Fully validated, SiZ is in use across industry, leading research institutions and international regulatory agencies.

• Design and analyze data by choosing from parametric or p-value based multiple comparison procedures

• Simulate and compare procedures to optimize your testing strategy

• Visualize design operating characteristics to help decide on the best trial options

Design and Analyze Multi-Arm Trials

Multi-Arm Clinical Trials

SiZ® modernizes trial planning for multiple arm studies by combining design, simulation, visual-ization, and data analysis within the Architect™ software standard environment. Trial designers can choose from a wide range of multiple comparison procedures – parametric and p-value based – to optimize the pairwise testing strategy of their fixed sample size design. Study planners can quickly compare design strate-gies using the fast simulation engine. With an array of tables, plots and graphs, SiZ clearly communi-cates trial concepts among study stakeholders.

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Design. Simulate. Analyze.

Cytel Inc.675 Massachusetts Avenue

Cambridge, MA 02139

T: +1.617.661.2011F: +1.617.661.4405

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• Simultaneously plot and contrast design performance for several multiple comparison procedures • Plot and compare Global power, Conjunctive power, Disjunctive power, and Family-Wise Error Rate • Customize tables and graphs for effective communication with team members

Multiple pairwise comparisons with a control:• Continuous endpoint: Difference of means• Binary endpoint: Difference of proportions

Parametric multiple comparison procedures:• Dunnett’s single step• Dunnett’s step down

P-value based multiple comparison procedures:• Bonferroni• Sidak• Weighted Bonferroni• Holm’s step down• Hochberg’s step up• Hommel’s step up• Fixed sequence• Fallback

Generate means through a DR curve

Global, disjunctive, conjunctive, and individual power

Family Wise Error Rate (FWER)

Comparative plots of power, FWER, box plots, estimated means