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Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. [email protected] 801-201-2002

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Page 1: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Segmenting Adult Web Users into Meaningful Age Categories

Robert W. Bailey, Ph.D.Computer Psychology, Inc.

[email protected]

801-201-2002

Page 2: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

What are the 4 Most Useful Age Categories?

Page 3: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

The Problem

• Virtually every study separates adult participants differently, i.e., designates different age segments

• Without reading each individual study, practitioners do not know how old "old" is for each researcher

• The goal is to have all researchers, who are doing work on ‘aging,’ use the same age categories

• Example– Young: 20-35– Middle-aged: 36-55– Old: 56-75– Old-old: 76 and over

• What age segments are most useful to practitioners?

Page 4: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

How Old is Old?

• It is rumored that Otto von Bismark, Prime Minister of Prussia in the 1860’s introduced old age pensions

• In preparation, he asked the mathematicians to determine the average age of death

• They found that it was “55”

• He said, “We’ll pay pensions at 65”

Page 5: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

How Old is Old?

• One prominent medical doctor recently made these observations on aging

• “Aging begins at 30”– Organs begin to lose their function– Increase of heart disease, diabetes, arthritis, etc.– Bones begin to become brittle

• “Many practicing physicians now refer to the elderly as those 75 and older, and the ‘old-old’ as those 85 and older”

Page 6: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

The Influence of Age and Experience on Data Entry

Czaja and Sharit, 1997

• Past research - Young people perform reliably better than older people on speed-related tasks– Data entry– File modification– Inventory management

• This study - Participants were 110 people who performed a data entry task for three days– Young - Mean of 29.8 years– Middle - Mean of 49.4– Old - Mean of 66.5 (Reliably less computer experience)

• Results– Young and middle-aged users entered reliably more data than

old users (p<.001)– No age-related differences with errors

Page 7: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Age, Luminance and Print LegibilityCharness and Dijkstra, 1999

• To survey homes, offices and public places– To determine existing ambient light levels– To assess whether ambient light levels in homes vary

with the occupant’s age

• To determine whether making changes to ambient light levels might improve the reading performance of older adults (intervention)

Page 8: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

PAST RESEARCH

• Study 1 - Older adults (aged 60-83)– Read serif fonts (Roman) 6% faster than sans serif fonts– The best reading speeds were attained with 14-point type

• Study 2 - Older adults with an average age of 75– Read using 14-point Times Roman and 9-point Helvetica– 14-point times was superior

• Study 3 - Adults over age 50 were more strongly affected by low light levels than were people under 50 years of age

Page 9: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Study 1• Participants were 98 Tallahassee residents

– 31 young (20-38, average 29)– 33 middle-aged (39-58, average 47)– 34 older (over 58, average 69)

• Performed five reading tasks• Results

– The older group• Used reliably higher light levels• Read reliably slower than the younger groups

– Adding lighting improved reading speed for all groups

Page 10: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Study 2

• Method– Visited 51 businesses– Measured the light level in work areas– Tested two people with reading tests

• One over 40• One under 40

• Results– Offices generally had adequate light levels– Only older users benefited from increasing the

light level

Page 11: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Study 3• Method

– Visited 51 public places– Measured the light level in areas where people would

read– Tested two people with reading tests

• One over 50• One under 50

• Results– The light levels in 71% of the locations were too low– Participants over age 50 read slower than those

under 50

Page 12: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

“Old” Defined

• Past research– 60-83– Average of 75– Over age 50

• These studies1. Mean of 66.52. Over age 58 with an average of 693. Over age 404. Over age 50

Page 13: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Cognitive and Perceptual Training by Older and Younger Adults

Mead and Fisk, 1997

• Investigated the type of information that should be presented during training– Young adults - Range of 18-30 (mean = 20)– Older adults - Range of 64-80 (mean = 69.9)

• The groups showed no reliable differences on– Simple reaction time tests– Corrected vision tests

Page 14: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Young vs. Older Users

• Young adults– Were more likely to have used an ATM (p<.0001)– Used computers more often (p<.0001)– Had higher scores on

• Perceptual speed (p<.0001)• Reading rate (p<.05)• Reading comprehension (p<.0001)• Working memory capacity (p<.0001)

– Had faster choice reaction times (p<.0001)• Older adults

– Were better educated (p<.05)– Had higher vocabulary scores (p<.05)

Page 15: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

An Investigation of Age Classifications

Timothy A. Nichols, Wendy A. Rogers, Arthur D. Fisk, and Lacy D. WestGeorgia Institute of Technology

Proceedings of the Human Factors and Ergonomics Society 45th Annual Meeting

2001

How Old are Your Participants?

Page 16: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Introduction • Designers should try to account for age-related

differences in their user populations• Gathered reported age data from all articles from

two journals– Human Factors Journal: 1998-2000– Psychology & Aging: 1995-1999

• Attempted to determine how researchers segmented their participants by age

Page 17: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Human Factors Journal

• Human Factors Journal reported 131 empirical articles– 49 (37%) provided no age data at all– 64 (51%) supplied some information– 18 (14%) listed a mean, standard deviation

and age ranges

• Psychology & Aging reported 202 empirical articles

Page 18: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Results

Classification HF P&A

Older 58-76 62-82

Middle-aged 40-59 41-57

Young 19-35 19-30

Page 19: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Longitudinal vs. Cross-Sectional Studies

Page 20: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Chronological Age

• Cannot “cause” anything

• Can help in defining the probability of occurrence of certain events

Page 21: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Age and Experience RelationshipsSri Kurniawan, Jason Allaire and Darin Ellis,

1999

• Examined the relationships among age, web experience and web ability

• Participants were 600 older adults (average age of 44.3 years)

• About 45% of the variance in Web ability was explained by the user’s age and experience– Web experience - 28% of the variance– Age - 9% of the variance– Shared age and experience - 8% of the variance

Page 22: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Longitudinal vs. Cross-Sectional Studies

• Longitudinal - Compare the same individuals over time (historical effects)

• Cross-sectional – Individuals are compared within their age groups– May belong to different age cohorts– May have had different life experiences

• The findings from the two types of studies do not always agree

Page 23: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Cross-Sectional vs. Longitudinal

Page 24: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Studying the Effects Aging

• Longitudinal– Measures the changes in one group of people over time– Usually considered superior to cross-sectional– Can be confounded by

• Selection bias• Selective attrition• Retest familiarization• ‘Historical’ effects (see ‘world record’ times)

• Cross-sectional– Evaluates for differences across the different age groups– Can be confounded by

• Older adults being more cautious (work slower)• Major educational and experience differences• Slowing of the central nervous system over a certain age• Some differences can be the result of testing only survivors (those who have

not yet died)

Page 25: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

World Record Timespersonal.rdg.ac.uk

1912 10.5 seconds1920 10.51924 10.21928 10.21932 10.21936 10.21948 10.21952 10.11956 10.11960 10.01964 10.0

1968 9.95 seconds1972 9.95 1976 9.951980 9.951984 9.931988 9.861992 9.861996 9.842000 9.792004 9.78

Page 26: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Abilities and Age

• Data from longitudinal studies will better measure age changes for those in– Good health, and– Stimulating environments

• Data from cross-sectional studies tend to over estimate loss of most abilities

• Cohort effects (e.g., differences in the amount of education) usually accounts for more variance than age-related factors

Page 27: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Six Ages of HumansPirow, 1994

• Birth• Starting age - The earliest age at which a

measured activity can take place• Competence - The age at which a person has

acquired the skill to perform well• Optimal - The age at which the person will

perform optimally at the task• Initial decrease - The age at which the

performance will start to decrease linearly• Rapid decrease - The age after which the

performance will decrease at an increasing rate

Page 28: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Running Example

Female Male

Starting 2 years 2 years

Competence 9 10

Optimal 22 24

Initial decrease 24 29

Rapid decrease 59 66

Page 29: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Correlation of Track and Field Performance with Chronological Aging

Fung and Ha, 1994

Correlation Female Male400 meters .98 .981500 meters .97 .96200 meters .95 .97800 meters .94 .985000 meters .94 .96100 meters .92 .94High jump .88 .91Discus .83 .78Shot put .81 .79Javelin .74 .94

Page 30: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

General Decline in Older Adults

• Sensitivity of most sensory organs

• Attention capacities

• Working memory

• Speed of motor performance

Page 31: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Abilities and AgeWoolf, 1998

• Reliable decrements can not be found for all abilities for all persons (until very late in life)

• Decline is most evident where ‘speed of response’ is involved

• Declines will be evident in most abilities– For those in their 50s and 60s who live in deprived

environments, and – For individuals of any age who have severe central

nervous system disease (e.g., Alzheimer’s)

Page 32: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Common Age-Related Changes in Vision

• Decreased sharpness of vision (visual acuity)• Decreased ability to focus on near objects• Decreased ability to focus on objects at varying distances (visual

accommodation)• Decreased ability to discriminate between certain color intensities

– Especially in the blue-green end of the color spectrum– The "yellowing" of the lens with age makes blues and greens appear

"washed out" or faded• Decreased ability to perceive or judge depth • Decreased ability to focus in low light levels• Slow responsiveness to changes in light levels (dark to light, and

light to dark)• Increased sensitivity to glare• Decreased ability to accurately judge distances• Increased need for light needed to see objects clearly

Page 33: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Age-Related Changes in Vision

Page 34: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Comfortable Listening LevelsCoren, 1994

• The number of people who have difficulty hearing and understanding voices increases with age– General conversations– Voices on

• The phone• Television• Radio• Computer

• Procedure– Used 799 subjects, ranging in age from 17 to 92– Each

• Listened to a running speech signal• Identified the level preferred for listening

Page 35: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Results

• The average `most comfortable listening level' for all participants was 63.4 dB

• They found– No differences between left and right ears– No differences between male and female

• Before the age of 40, the most comfortable listening level increased about 1/3 dB per year

• After the age of 65, the most comfortable listening level increased about 1/2 dB per year

Page 36: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Hearing Comfort Level by Age

50

55

60

65

70

75

80

85

90

15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 90

Age

De

cib

els

(d

B)

Page 37: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Primary Mental AbilitiesSchaie, 1958

Page 38: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Primary Mental AbilitiesShaie, 1972

Page 39: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002
Page 40: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Reaction TimeFozard, 1990

• Shortens from infancy into the late 20s• Increases slowly until the 50s and 60s• Lengthens faster as a person gets into the 70s and

beyond• Becomes more variable with age• When troubled by a distraction, older people tend to

devote their exclusive attention to one stimulus and ignore another (attention)

Page 41: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Normal Distributions by Age

Page 42: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Normal Distributions by AgeSlower Means

Page 43: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Normal Distributions by AgeSlower Means and More Variability

Page 44: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Longitudinal Analysis of Age-Related SlowingFozard, et.al., 1990

• The Baltimore Longitudinal Study of Aging has been gathering data since 1959– 1300 adults from 20 to 96 years of age– Continually evaluated using different measures

• Biographical• Physiological• Psychological

• One measure is reaction times– Simple – Responded to both high (1000 Hz) and low

(250 Hz) tones presented for 3 seconds at 62 dBA– Disjunctive (choice) – Responded only to high tones

Page 45: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Results

• Reaction time increases with age– Constant rate of slowing over the adult life

span – appears linear– Slows from 10-20 milliseconds per decade (1-

2 milliseconds per year)– Men remain reliably faster than women

• There seems to be a general slowing of central nervous system functions with aging

Page 46: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Aging and Computer‑based Task Performance

Sharit and Czaja, 1994

• Of particular interest are age‑related changes in information processing abilities, including the– Senses– Cognition processors– Responders

• There seems to be a general overall slowing in cognitive tasks

• The hypothesized `slowing factor' for cognitive tasks is 1:1.6 (young vs. old)

Page 47: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Cognitive Abilities and Job Performance

• There is little evidence that job performance declines with age

• Age alone is not a significant predictor of performance in most actual work activities

• Age effects are– Smaller for tasks where knowledge is an

important aspect of the task– Larger for tasks where successful

performance is primarily dependent on speed

Page 48: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Performance on Choice Reaction Time and Typing Tasks

Page 49: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Aging and ErrorsRabbitt, 1990

• Used a two-choice reaction time task• Four age groups

– 19-30– 50-59– 60-69– 70-79

• Conditions– No response to errors– Corrected each detected error– Signaled that an error was made (no correction)

Page 50: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Results

• All age groups – Made the same percentage of errors– Were equally proficient at ‘automatic’ error detection– Underestimated the number of errors made (after the

test)

• The 70-79 group ‘signaled’ reliably fewer errors• The ability to remember errors after the test

declined with age – beginning at age 50

Page 51: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

100 Meters Record by Ageworld-masters-athletics.org

05

10152025303540

Age

Seco

nds

Page 52: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Mile Run Records by Agehome.hetnet.nl

0123456789

Age

Min

utes

Page 53: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

High Jump Records by Ageworld-masters-athletics.org

0123456789

Age

Hei

ght (

feet

)

Page 54: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Shot Put Records by Ageworld-masters-athletics.org

01020304050607080

Age

Dis

tanc

e (fe

et)

Page 55: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Common Web-based Tasks

• Typing• Mousing• Linking• Paging• Using widgets• Scrolling• Reading• etc.

Page 56: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Comparing Age GroupsKoyani, Bailey, Ahmadi, Changkit and Harley, 2002

Ages 20-30 with Ages 71-80

0

20

40

60

80

100

120

140

Links Paging Widgets Scrolling

Common Web Activities

Se

co

nd

s

20-30

71-80

Page 57: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Comparing Age Groups20-30, ‘61-70’, 71-80

0

20

40

60

80

100

120

140

Links Paging Widgets Scrolling

Common Activities

Se

co

nd

s 20-30

61-70

71-80

Page 58: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Interventions

• Eyeglasses, contact lens, hearing aids• Recall vs. recognition memory• Length and type of training• TFT vs. CRT screens• Intensity (loudness) of auditory signals• Shape of the cursor• Time of day• Accessibility features

Page 59: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Mechanisms of Human Aging

Page 60: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Cognitive Correlates of Human Brain Aging

Coffey, et al., 2001

• Collected MRI data from 320 volunteers (ages 66-90)

• Compared the results with performance on– Attention– Information processing speed, and– Memory

• The findings suggest a relationship between age-related changes in brain structure and declines in attention, psychomotor speed and memory

Page 61: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Age-Related Gray and White Matter Changes – Longitudinal

Resnick, et al., 2003 • Conducted MRIs on 92 non-demented

older adults aged 59-85• Used the baseline, 2 year and 4 year

follow-ups in the BLSA• Found reliable age decreases in both gray

and white matter• There seemed to be slower rates of brain

atrophy in individuals who remained medically and cognitively healthy

Page 62: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Brain’s Gray and White Matter

Page 63: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Brain’s Gray and White Matter

Page 64: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Determining Gray vs. White Matter

Page 65: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Age-Related Gray and White Matter Changes – Cross-Sectional

Ge, et al., 2002

• 54 healthy volunteers aged 20 to 86 were given MRIs

• Findings– The percent of gray matter and white matter

were reliably less in older (over age 50) adults– The percent of gray matter decreased linearly

with age – beginning with the youngest participants

– There was no difference between sexes

Page 66: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Gray Matter

Page 67: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Does Loss of Brain Tissue Accelerate as People Get Older?

sciencedaily.com, 1998

• Divided patients into three age groups:– Young-old: 65-74 years old– Middle-old: 75-84 years old– Oldest-old: 85-95 years old

• Measured the changes in brain volume with magnetic resonance imaging (MRI) scans

• The loss of tissue among patients was a constant 1% or less per year

• Dementia is related to a more rapid brain tissue loss

Page 68: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Is Cognitive Decline Normal?Haan, et al., 1999

• Tracked changes in cardiovascular health, diabetes and cognitive function over a 7-year period

• The people were all 65 or over when recruited• 70% of the individuals showed no significant decline in

cognitive function (Modified Mini-Mental State Exam)• The greatest loss of cognitive ability occurred in people

who had– High levels of atherosclerosis or diabetes, and– The apolipoprotein E4 gene (ApoE4)

• They were 8 times more likely to show a decline in cognitive function

Page 69: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Chromosomes

• Humans have 23 chromosomes

• Twenty-two are numbered in order of size– Largest (number 1)– Smallest (number 22)

Page 70: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Chromosomes

Page 71: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Genes• Each chromosome

contains genes• Genes are stretches of

(deoxyribonucleic acid) DNA that comprise the recipes for proteins

Page 72: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Damaged Genes = Cognitive DeclineLu, et al., 2004

• Damaged genes can start in the late 30s and early 40s in some individuals (i.e., functioning at a reduced level)

• Evaluated patterns of gene expression in postmortem samples– Collected from 30 individuals– Ranged in age from 26 to 106

• Found two groups of genes with altered expression levels– Those related to learning and memory– Those related to gene repair mechanisms

• Conclusion: DNA damage may reduce the expression of certain vulnerable genes involved in learning, memory and neuronal survival

Page 73: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Proposed Age Categories

• Old-old: 75 and older

• Older: 60-74

• Middle-aged: 40-59

• Young: 18-39

Page 74: Segmenting Adult Web Users into Meaningful Age Categories Robert W. Bailey, Ph.D. Computer Psychology, Inc. bob@webusability.com 801-201-2002

Possibly More Important

• Overall level of cognitive activity• Severe nervous system diseases

– Alzheimer’s– Parkinson’s

• Circulation-related diseases– Atherosclerosis– Diabetes

• Certain medications• Deprived environment• Seriously hampered senses

– Cataracts– Glaucoma– Macular degeneration– Diabetic retinopathy

• Defective genes (DNA)