September 2016

© 2016 ICAGEN - CONFIDENTIAL 22

Selectide Corp

1990s 2009

2016

Icagen Inc

2015

1992 2011

Icagen Background

2003

2013

Caldera Pharmaceuticals

© 2016 ICAGEN - CONFIDENTIAL 3

ICAGENTechnology Plus Large Pharma Experience Base

Tucson, Arizona USA

Integrated Drug Discovery Site

Benefits:

- Cost effective

- Convenient, West Coast

Capabilities:

• Compound management

• HTS & Hit identification

• In vitro & in vivo pharmacology

• Medicinal chemistry

• ADME, PK/PD

Durham, North Carolina USA

ION Channel / XR-PRO Site

Benefits:

- Cost effective

- Convenient, East Coast

Capabilities:

• Ion Channel/Transporter

HTS & Lead Optimization

Support

• Ion Channel Profiling

• Assay Development

• X-Ray Fluorescence

Platform

3

© 2016 ICAGEN - CONFIDENTIAL 4

Information Technologies

- Data modeling- Collaborative tools- Workflow solutions- HPC capabilities

Analytics- HT QC methods- Solubility- LogD- Chemical stability- Methods Development

Logistics- Workflow support - Full automation - Information control- Physical security

4

Effective and Efficient Integration- A complete solution

Biology- uHTS- Assay Creation- Patient cell models- Stem cell biology- eADMET panels- Ion Channels- SLT Transporters

Chemistry- Small molecules- Peptides - Medicinal Chemistry - Library design

Drug Design- Target assessment- Ligand design- Virtual screening- Protein dynamics- Affinity prediction

PROJECT LEVEL

INTEGRATION

© 2016 ICAGEN - CONFIDENTIAL 5

Integrated Drug Discovery

Ion ChannelsSLT Solute Transporters