sk-influx

15
Care Specialties SK-influx ® o Ceramides 1+3+6, cholesterol, fatty acids o Phytosphingosine 1 Goldschmidt Personal Care • A skin identical lipid concentrate for an improved skin barrier function • Ideal for dry, sensitive and aging skin • A skin identical lipid concentrate for an improved skin barrier function • Ideal for dry, sensitive and aging skin

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Page 1: SK-influx

Care Specialties

SK-influx®

o Ceramides 1+3+6, cholesterol, fatty acids o Phytosphingosine

1Goldschmidt Personal Care

• A skin identical lipid concentrate

for an improved skin barrier function

• Ideal for dry, sensitive and aging skin

• A skin identical lipid concentrate

for an improved skin barrier function

• Ideal for dry, sensitive and aging skin

Page 2: SK-influx

Care Specialties

The lipid barrier of the Stratum Corneum

Ceramides(40-65% total lipids)

Stratum Corneum:the "Bricks and Mortar" model

OHHN

O

2Goldschmidt Personal Care

Glucoceramides

OH

OHOH

O

HO

OHOH

OH

HN

OH

O

O

OH

cerabrosidase

Ceramides

40%

Cholesterol

30%

Cholesteryl

sulphate

5%Free fatty acids

25%

Page 3: SK-influx

Care Specialties

The formation of the lipid barrier

StratumCorneum

Stratum

Multi-lamellar layer of ceramides and other skin lipids

Keratin Fibers

Stratum corneum

3Goldschmidt Personal Care

StratumBasal

StratumGranulosum

Lamellar bodies Stratum granulosum

Lamellar bodies

Page 4: SK-influx

Care Specialties

Formation of the lipid barrier by the skin

Restoration of the lipid barrier by SK-influx®

SK-influx® mimics the natural formation

of the lipid barrier

Stratum

Applicaton

SK-influx®

4Goldschmidt Personal Care

Stratum

Corneum

Stratum

Granulosum

Page 5: SK-influx

Care Specialties

Why is SK-influx® so efficient ?

Multi lamellar layers

Ceramides in Liquid

Crystalline form

SK-influx®

formulation

5Goldschmidt Personal Care

formulation

Lipid barrier in

the Stratum Corneum

Page 6: SK-influx

Care Specialties

Characteristics of SK-influx®

1.5 % Ceramide complex

- Ceramide I 0.001%

- Ceramide III 0.5%

- Ceramide IIIB 0.5%

- Ceramide VI 0.5%

0.5 % Cholesterol

±3.5 % Free fatty acid

Composition SK-influx®

Lipid concentrate 6.0 %Water q.s.100 %Lactylate 10 %

Carbomer 0.3 %

Xanthan gum 0.3 %Methyl paraben 0.3 %

6Goldschmidt Personal Care

0.5% PhytosphingosineMethyl paraben 0.3 %Propyl paraben 0.2 %

Physical properties• Aqueous system

• Multi lamellar layers

• Liquid Crystalline form

Notes• Ceramides, cholesterol and fatty acids act synergistically

• According to scientific literature, Ceramides 1, 3 and 6 are specifically required to restore damaged and sensitive skin

INCI name:Ceramide 3; Ceramide 6 II; Ceramide 1; Phytosphingosine; Cholesterol; Sodium Lauroyl Lactylate; Carbomer; Xanthan Gum

Page 7: SK-influx

Care Specialties

Designed for instant application

Typical dosages of SK-influx®

Normal skin 1.5 - 5 %Dry / Sensitive skin 3 - 5 %

7Goldschmidt Personal Care

Dry / Sensitive skin 3 - 5 %Aging skin 3 - 5 %

Skin repair / protection 3 - 15 %

• Suitable for a wide range of formulations

• SK-influx should be added to the water phase before the homogenisation step

• Cationic emulsifier systems should be avoided

Page 8: SK-influx

Care Specialties

Uptake of Ceramide by the skinEx-vivo study

25

30

35

SK-influx® increases the bioavailability of Ceramide by more than 38 %, compared to O/W emulsion

SK-influx® increases the bioavailability of Ceramide by more than 38 %, compared to O/W emulsion

lab

ele

d C

era

mid

e V

I

8Goldschmidt Personal Care

0

5

10

15

20

s1+s2 s3+s4 s5+s6 s7+s8 s9+s10

Propyleneglycol/ ethanol

O/W polyglyceryl ester

O/W ethoxylated sorbitan ester

SK-influx like formulation

Tape strip number

Am

ou

nt

of

C14

lab

ele

d C

era

mid

e V

I

3x50 µµµµl of 4 different formulations with 0.5% of C14 labeled Ceramide VI are applied on isolated stratum corneum

Page 9: SK-influx

Care Specialties

Repair of damaged barrier functionEx-vivo study

30

40

50

60

% r

ep

air

Addition of Cholesterol and Free fatty acids to Ceramides will have a synergistic effect

Addition of Cholesterol and Free fatty acids to Ceramides will have a synergistic effect

9Goldschmidt Personal Care

0

10

20

30

Vehicle

(based on

SK-influx)

Vehicle +Ceramide III

(based on

SK-influx)

SK-influx®

% r

ep

air

- Ex-vivo skin treated with acetone

- TEWL measured after 20 hours

will have a synergistic effect on the barrier repair of the skinwill have a synergistic effect on the barrier repair of the skin

Page 10: SK-influx

Care Specialties

Why is Sk-influx essential for aging skin ?

Age

Hands

21 - 30 years31 - 40 years41 - 50 years

Ceramide level

100 %78 %63 %

10Goldschmidt Personal Care

41 - 50 years

Face

21 - 30 years31 - 40 years41 - 50 years

63 %

100 %62 %37 %

N.B. Relative levels of Ceramides 1 through 6 do not change.

Source: A.V. Rawlings et al. in Biocosmetics-Skin aging, IFSCC, vol. I, 31-45 (1993).

Page 11: SK-influx

Care Specialties

Ceramides missing in the skin

Ceramide 1 , Ceramide 3 , Ceramide 6(Motta S et al., Arch. Dermatol. 130, 452 - 456 (1994))

Ceramide 1 , Ceramide 6

Why is Sk-influx essential for dry and sensitive skin conditions ?

Diseases

Psoriasis

Ichthyosis

11Goldschmidt Personal Care

Ceramide 1 , Ceramide 6(Paige DG et al., Proc. Br. Ass. Dermatol. 25 (1993))

Linoleate in Ceramide 1 (Ceramide 1 through 6 )

(Pershho K et al., J. Invest. Dermatol. 90, 350 - 353 (1988))

Ceramide 3 and 6(Di Nardo A et al., Acta Dermatol. Venereol. 78, 27 - 30 (1998))

Ceramide 3(Di Nardo A et al., Contact Dermatitis 35, 86 - 91 (1996))

Ichthyosis

Acne (vulgaris)

Atopic dermatitis

Surfactant-induced

dermatitis

Page 12: SK-influx

Care SpecialtiesClinical evaluation- Multi center studyPart 1

0.5

1

1.5

2

2.5

Overall disease severity

Day 0

Week 4

Week 8

12Goldschmidt Personal Care

0

0.5

Allergic

Contact

Dermatitis

Irritant Contact

Dermatitis

Atopic

Dermatitis

Week 8

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

E. Berardesca et al., Contact Dermatitis, 2001, 45, 280-285. Evaluation of efficacy of a skin lipid mixture

in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study

Page 13: SK-influx

Care Specialties

Clinical evaluation- Multi center studyPart 2

1

1.5

2

2.5

Allergic Contact Dermatitis

Day 0

Week 4

Week 8

1

1.5

2

Irritant Contact Dermatitis

Day 0

Week 4

Week 8

13Goldschmidt Personal Care

0

0.5

1

Dryness Erytheme Fissuring

Week 8

0

0.5

Dryness Erytheme Fissuring

Week 8

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

E. Berardesca et al., Contact Dermatitis, 2001, 45, 280-285. Evaluation of efficacy of a skin lipid mixture

in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study

Desquamation Pruritis Desquamation Pruritis

Page 14: SK-influx

Care Specialties

Clinical evaluation- Multi center studyPart 3

1

1.5

2

Atopic Dermatitis

Day 0

Week 4

Week 8

“Balanced lipid mixtures [Ceramides, cholesterol, fatty

acids] are effective in improving the barrier properties and the

clinical condition of the skin in

“Balanced lipid mixtures [Ceramides, cholesterol, fatty

acids] are effective in improving the barrier properties and the

clinical condition of the skin in

14Goldschmidt Personal Care

0

0.5

Dryness Erytheme Fissuring

Week 8

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

- Number of patients: Allergic Contact Dermatitis = 35, Irritant Contact Dermatitis = 123, Atopic Dermatitis = 24

- Product: W/O vehicle containing Ceramide 3, cholesterol and fatty acids in a nanoparticules technology.

- Application of the product: 1-2 times a day for maximum 8 weeks

- Evaluation of the symptoms: Randomly by dermatologists at day 0, week 4 and week 8

- Nature of the symptoms: Dryness, desquamation, erythema, pruritis, fissuring and overall severity

- Rating scale: 0=none; 1=mild; 2=moderate; 3=severe

clinical condition of the skin in contact dermatitis.”

clinical condition of the skin in contact dermatitis.”

E. Berardesca et al., Contact Dermatitis, 2001, 45, 280-285. Evaluation of efficacy of a skin lipid mixture

in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study

PruritisDesquamation

Page 15: SK-influx

Care Specialties

Advantages SK-influx®

• The best available lipid mix:

– Ceramides 1+3+6, cholesterol, fatty acids

– Phytosphingosine (anti-inflammation and anti-microbial properties)

15Goldschmidt Personal Care

• Resembles the structure of the lipid barrier in the skin

– multi-lamellar

– liquid crystalline

• Designed to allow uptake of Ceramides by the skin

• Ideal for dry, sensitive and aging skin