som 2012 rcprc research report final 20130308 · 2012 research report regional clinical practice...

School of Medicine Faculty of Health Sciences

2012 RESEARCH REPORT

Regional Clinical Practice Research Centre 2012 Research March 2013

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MESSAGE FROM THE DIRECTOR OF THE CENTRE ....................................................................... - 4 -

CENTRE MEMBERSHIP.............................................................................................................. - 5 - PROFESSIONAL, ACADEMIC AND HONORARY STAFF................................................................................... - 5 -

RESEARCH GRANTS AND CONTRACTS ..................................................................................... - 10 - COMPETITIVE FUNDING...................................................................................................................... - 10 -

RESEARCH PUBLICATIONS ...................................................................................................... - 12 - PEER REVIEWED PUBLICATIONS ........................................................................................................... - 12 -

APPROVED RESEARCH............................................................................................................ - 20 -

AWARDS AND PRIZES............................................................................................................. - 45 -

COMMUNITY AND PROFESSIONAL ACTIVITIES ........................................................................ - 46 -

MAJOR PARTNERS AND LINKAGES.......................................................................................... - 47 -

CONTACT DETAILS.................................................................................................................. - 48 -

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Regional Clinical Practice Research Centre Message from the Director of the Centre

2012 saw the finalisation of plans for the $2.255M HWA funded Nambour Academic and Research Centre (NARC). Upon the completion of the NARC in mid 2013 the Regional Clinical Practice Research Centre will share space with the Sunshine Coast Hospital & Health Service Research Office, the University of the Sunshine Coast and the Sunshine Coast Clinical School.

In 2012 the Research Board and Health Service restructured the Clinical Trials team and processes. Combined with the opening of the NARC, this will enable an increase in clinical trials and conduct of original clinical research studies. The Centre experienced a significant increase in research activity throughout 2012 which is evidenced by the below snapshot.

Activity 2011 Total 2012 Total Approved Grants $39,000 $110,000 (approx) Approved Research 40 projects 113 projects Publications 25 67

Associate Professor Steve Coverdale Acting Director, Regional Clinical Practice Research Centre

Architects impression – Nambour Academic and Research Centre

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Centre Membership

Professional, Academic and Honorary Staff

Title First Name Last Name UQ Appointment and Level , showing

School/Institute Hospital Appointment

Prof Dario SORRENTINO Conjoint - Professor School of Medicine, Sunshine Coast Clinical School

Sunshine Coast Health Service District - Nambour General Hospital

A/Prof Steven COVERDALE Conjoint - Associate Professor School of Medicine, Sunshine Coast Clinical School


A/Prof Geoffrey HAWSON Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School


A/Prof Peter T NASH Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School


A/Prof Johan VAN DEN BOGAERDE Academic Title-Associate Professor School of Medicine, Sunshine Coast Clinical School


A/Prof Edward WEAVER Conjoint - Associate Professor School of Medicine, Sunshine Coast Clinical School


Dr Aymen AL-TIMIMI Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Chris ANSTEY Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Lovell ASEERVATHAM Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Jennifer BROOM Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Victoria CAMPBELL Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Christopher H CANTOR Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

Private Practice Psychiatry

Dr James CHALLEN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Anthony CHAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Keat CHOONG Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Carolyn CLARK Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr James CRAIG Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


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Title First Name Last Name UQ Appointment and Level , showing School/Institute

Hospital Appointment

Dr Michelle CRONK Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Simon DUPRE Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Roger FAINT Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

General Practice Buderim Marketplace Medical Centre

Dr Gordon FAULDS Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Christine FAWCETT Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Peter GARRETT Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Nicholas GRAY Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Nanu GREWAL Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr David A GRIEVE Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Rohan GRIMLEY Conjoint - Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Pamela HUDSON-JESSOP Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Mark JOHNSON Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Clara I J JONSSON Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Mark D LANDY Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Peter LARSEN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Chris LAWSON Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

General Practice – Discipline Supervisor

Dr Christopher W LILLEY Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Jason LINDEMAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Jeremy E H LONG Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Kumaradevan MAHADEVAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


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Dr Matthew C MARRINAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Craig MASKIELL Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Tim MCNAMARA Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Roger M J MORRIS Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

General Practice Medicine on 2nd

Dr Glynn MOSELEY Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

General Practice Nambour Clinic

Dr Ian W MOTTARELLY Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Timothy R NATHAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Kenneth NG Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr David W NICHOLLS Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School

Private Practice Rheumatology

Dr Stella ROWLANDS Adjunct Appointment – Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Michael J SCHOEMAN Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Carl B SCOTT Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Dawid SMALBERGER Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Robyn M TAIKATO Academic Title-Senior Lecturer - School of Medicine, Sunshine Coast Clinical School


Dr James TUNGGAL Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Yusuke UENO-DEWHIRST Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Anne-Marie WELSH Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Helen WESTON Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Alexander WILLSON Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Joseph C H WONG Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


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Dr Drasko ZEMBIC Academic Title-Senior Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Matthew AMODEO Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Raguraman JANAKIRAMAN Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Vikram A MASURKAR Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Debra J TELLAM Academic Title - Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Prathmesh CONTRACTOR Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Brunhilde DAVIS Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Thushara DISSANAYAKE Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Elise GILBERTSON Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Anita HARRIS Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Rose IRON Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Leon KITIPORNCHAI Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Lidia KOVAL Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Kelvin LARWOOD Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Kim LATENDRESSE Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Julie LEE Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Matthew LEE-ARCHER Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Ashish K PANIGRAHI Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Haseeb A QURESHI Academic Title - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Jonathan ROBERTSON Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


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Dr Euan ROBINSON Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Timothy J SMITH Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Deepak L VARDESH Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Dr Antony J WINKEL Registrar - Associate Lecturer School of Medicine, Sunshine Coast Clinical School


Mr Robert PENFOLD Industry Fellow - Clinical Librarian School of Medicine, Sunshine Coast Clinical School


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Research Grants and Contracts

Competitive Funding

Years of funding

Total funding ($)

Amount ($) received in 2012

Grant title Granting agency / scheme Names of chief investigators UQ Admin Unit

2 $64,000 $34,500

Human Microbial gene expression in early Crohn’s disease: clues to aetiology and pathogenesis

Wishlist (Sunshine Coast) Prof Dario Sorrentino University of Queensland

1 $21,764 Approved in 2012

The evaluation of midkine levels in patients with kidney disease: a pilot study

Wishlist (Sunshine Coast) Dr Victoria Campbell Dr Nicholas Gray

N/A

1 $15,600 Approved in 2012

Telephone versus office outpatient trial

Wishlist (Sunshine Coast) Dr Nicholas Gray N/A

2 $13,837 Approved in 2012

Is teaching clinical documentation on the job adequately supporting the delivery of clinical care in 2013

Wishlist (Sunshine Coast) Associate Professor Steven Coverdale Dr Stella Rowlands

N/A

1 $10,000 Approved in 2012

Prevalence of IgE to galactose-a 1,3 galactose in patients with metastatic colorectal cancer in the Sunshine Coast Health Service District

Wishlist (Sunshine Coast) Dr Jeremy Long N/A

1 $5,000 Approved in 2012

Step Forward Program: Improving efficiency of care

Wishlist (Sunshine Coast) Dr Christine Fawcett N/A

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Years of funding

Total funding ($)

Amount ($) received in 2012

Grant title Granting agency / scheme Names of chief investigators UQ Admin Unit


Clinical handover is a vital aspect of continuity of patient care. Much of the focus of recent research has explored communication practices between nursing and medical staff at the change of shift. This project aims to establish the evidence base for delineating components of the clinical handover during preparation and transfer of a patient to the operative environment.

Wishlist (Sunshine Coast) Ms Suzanne Ryan Dr David Grieve

N/A


Predictors of end-stage kidney disease and mortality among patients referred to nephrology outpatient clinics

Wishlist (Sunshine Coast) Dr Christine Sammartino Dr Nicholas Gray

N/A

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Research Publications

Peer Reviewed Publications

Journal (peer reviewed)

A case of bilateral lower cranial nerve palsies after base of skull trauma With complex management issues case report and review of the literature. Lehn, Alexander Christoph, Lettieri, Jennie and Grimley, Rohan Neurologist (2012), 18 3: 152-154.

A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits. Ma, Henry, Parsons, Mark W., Christensen, Soren, Campbell, Bruce C. V., Churilov, Leonid, Connelly, Alan, Yan, Bernard, Bladin, Chris, Phan, Than, Barber, Alan P., Read, Stephen, Hankey, Graeme J., Markus, Romesh, Wijeratne, Tissa, Grimley, R., Mahant, N., Kleinig, Tim, Sturm, John, Lee, A., Blacker, D., Gerraty, Richard, Krause, M., Desmond, P. M., McBride, S. J., Carey, Leanne, Howells, David W., Hsu, C. Y., Davis, Stephen M. and Donnan, Geoffrey A. International Journal of Stroke (2012), 7 1: 74-80.

A randomised controlled trial of Heparin versus EthAnol Lock THerapY for the prevention of Catheter Associated infecTion in Haemodialysis patients – the HEALTHY-CATH trial. Jennifer K Broom, Rathika Krishnasamy, Carmel M Hawley, E Geoffrey Playford and David W Johnson. BMC Nephrology 2012 Nov 2;13:146.

Anti-TNFs for prevention of postoperative recurrence of Crohn's disease: A broken record?. Sorrentino, Dario Inflammatory Bowel Diseases (2012), 18 9: 1624-1625.

Atypical fractures associated with bisphosphonate use post renal transplantation. Burke MT, Hollett PR, Gray NA. Nephrology 2012; 17 (Supp 1): 1-4

Bringing top end endoscopy to regional Australia: hurdles and benefits. Van den Bogaerde J., Sorrentino D. Diagn Ther Endosc. 2012;2012:347202

Carcinoid tumour management in haemodialysis: a case report. Burke MT, Gray NA. Nephrology 2012; 17(2): 198

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Clinical remission after stopping infliximab in Crohn's Disease: Is all that glitters true gold?. Sorrentino, Dario and Radford-Smith, Graham Gastroenterology (2012), 142 5: E17-E17.

Coccidioidomycosis in returned immunocompetent Australian Travellers. Subedi Shradha, Broom Jennifer, Sowden David, Bint Michael and Caffery Michael. Internal Medicine Journal. 2012 Aug;42(8):940-3

Computed tomography-based sizing recommendations for transcatheter aortic valve replacement with balloon-expandable valves: Comparison with transesophageal echocardiography and rationale for implementation in a prospective trial Willson, Alexander B.; Webb, John G.; Freeman, Melanie; et al. Journal of Cardiovascular Computed Tomography Volume: 6 Issue: 6 Pages: 406-414 Published: NOV-DEC 2012

Dialysis in public and private hospitals in Queensland. Gray NA, Dent H, McDonald SP. Internal Medicine Journal 2012; 42(8): 887-893

Early diagnosis and treatment of postoperative endoscopic recurrence of Crohn's disease: partial benefit by infliximab--a pilot study. Sorrentino D, Terrosu G, Paviotti A, Geraci M, Avellini C, Zoli G, Fries W, Danese S, Occhipinti P, Croatto T, Zarifi D. Dig Dis Sci. 2012 May;57(5):1341-8

Impact of tactile dysfunction on upper-limb motor performance in children with unilateral cerebral palsy. Auld, Megan, Boyd, Roslyn, Moseley, G. Lorimer, Ware, Robert S. and Johnston, Leanne M. Archives of Physical Medicine And Rehabilitation (2012), 93 4: 696-702.

Immunogenicity, safety and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: Results from accompany, a phase III study. Nash P, Nayiager S, Genovese MC, Kivitz AJ, Oelke K, Ludivico C, Palmer W, Rodriguez C, Delaet I, Elegbe A, Corbo M. Arthritis Care Res (Hoboken). 2012 Oct 24. doi: 10.1002/acr.21876. [Epub ahead of print]

Intensive Enough?. Campbell, Victoria New England Journal of Medicine (2012), 366 22: 2124-2125.

Living donor registries are needed. Sammartino C, Clark C, Gray N. BMJ 2012; 344: e2727

Long Term Survival in HIV positive patients with up to 15 years of Antiretroviral Therapy. McManus H, O’Connor CC, Boyd M, Broom J, Russell D, Watson K, Roth N, Read PJ, Petoumenos K, Law M on Behalf of the Australian HIV Observational Database (AHOD) PLoS One. 2012;7(11)

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Moving from Viral Suppression to Comprehensive Patient-Centered Care: The High Prevalence of Comorbid Conditions and Health Risk Factors in HIV-1-Infected Patients in Australia. Broom J, Sowden, D, Williams M, Taing K, Morwood K, and McGill K. J Int Assoc Physicians AIDS Care (Chic). 2012 Mar-Apr;11(2):109-14.

Mucosal healing and clinical remission in inflammatory bowel diseases: Are we missing something here? Sorrentino D. Inflamm Bowel Dis. 2012 Apr 19 doi: 10.1002/ibd.22999.

N-terminal pro-brain natriuretic peptide in a novel screening algorithm for pulmonary arterial hypertension in systemic sclerosis: a case-control study. Thakkar V, Stevens WM, Prior D, Moore OA, Byron J, Liew D, Patterson K, Hissaria P, Roddy J, Zochling J, Sahhar J, Nash P, Tymms K, Celermajer D, Gabbay E, Youssef P, Proudman SM, Nikpour M. Arthritis Res Ther. 2012 Jun 12;14(3):R143. doi: 10.1186/ar3876.

Percutaneous Aortic Valve Replacement Toggweiler, Stefan; Gurvitch, Ronen; Leipsic, Jonathon; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 59 Issue: 2 Pages: 113-118 Published: JAN 10 2012

Predictive value according to location of incidental focal colorectal fluorodeoxyglucose uptake on positron emission tomography scans. Lee, J. C., Hartnett, G. F. and Ravi Kumar, A. S. Colorectal Disease (2012), 14 5: 642-643.

Prevalence, correlates and clinical usefulness of antibodies to RNA polymerase III in systemic sclerosis: a cross-sectional analysis of data from an Australian cohort. Nikpour M, Hissaria P, Byron J, Sahhar J, Micallef M, Paspaliaris W, Roddy J, Nash P, Sturgess A, Proudman S, Stevens W Arthritis Res Ther. 2011;13(6):R211. doi: 10.1186/ar3544. Epub 2011 Dec 22.

Renal replacement therapy in rural and urban Australia. Gray NA, Dent H, McDonald SP. Nephrol Dial Transplant 2012; 27(5): 2069-2076

Recommendations for the treatment of Crohn's disease with tumor necrosis factor antagonists: An expert consensus report. Feagan, Brian G., Lemann, Marc, Befrits, Ragnar, Connell, William, D'Haens, Geert, Ghosh, Subrata, Michetti, Pierre, Ochsenkuhn, Thomas, Panaccione, Remo, Schreiber, Stefan, Silverberg, Mark, Sorrentino, Dario, van der Woude, C. Janneke, Vermeire, Severine and Rutgeerts, Paul Inflammatory Bowel Diseases (2012), 18 1: 152-160.

Recommendations for the treatment of ulcerative colitis with infliximab: A gastroenterology expert group consensus. Reinisch, Walter, Van Assche, Gert, Befrits, Ragnar, Connell, William, D'Haens, Geert, Ghosh, Subrata, Michetti, Pierre, Ochsenkuhn, Thomas, Panaccione, Remo, Schreiber, Stefan, Silverberg, Mark S., Sorrentino, Dario, van der Woude, Janneke, Vermeire, Séverine and Panes, Julian Journal of Crohns and Colitis (2012), 6 2: 248-258.

Reproducibility of tactile assessments for children with unilateral cerebral palsy. Auld, Megan Louise, Ware, Robert S., Boyd, Roslyn Nancy, Moseley, G.Lorimer and Johnston, Leanne Marie Physical and Occupational Therapy in Paediatrics (2012), 32 2: 151-166.

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Sex Differences in Mortality After Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis Humphries, Karin H.; Toggweiler, Stefan; Rodes-Cabau, Josep; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 60 Issue: 10 Pages: 882-886 Published: SEP 4 2012

Structural Integrity of Balloon-Expandable Stents After Transcatheter Aortic Valve Replacement Assessment by Multidetector Computed Tomography Willson, Alexander B.; Webb, John G.; Gurvitch, Ronen; et al. Jacc-Cardiovascular Interventions Volume: 5 Issue: 5 Pages: 525-532 Published: MAY 2012

Tactile function in children with unilateral cerebral palsy compared to typically developing children. Auld, Megan Louise, Boyd, Roslyn, Moseley, G. Lorimer, Ware, Robert and Johnston, Leanne Marie Disability and Rehabilitation (2012), 34 17: 1488-1494.

The development of candidate composite disease activity and responder indices for psoriatic arthritis. Helliwell, P.S., FitzGerald, O., Fransen, J., Gladman, D.D., Kreuger, G.G., Callis-Duffin, K., McHugh, N., Mease, P.J., Strand, V., Waxman, R., Azevedo, V.F., Ostos, A.B., Carneiro, S, Cauli, A., Espinoza, L.R., Flynn, J.A., Hassan, N., Healy, P., Kerzberg, E.M., Lee, Y.J., Lubrano, E., Marchesoni, A., Marzo-Ortega, H., Porru, G., Moreta, E.G., Nash, P., Raffayova, H., Ranza, R., Raychaudhuri, S.P., Roussou, E., Scarpa, R., Song, Y., Soriano, E., Tak, P.P., Ujfalussy, I., de Vlam, K. and Walsh, J.A. (2012) Annals of the Rheumatic Diseases, in press

The race for mainstream gastrointestinal endoscopy: frontrunners. Seltenreich, H., Van den Bogaerde, J. and Sorrentino, D. Expert Review of Gastroenterology and Hepatology (2012), 6 4: 467-479.

The role of magnetic resonance imaging in detecting intestinal fibrosis in Crohn's disease. Fiorino, Gionata, Cesarini, Monica, Malesci, Alberto, Danese, Silvio and Sorrentino, Dario Current Drug Targets (2012), 13 10: 1273-1279.

The use of Key Performance Indicators to benchmark individual clinic performance in the management of a complex chronic infectious disease. Kelly M, Broom J, Young S. Med J Aust. 2012 Sep 17;197(6):330-1

Tofacitinib or adalimumab versus placebo in rheumatoid arthritis. van Vollenhoven RF, Fleischmann R, Cohen S, Lee EB, GarcÃa Meijide JA, Wagner S, Forejtova S, Zwillich SH, Gruben D, Koncz T, Wallenstein GV, Krishnaswami S, Bradley JD, Wilkinson B; ORAL Standard Investigators (Peter Nash) N Engl J Med. 2012 Aug 9;367(6):508-19. doi: 10.1056/NEJMoa1112072.

Transcatheter Aortic Valve Replacement Outcomes of Patients With Moderate or Severe Mitral Regurgitation Toggweiler, Stefan; Boone, Robert H.; Rodes-Cabau, Josep; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 59 Issue: 23 Pages: 2068-2074 Published: JUN 5 2012

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Transcatheter Aortic Valve Replacement With the St. Jude Medical Portico Valve First-in-Human Experience Willson, Alexander B.; Rodes-Cabau, Josep; Wood, David A.; et al. Journal of the American College of Cardiology Volume: 60 Issue: 7 Pages: 581-586 Published: AUG 14 2012

Transcatheter Valve-In-Valve Implantation for Failed Balloon-Expandable Transcatheter Aortic Valves Toggweiler, Stefan; Wood, David A.; Rodes-Cabau, Josep; et al. (Alexander Willson) Jacc-Cardiovascular Interventions Volume: 5 Issue: 5 Pages: 571-577 Published: MAY 2012

Book chapter

Anti-TNF’s for prevention of postoperative recurrence of Crohn’s disease: The state of the art. Sorrentino D. Buckton S. From: Medrano Acevedo AD and Fajardo Gaitan M. Editors: Infliximab: Pharmacology, Uses and Limitations. Nova Science Publishers, Inc., Hauppauge, NY, USA 2012 pp 135-150.

Diagnosis and assessment of Crohn’s disease. Hilton D, Marr K, Sandford A, Van den Bogaerde J. Sorrentino D. From: LeBlanc, J.G., de Moreno de LeBlanc, A. Editors: Crohn’s Disease: Etiology, Diagnosis and Treatment Options, Nova Science Publishers, Inc., Hauppauge, NY, USA 2012 pp 39-57

Innovative Uses and Emerging Technologies in Endoscopy. Van den Bogaerde J., Sorrentino D. From Endoscopy / Book 2", ISBN 980-953-307-457-8. Open Science Publisher 2012

Published abstract

Analysis of plasma biomarkers potentially associated with antiangiogenic resistance in NCIC CTG/AGITG CO.20: A phase III randomized trial of cetuximab (CET) plus either brivanib alaninate (BRIV) or placebo in patients (pts) with chemotherapy refractory, k-RAS wild-type (WT), metastatic colorectal carcinoma (mCRC). Jeremy David Shapiro, Lillian L. Siu, Christopher J O'Callaghan, John Raymond Zalcberg, Malcolm J. Moore, Timothy Jay Price, Catherine Doyle, John Simes, Brian Peter Findlay, Michelle F. Cronk, Asif Shaikh, Warren Lance Joubert, Benoit Samson, Antonino Bonaventura, Craig Underhill, David Wyld, Ian B. Walters, Penny Phillips, Dongsheng Tu, Derek J. Jonker, and NCIC CTG AND AGITG Journal of Clinical Oncology, 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 30, No 15_suppl (May 20 Supplement), 2012: TPS4137

Anti-glomerular basement membrane disease occurring during pregnancy. O’Shea S, Francis R, Sammartino C, Ratanjee S, Gray N. Nephrology 2012; 17(Sup 2): A44

Does prescribed and delivered haemodialysis treatment time differ? Noble E, Sullivan M, Gray NA. Nephrology 2012; 17(Sup 2): A41

FIRST-IN-MAN TRANSFEMORAL TRANSCATHETER AORTIC VALVE REPLACEMENT WITH THE 29MM EDWARDS SAPIEN XT VALVE Freeman, M.; Rodes-Cabau, J.; Alcazar, M. Urena; et al. (Alexander Willson) Canadian Journal of Cardiology Volume: 28 Issue: 5 Pages: S252-S253 Published: SEP-OCT 2012

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PAN1: A randomized phase II study evaluating potential predictive biomarkers in the treatment of metastatic pancreatic cancer. Yu Jo Chua, Christos Stelios Karapetis, Craig Underhill, Louise M. Nott, David Goldstein, Michelle F. Cronk, Val Gebski, Nicole Wong, Katrin Marie Sjoquist, Andrew Victor Biankin and Australasian Gastrointestinal Trials Group (AGITG) Journal of Clinical Oncology, 2012 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 30, No 15_suppl (May 20 Supplement), 2012: TPS4137

Patient information about options for treatment (PINOT) follow up study: answering important questions in home dialysis and conservative care. Morton R, Connolly M, Snelling P, Gray N, Webster A, Howard K, McGeechan K, Kerr P. Nephrology 2012; 17(Sup 2): A99

Peritoneal dialysis in rural Australia. Gray NA, Grace B, McDonald SP. Nephrology 2012; 17(Sup 2): A136

Safety profile of subcutaneous abatacept focusing On clinically relevant events in patients with rheumatoid arthritis and up to 4.5 years of exposure Alten, Rieke, Kaine, Jeffrey L., Keystone, Edward, Nash, Peter T., Delaet, Ingrid, Qi, Keqin and Genovese, Mark C. In: Rheumatology 2012 Abstracts: Poster Viewing II. Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (127-128). 1 - 3 May 2012

THREE-DIMENSIONAL AORTIC ANNULAR ASSESSMENT BY MULTIDETECTOR COMPUTED TOMOGRAPHY PREDICTS MODERATE OR SEVERE PARAVALVULAR REGURGITATION AFTER TRANSCATHETER AORTIC VALVE REPLACEMENT: A MULTICENTER RETROSPECTIVE ANALYSIS Willson, Alex; Webb, John; LaBounty, Troy; et al. Journal of the American College of Cardiology Volume: 59 Issue: 13 Pages: E325-E325 Published: MAR 27 2012

Transcatheter Aortic Valve Replacement with a New Self-expanding Percutaneous Heart Valve and Motorized Delivery System Binder, Ronald; Schaefer, Ulrich; Kuck, Karl-Heinz; et al. (Alexander Willson) Journal of the American College of Cardiology Volume: 60 Issue: 17 Pages: B233-B233 Published: OCT 23 2012

Conference Paper (peer reviewed)

A Longitudinal Study of Prognostic Factors in Patients with Early RA Providing Direction for Future Clinical Treatment- Predict Study. Bird P, Nicholls D, de Jager J, Griffiths H, Roberts L, Tymms K, Zochling J, Arnold M, Littlejohn G. In: ACR/ARHP Annual Meeting (2012) Washington, D.C., November 9-14, 2012

A retrospective chart review of Mabthera (rituximab) for rheumatoid arthritis in Australian rheumatology practice. Nicholls, D. Australian Rheumatology Association Annual Scientific Meeting Canberra 2012 – Clinical Free Paper

A survey study of methotrexate use by rheumatologists and their patients with rheumatoid arthritis. Nash, Peter and Nicholls, Dave In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting (2012). Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S670-S670). 9-14 November 2012.

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Australian psoriasis treatment goals project. Foley, P., Baker, C., Cooper, A., Chan, J., Fischer, G., Soyer, H. P., Shumack, S., Sidhu, S., Wu, J., Nash, P., Rawlin, M. and Radulski, B. In: The Australasian College of Dermatologists 45th Annual Scientific Meeting (2012). The Australasian College of Dermatologists 45th Annual Scientific Meeting, Brisbane, Australia, (18-19). 20-23 May 2012.

DAS in Australian RA patients inversely relates to socioeconomic status. Arnold M, Franklyn K, Scott J, Bird P, de Jager J, Griffiths H, Littlejohn G, Nicholls D, Roberts L, Tymms K, Zochling J. In: Australian Rheumatology Association Annual Scientific Meeting Canberra 2012

Efficacy, safety and pharmacokinetics of subcutaneous abatacept in patients with rheumatoid arthritis, with or without an intravenous loading dose. Nash, Peter T., Ludivico, Charles L., Delaet, Ingrid, Qi, Keqin, Murthy, Bindu, Corbo, Michael and Kaine, Jeffrey L. In: Rheumatology 2012 Abstracts (2012). Annual Meeting of the British-Society-for-Rheumatology, Glasgow Scotland, (iii133-iii134). May 1-3 2012.

Efficacy, safety and pharmacokinetics of subcutaneous abatacept in patients with rheumatoid arthritis, with or without an intravenous loading dose. Nash, P., Ludivico, C., Delaet, I., Qi, K., Murthy, B., Corbo, M. and Kaine, J. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). Australian Rheumatology Association in Conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia, (12-12). 12-15 May 2012.

Impact of etanercept-methotrexate therapy on patient-reported outcomes in moderately active rheumatoid arthritis: Australian results from the induction period of preserve trial. Nash, P., Hall, S., Bird, P., Bananis, E., Koenig, A., Szumski, A., Jones, H., Kotak, S., Witcombe, D. and Thirunavukkarasu, K. In: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, ACT, Australia, (12-13). 12-15 May 2012.

Long-term safety of tocilizumab in rheumatoid arthritis clinical trials. Taylor, A., Nash, P., Hall, S., Jones, G., Youssef, P., Porter-Brown, B., Thompson, L. and Genovese, M. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (14-14). 12-15 May 2012.

Matrix: Mapping Australian Treatment Reality Involving Methotrexate (mtx), a Survey Study of Rheumatologists and Their Patients with Rheumatoid Arthritis (ra). Nash, P. and Nicholls, D. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (13-13). 12-15 May 2012.

Medication Choices and Medication Survival in a National Multi-centre Community Based Rheumatoid Arthritis Cohort Roberts L, Tymms K, de Jager J, Littlejohn G, Griffiths H, Nicholls D, Bird P, Hill J, McCloud P, Scott J, Zochling J, on behalf of the OPAL consortium. In: 2012 ACR/ARHP Annual Meeting, Washington, D.C., November 9-14, 2012

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Patient information about options for treatment (PINOT) follow up study: answering important questions in home dialysis and conservative care. Morton, R., Connolly, M., Snelling, P., Gray, N., Webster, A., Howard, K., McGeechan, K. and Kerr, P. In: Special Issue: Abstracts of the 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology (2012). 48th Annual Scientific Meeting of the Australian and New Zealand Society of Nephrology, Auckland, (53-53). 27-29 August 2012.

Prolonged exposure to subcutaneous and intravenous abatacept in patients with rheumatoid arthritis does not affect rates of infection, malignancy and autoimmune events: results from pooled clinical trial data. Genovese, M. C., Hochberg, M. C., Cohen, R. B., Weinblatt, M. E., Kaine, J., Keystone, E., Nash, P., Delaet, I. and Alten, R. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals (2012), Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S725-S725). 9-14 November 2012.

Subcutaneous abatacept: long-term data from the Acquire Trial. Genovese, M. C., Pacheco-Tena, C., Covarrubias, A., Leon, G., Mysler, E., Keiserman, M., Valente, R., Nash, P., Simon-Campos, J. A., Box, J., Legerton, C., III, Nasonov, E., Durez, P., Delaet, I. and Alten, R. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting (2012). Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S201-S201). 9-14 November 2012.

Subcutaneous abatacept versus intravenous abatacept in patients with rheumatoid arthritis: Long-term data from the acquire trial. Genovese, Mark C., Cobos, Arturo, Leon, Gustavo, Mysler, Eduardo F., Keiserman, Mauro W., Valente, Robert M., Nash, Peter T., Campos, J. Abraham Simon, Porawska, Wiewlsawa, Box, Jane H., Legerton, Clarence W., Nasonov, Evgeny L., Durez, Patrick, Pappu, Ramesh, Delaet, Ingrid, Teng, Julie and Alten, Rieke In: Rheumatology 2012 Abstracts: Poster Viewing II. Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (128-129). 1 - 3 May 2012.

Safety profile of subcutaneous abatacept focusing On clinically relevant events in patients with rheumatoid arthritis and up to 4.5 years of exposure. Alten, Rieke, Kaine, Jeffrey L., Keystone, Edward, Nash, Peter T., Delaet, Ingrid, Qi, Keqin and Genovese, Mark C. In: Rheumatology 2012 Abstracts: Poster Viewing II (2012). Annual Meeting of the British-Society-for-Rheumatology, Glasgow, Scotland, (127-128). 1 - 3 May 2012.

Tofacitinib (cp-690,550), an oral Janus Kinase Inhibitor: Pooled phase 3 analysis in an Australian Rheumatoid Arthritis Study Population. Hall, S., Nash, P., Rischmueller, M., Bossingham, D., Cook, N., Kwok, K. and Thirunavukkarasu, K. In: Special Issue: Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting (2012). 53rd Annual Scientific Meeting of the Australian Rheumatology Association in conjunction with Rheumatology Health Professionals, Canberra ACT, Australia, (14-14). 12-15 May 2012.

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Weekly subcutaneous abatacept confers comparable onset of treatment response and magnitude of efficacy improvement over 6 months when administered with or without an intravenous abatacept loading dose. Schiff, M., Alten, R., Weinblatt, M., Nash, P., Fleischmann, R., Durez, P., Kaine, J., Delaet, I., Kelly, S., Maldonado, M., Patel, S. and Genovese, M. C. In: Abstracts of the American College of Rheumatology & Association of Rheumatology Health Professionals (2012), Annual Scientific Meeting. Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Washington, DC, United States, (S1076-S1076). 9-14 November 2012.

Approved Research

HREC Reference: HREC/04/QRBW/205 Trial Name: A phase III trial evaluating the role of ovarian function suppression and the role of Exemestane as adjuvant therapies for premenopausal

women with endorcrine responsive breast cancer: Suppression of Ovarian Function Trial (SOFT) Commenced: 2006 Study Type: Drug Trial Local Chief Investigator: Geoffrey Hawson Local Co-Investigators: Geoffrey Hawson

HREC Reference: HREC/05/QRBW/35 Trial Name: IST-3: The Third International Stroke Trial (IST-3) of thrombolysis for acute ischaemic stroke. An international multi-centre, randomised,

controlled trial to investigate the safety and efficacy of treatment with intravenouse recombinant tissue plasminogen activator (rt-PA) within six hours of onset of acute ischaemic stroke

Commenced: Study Type: Other Trial Local Chief Investigator: Rohan Grimley Local Co-Investigators: Rohan Grimley

HREC Reference: HREC/07/QRBW/169 Trial Name: A phase 3, multi-centre randomized controlled trial of very early rehabilitation after stroke (AVERT) Commenced: 2008 Study Type: Other Trial Local Chief Investigator: Rohan Grimley Local Co-Investigators: Rohan Grimley

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HREC Reference: HREC/08/QPAH/168 Trial Name: To implement an evidence based falls clinic and determine its effectiveness in reducing falls and fall related injuries Commenced: 2008 Study Type: Clinical Research Local Chief Investigator: Christine Fawcett Local Co-Investigators: Christine Fawcett

Chris Bourke Jeremy O'Leary Michael Creen

HREC Reference: HREC/08/QTDD/35 Trial Name: CARIATIDE : Compliance of ARomatase Inhibitors AssessmenT In Daily practice through educational approach. A multi-country,

observational study to evaluate the impact of educational material on the compliance and persistence rates to adjuvant aromatase inhibitor (AI) medication for post-menopausal women with hormone sensitive early breast cancer

Commenced: 2008 Study Type: Trial Clinical Local Chief Investigator: Michelle Cronk Local Co-Investigators:

HREC Reference: HREC/09/QNRC/15 Trial Name: A double blind randomised trial of cediranib versus placebo in patients receiving paclitaxel / carboplatin chemotherapy for the treatment of

advanced or metastatic non-small cell lung cancer Commenced: 2009 Study Type: Drug Trial Local Chief Investigator: Jeremy Long Local Co-Investigators: Jeremy Long

Michelle Cronk Geoffery Hawson

HREC Reference: HREC/09/QNRC/17 Trial Name: A randomised, placebo controlled trial of oxpentifylline on haemoglobin levels in patiens with erythropoietin resistant anaemia Commenced: 2009 Study Type: Drug Trial Local Chief Investigator: Kumar Mahadevan Local Co-Investigators: Kumar Mahadevan

Nicholas Gray Euan Nobel Peter Hollett

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HREC Reference: HREC/09/QNRC/32 Trial Name: A randomised double-blind, placebo-controlled study of everolimus in combination with exemestane in the treatment of postmenopausal

women with estrogen receptor positive, locally advanced or metastatic breast cancer who are refractory to letrozole or anas Commenced: 2009 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

Jeremy Long Geoffrey Hawson

HREC Reference: HREC/09/QNRC/34 Trial Name: CONCORDANCE - Cooperative National Registry of Acute Coronary Care Guideline Adherence and Clinical Events Commenced: 2009 Study Type: Clinical Research Local Chief Investigator: Steven Coverdale Local Co-Investigators: Steven Coverdale

Matthew Marrinan HREC Reference: HREC/09/QNRC/5 Trial Name: A phase III randomised trial of adding niroglycerin to first line chemotherapy for advanced non-small cell lung cancer Commenced: 2009 Study Type: Drug Trial Local Chief Investigator: Jeremy Long Local Co-Investigators: Jeremy Long


HREC Reference: HREC/09/QNRC/56 Trial Name: ACTIVE Dialysis: A clinical trial of intensive dialysis. A multi-centre unblinded randomised controlled trial to assess quality of life, clinical

outcomes and cost utility for extended versus standard duration of dialysis in patients with ESKD Commenced: 2009 Study Type: Other Trial Local Chief Investigator: Nicholas Gray Local Co-Investigators: Kumar Mahadevan

Nicholas Gray Euan Nobel Peter Hollett

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HREC Reference: HREC/09/QNRC/59 Trial Name: Prostatectomy Patient Education Program Research Project Commenced: 2010 Study Type: Health Research Local Chief Investigator: Tim Nathan Local Co-Investigators: Tim Nathan

Erica Mohr Sue Torr John Buchanan

HREC Reference: HREC/09/QNRC/71 Trial Name: SCOT - Short Course Oncology Therapy, A study of adjuvant chemotherapy in colorectal cancer Commenced: 2010 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Jeremy Long


HREC Reference: HREC/09/QNRC/72 Trial Name: A multicenter, randomized, double-blind, placebo-controlled study to evaluate cardiovascular outcomes following treatment with alogliptin in

addition to standard of care in subjects with Type 2 Diabetes and Acute Coronary Syndrome: EXAMINE Commenced: 2010 Study Type: Drug Trial Local Chief Investigator: Steven Coverdale Local Co-Investigators: Steven Coverdale

Matthew Marrinan Steven Hamwood Shyam Sunder

HREC Reference: HREC/09/QNRC/74 Trial Name: Program for the assessment of clinical cancer tests (PACCT-1): Trial assigning individualized options for treatment (The TAILORx Trial) -

ANZ 0901 Commenced: 2010 Study Type: Other Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Jeremy Long


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HREC Reference: HREC/09/QNRC/75 Trial Name: Multinational, randomized, double-blind, phase III study of IMC-1121B plus Docetaxel vs Placebo plus Docetaxel in previously untreated

patients with HER2-Negative, unresectable, locally-recurrent or metastatic breast cancer: TRIO-012 (ANZ 0802) Commenced: 2010 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Jeremy Long


HREC Reference: HREC/10/QGC/114 Trial Name: Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the

Prevention of Recurrence in Crohn’s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence Commenced: 2010 Study Type: Drug Trial Local Chief Investigator: Dario Sorrentino Local Co-Investigators: Dario Sorrentino

Hansjoerg Seltenreich Ratna Aseervatham

HREC Reference: HREC/10/QGC/129 Trial Name: Paroxysmal Nocturnal Haemoglobinuria (PNH) Registry Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Christine Lambooy Local Co-Investigators: Christine Lambooy

Helen Weston HREC Reference: HREC/10/QHC/41 Trial Name: Chronic kidney disease Queensland (CKD.QLD) database and registry Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Nicholas Gray Local Co-Investigators: Kumar Mahadevan

Nicholas Gray Euan Nobel Peter Hollett Victoria Campbell

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HREC Reference: HREC/10/QHC/51 Trial Name: Discovery Interviews: Consumer, Carer and Clinician perceptions and experiences of Queensland Health Services Commenced: 2011 Study Type: Health Research Local Chief Investigator: Shoni Colquist Local Co-Investigators: Nicholas Gray

HREC Reference: HREC/10/QNRC/29 Trial Name: A survey of knowledge about chronic kidney disease among nephrology outpatients Commenced: 2010 Study Type: Health Research Local Chief Investigator: Nicholas Gray Local Co-Investigators: Nicholas Gray

HREC Reference: HREC/10/QPCH/126 Trial Name: Evaluation of the Safety and Efficacy of Short-term A-002 Treatment in Subjects with Acute Coronary Syndromes Commenced: 2010 Study Type: Drug Trial Local Chief Investigator: Peter Larsen Local Co-Investigators: Peter Larsen

Matthew Marrinan HREC Reference: HREC/10/QPCH/165 Trial Name: A Double Blind Placebo Controlled Randomized Trial Of Pf-00299804 (PF-804) In Patients With Incurable Stage Iiib/Iv Non-Small Cell Lung

Cancer After Failure Of Standard Therapy For Advanced Or Metastatic Disease Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Geoffrey Hawson Local Co-Investigators: Geoffrey Hawson

Jeremy Long Michelle Cronk

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HREC Reference: HREC/10/QPCH/84 Trial Name: Procalcitonin Guided Antibiotic Rational Decision Making in ICU Patients (ProGUARD) Commenced: 2011 Study Type: Other Trial Local Chief Investigator: Peter Garrett Local Co-Investigators: Peter Garrett

Vikram Masurkar Chris Anstey Gerard Joyce Mark Landy Victoria Campbell Carl Scott Chris Graves

HREC Reference: HREC/10/QRBW/238 Trial Name: An assessment of the difference in elapsed time to re-excision in breast conserving surgery between public and private patients in the

Nambour region Commenced: 2010 Study Type: Health Research Local Chief Investigator: David Grieve Local Co-Investigators: David Grieve

Matthew Solomon Colin Cochrane

HREC Reference: HREC/10/QRBW/302 Trial Name: A Multicentre, Randomised, Double-Blind, Placebo-controlled Phase Iib Study to Compare the Efficacy and Safety of Two dosing Regimens

of Intravenouse Infusions of CytoFab TM (AZD9773) in Adult Patients with severe Sepsis and/or Septic Shock Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Peter Garrett Local Co-Investigators: Peter Garrett

Vikram Masurkar Chris Anstey Gerard Joyce Mark Landy Victoria Campbell Chris Graves

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HREC Reference: HREC/10/QRBW/341 Trial Name: Stroke imaging prevention and treatment (START) EXTEND: Extending the time for thrombolysis in emergency neurological deficits Commenced: 2010 Study Type: Drug and Device Trial Local Chief Investigator: Rohan Grimley Local Co-Investigators: Rohan Grimley

Mark Denhan Antony Tampiyappa Tomin Mooney

HREC Reference: HREC/11/QGC/134 Trial Name: TR701-113 A phase 3 randomised, double-blind, multicentre study comparing the efficacy and safety of intravenous to oral 6-day TR-701

Free Acid and intravenous to oral 10 day Linezolid for the treatment of acute bacterial skin and skin structure infection Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: David Sowden Local Co-Investigators: David Sowden

Jennifer Broom Keat Choong Matthew Amodeo Andrew Henderson

HREC Reference: HREC/11/QNRC/12 Trial Name: Improving the practice of nutrition therapy in the critically ill: International Nutrition Survey Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Peter Garrett Local Co-Investigators: Peter Garrett

Shona McDonald Anne Buckley

HREC Reference: HREC/11/QNRC/37 Trial Name: Patient satisfaction with the inpatient services on the Surgival Ward at Nambour General Hospital Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: David Grieve Local Co-Investigators: David Grieve

Lidia Koval Nai Kid Lai

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HREC Reference: HREC/11/QNRC/38 Trial Name: Efficacy of the current plaster splinting in providing pain relief for patients with acute fractures of the ankle: a single centre experience Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Kim Latendresse Local Co-Investigators: Kim Latendresse

Lidia Koval James Tunggal

HREC Reference: HREC/11/QNRC/58 Trial Name: Non fixation of mesh in open inguinal hernia repair - single surgeon experience Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: David Grieve Local Co-Investigators: David Grieve

Thushara Dissanayake Nicolas Copertino Ratna Aseervatham

HREC Reference: HREC/11/QNRC/59 Trial Name: Patterns of injury in trauma patients requiring inter-hospital transfer from a major regional hospital to its tertiary referring facilities Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Kevin Chan Local Co-Investigators: Kevin Chan

David Grieve HREC Reference: HREC/11/QNRC/73 Trial Name: A prospective audit of the use and utility of diagnostic imaging in the diagnosis and management of acute appendicitis Commenced: 2011 Study Type: Health Research Local Chief Investigator: David Grieve Local Co-Investigators: David Grieve

Emily Hales

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HREC Reference: HREC/11/QNRC/9 Trial Name: ICU Nursing Clinical Scenario - Identifying and managing a potential organ donor Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Susan Priebe Local Co-Investigators: Susan Priebe

Jenny Jaspers Peter Garrett Shona McDonald Mark Kelly Danielle Jackson

HREC Reference: HREC/11/QPAH/121 Trial Name: A randomised phase II study evaluating potential predictive biomarkers in the treatment of metastatic pancreatic cancer Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


HREC Reference: HREC/11/QPAH/170 Trial Name: A Trial in the Timing of Surgery and Adjuvant Chemotherapy for Hepatic Metastases from Colorectal Cancer Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

Jeremy Long Geoffrey Hawson Ratna Aseervatham

HREC Reference: HREC/11/QPAH/300 Trial Name: The influence of host genetics and viral factors in chronic hepatitis C infection. ML25629 Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Andrew Sloss Local Co-Investigators: Andrew Sloss

Nicola Weston Johan van den Bogaerde

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HREC Reference: HREC/11/QPAH/335 Trial Name: Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of

Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn’s Disease Who Have Failed or Are Intolerant Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Dario Sorrentino Local Co-Investigators: Dario Sorrentino

Stephanie Buckton Andrew Sloss Hansjorg Seltenreich

HREC Reference: HREC/11/QPAH/336 Trial Name: A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of

Ustekinumab Induction Therapy in Subjects with Moderately to Severely Active Crohn’s Disease Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Dario Sorrentino Local Co-Investigators: Dario Sorrentino


HREC Reference: HREC/11/QPAH/337 Trial Name: A Phase 3, Randomized, Double-blind, Placebo controlled, Parallel-group, Multicenter Study to Evaluate the Safety and Efficacy of

Ustekinumab Maintenance Therapy in Subjects with Moderately to Severely Active Crohn’s Disease Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Dario Sorrentino Local Co-Investigators: Dario Sorrentino


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HREC Reference: HREC/11/QPAH/358 Trial Name: Bardoxolone methyl evaluation in patients with chronic kidney disease and type 2 diabetes: the occurrence of renal events Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Nicholas Gray Local Co-Investigators: Nicholas Gray

Peter Hollett Kumar Mahadevan Euan Noble Victoria Campbell

HREC Reference: HREC/11/QPAH/400 Trial Name: A randomised, open-label study to evaluate the efficacy and safety of maraviroc (MVC) as a switch for N(t)RTI or PI/r in HIV-1 infected

individuals with stable, well-controlled plasma HIV-RNA while taking their first N(t)RTI+PI/r regimen of cART Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: David Sowden Local Co-Investigators: David Sowden

Kuong Taing Jennifer Broom Karen Morwood

HREC Reference: HREC/11/QPAH/619 Trial Name: A randomised blinded placebo controlled trial of hydrocortisone in critically ill patients with septic shock (ADRENAL Study) Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Peter Garrett Local Co-Investigators: Peter Garrett

Vikram Masurkar Anne-Marie Welsh Mark Landy

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HREC Reference: HREC/11/QPCH/14 Trial Name: Multicentre, Single-arm, Open Label Clinical Trial Intended to Provide Early Access to Cabazitaxel in Patients with Metastatic Hormone

Refractory Prostate Cancer Previously Treated with a Docetaxel-Containing Regimen and document safety of Cabazitaxel in Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


HREC Reference: HREC/11/QPCH/187 Trial Name: The tyranny of distance: exploring contributory factors for delays in transfer and intervention in multi-trauma patients Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Martin Wullschleger Local Co-Investigators: Peter Garrett

HREC Reference: HREC/11/QPCH/199 Trial Name: Local staging of prostate cancer with 3T MRI Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: James Challen Local Co-Investigators: James Challen

David O'Regan Alex Splatt

HREC Reference: HREC/11/QPCH/33 Trial Name: HIV in Queensland: 2011 Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Kuong Taing Local Co-Investigators: Kuong Taing

David Sowden Jennifer Broom Karen Morwood

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HREC Reference: HREC/11/QRBW/12 Trial Name: Australian Stroke Clinical Register: AuSCR Queensland Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Rohan Grimley Local Co-Investigators: Rohan Grimley

Anthony Tampiyappa Donna Rowley Eva Salud

HREC Reference: HREC/11/QRBW/148 Trial Name: Too much, too soon? The impact of treatment-focused genetic testing in patients newly diagnosed with breast cancer Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: David Grieve Local Co-Investigators: David Grieve

Karen Crowe HREC Reference: HREC/11/QRBW/150 Trial Name: Prolonged Outcome Study - Renal Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Peter Garrett Local Co-Investigators: Peter Garrett

Victoria Campbell HREC Reference: HREC/11/QRBW/239 Trial Name: Gabapentin for taxane acute pain syndrome - a phase III randomised, placebo-controlled, crossover trial Commenced: 2011 Study Type: Drug Trial Local Chief Investigator: Jeremy Long Local Co-Investigators: Jeremy Long

Michelle Cronk Peter Smith Christine Cocks

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HREC Reference: HREC/11/QRBW/243 Trial Name: The evaluation of tele health support services for patients with head and neck cancer Commenced: 2011 Study Type: Health Research Local Chief Investigator: Clare Burns Local Co-Investigators: Karen Malcolm

HREC Reference: HREC/11/QRBW/300 Trial Name: Phase II study of aromatase inhibitors in women with potentially hormone responsive recurrent/metastatic gynaecological neoplasms:

PARAGON Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


HREC Reference: HREC/11/QRCH/181 Trial Name: Magnesium sulphate at 30 to 34 weeks gestational age: Neuroprotection Trial Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Edward Weaver Local Co-Investigators: Edward Weaver

Tom Hurley HREC Reference: HREC/11/QRCH/38 Trial Name: Clinical Trials Group (CTG) ICU Point Prevalence Program Commenced: 2011 Study Type: Clinical Research Local Chief Investigator: Chris Anstey Local Co-Investigators: Chris Anstey

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HREC Reference: HREC/12/Austin/29 Trial Name: A randomized, double-clinded, active-controlled study of CB-183,315 in patiens with Clostridium difficile Associated Diarrhea Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: David Sowden Local Co-Investigators: David Sowden

Jennifer Broom Keat Choong Matthew Amodeo Andrew Henderson Johan van den Bogaerde

HREC Reference: HREC/12/CIC/6 Trial Name: INTEGRATE: A randomised phase II double-blind placebo-controlled study of regorafenib in refractory advanced oesophago-gastric cancer

AOGC: Protocol Number AG0212OG Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


HREC Reference: HREC/12/QGC/24 Trial Name: Phase II trial of panitumumab, cisplatin and gemcitabine in biliary tract cancer Commenced: 2012 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


HREC Reference: HREC/12/QGC/47 Trial Name: A prospective, multi-centre observational study in pateints admitted to intensive care to estimate daily sodium balance Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Victoria Campbell Local Co-Investigators: Victoria Campbell

Peter Garrett

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HREC Reference: HREC/12/QHC/49 Trial Name: Final year medical students perspectives on the importance of clinical documentation in the delivery of health care in a public health hospital Commenced: 2012 Study Type: Health Research Local Chief Investigator: Stella Rowlands Local Co-Investigators: Stella Rowlands

Steven Coverdale HREC Reference: HREC/12/QNRC/22 Trial Name: Phase II randomised, double blind, multicentre study to assess the efficacy of AZD2281 in the treatment of patients with platinum containing

regimens. Protocol D0810C00019 Commenced: 2008 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

HREC Reference: HREC/12/QPAH/267 Trial Name: Carers of the Active Diaylsis Trial (CO-ACTIVE) Commenced: 2012 Study Type: Health Research Local Chief Investigator: Nicholas Gray Local Co-Investigators: Nicholas Gray

HREC Reference: HREC/12/QPAH/450 Trial Name: Citrate anticoagulation in continuous renal replacement therapy; more time on filter, less cost? Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: David Gutierrez Local Co-Investigators: David Gutierrez

Victoria Campbell

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HREC Reference: HREC/12/QPCH/14 Trial Name: The study of heart and renal protection - extended review Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Nicholas Gray Local Co-Investigators: Nicholas Gray

Kumar Mahadevan Euan Noble Victoria Campbell Carolyn Clark Peter Hollett

HREC Reference: HREC/12/QPCH/23 Trial Name: Determinants and prevalence of vitamin D deficiency in HIV-infected adults living in Queensland, Australia Commenced: 2012 Study Type: Health Research Local Chief Investigator: Karen Klassen Local Co-Investigators: Jennifer Broom

HREC Reference: HREC/12/QPCH/33 Trial Name: What complementary and alternative medicine is taken by patients with solid tumour malignancies receiving for the first time curative intent

chemotherapy in a hospital day unit and what factors influence selection at that time Commenced: 2012 Study Type: Health Research Local Chief Investigator: Peter Smith Local Co-Investigators: Peter Smith

Jeremy Long HREC Reference: HREC/12/QPCH/72 Trial Name: Orthogeriatric Service-Nambour General Hospital: An audit of patients aged over 60 with fractured neck of femur - comparing two models of

care. Commenced: 2012 Study Type: Clinical Research Local Chief Investigator: Pathiranage Abeyratne Local Co-Investigators: Pathiranage Abeyratne

Vanessa Harrington Gillian Puckeridge Rohan Grimley

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HREC Reference: HREC/2006/QNRC/067 Trial Name: A phase 3 double blind placebo controlled study of maintenance pemetrexed plus best supportive care versus best supportive care

immediately following induction treatment for advanced non-small cell lung cancer Commenced: 2007 Study Type: Trial Clinical Local Chief Investigator: Michelle Cronk

HREC Reference: HREC/2006/QNRC/068 Trial Name: A randomised, multicentre phase IIIb, open label study of letrozole vs anastrozole in the adjuvant treatment of postmenopausal women with

hormone receptor and node positive breast cancer. Face Study. CFEM345D2411 Commenced: 2007 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

HREC Reference: HREC/2007/QNRC/001 Trial Name: A randomised, multi-centre, open-label, phase III study of adjuvant lapatinib, trastuzumab, their sequence and their combination in patients

with HER2ErbB2 positive primary breast cancer. The ALTTO trial. Commenced: 2008 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

HREC Reference: HREC/2007/QNRC/005 Trial Name: Protocol BO20289, An international multi-centre open-label 2-arm phase III trial of adjuvant bevacizumab in triple negative breast cancer. Commenced: 2007 Study Type: Drug Trial Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

Geoffrey Hawson HREC Reference: HREC/2007/QNRC/009 Trial Name: A phase III randomized study of brivanib alaninate (BMS-582664) in combination with cetuximab (Erbitux) versus placebo in combination with

cetuximab (Erbitux) in patients previously treated with combination chemotherapy for metastatic colorectal carcinoma. Commenced: Study Type: Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk

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HREC Reference: HREC/2008/QNRC/006 Trial Name: A comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome (ACS) Sugjects with unstable angina/non-ST-elevation myocardial

infarction (UA/NSTEMI) who are medically managed - The TRILOGY ACS Study Commenced: 2008 Study Type: Drug Trial Local Chief Investigator: Matthew Marrinan Local Co-Investigators: Matthew Marrinan

HREC Reference: HREC/2008/QNRC/018 Trial Name: Preferences for adjuvant chemotherapy in non-small-cell lung cancer: What makes it worthwhile to patients and their doctors? Commenced: 2008 Study Type: Clinical Research Local Chief Investigator: Michelle Cronk Local Co-Investigators: Michelle Cronk


Trial Name: M10-791A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumabin Subjects with Axial

Spondyloarthritis Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: M10-883A Multicenter Study of the Efficacy and Safety of the Human Anti-TNF Monoclonal Antibody Adalimumab in Subjects with Peripheral

Spondyloarthritis Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: SERAPHIN OL; Study with Endothelin Receptor Antagonist in Pulmonary arterial Hypertension to Improve cliNical outcome. (Open Label) Long

term single arm open-label extension study of the SERAPHIN study, to assess the safety and tolerability of ACT-064992 in patients with symptomatic pulmonary hypertension. AC-055-303

Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls Local Co-Investigators: David Nicholls

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Trial Name: Protocol IM133004: A Phase 2b, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Multi-Center Study to Evaluate the Efficacy and Safety of BMS-945429 subcutaneous Injection in Adults with Active Psoriatic Arthritis

Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: BMS 101-226 :A Phase 3b, Randomized, Active Controlled Trial to Evaluate the Efficacy and Safety of Abatacept SC in Combination with

Methotrexate in Inducing Clinical Remission Compared to Methotrexate Monotherapy in Adults with Very Early RA Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLEBLIND,PLACEBO-CONTROLLED, PARALLEL-GROUPSTUDY TO EVALUATE THE

EFFICACY AND SAFETY OF APREMILAST (CC-10004) IN THE TREATMENT OFACTIVE ANKYLOSING SPONDYLITIS Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A PHASE 3, MULTICENTER, RANDOMIZED,DOUBLE-BLIND, PLACEBO-CONTROLLED,PARALLEL-GROUP, EFFICACY AND SAFETY

STUDY OF TWO DOSES OF APREMILAST (CC-10004) IN SUBJECTS WITH ACTIVE PSORIATIC ARTHRITIS AND A QUALIFYING PSORIASIS LESION


Trial Name: A PHASE 11B, MULTI-DOSE, MULTI-CENTER, RANDOMISED, DOUBLE BLIND, PLACEBO0CONTROLLED STUDY TO EVALUATE THE

EFFICACY AND SAFETY OF ABATACEPT VERSUS PLACEBO IN THE TREATMENT OF PSORIATIC ARTHRITIS BMS101158 Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A PHASE 111b, MULTI-CENTER, STRATIFIED, OPEN LABEL, STUDY TO EVALUATE THE IMMUNOGENICITY, STEADY STATE TROUGH

LEVEL AND SAFETY OF SUBCUTANEOUS ABATACEPT (BMS18867) IN SUBJECTS WITH RHEUMATOID ARTHRITIS ADMINISTERED WITH OR WITHOUT BACKGROUND METHOTREXATE. PROTOCOL BMS101-173


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Trial Name: A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial of Golimumab, an Anti-TNFa Monoclonal Antibody, Administered Intravenously, in Subjects with Active Rheumatoid Arthritis Despite Methotrexate Therapy - CNTO148ART3001


Trial Name: A prospective, multi centre randomised, double-blind, active comparator-controlled, parallel groups study comparing the fully monoclonal anti-

TNF α antibody Adalimumab given every second week with methotrexate given weekly and in combination of Adalimumab and methotrexate administered over 2 years in patients with early rheumatoid arthritis (PREMIER) (Study protocol DE 013)


Trial Name: AUX-CC-867: A Phase 3b open-label, historically-controlled study to assess the safety and efficacy of two concurrent injections of AA4500 in adult

subjects with multiple Dupuytren’s contractures with palpable cords. Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Evaluating the Efficacy and Safety of Baricitinib (LY3009104) in Patients with

Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Tumor Necrosis Factor Inhibitors JADW Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Baricitinib (LY3009104) in Patients with

Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs with Moderately to Severely Active Rheumatoid Arthritis JADX


Trial Name: Protocol H9B-MC-BCDT(a) A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of

Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE) (ILLUMINATE-2) Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

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Trial Name: Protocol H9B-MC-BCDX Phase 3b, Multicenter,Open Label Study to Evaluate the Long Term Safety and Efficacy of Subcutaneous LY2127399 in Patients with Systemic Lupus Erythematosus (SLE)


Trial Name: BEL 116301 : Observational Study of treatment, disease activity and flare in Systemic Lupus Erythematosus(SLE) in Asia Pacific Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: Protocol No. IMM 10-0107 MRI and Radiological Study of rheumatoid arthritis treated with Adalimumab and non-biological agents to assess the

impact of disease control on MRI manifestations and joint structure preservation. Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A randomized, double-blind, placebo-controlled, multicenter study of secukinumab to demonstrate the efficacy at 24 weeks and to assess the long

term safety, tolerability and efficacy up to 2 years in patients with active psoriatic arthritis. CAIN457F2306 Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: A3921069: PHASE 3, RANDOMIZED, DOUBLE-BLIND STUDY OF THE EFFICACY AND SAFETY OF 2 DOSES OF CP-690,550 COMPARED

TO METHOTREXATE IN METHOTREXATE NAIVE PATIENTS WITH RHEUMATOID ARTHRITIS Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: B3281001: A RANDOMIZED, DOUBLE-BLIND, STUDY COMPARING THE PHARMACOKINETICS AND PHARMACODYNAMICS, AND

ASSESSING THE SAFETY OF PF-05280586 AND RITUXIMAB IN SUBJECTS WITH ACTIVE RHEUMATOID ARTHRITIS ON A BACKGROUND OF METHOTREXATE WHO HAVE HAD AN INADEQUATE RESPONSE TO ONE OR MORE TNF ANTAGONIST THERAPIES


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Trial Name: A3921024: A Long-term, Open-label Follow-up Study of CP-690,550, a Moderately Selective Janus Kinase 3 Inhibitor, for Treatment of Rheumatoid Arthritis


Trial Name: A Phase 3 Multicenter, Randomized, Double-blind Placebo-controlled trial of Ustekinumab, a Fully Human anti-IL-12/23p40 Monoclonal Antibody,

Administered Subcutaneously, in Subjects with Psoriatic Arthritis. CNTO127PSA3001 Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: WA17044 : A Randomised, Double-Blind, International Study To Evaluate The Efficacy And Safety Of Various Re-treatment Regimens Of

Rituximab In Combination With Methotrexate In RA Patients With An Inadequate Response To Methotrexate Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: WA19926 –A Multi-center, randomized, double-blind, parallel group study of the safety, disease remission and prevention of structural joint

damage during treatment with tocilizumab (TCZ), as a monotherapy and in combination with methotrexate (MTX), versus methotrexate in patients with early, moderate to severe rheumatoid arthritis


Trial Name: A randomized, double-blind, parallel group study of the safety and effect on clinical outcome of tocilizumab SC versus tocilizumab IV, in

combination with traditional disease modifying anti-rheumatoid arthritis drugs (DMARDs), in patients with moderate to severe active rheumatoid arthritis. WA22762A


Trial Name: EFC11072 MOBILITY EXTENSION STUDY : A multi center, uncontrolled extension study evaluating efficacy and safety of SAR153191 on top of

DMARDs in patients with active Rheumatoid Arthritis (RA). Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

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Trial Name: LTS11210 MOBILITY EXTENSION STUDY : A multi center, uncontrolled extension study evaluating efficacy and safety of SAR153191 on top of DMARDs in patients with active Rheumatoid Arthritis (RA).


Trial Name: WA19924 : A Multi-center ,randomized, blinded, parallel-group study of the reduction of signs and symptoms during monotherapy treatment with

tocilizumab 8mg/kg intravenously versus adalimumab 40mg subcutaneously in patients with rheumatoid arthritis. Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: CL3- 018 : A prospective multicentre, international, double-blind, placebo-controlled study for the efficacy and safety of two doses of strontium

ranelate (1g and 2g per day) versus placebo administered orally for 2 years in the treatment of knee osteoarthritis. Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: RA0055 : A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND,PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND

SAFETY OF CERTOLIZUMAB PEGOL IN COMBINATION WITH METHOTREXATE FOR INDUCING AND SUSTAINING CLINICAL RESPONSE IN THE TREATMENT OF DMARD-NAÏVE ADULTS WITH EARLY ACTIVE RHEUMATOID ARTHRITIS


Trial Name: RA0077: A MULTICENTER, SINGLE-BLIND, RANDOMIZED PARALLEL-GROUP STUDY TO ASSESS THE SHORT- AND LONG-TERM

EFFICACY OF CERTOLIZUMAB PEGOL PLUS METHOTREXATE COMPARED WITH ADALIMUMAB PLUS METHOTREXATE IN SUBJECTS WITH MODERATE TO SEVERE RHEUMATOID ARTHRITIS RESPONDING INADEQUATELY TO METHOTREXATE


Trial Name: EMBODY 1 SL0009 - A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED,MULTICENTER STUDY OF THE EFFICACY

AND SAFETY OF FOUR 12-WEEK TREATMENT CYCLES (48 WEEKS TOTAL) OF EPRATUZUMAB IN SYSTEMIC LUPUS ERYTHEMATOSUS SUBJECTS WITH MODERATE TO SEVERE DISEASE.


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Trial Name: (EMBODY 4)PROTOCOL SL0012A Phase 3, Multicenter, Open-Label, Extension Study to Assess the Safety and Tolerablilty of Epratuzumab Treatment in Systemic Lupus Erythematosus Subjects


Trial Name: Protocol WA16855 : AN OPEN LABEL STUDY OF THE EFFICACY AND SAFETY OF RE-TREATMENTS WITH RITUXIMAB

(MABTHERA/RITUXAN) IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS. Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: FX006 - ;A Double-Blind, Randomized, Parallel Group, Dose-Ranging Study Comparing FX006 to Commercially Available Triamcinolone

Acetonide Injectable Suspension in Patients with Osteoarthritis of the Knee Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Trial Name: CL3-12911-040: Knee joint replacement over 5 years in patients with knee osteoarthritis. A long term follow up study in patients of the CL3-12911

018 study Study Type: Clinical Trial Local Investigator: Peter Nash Local Co-Investigators: David Nicholls

Awards and Prizes

Name of

Recipient Impact Name of Award Awarding

entity/organisation Area or Project

Dr Nicholas Gray

National Rural Science Award Australia and New Zealand Society of Nephrology

Peritoneal dialysis in rural Australia

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Community and Professional Activities

Title Name of Staff Member National/ International

Name of Society Position Held

Dr Nicholas Gray State Statewide Renal Clinical Network Co-Chair Dr Nicholas Gray National

Australia and New Zealand Society of Nephrology Member, Scientific Program

and Education Committee Dr Nicholas Gray National

Royal Australasian College of Physicians

Member, Specialist Advisory Committee in Nephrology

Dr Nicholas Gray National

Australia and New Zealand Dialysis and Transplant Registry

Member, steering committee

Dr Rohan Grimley State Statewide Stroke Clinical Network Clinical Chair Dr Rohan Grimley National Australian Stroke Units Network National Committee State Representative Dr Peter Larsen State Statewide Cardiac Clinical Network Member Dr Kelvin Larwood National Royal Australian and New Zealand College of

Obstetricians and Gynaecologists Member

A/Prof Peter Nash International Group for Research Psoriasis and Psoriatic Arthritis Steering Committee Member A/Prof Peter Nash International EPOSS (Outcome measures in Pulmonary

Hypertension Systemic Sclerosis) Steering Committee Member

A/Prof Peter Nash National Australian Rheumatology Association

Professional Affairs Committee Member

A/Prof Peter Nash National Scientific Advisory Committee Australian Rheumatology Association

Member

A/Prof Peter Nash National Therapeutics Committee Australia and New Zealand Bone and Mineral Society

Member

A/Prof Edward Weaver National Royal Australian & New Zealand College of Obstetricians and Gynaecologists

Councillor

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Major Partners and Linkages

Project: Differential expression of microRNA in psoriasis and psoriatic arthritis Principal Investigator: A/Prof Peter Nash Partners: Kuballa A., University of the Sunshine Coast Project: Efficacy of IL6 inhibition with Tocilizumab in Asthma Principal Investigator: A/Prof Peter Nash Partners: Ferreira, M., Queensland Institute of Medical Research Project: Human and microbial gene expression in early Crohn’s disease: clues to aetiology and pathogenesis Principal Investigator: Prof Dario Sorrentino Partners: University of Woollongong CSIRO Sydney University of the Sunshine Coast

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Contact Details

Associate Professor Steven Coverdale Acting Director, Regional Clinical Practice Research Centre University of Queensland, Sunshine Coast Clinical School Nambour General Hospital GPO Box 547 NAMBOUR QLD 4560 Phone: 07 5470 5644 Fax: 07 5470 5720 Email: [email protected]

som 2012 rcprc research report final 20130308 · 2012 research report regional clinical practice...

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