Research on Development about Nanotechnology in UFRN

Sibele B. C. PergherUFRN

II BRAZILIAN-TURKISH NANOTECHNOLOGY WORKSHOP

UFRN

Rectory

Numbers

2

Drug DeliveryPla

smati

c Le

vel

Toxic Range

Therapeutic Range

Sub Therapeutic Range

Time (days)

3

Synthesis of new hybrid materials from montmotillonite and biopolymer for Olanzapine

deliveryArtur de Santana Oliveira and Sibele Pergher

H3C

N

N

N

NH

H3CS

Olanzapine Structure

T

O

T

T

O

T

Carregadanegativamente

Cátions trocáveis

Drug Delivery

Montmorillonite Structure

0,97nm

Cations

4

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

Drug Delivery

Xanthan Gum

Alginate

5

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

Drug Delivery

6

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

Projects in developmentStudy of the effect of dexamethasone combined with

multifunctional gold nanoparticles on inflammatory response of experimental oral mucositis: targeted and photothermal therapy- Caroline A. C. X. de Medeiros

Assessment of the effects of gold nanoparticles in cancer cells - Raimundo F. de Araujo Junior

Development of Nanostructured Lipid Carrier containing oily fraction of BIXA ORELLANA l. as alternative therapy in the treatment of leishmaniasis - Fernanda N. Raffin

Collection and characterization of polymeric nanolattices with low concentration of surfactant for biomedical applications - Juliana de S. Nunes

Drug Delivery

7

Projects in development Extraction of silk fibers nanoparticles and their potential

application in drug delivery nano systems - Rasiah Ladchumananandasivam

Development and characterization of nanoparticles containing copaiba essential oil for the treatment of infectious diseases - Eryvaldo Socrates Tabosa Do Egito

Development of mesoporous magnetic nanoparticles for application in hyperthermia and controlled release of drugs - Artur da Silva Carrico

Drug Delivery

8

Sensors and Actuators B 196 (2014) 306–313

Nanomaterials

9

LENA: Laboratório de Eletroquímica e Nanopartículas AplicadasLuiz Henrique Gasparotto

RSC Adv., 2015, 5, 66886

Nanomaterials

10

LENA: Laboratório de Eletroquímica e Nanopartículas AplicadasLuiz Henrique Gasparotto

Aim: Use of Mg-nanomotor for rapid and effective remeadiation of nitrite from drinking water/groundwater.Motivation: Nitrite is a toxic inorganic contaminant that is hazardous to the health of humans. Approach: Mg nanoparticle is used to reduce the nitrite into ammonia (60-95%) and nitrogen.NO2

- + 2Mg + 3H2O → NH3 + 2Mg(OH)2 + OH-

2NO2- + 2Mg + 4H2O → N2 + 2Mg(OH)2 +

2OH-

Mg-nanomotors for removing Nitrite from water

Water purification by nanomotorsA B

C

SEM images illustrating the Mg-nanomotor surface: (A) Ti coated Mg micromotor. EDX spectroscopy images of an Mg micromotor illustrating the distribution of (B) Titanium and (C) Magnesium. (D) Propulsion images of Mg micromotor showing the circular trajectory in 2 % NaCl solution and 1% Triton X-100.

D

400 500 600

0.0

0.1

0.2

0.3

/nm

Abs.

a: Std. Nitrite solutionb: PEDOT motor (1.41%) c: Mg Micromotor (92.83%)

a

b

c

O2

H2

2NO2- N2(g) + 2OH-

(aq) + 4H2O(l)

2NO2- N2(g) + 2OH-

(aq) + 4H2O(l)

Mg-nanomotors

Nano-rockets

Next objective: The use of nano-rockets for removing organic pollutants from water

Laboratory of Environmental and Applied Electrochemistry – Prof. Carlos A Martinez Huitle (carlosmh@quimica.ufrn.br)

Electrocatalytic materials decorated with nanomaterials for removing pollutants from water

Water purification by electrochemistryLaboratory of Environmental and Applied Electrochemistry – Prof. Carlos A Martinez Huitle (carlosmh@quimica.ufrn.br)

Aim: Large disk electrodes of Ti/TiO2-nanotubes/PbO2 (65 cm2 of geometrical area) are successfully synthesized by anodization and electrodeposition procedures. Characterization of anodes was performed by SEM, EDS, AFM and electrochemical measurements, aiming towards environmental applications. PbO2, an electrocatalytic material, promotes the production of strong oxidizing species (hydroxyl radicals) that can be used for decontamination of water.

13

Zeolites

https://research.chemistry.ohio-state.edu/dutta/group-members/michael-severance/

Oxygen

Silicon or Aluminum

Nanomaterials

14

Shape SelectivityReagent Selectivity

+

Zeólitas

15

Product Selectivity

CH3OH +

Zeólitas

Shape Selectivity

16

Transition State Selectivity

Zeólitas

Shape Selectivity

17

Layered Zeolitic precursor

MCM-22

MCM-36

ITQ-2

Calcination

Pillarization Delamination

Nanomaterials

Pergher, S. B. C.; Corma, A.; Fornés, V.; Quím. Nova 2003, 26, 795.Pergher, S. B. C.; Corma, A.; Fornés, V.; Acta Scientiarum. Tecnology. 2003, 25, 83.Corma, A.; Fornes, V.; Pergher, S. B. C.; Patente Mundial WO9717290A1, 1997.Corma, A.; Fornes, V.; Pergher, S. B. C.; Maesen Th. L.; Buglass, J. G.; Nature 1998, 396, 353.

MCM-22

18

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

Nanomaterials

19

SBET

(m2/g)Vtotal

(cm3/g)VBJH

(cm3/g)M22-50 451 0.5239 0.1692M36-50 810 0.5920 0.3159ITQ2-50 841 0.9478 0.8533

0,0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1,00

100

200

300

400

500

600

700

ITQ2-50

M36-50

M22-50

Vol

umen

Ads

orbi

do (

cm3 /

g)

p/po

N2 Adsorption Isotherm

  150oC   250oC   350oC  

  Lewis Brönsted

Lewis Brönsted

Lewis Brönsted

MCM-22

15,0 24,9 10,5 20,7 9,0 15,4

ITQ-2 17,4 13,6 16,2 11,8 10,8 4,7

ITQ-2

Nanomaterials

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

20

0,3 0,4 0,5 0,6 0,7 0,810

20

30

40

50

60C

onve

rsió

n (%

) M22-50

ITQ2-50

M36-50

CAT/OIL

Cracking of n-Decane

15 20 25 30 35 40 45 50 55 604

6

8

10

12

14 M22-50

ITQ2-50

M36-50

C5-

C9

(%)

Conversión (%)

15 20 25 30 35 40 45 50 55 60

10

20

30

40

M22-50

ITQ2-50

M36-50

Gas

es (

%)

Conversión (%)15 20 25 30 35 40 45 50 55 60

1

2

3

4

5

6

7 M22-50

ITQ2-50

M36-50C

oque

(%

)

Conversión (%)

Nanomaterials

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

21

0,1 0,2 0,3 0,4 0,5 0,6 0,7

30

40

50

60

Co

nv

ersi

ón

(%

)

M22-50

ITQ2-50

M36-50

CAT/OIL

Cracking of Gasoil

30 35 40 45 50 55 6010

15

20

25M22-50

ITQ2-50

M36-50

Gas

oli

na

(%)

Conversión (%)30 35 40 45 50 55 60

6

8

10 M22-50

ITQ2-50

M36-50

Die

sel

(%)

Conversión (%)

Nanomaterials

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

22

30 35 40 45 50 55 60

10

15

20

25 M22-50

ITQ2-50

M36-50

Gas

es (

%)

Conversión (%)30 35 40 45 50 55 60

1

2

3

4 M22-50

ITQ2-50

M36-50

Co

qu

e (%

)

Conversión (%)

Cracking of Gasoil

Nanomaterials

LABPEMOL- Laboratório de Peneiras MolecularesSibele Pergher

Projects in developmentSynthesis, characterization and application of magnetic

nanostructures and of noble metals - Luiz Henrique da S. Gasparotto

Synthesis and characterization of nanocomposites based on zeolites and ceramic membranes for its use in catalysis - Sibele B. C. Pergher

Synthesis of Nanoparticles by Sputtering Deposition in Lubricants - Salete Martins Alves

Extraction and separation of rare earth minerals of Brazil and its application in development of metamaterials to high performance permanent magnets - Jose Humberto de Araujo

Physical properties of nanostructured materials - Luiz Felipe Cavalcanti Pereira

Nanomaterials

23

Projects in developmentSynthesis and characterization of nanostructured mixed

tantalum and niobium carbide from columbite, doped with cobalt - Carlson Pereira De Souza

Obtain a new smart and functional textile material for synthesis, study and application of photosensitive nanocapsules - Jose Heriberto O. do Nascimento

Nanostructured multifunctional materials: development of routes for production of Ferromagneto/AlN multilayers - Marcio Assolin Correa

Capture of CO2 to Produce Glycerine Carbonate - Carlos Alberto Paskocimas

Cellulosic Fibers Nanocrystals and Biocomposites - Clovis de Medeiros Bezerra

Nanomaterials

24

NATAL

Thank you