sensoring (multiplexed) in process design & investigating ... · sensoring (multiplexed) in...

CONFIDENTIAL

Sensoring (Multiplexed) inprocess design &

investigating matterfrom an industrial perspective

Time to solve the challenges

M. Honing December 14th 2016

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Integrated Analytical Sciences – Historic Approach

Sensoring (Multiplexed) in process design & investigating matter - Analytics

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Color & Viscosity(Ethanol)

Aroma & VolatileMolecules (Amines)

Taste, Bitterness,(Tannins)

Integrated Analysis Crucial for Characterization

Sensoring (Multiplexed) in process design & investigating matter - Analytics

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Objective

A flavor on the needs and challenges for “sensoring” due to paradigm shift inindustrial R&D laboratories.

- Process design – translate screening technologies to robust process control.

- Material properties – investigate matter on extreme length scales.

- Have the lab moved to the field - off-odor

Sensoring (Multiplexed) in process design & investigating matter

Rational product design withtailored functionalities requirefundamental understanding oftranslation molecularassemblies, meso- &marcoscopic properties.

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Sensoring (Multiplexed) in process design & investigating matter – Way forward

Sufficient attention in the Dutch “R&D environment!

&

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Process Analytics – The “Old” Definition:

A Mechanism to design, analyze, and control processes through themeasurement of Critical Process Parameters which affect Critical QualityCharacteristics.

An Effective, Structured & Integralapproach to obtain Process Understanding

A B

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Combination of Differential Scanning Calorimetry(heat transfer) & Raman or NMR leads to “pivotalknowledge” materials processing

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Not new – (N)IR or Raman, yet still not universal enough

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Multiplexed sensoring & “Big data”.

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Investigating matter: importance of nano- & micro devices in Analytical Sciences

Fast Scanning Calorimetry – Mimicking materials processing

From sensing molecules to sensing material processing

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Sensoring (Multiplexed) in process design & investigating matter - Morphology

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Sensoring (Multiplexed) in process design & investigating matter - Morphology

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Sensoring (Multiplexed) in process design & investigating matter – Morphology &…

Multiplexing AFM-Tip enhanced Raman Spectroscopy

We need spatial & chemical resolution

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Sensoring (Multiplexed) in process design & investigating matter - kinetics

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Sensoring (Multiplexed) in process design & investigating matter - Kinetics

We need SPR(QCM) in combination with IR/Raman/MS!!

Besides kinetics, we would like to combine it with structure

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Sensoring (Multiplexed) in process design & investigating matter – “off-odor”

The challenge of sensors in complex “off-odor” systems – we need a step forward

One of the major applications of Sarlink thermoplasticvulcanisate (TPV) is as wine corc skin for synthetic winecorcs. Advantages of synthetic wine corcs over natural corcsare the absence of bio-contaminations, which may affect thequality of the wine, and the lower costs. The market ofsynthetic wine corcs is growing with double digits per year,which makes it very interesting one. In the last year anincreasing number of smell complaints has been reported byNomacorc, one of the leading synthetic wine corcs producersand purchaser of Sarlink TPV, and by Nomacorc customers.

As a result, in Feb. 2006 a DSM/Nomacorc crash team hasbeen formed to address the smell problem. The Sarlink grouphas tried to restore the damaged relationship with Nomacorcand has started a series of experimental investigations toimprove the smell of Sarlink TPV. Amongst others, a seriesof experimental design experiments (DOE) were performed.By varying the TPV formulation and the extruder and de-smelling conditions a set of samples was produced, whichwere tested by Nomacorc. It seems that a solution of thesmell problem has been found and a 20-ton de-smelled lothas been produced half May.

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Resume

- Miniaturization crucial in analytical technologies and future laboratories.

- Process design & control will need multiplex sensors during design & control

- Chemical & Spatial Resolution essential for matter.

- Selectivity and universal detection remain technological challenge.

- Solving fouling & hardware reliability essential

We need a multi step forward – a paradigm shift- Binding assays NO option?- Miniaturization of conventional technologies!??

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