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Soluble amyloid Soluble amyloid --proteinprotein

dimers isolateddimers isolatedfrom Alzheimer cortex directlyfrom Alzheimer cortex directly

induce Tauinduce Tau

hyperphosphorylation andhyperphosphorylation andneuritic degenerationneuritic degeneration

Ming Jin, Nina Shepardson, Ting Yang, Gang Chen1,Dominic Walsh, and Dennis J. Selkoe2PNAS | April 5, 2011 | vol. 108 | no. 14 | 58195824

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