2000-07 -08 2007-17 06 06 06

White NHef 2000-07 -06 2007-17 07 07 07

Black 2000-17 02 02 02

Black NHef 2000-17 03 03 03

APIe 2000-17 18 18 18

AIANeg 2000-17 13 13 13

Hispanicf 2000-17 05 05 05

Table 33

Cancer of the Brain and Other Nervous System (Invasive)

Trends in SEER Incidenceab and US Mortalityc Using the Joinpoint Regression Program

1975-2017 With up to Five Joinpoints 2000-2017 With up to Three Joinpoints

Females by RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 686 802 585 761 899 638 468 431 4872010 661 759 573 734 832 643 428 458 4032011 672 791 567 755 874 647 444 488 4082012 658 776 556 734 859 623 454 596 3552013 658 760 568 731 834 639 411 506 3292014 639 774 519 723 872 587 359 409 3102015 670 802 556 758 902 628 376 421 3422016 631 762 517 710 849 586 388 456 3392017 644 758 548 724 833 630 406 528 323

Table 34Cancer of the Brain and Other Nervous System (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 659 787 551 723 860 605 408 481 3501975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 685 801 584 760 897 636 467 430 4862010 659 757 572 731 830 641 426 456 4012011 669 787 565 751 870 644 441 485 4052012 655 772 553 729 853 618 450 591 3522013 653 755 564 725 827 633 406 500 3262014 634 768 515 716 863 581 354 403 3062015 662 792 549 747 889 619 369 413 3372016 621 750 508 697 833 574 380 447 3322017 627 738 532 701 808 610 393 511 311

Table 35Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 4: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Reference Cancer Incidence Rates Adjusted for Reporting DelayIndividual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Review

a SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

- Delay-adjusted rate is not shown for observed rates based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 686 802 585 761 899 638 468 431 4872010 661 759 573 734 832 643 428 458 4032011 672 791 567 755 874 647 444 488 4082012 658 776 556 734 859 623 454 596 3552013 658 760 568 731 834 639 411 506 3292014 639 774 519 723 872 587 359 409 3102015 670 802 556 758 902 628 376 421 3422016 631 762 517 710 849 586 388 456 3392017 644 758 548 724 833 630 406 528 323

Table 34Cancer of the Brain and Other Nervous System (Invasive)

Delay-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 659 787 551 723 860 605 408 481 3501975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 685 801 584 760 897 636 467 430 4862010 659 757 572 731 830 641 426 456 4012011 669 787 565 751 870 644 441 485 4052012 655 772 553 729 853 618 450 591 3522013 653 755 564 725 827 633 406 500 3262014 634 768 515 716 863 581 354 403 3062015 662 792 549 747 889 619 369 413 3372016 621 750 508 697 833 574 380 447 3322017 627 738 532 701 808 610 393 511 311

Table 35Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 5: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for diagnosis years 1975-1979 available in web browser version of Cancer Statistics Reviewa SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Diagnosis1975-2017 659 787 551 723 860 605 408 481 3501975-1979 595 719 491 634 766 524 370 466 2921980 630 758 524 681 820 565 314 335 2921981 651 807 520 690 844 563 502 724 3161982 642 793 524 692 857 564 371 440 3051983 631 760 519 688 820 574 275 379 1841984 612 718 520 649 764 549 453 534 3881985 694 850 566 743 907 607 488 562 4181986 685 806 582 738 861 634 406 475 3411987 701 816 605 760 873 668 425 563 3131988 683 789 591 739 858 637 445 448 4381989 687 852 547 745 925 592 490 593 4121990 705 811 618 758 875 662 433 518 3641991 696 857 565 761 929 623 362 443 3091992 698 867 561 765 948 617 366 413 3281993 676 805 568 738 886 616 393 397 3801994 663 799 545 714 857 591 424 452 3971995 650 797 530 704 860 576 411 515 3311996 669 824 535 729 898 581 406 521 3371997 677 811 563 744 888 618 400 530 3071998 665 776 573 727 845 628 425 456 4081999 693 837 571 769 922 638 375 505 2702000 682 824 567 753 912 622 448 547 3742001 665 800 555 732 869 617 407 513 3382002 677 811 568 754 895 637 425 550 3362003 667 765 585 727 838 633 467 449 4652004 685 801 580 764 889 649 417 466 3612005 676 782 585 749 871 643 454 497 4162006 644 785 523 721 880 576 376 426 3462007 661 778 558 733 877 604 460 487 4362008 674 803 568 761 892 651 360 454 2972009 685 801 584 760 897 636 467 430 4862010 659 757 572 731 830 641 426 456 4012011 669 787 565 751 870 644 441 485 4052012 655 772 553 729 853 618 450 591 3522013 653 755 564 725 827 633 406 500 3262014 634 768 515 716 863 581 354 403 3062015 662 792 549 747 889 619 369 413 3372016 621 750 508 697 833 574 380 447 3322017 627 738 532 701 808 610 393 511 311

Table 35Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted SEER Incidencea Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 6: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Individual rates for years of death 1975-1979 available in web browser version of Cancer Statistics Reviewa US Mortality Files National Center for Health Statistics Centers for Disease Control and Prevention

Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

Year of Death1975-2017 450 550 368 483 588 396 263 323 2171975-1979 433 529 354 455 555 373 259 328 2051980 437 545 347 462 577 366 246 304 2021981 436 533 359 460 558 380 255 331 1981982 443 538 367 467 567 388 264 337 2091983 439 531 364 466 564 385 249 291 2181984 455 557 374 482 586 400 256 335 1941985 457 560 375 485 592 399 254 322 2021986 453 559 368 478 590 387 277 347 2271987 471 568 393 499 600 417 289 355 2361988 472 589 379 498 621 400 291 363 2391989 473 582 388 501 615 412 273 347 2231990 487 597 399 516 630 424 297 366 2421991 495 601 411 527 637 437 284 342 2411992 485 588 403 517 626 430 282 341 2391993 479 587 391 509 623 417 283 359 2271994 484 588 397 517 626 425 269 323 2261995 467 567 386 497 602 411 277 340 2331996 473 574 391 507 614 419 264 324 2211997 468 566 390 499 603 413 287 330 2551998 468 570 383 500 606 412 273 339 2241999 464 566 381 498 604 410 273 328 2292000 453 558 367 486 596 393 270 328 2242001 445 549 359 478 588 386 258 313 2192002 445 546 362 478 583 390 263 320 2212003 440 536 362 474 573 392 266 336 2112004 431 522 353 464 559 382 246 298 2042005 434 531 353 469 569 384 252 323 1992006 417 512 339 453 553 367 234 291 1932007 421 510 347 458 552 378 237 275 2072008 428 525 346 464 565 377 248 315 2012009 435 527 357 473 572 388 253 298 2172010 425 522 342 459 563 368 254 308 2152011 425 520 344 464 566 376 237 282 2012012 440 543 352 478 585 385 268 344 2142013 434 523 360 474 565 396 243 316 1892014 443 542 359 481 588 388 281 330 2422015 443 538 361 483 584 394 261 315 2182016 449 548 364 492 597 399 258 320 2112017 439 531 360 480 578 395 263 315 224

Table 36Cancer of the Brain and Other Nervous System (Invasive)

Age-adjusted US Deatha Rates by Year Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 7: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a SEER 21 areas Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)unless noted

b US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) unless noted

c Rates are per 100000 and are age-adjusted to the world (WHO 2000-2025) standard million- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER IncidenceAge at DiagnosisAge-Adjusted Rates 2013-2017All ages 64 75 54 71 83 60 39 45 33Under 65 46 52 39 50 57 44 29 34 2565 and over 189 235 154 209 259 170 102 123 89

All ages (WHO world std)c 55 64 47 61 71 52 34 40 30

Age-Specific Rates 2013-2017lt1 39 40 37 39 43 36 26 - -1-4 43 44 42 46 46 45 34 35 335-9 35 35 35 37 37 37 30 26 3410-14 29 33 26 32 35 29 20 25 1515-19 23 26 21 25 28 22 20 20 1920-24 22 24 19 24 27 21 13 12 1525-29 28 32 25 32 35 28 17 22 1330-34 34 39 29 39 44 33 18 20 1635-39 38 43 32 42 48 37 23 27 1940-44 42 49 35 47 53 40 27 33 2245-49 55 64 46 61 70 52 34 41 2850-54 74 86 63 83 95 72 48 61 3755-59 100 120 81 112 134 91 63 80 4860-64 126 155 100 142 174 112 65 83 5065-69 158 194 126 176 214 142 91 111 7570-74 188 233 151 209 259 166 101 113 9375-79 211 263 170 235 290 191 116 157 9080-84 224 283 184 247 314 199 109 107 11185+ 181 228 156 195 246 168 100 131 86

US MortalityAge at DeathAge-Adjusted Rates 2013-2017All ages 44 54 36 48 58 39 26 32 22Under 65 24 29 19 27 32 21 15 19 1365 and over 183 224 151 197 241 163 100 124 85

All ages (WHO world std)c 31 38 26 34 41 28 19 23 16

Age-Specific Rates 2013-2017lt1 04 03 04 03 03 04 - - -1-4 06 06 05 06 07 05 06 06 065-9 09 10 09 10 10 09 09 09 0910-14 07 08 05 07 08 06 06 07 0615-19 05 06 05 05 06 05 05 06 0420-24 05 06 05 06 07 05 03 04 0325-29 07 09 05 08 10 06 05 06 0530-34 12 14 09 13 16 10 06 07 0535-39 17 21 14 19 23 15 10 12 0840-44 23 28 19 26 32 21 14 14 1345-49 35 43 28 39 47 31 22 28 1850-54 54 66 43 60 73 48 35 45 2655-59 82 99 65 90 109 72 47 59 3660-64 111 134 90 122 145 100 66 86 5065-69 144 172 119 157 186 130 82 101 6870-74 174 211 143 190 228 156 92 119 7375-79 205 251 169 223 271 184 102 120 9180-84 222 275 184 238 294 197 116 150 9785+ 202 263 170 212 277 177 136 159 126

Table 37Cancer of the Brain and Other Nervous System (Invasive)

SEER Incidencea and US Deathb Rates Age-Adjusted and Age-Specific Rates by Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 8: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on End Results data from a series of hospital registries and one population-based registryb SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)

Based on follow-up of patients into 2017 Expected survival rates are derived from the US Annual Life Tablesc SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta San Jose-Monterey

Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey andGeorgia excluding ATLRG) Expected survival rates are derived from life tables by socio-economic status geography and racedeveloped by the SEER programBased on follow-up of patients into 2017

d Period survival provides a 2016 estimate of survival by piecing together the most recent conditional survival estimatesfrom several cohorts It is computed here using three year calendar blocks (2010-2012 0-1 year survival)(2009-2011 1-2 year survival) (2008-2010 2-3 year survival) (2007-2009 3-4 year survival) (2006-2008 4-5 years survival)

e Stage at diagnosis is classified using SEER Summary Stage 2000 Stage distribution percentages may not sum to 100 due to roundingf The difference between 1975-1977 and 2010-2016 is statistically significant (plt05)g The standard error is between 5 and 10 percentage pointsh The standard error is greater than 10 percentage points- Statistic could not be calculated due to fewer than 25 cases during the time period

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

5-Year Relative Survival (Percent)Year of Diagnosis1960-1963a - - - 18 16 21 19 17 211970-1973a - - - 20 18 22 19 19 191975-1977b 225 207 248 219 202 241 249 196 336g

1978-1980b 236 224 251 230 220 244 282 287 2751981-1983b 242 231 255 234 225 246 308 317 292g

1984-1986b 269 256 285 262 248 279 309 328 2851987-1989b 290 274 310 283 264 308 319 340 2931990-1992b 301 305 297 291 294 288 393 402 3811993-1995b 322 330 313 309 314 302 419 461 3731996-1998b 313 307 320 306 302 310 360 337 3831999-2001b 340 310 379 332 304 367 384 330 4562002-2004b 351 342 362 342 338 346 395 334 4582005-2009b 358 345 373 342 330 357 431 411 4482010-2016b 334f 319f 353f 321f 307f 340f 395f 381f 410

5-Year Period Survival (Percent)cd

2016 318 301 339 304 287 327 372 352 394

Stage Distribution () 2010-2016ce

All StagesNumber of cases 34955 19533 15422 29753 16714 13039 2533 1352 1181Percent 100 100 100 100 100 100 100 100 100Localized 77 77 77 77 78 77 75 77 74Regional 15 15 15 15 15 15 15 14 16Distant 2 3 2 2 2 2 3 3 4UnstagedUnknown 6 5 6 5 5 6 7 7 7

5-Year Relative Survival (Percent) 2010-2016c

Age at DiagnosisAges lt45 691 669 720 698 677 725 661 630 695Ages 45-54 314 286 354 312 284 353 270 232 322Ages 55-64 155 140 176 149 135 168 162 149 180Ages 65-74 92 77 111 89 70 113 116 144 88Ages 75+ 43 42 44 39 38 39 95 108 79Ages lt65 445 419 482 436 410 472 464 426 508Ages 65+ 70 63 79 66 57 77 111 138 86

StageeAll Stages 326 313 342 313 300 330 389 372 407Localized 353 340 368 340 327 357 405 396 416Regional 203 192 217 191 183 201 269 213 324Distant 327 294 372 309 279 352 435g 393g 476g

UnstagedUnknown 290 266 317 263 238 291 440 407g 476g

Table 38Cancer of the Brain and Other Nervous System (Invasive)

5-Year Relative and Period Survival (Percent) by Race Sex Diagnosis Year Stage and Age

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 9: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 463 474 507 526 526 532 512 538 553 556 571 592 572 569 585 615 621 624 624 620 615 631 645 635 626 5902-year 323 339 369 389 392 407 380 408 404 418 424 466 436 430 458 473 474 467 470 468 454 464 485 458 4553-year 279 294 327 349 360 366 341 357 361 384 390 406 381 382 400 406 410 410 414 399 398 387 402 3824-year 252 266 300 325 343 346 319 330 338 361 367 382 360 360 372 382 375 376 382 370 362 355 3755-year 231 246 280 308 333 325 303 311 324 349 348 361 342 350 349 359 355 361 363 343 339 3346-year 215 231 266 296 323 312 282 298 308 334 337 345 329 334 329 342 335 345 347 325 3277-year 205 219 255 283 313 303 275 288 301 317 326 336 314 320 319 334 325 331 336 3138-year 194 209 242 274 304 289 268 279 294 310 317 327 304 310 306 318 317 321 3309-year 184 199 234 266 299 277 256 272 283 301 311 317 296 302 298 307 307 31010-year 178 189 226 259 289 271 246 264 278 294 306 309 292 293 291 301 29911-year 172 182 220 252 281 261 239 259 269 283 297 300 289 284 281 29412-year 166 176 215 246 278 252 231 252 261 275 290 295 283 279 27713-year 162 170 209 241 266 248 228 244 256 268 284 290 276 27314-year 159 166 203 235 260 246 225 239 251 264 278 284 26915-year 154 161 196 229 253 240 224 226 249 261 274 28016-year 151 156 193 225 242 233 216 223 247 252 26517-year 147 153 188 220 240 232 212 221 244 25018-year 144 149 183 215 238 228 210 218 23919-year 141 144 179 213 231 225 205 21220-year 138 140 176 207 230 225 201

Table 39Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males and Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 10: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 457 484 509 543 546 546 542 538 553 541 548 588 574 589 579 635 620 629 635 636 624 632 658 646 608 5772-year 313 335 361 397 403 397 394 399 389 395 385 462 421 444 448 472 458 462 461 472 450 472 474 448 4253-year 264 293 316 354 372 358 350 353 343 358 353 392 363 393 392 398 394 404 411 396 394 388 384 3694-year 240 260 285 331 359 336 328 319 316 333 325 363 345 367 367 369 347 357 371 364 354 353 3585-year 216 236 264 311 348 313 305 302 299 321 308 336 332 357 345 354 333 343 351 338 328 3316-year 200 222 250 300 334 297 283 282 285 306 299 316 318 342 318 334 313 323 330 315 3177-year 190 212 238 286 321 287 272 271 279 284 288 305 302 326 304 326 305 312 322 3018-year 179 202 226 278 309 271 267 263 270 277 278 296 289 312 289 307 294 302 3179-year 169 191 220 269 301 260 260 252 254 267 273 287 284 301 283 295 285 29010-year 163 181 211 262 291 256 249 246 246 256 273 280 279 288 277 286 27511-year 156 175 206 254 283 248 245 239 232 248 263 268 279 277 271 27912-year 150 170 201 248 280 236 233 230 226 239 252 260 272 271 26413-year 146 165 196 244 265 233 232 227 224 237 249 252 263 25914-year 145 159 190 236 255 233 228 221 219 232 244 248 25415-year 140 155 185 229 248 228 227 211 217 229 243 24416-year 139 149 181 226 231 219 222 209 215 223 23617-year 135 145 178 220 228 216 218 207 212 21818-year 133 142 172 217 226 214 218 202 20519-year 129 138 168 214 218 211 214 19720-year 127 135 166 210 216 210 209

Table 310Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Males

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 11: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Based on the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta)Expected survival rates are derived from the US Annual Life Tables

1975- 1980- 1985- 1990-1979 1984 1989 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

SurvivalTime

1-year 470 461 504 504 499 513 473 539 554 575 600 596 571 543 592 589 623 617 611 600 604 630 628 620 650 6082-year 336 343 379 379 377 420 362 419 425 447 474 471 453 412 469 475 494 473 480 462 459 455 499 471 4953-year 299 295 340 343 344 376 330 363 384 416 438 423 403 368 409 418 431 418 419 403 402 386 426 4014-year 268 273 318 318 322 357 308 344 366 397 421 406 377 351 378 399 410 399 396 377 372 357 3985-year 251 259 300 303 313 341 298 321 355 384 398 392 353 341 354 366 383 382 378 349 352 3366-year 234 242 286 290 307 332 282 317 339 369 387 380 341 324 342 351 363 370 366 336 3387-year 224 229 275 279 301 323 279 307 329 359 374 374 328 313 337 343 352 354 354 3278-year 214 217 262 269 297 311 267 298 324 352 367 365 321 308 325 332 345 344 3459-year 204 209 252 262 296 299 251 294 321 344 359 354 309 302 315 322 335 33310-year 197 199 245 256 286 292 241 284 320 340 348 345 306 298 307 319 32811-year 192 189 238 250 276 278 232 283 317 328 341 340 302 293 293 31412-year 187 184 232 243 274 272 228 275 308 320 337 338 295 290 29313-year 183 177 224 239 267 268 224 263 296 308 329 336 291 28814-year 177 175 218 232 265 262 222 259 293 304 322 329 28715-year 172 169 211 228 259 256 219 243 291 301 311 32416-year 167 164 208 224 256 250 208 238 289 290 30217-year 162 162 202 219 254 250 204 236 286 29018-year 159 158 196 214 253 247 198 236 28219-year 157 152 192 210 247 244 193 23020-year 152 148 189 204 246 243 190

Table 311Cancer of the Brain and Other Nervous System (Invasive)

SEERa Relative Survival (Percent)By Year of Diagnosis

All Races Females

Year of Diagnosis

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 12: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 062 047 Asian 0 003 005 006 041 032

10 003 005 008 059 047 Pacific 10 002 003 006 038 031

20 002 006 010 056 047 Islander 20 002 004 007 036 031

30 004 008 016 055 047 30 002 005 010 035 031

40 005 013 025 052 046 40 003 007 014 033 030

50 008 021 036 048 044 50 005 011 019 030 029

60 013 029 040 042 040 60 007 015 023 026 026

70 018 030 - 032 032 70 009 017 - 021 022

80 016 - - 020 020 80 010 - - 014 017

White 0 004 007 009 068 052 American 0 002 004 005 037 025

10 003 005 009 065 052 Indian 10 002 003 005 035 025

20 003 006 012 062 051 Alaska 20 001 004 007 033 024

30 004 009 018 060 051 Nativea 30 002 006 010 032 024

40 005 014 028 057 050 40 003 007 013 031 024

50 009 024 040 053 048 50 004 010 017 028 023

60 015 032 044 046 043 60 006 013 018 026 022

70 019 032 - 035 034 70 008 013 - 022 018

80 017 - - 021 021 80 006 - - 019 014

Black 0 003 005 006 035 025 Hispanicb 0 003 005 007 055 038

10 002 003 005 032 025 10 002 004 006 052 038

20 001 003 006 031 024 20 002 004 008 051 038

30 002 005 010 030 024 30 003 006 013 049 038

40 003 008 014 028 024 40 004 010 020 047 037

50 005 012 019 026 023 50 007 017 030 044 036

60 007 015 020 023 021 60 010 025 036 039 033

70 009 015 - 018 017 70 016 028 - 031 028

80 008 - - 012 013 80 015 - - 019 019

Table 312

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Both Sexes 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 13: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 007 009 069 053 Asian 0 003 006 007 046 035

10 003 005 009 066 053 Pacific 10 002 004 007 043 034

20 003 007 012 064 053 Islander 20 002 005 009 041 034

30 004 009 019 062 053 30 003 007 012 039 033

40 005 015 030 059 052 40 004 009 017 036 033

50 010 025 042 055 050 50 006 013 023 033 031

60 016 034 046 048 045 60 008 018 025 028 029

70 021 035 - 037 036 70 011 018 - 022 024

80 019 - - 023 024 80 010 - - 014 017

White 0 004 007 010 076 058 American 0 003 005 007 041 025

10 003 006 010 073 058 Indian 10 002 003 005 038 025

20 003 007 013 070 057 Alaska 20 002 003 007 036 024

30 004 010 021 068 057 Nativea 30 002 006 011 036 024

40 006 016 033 065 056 40 004 009 015 035 024

50 011 028 046 060 054 50 005 011 020 033 023

60 018 038 051 053 049 60 006 016 025 030 022

70 023 038 - 041 039 70 012 022 - 027 021

80 021 - - 024 025 80 015 - - 022 021

Black 0 003 005 006 038 027 Hispanicb 0 003 005 007 059 041

10 002 003 006 035 027 10 002 004 007 057 041

20 002 004 007 034 027 20 002 005 009 055 041

30 002 006 011 033 027 30 003 007 015 054 040

40 003 009 017 031 026 40 005 012 022 052 040

50 006 014 023 029 026 50 007 018 033 048 039

60 009 018 023 025 023 60 012 028 040 043 036

70 012 018 - 020 019 70 018 032 - 035 031

80 010 - - 013 014 80 018 - - 023 022

Table 313

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Males 2015-2017 By RaceEthnicity

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 14: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Devcan 678 April 2020 National Cancer Institute (httpssurveillancecancergovdevcan)Source Incidence data are from the SEER 21 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta

San Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts) Mortality data are from the NCHS public use data file for the total US

a Underlying incidence and mortality data for American IndianAlaska Native are based on the PRCDA(PurchasedReferred Care DeliveryAreas) counties

b Hispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska NativesUnderlying incidence data for Hispanics are based on NHIA and exclude cases from the Alaska Native Registry

- Statistic could not be calculatedA percent of 000 represents a value that is below 0005

Risk of Being Risk of Being

Race Current Diagnosed with Cancer Risk of Dying Race Current Diagnosed with Cancer Risk of Dying

Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer Ethnicity Age +10 yrs +20 yrs +30 yrs Ever from Cancer

All Races 0 004 006 008 055 042 Asian 0 003 004 005 036 029

10 002 004 007 052 042 Pacific 10 001 003 004 034 029

20 002 005 009 050 041 Islander 20 001 003 005 033 029

30 003 007 014 048 041 30 002 004 008 031 028

40 004 011 021 045 040 40 002 006 011 030 028

50 007 017 030 042 039 50 004 009 016 028 027

60 011 024 034 037 035 60 006 012 021 025 024

70 014 025 - 028 028 70 007 016 - 020 021

80 014 - - 017 018 80 010 - - 014 016

White 0 004 006 008 061 046 American 0 002 003 004 032 025

10 002 005 008 057 046 Indian 10 001 003 005 031 025

20 002 006 010 055 045 Alaska 20 001 004 007 029 024

30 003 008 016 053 045 Nativea 30 003 006 008 028 024

40 005 012 024 050 044 40 003 006 012 026 024

50 008 020 034 046 042 50 003 009 014 024 023

60 012 027 037 040 038 60 006 011 012 022 022

70 016 028 - 031 030 70 005 006 - 017 016

80 015 - - 018 019 80 001 - - 016 009

Black 0 003 004 006 032 023 Hispanicb 0 003 004 006 051 036

10 002 003 005 030 023 10 001 003 005 048 036

20 001 003 006 028 023 20 002 004 007 047 035

30 002 005 008 027 022 30 002 005 011 045 035

40 003 006 012 025 022 40 003 009 018 043 034

50 004 009 016 023 021 50 006 015 028 041 033

60 006 013 018 021 019 60 009 023 032 036 031

70 008 014 - 017 016 70 014 024 - 028 026

80 008 - - 012 012 80 012 - - 017 018

Table 314

Cancer of the Brain and Other Nervous System (Invasive)

Risk of Being Diagnosed With Cancer in 10 20 and 30 Years

Lifetime Risk of Being Diagnosed with Cancer Given Alive and Cancer-Free at Current Age and

Lifetime Risk of Dying from Cancer Given Alive at Current Age

Females 2015-2017 By RaceEthnicity

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 15: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

The AAPC is the Average Annual Percent Change over the time interval The AAPCs are calculated bythe Joinpoint Regression Program Version 48 April 2020 National Cancer Institute

- Statistic not shown Rate based on less than 16 cases for the time intervalTrend based on less than 10 cases for at least one year within the time interval

a Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) Trendsare based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico SeattleUtah and AtlantaThe SEER 21 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the AlaskaNative Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New JerseyGeorgia excluding ATLRG Idaho New York and Massachusetts

c The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 3 Joinpoints overdiagnosis years 2000-2017

d The 2008-2017 AAPC estimates are based on a Joinpoint analysis with up to 5 Joinpoints overdiagnosis years 1975-2017

e Hispanic and Non-Hispanic are not mutually exclusive from whites blacks AsianPacificIslanders and American IndiansAlaska Natives Incidence data for Hispanics and Non-Hispanicsare based on NHIA and exclude cases from the Alaska Native Registry

f Incidence data for American IndianAlaska Native are based on the PurchasedReferred CareDelivery Area (PRCDA) counties

g US Mortality Files National Center for Health Statistics CDCh The 2008-2017 mortality AAPCs are based on a Joinpoint analysis using years of death 2000-2017 The APC is significantly different from zero (plt05)

SEER Incidence SEER 21 Areasb SEER 21 Areasb SEER 9 Areasb

Rate 2013-2017 Trend 2008-2017c Trend 2008-2017d

Rate per 100000 persons AAPC () AAPC ()

Total Males Females Total Males Females Total Males Females RaceEthnicity

All Races 64 75 54 -05 -05 -05 -02 -03 -02

White 71 83 60 -04 -04 -04 -01 -03 00White Hispanice 53 61 47 -07 -08 -08 - - -White Non-Hispanice 75 89 64 -02 -02 -02 - - -

Black 39 45 33 -06 -03 -09 00 -01 02

AsianPacific Islander 38 45 32 02 04 -21 - - -

Amer IndAlaska Natf 34 43 26 00 06 -11 - - -

Hispanice 51 59 44 -07 -08 -07 - - -

US Mortalityg Rate 2013-2017 Trend 2008-2017h

Rate per 100000 persons AAPC ()

Total Males Females Total Males FemalesRaceEthnicity

All Races 44 54 36 05 05 05

White 48 58 39 06 06 06White Hispanice 32 38 28 05 05 06White Non-Hispanice 51 61 41 07 07 07

Black 26 32 22 01 01 02

AsianPacific Islander 22 26 19 11 04 18

Amer IndAlaska NatTotal US 19 21 17 00 -06 06PRCDA Counties 25 28 24 10 08 13Non-PRCDA Counties 12 14 09 -16 -26 -97

Hispanice 30 35 26 11 03 05

Table 315Cancer of the Brain And Other Nervous System (Invasive)

SEER Incidence and US MortalityAge-Adjusted Rates and Trendsa

By RaceEthnicity and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 16: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and Atlanta

The SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Incidence Ratesa 2013-2017

California 595 705 498 667 782 562 374 474 287Greater Bay Area 600 727 488 711 848 586 363 453 280San Francisco-Oakland 591 724 472 711 861 575 338 418 271San Jose-Monterey 614 730 511 705 824 598 512 - -

Los Angeles 536 637 450 617 726 523 361 461 279Greater California 622 729 524 676 788 572 389 497 295

Connecticut 690 818 583 710 842 599 419 511 334Detroit 631 758 529 703 852 572 402 426 394Georgia 603 706 519 703 815 609 391 442 353Atlanta 581 720 471 746 870 646 373 502 279Rural Georgia 544 499 582 567 - 687 - - -Greater Georgia 615 707 541 689 805 590 404 392 415

Hawaii 418 495 343 716 836 575 - - -Idaho 732 909 570 733 918 563 - - -Iowa 701 802 612 716 824 619 368 - -Kentucky 753 880 639 781 917 658 469 449 469Louisiana 596 719 490 707 838 589 352 430 289Massachusetts 655 763 563 684 803 583 319 285 345New Jersey 682 807 579 733 858 628 440 526 381New Mexico 526 602 459 555 639 480 - - -New York 665 788 557 746 876 631 383 467 318Seattle-Puget Sound 751 887 628 813 948 689 432 467 390Utah 684 814 562 705 830 589 - - -

SEER 9 Areasb 639 761 533 717 844 604 381 457 322SEER 13 Areasb 614 730 513 693 815 585 379 461 315SEER 18 Areasb 629 742 529 698 819 591 391 458 338SEER 21 Areasb 637 753 536 705 828 596 386 453 333

Table 316Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Incidence Ratesa

By Registry Race and Sex

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 17: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control and PreventionRates are per 100000 and are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130)

b The SEER 9 areas are San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah and AtlantaThe SEER 13 areas comprise the SEER 9 areas plus San Jose-Monterey Los Angeles the Alaska Native Registry and Rural GeorgiaThe SEER 18 areas comprise the SEER 13 areas plus California excluding SFSJMLA Kentucky Louisiana New Jersey and Georgiaexcluding ATLRGThe SEER 21 areas comprise the SEER 18 areas plus Idaho New York and Massachusetts

- Statistic not shown Rate based on less than 16 cases for the time interval

All Races Whites Blacks Total Males Females Total Males Females Total Males Females

SEER Death Ratesa 2013-2017

California 434 532 350 491 597 398 280 374 205Greater Bay Area 408 505 325 482 594 380 273 334 217San Francisco-Oakland 394 493 309 484 597 382 275 349 212San Jose-Monterey 432 526 353 478 588 378 - - -

Los Angeles 411 508 331 484 589 395 282 352 233Greater California 453 552 367 496 602 404 278 406 171

Connecticut 434 544 343 460 580 361 297 297 285Detroit 442 544 361 500 612 406 276 331 243Georgia 427 522 347 502 611 404 260 303 228Atlanta 414 525 326 541 663 431 239 317 187Rural Georgia 377 593 - 422 615 - - - -Greater Georgia 437 521 364 491 595 399 276 287 264

Hawaii 292 343 243 492 547 435 - - -Idaho 513 693 353 525 709 359 - - -Iowa 507 609 414 516 623 419 - - -Kentucky 484 578 400 498 599 408 336 352 317Louisiana 437 519 369 505 588 432 273 347 222Massachusetts 460 569 372 491 609 394 211 260 171New Jersey 412 503 337 464 562 382 239 328 181New Mexico 379 444 323 401 476 333 - - -New York 385 468 318 444 532 370 196 251 157Seattle-Puget Sound 490 578 411 532 629 444 287 334 -Utah 470 606 346 483 620 357 - - -

SEER 9 Areasb 434 532 350 492 600 395 260 317 217SEER 13 Areasb 429 525 346 489 594 395 266 330 219SEER 18 Areasb 437 532 355 489 593 398 269 336 220SEER 21 Areasb 430 525 350 482 586 392 248 312 202

Total US 442 536 361 482 582 394 261 319 217

Table 317Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted SEER Death Ratesa

By Registry Race and Sex

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 18: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 442 002

High Five StatesVermont 576 040 01(0125) 3047c

Wyoming 556 043 02(0138) 2578c

South Dakota 531 033 03(0136) 2014c

Idaho 513 024 04(0131) 1620c

Maine 513 025 05(0133) 1613c

Low Five StatesMaryland 410 011 47(3049) -727New York 385 006 48(4549) -1275New Mexico 379 018 49(3449) -1415Hawaii 292 019 50(4951) -3380c

DC 228 026 51(5051) -4827c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 512 014 06(0121) 1599c Montana 472 028 20(0247) 690Alaska 418 037 43(0349) -532 Nebraska 505 022 09(0134) 1438Arizona 427 011 39(2548) -330 Nevada 455 017 28(0746) 311Arkansas 494 017 13(0232) 1178 New Hampshire 483 025 17(0146) 924California 434 005 36(2843) -180 New Jersey 412 009 46(3248) -678Colorado 437 013 33(1847) -102 New Mexico 379 018 49(3449) -1415Connecticut 434 015 35(1648) -173 New York 385 006 48(4549) -1275Delaware 427 028 38(0749) -328 North Carolina 431 009 37(2547) -236DC 228 026 51(5051) -4827c North Dakota 441 033 31(0249) -016Florida 418 006 42(3448) -530 Ohio 466 008 24(1333) 555Georgia 427 009 40(2647) -331 Oklahoma 481 015 18(0435) 879Hawaii 292 019 50(4951) -3380c Oregon 497 015 11(0229) 1247Idaho 513 024 04(0131) 1620c Pennsylvania 446 008 30(2040) 098Illinois 418 008 44(3148) -542 Rhode Island 472 028 19(0148) 691Indiana 455 011 29(1441) 309 South Carolina 459 013 27(1041) 398Iowa 507 017 08(0127) 1487 South Dakota 531 033 03(0136) 2014c

Kansas 497 018 10(0231) 1254 Tennessee 484 012 15(0430) 956Kentucky 484 014 16(0332) 955 Texas 421 006 41(3247) -465Louisiana 437 013 34(1847) -117 Utah 470 019 22(0344) 645Maine 513 025 05(0133) 1613c Vermont 576 040 01(0125) 3047c

Maryland 410 011 47(3049) -727 Virginia 417 010 45(2948) -560Massachusetts 460 011 26(1238) 420 Washington 496 011 12(0325) 1221Michigan 464 009 25(1235) 502 West Virginia 470 021 23(0345) 645Minnesota 471 013 21(0736) 657 Wisconsin 493 012 14(0328) 1165Mississippi 512 018 07(0126) 1599c Wyoming 556 043 02(0138) 2578c

Missouri 438 011 32(1946) -080

Table 318Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males and Females

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 19: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 536 003

High Five StatesIdaho 693 041 01(0121) 2919c

Vermont 671 063 02(0145) 2510c

Maine 658 041 03(0132) 2262c

South Dakota 639 053 04(0146) 1906c

Alabama 625 022 05(0125) 1643c

Low Five StatesNew York 468 010 47(4249) -1285New Mexico 444 028 48(3150) -1730c

Alaska 408 052 49(1751) -2390c

Hawaii 343 030 50(4851) -3613c

DC 312 046 51(4751) -4188c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 625 022 05(0125) 1643c Montana 561 044 27(0148) 450Alaska 408 052 49(1751) -2390c Nebraska 608 036 09(0142) 1342Arizona 510 017 40(2448) -498 Nevada 520 027 35(1148) -305Arkansas 610 028 06(0134) 1372 New Hampshire 582 040 18(0147) 849California 532 008 33(2440) -087 New Jersey 503 015 42(2648) -615Colorado 498 020 45(2449) -719 New Mexico 444 028 48(3150) -1730c

Connecticut 544 024 31(0747) 140 New York 468 010 47(4249) -1285Delaware 514 045 38(0349) -418 North Carolina 519 015 36(2346) -319DC 312 046 51(4751) -4188c North Dakota 563 055 26(0149) 499Florida 509 009 41(3046) -514 Ohio 569 014 22(0934) 610Georgia 522 015 34(2147) -275 Oklahoma 577 024 20(0340) 760Hawaii 343 030 50(4851) -3613c Oregon 599 023 12(0234) 1170Idaho 693 041 01(0121) 2919c Pennsylvania 551 013 30(1438) 266Illinois 511 013 39(2647) -480 Rhode Island 567 045 25(0148) 573Indiana 568 019 24(0539) 587 South Carolina 555 021 28(0743) 353Iowa 609 027 08(0133) 1358 South Dakota 639 053 04(0146) 1906c

Kansas 594 028 15(0239) 1069 Tennessee 607 019 10(0228) 1321Kentucky 578 023 19(0339) 774 Texas 498 009 44(3347) -719Louisiana 519 022 37(1548) -323 Utah 606 032 11(0138) 1298Maine 658 041 03(0132) 2262c Vermont 671 063 02(0145) 2510c

Maryland 498 019 43(2649) -713 Virginia 491 016 46(3049) -844Massachusetts 569 018 23(0638) 607 Washington 597 018 14(0230) 1134Michigan 571 015 21(0835) 642 West Virginia 555 032 29(0347) 343Minnesota 590 021 17(0335) 993 Wisconsin 593 020 16(0332) 1061Mississippi 610 029 07(0135) 1365 Wyoming 599 064 13(0149) 1163Missouri 534 018 32(1346) -044

Table 319Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Males

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 20: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

a US Mortality Files National Center for Health Statistics Centers for Disease Control andPrevention Rates are per 100000 and are age-adjusted to the 2000 US Std Population (19age groups - Census P25-1130)

b Difference between state rate and total US rate is statistically significant (plt=0002)c Absolute percent difference between state rate and total US rate is 15 or mored Rank of state level death rate and the 95 confidence intervals (low high) for the rankSE Standard error of the ratePD Percent difference between state rate and total US rate- Statistic not shown Rate based on less than 16 cases for the time interval

State Rate SE Rank(CI)d PD TOTAL US 361 002

High Five StatesWyoming 521 058 01(0137) 4434c

Vermont 500 051 02(0135) 3872c

South Dakota 449 044 03(0147) 2437c

Mississippi 436 022 04(0126) 2097c

Alaska 426 053 05(0149) 1809c

Low Five StatesMaryland 334 014 47(2249) -736New Mexico 323 023 48(1550) -1057New York 318 007 49(4149) -1190Hawaii 243 024 50(4751) -3254c

DC 161 030 51(5051) -5524c

State Rate SE Rank(CI)d PD State Rate SE Rank(CI)d PD

Alabama 420 017 06(0227) 1630c Montana 391 035 20(0149) 830Alaska 426 053 05(0149) 1809c Nebraska 416 028 07(0145) 1539c

Arizona 353 013 38(1548) -228 Nevada 394 022 17(0245) 924Arkansas 397 021 15(0244) 1010 New Hampshire 400 032 14(0149) 1092California 350 006 39(2646) -303 New Jersey 337 011 45(2549) -653Colorado 384 016 22(0444) 641 New Mexico 323 023 48(1550) -1057Connecticut 343 018 42(1549) -491 New York 318 007 49(4149) -1190Delaware 360 035 30(0250) -031 North Carolina 358 011 34(1747) -090DC 161 030 51(5051) -5524c North Dakota 337 040 46(0350) -658Florida 338 007 44(3149) -644 Ohio 378 010 25(1039) 480Georgia 347 011 40(2049) -374 Oklahoma 397 019 16(0343) 992Hawaii 243 024 50(4751) -3254c Oregon 405 018 10(0238) 1223Idaho 353 027 37(0449) -221 Pennsylvania 360 009 31(1746) -032Illinois 340 010 43(2649) -568 Rhode Island 394 035 19(0149) 914Indiana 358 014 32(1448) -064 South Carolina 380 016 23(0545) 533Iowa 414 021 08(0236) 1486 South Dakota 449 044 03(0147) 2437c

Kansas 412 023 09(0140) 1432 Tennessee 378 014 24(0644) 482Kentucky 400 017 13(0339) 1097 Texas 355 007 36(2245) -148Louisiana 369 017 28(0748) 222 Utah 346 023 41(0749) -402Maine 388 030 21(0249) 754 Vermont 500 051 02(0135) 3872c

Maryland 334 014 47(2249) -736 Virginia 356 012 35(1548) -135Massachusetts 372 013 27(0945) 304 Washington 404 014 11(0332) 1191Michigan 373 011 26(1143) 340 West Virginia 394 026 18(0248) 919Minnesota 366 015 29(0947) 148 Wisconsin 401 015 12(0335) 1121Mississippi 436 022 04(0126) 2097c Wyoming 521 058 01(0137) 4434c

Missouri 358 014 33(1349) -080

Table 320Cancer of the Brain and Other Nervous System (Invasive)

Age-Adjusted Cancer Deatha Rates By State All Races 2013-2017

Females

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 21: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

a US 2017 cancer prevalence counts are based on 2017 cancer prevalence proportions from the SEER 13 Areas (excluding the AlaskaNative Registry) and 112017 US population estimates based on the average of 2016 and 2017 population estimates from theUS Bureau of the CensusPrevalence was calculated using the first invasive tumor for each cancer site diagnosed during the previous 25 years

b Maximum limited-duration prevalence is 25 years for 1992-2017 datac Percentages are age-adjusted to the 2000 US Standard Population (19 age groups - Census P25-1130) by 5-year age groupsd Cases diagnosed more than 25 years ago were estimated using the completeness index method (Capocaccia et al 1997

Merrill et al 2000)e Complete prevalence is obtained by summing lt=25 and gt 25- Statistic not shown Statistic based on fewer than 5 cases estimated alive in SEER for the time interval+ Not available

Years Since Diagnosis 0 to 5 gt 5 to 10 gt 10 to 15 gt 15 to 20 gt 20 to 25 lt=25b gt 25d Completee

Race Sex All Races Both Sexes 47697 27833 22588 17797 14239 130154 38340 168494

Males 26219 14573 11477 9236 7516 69020 17798 86818Females 21478 13261 11111 8561 6723 61134 20542 81676

White Both Sexes 41008 23749 19674 15513 12260 112203 36908 149112Males 22644 12527 10192 8084 6470 59917 18497 78415Females 18365 11221 9483 7428 5789 52286 18411 70697

Black Both Sexes 3872 2516 1840 1506 1239 10973 4369 15342Males 2103 1141 751 772 632 5398 1702 7099Females 1769 1375 1089 734 608 5575 2667 8242

Asian Both Sexes 1793 981 731 495 375 4376 + +Pacific Males 926 534 326 230 195 2212 + +Islander Females 867 446 405 266 180 2163 + +

Hispanic Both Sexes 5566 3806 2893 2178 1427 15870 + +Males 2933 2021 1520 1160 703 8338 + +Females 2633 1785 1372 1018 724 7532 + +

Age Specific (Crude) Age-Adjustedc Age at Prevalence All Ages 0-9 10-19 20-29 30-39 40-49 50-59 60-69 70-79 80+ All Ages

Race Sex All Races Both Sexes 00402 00155 00352 00426 00429 00436 00512 00506 00452 00286 00391

Males 00432 00149 00374 00455 00450 00478 00547 00579 00500 00354 00421Females 00372 00162 00330 00396 00408 00395 00479 00441 00412 00244 00363

White Both Sexes 00443 00166 00386 00473 00475 00488 00570 00547 00486 00296 00430Males 00478 00157 00412 00510 00493 00525 00611 00621 00539 00371 00461Females 00410 00175 00358 00433 00456 00450 00531 00479 00442 00248 00400

Black Both Sexes 00241 00114 00239 00290 00301 00245 00229 00293 00243 00215 00241Males 00247 00118 00241 00295 00299 00285 00200 00351 00230 00203 00248Females 00235 00109 00236 00286 00303 00209 00256 00248 00252 00221 00234

Asian Both Sexes 00210 00099 00213 00215 00196 00219 00287 00260 00236 00158 00207Pacific Males 00221 00096 00229 00197 00226 00242 00316 00274 00265 00158 00220Islander Females 00199 00102 00197 00232 00170 00198 00262 00249 00213 00158 00195

Hispanic Both Sexes 00273 00124 00253 00281 00250 00324 00422 00417 00382 00227 00286Males 00284 00111 00274 00292 00244 00355 00466 00442 00379 00266 00300Females 00262 00137 00232 00270 00256 00293 00378 00394 00385 00203 00273

Table 321Brain and Other Nervous System (Invasive)

Estimated United States Cancer Prevalence Countsa on January 1 2017By RaceEthnicity Sex and Years Since Diagnosis

Estimated prevalence percenta on January 1 2017 of the SEER population diagnosed in the previous 25 yearsBy Age at Prevalence RaceEthnicity and Sex

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 22: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

1975 1985 1995 2005 2017

Delay-Adj IncidenceDelay-Adj Incidence

Observed IncidenceObserved Incidence

MortalityMortality

SEER Observed Incidence SEER Delay Adjusted Incidence and US Death RatesCancer of the Brain and Other Nervous System by Race and Sex

a

Figure 31

Source SEER 9 areas and US Mortality Files (National Center for Health Statistics CDC)Rates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines and APCs are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer InstituteThe APC is the Annual Percent Change for the regression line segments The APC shown on the graph is for the most recent trendThe APC is significantly different from zero (p lt 005)

a

White Male Black Male White Female Black FemaleRate per 100000 Rate per 100000 Rate per 100000 Rate per 100000

Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath Year of DiagnosisDeath

SEER Incidence APCsDelay Adj 1989-17 = -02Observed 1990-17 = -03

US Mortality APC2006-17 = 05

SEER Incidence APCsDelay Adj 1975-17 = -01Observed 1975-17 = -01

US Mortality APC2007-17 = 07

SEER Incidence APCsDelay Adj 1987-17 = 00Observed 1987-17 = 00

US Mortality APC2007-17 = 06

SEER Incidence APCsDelay Adj 1975-17 = 03Observed 1975-17 = 02

US Mortality APC2005-17 = 09

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 23: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

Joinpoint Analyses for Whites and Blacks from 1975-2017and for AsianPacific Islanders American IndiansAlaska Natives and Hispanics from 2000-2017

0

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 20170

1

2

3

4

5

6

7

8

9

10

1975 1985 1995 2005 2017

White

Black

API

AIAN

Hispanic

SEER Incidence and US Death RatesCancer of the Brain and Other Nervous System Both Sexes

Figure 32

Source Incidence data for whites and blacks are from the SEER 9 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah Atlanta)Incidence data for AsianPacific Islanders American IndiansAlaska Natives and Hispanics are from the SEER 21 areas (SEER 9 areas San Jose-MontereyLos Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLA Kentucky Louisiana New Jersey Georgia excluding ATLRG Idaho New York andMassachusetts)Mortality data are from US Mortality Files National Center for Health Statistics CDCRates are age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1103)Regression lines are calculated using the Joinpoint Regression Program Version 48 April 2020 National Cancer Institute Joinpoint analyses for Whites andBlacks during the 1975-2017 period allow a maximum of 5 joinpoints Analyses for other ethnic groups during the period 2000-2017 allow a maximum of 3 joinpointsAPI = AsianPacific IslanderAIAN = American IndianAlaska Native Rates for American IndianAlaska Native are based on the PurchasedReferred Care Delivery Area (PRCDA) countiesHispanic is not mutually exclusive from whites blacks AsianPacific Islanders and American IndiansAlaska Natives Incidence data for Hispanics are based onNHIA and exclude cases from the Alaska Native Registry

Incidence MortalityRate per 100000 Rate per 100000

Year of Diagnosis Year of Death

a

d

a

b

c

c

b

d

SEE

R C

ancer Statistics Review

1975-2017N

ational Cancer Institute

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival
Page 24: SEER Cancer Statistics Review 1975-2017...The APC is the Annual Percent Change based on rates age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130). a Trends

Figure 33

Cancer of the Brain and Other Nervous System5-Year SEER Conditional Relative Survival and

95 Confidence Intervals

Source SEER 18 areas (San Francisco Connecticut Detroit Hawaii Iowa New Mexico Seattle Utah AtlantaSan Jose-Monterey Los Angeles Alaska Native Registry Rural Georgia California excluding SFSJMLAKentucky Louisiana New Jersey and Georgia excluding ATLRG)Percent surviving is not shown if based on less than 25 casesConfidence intervals are not shown if length of the confidence interval is greater than 5 times the standard error

0

20

40

60

80

100Percent Surviving Next 5 Years

Stage at Diagnosis

Probabilty of surviving the next 5 years given the cohort has already survived 0 1 or 3 years

2000-2015 by stage at diagnosis

Survival Time Since Diagnosis

Localized Regional Distant Unstaged

0 year (at diagnosis) 1 year 3 years

SEER Cancer Statistics Review 1975-2017 National Cancer Institute

  • Trends in SEER Incidence and US Mortality Both Sexes
  • Trends in SEER Incidence and US Mortality Males
  • Trends in SEER Incidence and US Mortality Females
  • Annual Delay-adjusted Incidence Rates
  • Annual Incidence Rates
  • Annual Death Rates
  • Incidence and Mortality Rates by Age
  • 5-year Relative and Period Survival
  • Relative Survival by Year of Diagnosis Both Sexes
  • Relative Survival by Year of Diagnosis Males
  • Relative Survival by Year of Diagnosis Females
  • Risk of DevelopingDying Both Sexes
  • Risk of DevelopingDying Males
  • Risk of DevelopingDying Females
  • Rates and Trends by RaceEthnicity
  • Age-Adjusted SEER Incidence Rates by Registry
  • Age-Adjusted SEER Death Rates by Registry
  • Age-Adjusted Cancer Death Rates By State Both Sexes
  • Age-Adjusted Cancer Death Rates By State Males
  • Age-Adjusted Cancer Death Rates By State Females
  • US Prevalence Estimates
  • Graph - SEER Incidence Delay Adjusted Incidence and US Death Rates by Race and Sex
  • Graph - SEER Incidence and US Death Rates by RaceEthnicity
  • Graph - 5-Year SEER Conditional Relative Survival