skin radiance / skin lightening whitening / anti-dark...
TRANSCRIPT
MELANOSTATINEtrade5
FOCUSING ON WHITENING
SKIN RADIANCE SKIN LIGHTENING
ndash WHITENING ANTI-DARK SPOT
bull Mechanism of action
bull Antagonist effect of Melanostatinetrade5 on camp
bull Inhibition of Tyrosinase
bull Inhibition hyper-stimulation of melanin
bull Reversing hyper-pigmentation
bull Lightening improvement in Asian skin
bull Cosmetics properties
bull Features and benefits
bull Applications
bull Formulation
Mechanism of action
a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation
Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R
The stimulation of the tyrosinase activity induces the hydroxylation of the amino
acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone
The final step is the synthesis of melanin in organelles called melanosomes in melanocytes
Mechanism of action
Decreases the melanin
synthesis and blocks the
melanin hyper-production
through the inhibition of the
MC1-R
The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity
Antagonist effect of Melanostatinetrade5 on camp
IC50 of Melanostatinetrade5 is 37nM
Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
bull Mechanism of action
bull Antagonist effect of Melanostatinetrade5 on camp
bull Inhibition of Tyrosinase
bull Inhibition hyper-stimulation of melanin
bull Reversing hyper-pigmentation
bull Lightening improvement in Asian skin
bull Cosmetics properties
bull Features and benefits
bull Applications
bull Formulation
Mechanism of action
a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation
Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R
The stimulation of the tyrosinase activity induces the hydroxylation of the amino
acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone
The final step is the synthesis of melanin in organelles called melanosomes in melanocytes
Mechanism of action
Decreases the melanin
synthesis and blocks the
melanin hyper-production
through the inhibition of the
MC1-R
The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity
Antagonist effect of Melanostatinetrade5 on camp
IC50 of Melanostatinetrade5 is 37nM
Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Mechanism of action
a-MSH is the natural substance produced by our body which is responsible for several physiological activities like pigmentation
Tyrosinase is stimulated by the bonding of a-MSH on its specific receptor MC1-R
The stimulation of the tyrosinase activity induces the hydroxylation of the amino
acid tyrosine to DOPA and catalyses its oxidation to DOPA-quinone
The final step is the synthesis of melanin in organelles called melanosomes in melanocytes
Mechanism of action
Decreases the melanin
synthesis and blocks the
melanin hyper-production
through the inhibition of the
MC1-R
The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity
Antagonist effect of Melanostatinetrade5 on camp
IC50 of Melanostatinetrade5 is 37nM
Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Mechanism of action
Decreases the melanin
synthesis and blocks the
melanin hyper-production
through the inhibition of the
MC1-R
The ideal skin lightening agent for cosmetic products is one that inhibits melanogenesis without cytotoxicity
Antagonist effect of Melanostatinetrade5 on camp
IC50 of Melanostatinetrade5 is 37nM
Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Antagonist effect of Melanostatinetrade5 on camp
IC50 of Melanostatinetrade5 is 37nM
Melanostatinetrade5 antagonizes the signal transduction induced by 10-7M a-MSH
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Inhibition of Tyrosinase
The tyrosinase activity is detected with a Western blot
Tyrosine is labelled by specific anti-tyrosinase monoclonal antibody
Melanostatinetrade5 blocks the melanogenesis pathway and inhibits tyrosinase activity and melanin synthesis
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Melanostatinetrade5 inhibits the synthesis of melanin induced by α-MSH by 33
Inhibiting hyper-stimulation of melanin
The total proteins content + melanin synthesis
were determined by the colorimetric method
Pierce BCA (Bicinchoninic Acid) Protein Assay
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
α-MSH numerous highly DOPA-
positive melanocytes
α-MSH + MELANOSTATINEtrade5 less
DOPA-positive melanocytes
Reversing hyper-pigmentation
These microscope images demonstrate that Melanostatinetrade5 does not interfere with the melanocytersquos functions However when melanocytes are stimulated
Melanostatinetrade5 opposes the hyperproduction of melanin
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Test protocol 50 Asian (female) volunteers applied a whitening cream containing 2 TyrostatTM-11 and 4 Melanostatinetrade5 2xday for 4 weeks
Lightening improvement in Asian skin
With complementary and synergic pathways TyrostatTM-11 and Melanostatinetrade5 reduce sun spots freckles and uneven pigmentation
allowing a lighter and luminous skin tone
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
New concept in the inhibition of Melanogenesis Hyper-Stimulation
Decreases a-MSH induced melanin synthesis
Reduces cutaneous hyper pigmentation
Cosmetic Properties
NEW GENERATION OF CUTANEOUS WHITENER-LIGHTENER
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Features and benefits
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Recommended dosage 4 ndash 8
Potential Applications
Incorporation at the end of the formulation (3540˚C) pH5-7
INCI name Water (and) Dextran (and) Nonapeptide-1
bull Lightening care
bull Whitening
bull Skin tone equalizer
bull Aging spot corrective care
bull Photoaging
bull Ethnic skin care
bull Hand cream
bull Reducing brown spots cream
bull Skin illumination-brilliance (foundation-powder)
Product information
Formulation
Formulation