sodium bicarbonate administration during cardiopulmonary resuscitation

2
f Another Viewpoint: Is Emergency Medicine a Specialty? This letter has been sent to the editor of the Bulletin of the American College of Physicians and is published here for the information of our readers. IN THE NOVEMBER, 1976 issue of the Bulletin of The American College of Physicians (pp 2 and 28), the presi- dent of the American College of Physicians offered an editorial in which he expressed doubts that emergency medicine fulfilled the five ~Criteria of a Primary Spe- cialty Board" as promulgated by the Liaison Committee on Specialty Boards of the American Medical Association (AMA). It is my personal belief that of all the criteria, the most difficult to demonstrate is that emergency medicine ~En- compasses an identifiable body of knowledge which has scientific validity, is generally recognized by the profes- sion, and is not generally possessed by all physicians." Indeed, there seems to be great difficulty among other primary specialists (most of whom are involved from time to time in the care of emergency problems) in appreciat- ing that their involvement is almost always in pre- selected cases involving disease processes IN THEIR OWN SPECIALTY. I am a board certified surgeon who has practiced that specialty since 1962. I have been interested in emergency medicine and have been active in treating emergency problems since that time. Until about April of 1976, I, too, shared the viewpoint that I was as much an emer- gency physician as any of the practitioners who had cho- sen to limit their practices to emergency medicine. De- spite the prodding and urging of my friends in emergency medicine, I remained stiff-necked; I maintained that I could think and function in emergency medicine as well as any of them. In April, 1976 I was ~reborn" in my medical thinking and in my intellectual approach: I began to work as a part-time emergency physician. Almost a year later, I find that I am not yet one of ~them." The stark reality hit me that the last time I personally had faced the onrush- ing mob of undifferentiated patients was in 1957 -- and then for only eight weeks. Since that time, all my emer- gency patients have been culled and selected for me. I have discovered (at considerable damage to my ego) that I neither know it all, remember it all nor can do it all -- especially with the Brobdingnagian advances in health care knowledge, technique, organization and delivery that have occurred in the past 20 years. ~ On New Year's Eve, 1976, I had learned (relearned? recalled?) enough to be able to correctly diagnose and treat such disparate problems as: varicella viremia in a 5-raonth-old; pneumonia with meningitis in a 3-week-old, Editorials an anteroseptal myocardial infarction with shock and ar- rythmia in a 62-year-old, a threatened abortion in a 15- year-old primipara, xiphisternal costochondritis mas- querading as a recurrent pulmonary embolus in a 67- year-old preketotic diabetic woman and methemoglo- binemia in a 58-year-old emphysematous man. These, of course, were interspersed among the usual fractures, shootings, upper respiratory infections and such that are the ~bread and butter" of emergency medical practice. I challenge any of my colleagues in any of the traditional specialities to allow themselves the exercise in critical objectivity to contemplate their own personal abilities, today, without retraining, to deal with problems as far afield as those above. I admit that I do not work unsupervised. I am, rather, virtually a preceptee at the elbows of a group of real emergency physicians -- all younger than I and all con- siderably better at this speciality than I am today. This personal vignette is an humbling self-reassess- ment and reevaluation. I now know that a surgeon (or, at least this surgeon) thinks in a different way and in a different context than does an emergency physician. I am also now convinced that each of us specialists views the world of illness and patients with the biases of our own personalities, training, experiences, collegialities and turf. More especially, I am convinced that the ability and skills necessary to undertake the care of a large body of undifferentiated patients (whose illnesses may well in- volve threat to life and limb in any specialty area), to be able to appropriately triage and prioritize care; to safely and appropriately diagnose and manage the first critical portion of care; and to deliver the patient alive and im- proving to the appropriate specialist in another arena comprises both an identifiable body of knowledge and is no__t generally possessed by other physicians. I hope that the reader will search himself in terms of my experience and conclude with me that there is indeed a speciality called emergency medicine that complements rather than threatens the house of medicine. If one agrees with this premise and recognizes the complexity of the new specialty, it follows that a board in emergency medicine is an important quality control --just as it is in other specialities. Carl Jelenko, III, MD, FACS Professor of Surgery Medical College of Georgia, Augusta Sodium Bicarbonate Administration During Cardiopulmonary Resuscitation ~¢EFFECTS OF SODIUM BICARBONATE Administration during Cardiopulmonary Resuscitation," by White, et al (p 187) brings up a number of subjects for discussion. J ~ P 6:5 (May) 1977 221/65

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Page 1: Sodium bicarbonate administration during cardiopulmonary resuscitation

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Another Viewpoint: Is Emergency Medicine a Specialty?

This letter has been sent to the editor of the Bul le t in of the American College of Physic ians and is published here for the information of our readers.

IN THE NOVEMBER, 1976 issue o f the Bulletin of The American College of Physicians (pp 2 and 28), the presi- dent of the Amer ican College o f Phys ic ians offered an editorial in which he expressed doubts t ha t emergency medicine fulfi l led the five ~Cri ter ia of a P r i m a r y Spe- cialty Board" as p romulga ted by the Liaison Commi t t ee on Specialty Boards of the Amer ican Medical Associa t ion (AMA).

It is my personal bel ief t ha t of a l l the cr i te r ia , the most difficult to demons t ra te is t ha t emergency medic ine ~En- compasses an ident i f iable body of knowledge which has scientific va l id i ty , is genera l ly recognized by the profes- sion, and is not genera l ly possessed by all physic ians ." Indeed, there seems to be g rea t diff iculty among o ther primary specia l is ts (most of whom are involved from t ime to time in the care of emergency problems) in apprec ia t - ing t h a t t h e i r i n v o l v e m e n t is a l m o s t a l w a y s in pre- selected cases invo lv ing d i sease processes IN T H E I R OWN SPECIALTY.

I am a board cert if ied surgeon who has pract iced t h a t specialty since 1962. I have been in te res ted in emergency medicine and have been act ive in t r e a t i n g emergency problems since tha t t ime. Unt i l about Apr i l of 1976, I, too, shared the viewpoint t h a t I was as much an emer- gency phys ic ian as any of the p rac t i t ioners who had cho- sen to l imi t the i r pract ices to emergency medicine. De- spite the prodding and urg ing of my fr iends in emergency medicine, I r ema ined stiff-necked; I m a i n t a i n e d t ha t I could t h ink and function in emergency medic ine as wel l as any of them.

In April , 1976 I was ~reborn" in my medical t h i n k i n g and in my in te l l ec tua l approach: I began to work as a part-t ime emergency physician. Almost a yea r la ter , I find tha t I am not ye t one of ~them." The s t a rk r ea l i t y h i t me that the l as t t ime I persona l ly had faced the onrush- ing mob of undi f fe rent ia ted pa t i en t s was in 1957 - - and then for only e ight weeks. Since t ha t t ime, a l l my emer- gency pa t ien t s have been cul led and selected for me. I have discovered (at considerable damage to my ego) t h a t I nei ther know it all , r e m e m b e r i t al l nor can do i t al l - - especially wi th the Brobd ingnag ian advances in h e a l t h care knowledge, technique , o rgan iza t ion and de l i ve ry that have occurred in the pas t 20 years . ~

On New Year ' s Eve, 1976, I had learned (re learned? recalled?) enough to be able to correct ly diagnose and treat such d i spa ra t e problems as: var ice l la v i r emia in a 5-raonth-old; pneumonia wi th men ing i t i s in a 3-week-old,

Editorials an an te rosep ta l myoca rd ia l infarc t ion with shock and ar- r y t h m i a in a 62-year-old, a t h r e a t e ne d abor t ion in a 15- yea r -o ld p r i m i p a r a , x i p h i s t e r n a l cos tochondr i t i s mas- que rad ing as a r ecu r r en t pu lmona ry embolus in a 67- yea r -o ld p reke to t i c d iabe t i c w o m a n and me themog lo - b inemia in a 58-year-old emphysema tous man. These, of course, were i n t e r s p e r s e d a m o n g the u sua l f r ac tu res , shootings, upper r e sp i r a to ry infections and such t h a t are the ~bread and but te r" of emergency medical pract ice. I chal lenge any of my col leagues in any of the t r ad i t i ona l special i t ies to allow themse lves the exercise in cr i t ica l object ivi ty to con templa te the i r own personal abi l i t ies , today, wi thou t r e t r a in ing , to deal wi th problems as far afield as those above.

I admi t t ha t I do not work unsupervised. I am, ra the r , v i r t ua l ly a preceptee at the elbows of a group of rea l emergency phys ic ians - - a l l younger than I and al l con- s iderab ly be t t e r at th is spec ia l i ty t han I am today.

This persona l v igne t t e is an h u m b l i n g sel f - reassess- ment and reeva lua t ion . I now know tha t a surgeon (or, a t leas t th is surgeon) t h inks in a different way and in a different context t h a n does an emergency physician. I am also now convinced t ha t each of us special is ts views the world of i l lness and pa t i en t s wi th the biases of our own pe r sona l i t i e s , t r a i n i n g , exper iences , co l l eg ia l i t i e s and turf. More especial ly , I am convinced tha t the ab i l i ty and ski l ls necessary to u n d e r t a k e the care of a large body of undi f fe ren t ia ted pa t i en t s (whose i l lnesses m a y well in- volve t h r e a t to life and l imb in any special ty area), to be able to appropr i a t e ly t r i age and pr ior i t ize care; to safely and appropr i a t e ly d iagnose and manage the first cr i t ica l port ion of care; and to de l iver the pa t i en t al ive and im- proving to the appropr ia t e specia l i s t in another a r ena comprises both an ident i f iab le body of knowledge and is no__t genera l ly possessed by o ther physicians.

I hope t ha t the r eade r wil l search h imse l f in t e rms of my experience and conclude wi th me tha t there is indeed a special i ty cal led emergency medicine tha t c o m p l e m e n t s r a t h e r t h a n t h r e a t e n s t h e house of medic ine . I f one agrees wi th th is premise and recognizes the complexi ty of the new special ty, it follows t ha t a board in emergency medicine is an impor t an t qua l i ty control - - j u s t as it is in o ther special i t ies .

Carl Jelenko, III, MD, FACS Professor of Surgery

Medical College of Georgia, Augusta

Sodium Bicarbonate Administration During Cardiopulmonary Resuscitation

~ ¢ E F F E C T S OF SODIUM BICARBONATE A d m i n i s t r a t i o n dur ing Ca rd iopu lmona ry Resusci ta t ion," by Whi te , e t al (p 187) br ings up a n u m b e r of subjects for discussion.

J ~ P 6:5 (May) 1977 221/65

Page 2: Sodium bicarbonate administration during cardiopulmonary resuscitation

Above all, i t points out the impor tance of ind iv idua l iz ing sodium b icarbona te the rapy and d rawing a r t e r i a l blood for gas a n a l y s e s du r ing any r e susc i t a t ion t ha t is not r ap id ly successful.

Our own expe r i ence has shown t h a t the ac id -base changes d u r i n g ca rd iopu lmona ry resusc i t a t ion are ex- t r eme ly varied. Minute vent i la t ion dur ing resusc i ta t ion is gene ra l ly at leas t 11/2 to 2 t imes normal values and produces a PCO2 of 25 to 35 mm Hg in most pa t ients . H o w e v e r , i f t h e p a t i e n t has s e v e r e ch ron i c a i r w a y obst ruct ion or very advanced shock, the PCO2 may be g rea te r t h a n 45 mm Hg. It is also not inf requent under these c i r c u m s t a n c e s t h a t the e n d o t r a c h e a l t ube pro- gresses into the r igh t ma in stem bronchus, reducing ven- t i l a t ion in the left lung. This is not a lways c l in ical ly ap- pa r en t and is 'of ten noted only o n c h e s t x-ray films.

In the Whi te ar t icle , i t is not su rp r i s ing t ha t the PCO2 in al l the pa t i en t s who recovered was less t han 50 mm Hg. In contrast , two of the pa t ien ts who were not successfully re- susc i ta ted had a r t e r i a l PCO2 of 90 and 106 mm Hg. Ideal ly, the a r t e r i a l PCO2 should be in the range of 30 to 40 mm Hg, and i f i t is not, the s ta tus of the pa t i en t ' s ven t i l a t ion should be r e -eva lua ted and corrected accordingly.

The a r t e r i a l PO2 levels in six ins tances were r a t h e r low (less t h a n 60 mm Hg). Dur ing ex t e rna l cardiac mas- sage, when the cardiac output is often 1.0 l i t e r /min or less, the PO2 should be at leas t 100 mm Hg; and much h igher PO2s t ha t require 100% oxygen are probably pref- e r ab l e . H o w e v e r , i f t he m i n u t e v e n t i l a t i o n is much g rea te r t h a n the ra te of oxygen del ivery, the FiO2 will be s igni f icant ly reduced, and if pu lmonary function is se- vere ly impai red , the a r t e r i a l PO2 m a y be very low in spite of al l the physic ian ' s efforts.

The b icarbona te level appears to be la rge ly de te rmined by the pa t i en t s ' p r ior acid-base s ta tus , t h e r ap id i ty wi th which resusc i ta t ion is begun, and the effect iveness of the cardiac massage . Pa t i en t s who are doing re l a t ive ly well and then have a cardiac a r res t in the opera t ing room or in tens ive care uni t (where the d iagnosis is r ap id ly made and effective massage begun a lmost immedia te ly ) tend to have r e l a t ive ly normal b icarbonate levels. On severa l oc- casions we have noted such ind iv idua ls wi th a pH exceed- ing 7.70 up to ten minu tes af ter the f irst two ampules of b icarbonate were given.

In contras t , pa t i en t s who were c r i t i ca l ly ill wi th shock or hepat ic or r ena l fai lure will often develop a pH less than 7.0 and b ica rbona te levels less t h a n 5 mEq/ l i t e r wi th in 2 to 3 minu tes of the cardiac ar res t . The under ly- ing condit ion of the pa t ien t s in the repor t by White , et al is not s ta ted, but since t r a u m a vict ims were excluded, it is l ike ly t h a t they were an older age group wi th signifi- cant under ly ing disease. Fur the rmore , the de lay before resusc i ta t ion was begun and the dura t ion and effective- ness of the resusc i ta t ive maneuvers pr ior to a r r iva l a t the hospi ta l a re also not apparent . In al l l ikelihood, there were at leas t 15 minu tes of resusc i ta t ion pr ior to a r r iva l in the emergency depar tment .

Ano the r factor which must be considered is the type and volume of o ther fluids adminis te red . If large volumes of 0.3 normal sa l ine were given, they could pa r t i a l l y di-

lute out the sodium ions, b ica rbona te ions, and osmolar. i ty changes t h a t might occur wi th sodium bicarbonat~ a d m i n i s t r a t i o n . I f the u n d e r l y i n g p r o b l e m was a~t t r a u m a or h e m o r r h a g e , i t is u n l i k e l y t h a t excessivs quant i t i es of fluid were given. In some pa t ien ts with rel. a t ive ly good rena l function, some (but probably not a large amount ) of the sodium and osmola r load might have been excreted.

I found the high glucose levels (which were greater t han 300 rag/100 ml in 12 of the 17 pat ients) somewhat dis turbing. The r e su l t ing hyperosmola l i ty , par t icular ly if g rea te r t han 350 mOsm/kg, may have a signif icant del. e ter ious effect. Fu r the rmore , if the sodium concentra. t ions were corrected upward by 1.6 mEq/ l i te r for each 100 mg/100 ml t ha t the glucose levels were above normal, the sodium levels would be 150 mEq/ l i t e r or h igher in 8 of the 17 pa t ien ts . The exact causes of the high glucose levels are not clear. However, as the authors mention, mul t ip le endocrine factors tend to cause hyperglycemia and added glucose may severe ly aggrava te the situation.

Ser ia l a r t e r i a l blood gases should probably be drawn, preferably th rough an a r t e r i a l ca the ter , every ten rain. utes dur ing a resusci ta t ion t ha t is not rap id ly successful. An a r t e r i a l ca the t e r is very helpful ~n obta in ing serial samples and prevents the i nadve r t en t d rawing of venous s a m p l e s t h a t o c c a s i o n a l l y occurs w i th percutaneous needle aspi ra t ions . Al though it may t ake 10 to 15 rain, utes or longer to obta in a full blood gas report, it usually only t akes a minu te or two to get a pH, which in itself can be ex t r eme ly helpful. A high pH (par t icular ly above 7.55) i n d i c a t e s t h a t b i c a r b o n a t e is not immedia te ly needed and t ha t the minu te ven t i l a t ion should be re. duced somewhat . A low pH (par t i cu la r ly below 7.20) is probably due to a low bicarbonate , due to poor t issue per- fusion. Under such c i rcumstances , b icarbonate can be giv- en. Efforts to ra ise the pH by inc reas ing vent i la t ion may occasional ly be war ran ted . However , if the a r te r ia l PC02= is pushed below 25 mm Hg, th is may interfere with cere- bral c irculat ion.

Another advan tage of an i n t r a - a r t e r i a l ca the te r is that it can be then hooked up to a blood pressure recorder, The effectiveness of cardiac massage can be evaluated much more accura te ly than by pa lpa t ion of pulses. We have f requent ly found tha t the systolic pressure produced by ex te rna l cardiac massage was less than 60 mm I-Ig. When the phys ic ians were informed of the fact, they al- most inva r i ab ly were able to rap id ly adjust the i r efforts to produce a systolic blood pressure of 80 to 100 mm Hg or higher.

In summary , I bel ieve t ha t the use of sodium bicarbo- na te dur ing ca rd iopu lmonary resusc i ta t ion must be indi- vidualized. The cur ren t fo rmula should serve only as a rough guide. Ar t e r i a l blood gases should probably be ob- ta ined at leas t every ten minu tes dur ing any resuscita" t ive effort not rap id ly successful.

Robert F. Wilson, MD

(Dr. Wilson is Professor of Surgery and Director of Tho" racic and Cardiovascular Surgery at Wayne State U hi° versity School of Medicine, Detroit, Michigan.)

661222 B:5 (May) 1977 , ,~P