some struggle to find patients as cancer drug tests ... · beijing n a diplomatici gamble,...

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Late Edition VOL. CLXVI . . No. 57,688 © 2017 The New York Times Company NEW YORK, SUNDAY, AUGUST 13, 2017 HAMPTON, Iowa — It was quitting time. Edith Rivera took one last lunch or- der, dropped off a basket of tortilla chips and set off from work, heading out to the farm roads where other immigrants feared to drive. Like them, Ms. Rivera, 33, had no legal status in the country where she had lived for 18 years. She had no driver’s license, apart from the long-expired North Car- olina identification she held safe, like a tal- isman, in her wallet. But as she skimmed past the northern Iowa cornfields on her way to her son Steven’s seventh-grade track meet, she did not share other immigrants’ fears. Not of being pulled over. Not of raids or depor- tation. Not of the man in the White House. Not of the new Franklin County sheriff’s quest to make sure this rapidly diversi- fying community of hog barns and egg farms would never again be known as an immigrant sanctuary. Her American journey was waning, and she had little left to lose. Her husband, Jesús Canseco-Rodri- guez, was already gone — deported to Mexico in 2015. Ms. Rivera had jettisoned their apartment and sold off what the fam- ily had built here in Hampton: their small business power-washing hog barns, Mr. Canseco’s work truck, their furniture. Now, at this tense juncture for immi- grants and their adoptive hometowns across the conservative swaths of rural America, Ms. Rivera planned to sever one last tie. She was returning to Mexico — and to her husband — with Steven, 13 years old and American-born. Some politicians call it “self-deporta- tion.” She called it her family’s only hope of being together. Steven Canseco, 13, and his mother, Edith Rivera, in Hampton, Iowa. To re- unite the family, she took her American-born son to Mexico to join his father. PHOTOGRAPHS BY TIM GRUBER FOR THE NEW YORK TIMES LOVING AND LEAVING AMERICA Stay, Hide, ‘Self-Deport’? Facing Hard Choices in the Heartland By JACK HEALY Continued on Page 16 BEIJING — In a diplomatic gamble, President Trump is seek- ing to enlist China as a peacemak- er in the bristling nuclear-edged dispute with North Korea at the very moment he plans to ratchet up conflict with Beijing over trade issues that have animated his poli- tical rise. Mr. Trump spoke late Friday with his counterpart, President Xi Jinping of China, to press the Chi- nese to do more to rein in North Korea as it races toward develop- ment of long-range nuclear weap- ons that could reach the United States. Mr. Xi sought to lower the temperature after Mr. Trump’s vow to rain down “fire and fury” on North Korea, urging restraint and a political solution. But the conversation came as Mr. Trump’s administration was preparing new trade action against China that could inflame the relationship. Mr. Trump plans to return to Washington on Mon- day to sign a memo determining whether China should be investi- gated for intellectual property vio- Continued on Page 11 To Enlist China, Trump Gambles On Dual Fronts By JANE PERLEZ and PETER BAKER BRIDGEWATER, N.J. — After a four-day fusillade of apocalyp- tic threats against North Korea, President Trump left many in Washington and capitals throughout the Pacific wondering whether it was more method or madness. Among those won- dering were members of Mr. Trump’s own administration. It was not the first time in his unconventional presidency that Mr. Trump had unnerved friend and foe alike, but never before had it seemed so consequential. Unrestrained attacks on uncoop- erative members of his own party, the “dishonest media” and the cast of “Saturday Night Live” generally do not raise fears of nuclear war. But as with so much with Mr. Trump, the line between calculation and impulse can be blurry. In the broadest sense, Mr. Trump’s “fire and fury” and “locked and loaded” warnings fit the strategic imperatives of the Continued on Page 10 NEWS ANALYSIS Leader of U.S. Has New Role: The Wild Card By GLENN THRUSH and PETER BAKER Dupont Underground, in a long-vacant former trolley tunnel, is part of a wave of spaces where artists can showcase their work in Washington. PAGE 12 NATIONAL 12-17 Art Goes Underground The company’s troubles reflect the deterioration in much of retail. But what may ultimately lead to its collapse is Wall Street financial engineering. PAGE 1 SUNDAY BUSINESS The Epic Decline of Sears Gertrude Mokotoff and Alvin Mann met at the gym, as many young people do, and dated for eight years before she popped the question. PAGE 10 SUNDAY STYLES Newlyweds: She’s 98, He’s 94 England bans betting in soccer but has unwritten rules for team owners, like Brighton & Hove Albion’s Tony Bloom, with major gambling interests. PAGE 1 SPORTSSUNDAY Gambling Prohibited, Mostly Nuruddin Farah PAGE 7 SUNDAY REVIEW U(D5E71D)x+%!@!/!=!/ S. Mueller III, is in talks with the West Wing about interviewing current and former senior admin- istration officials, including the re- cently ousted White House chief of staff, Reince Priebus, according to three people briefed on the dis- cussions. Mr. Mueller has asked the White House about specific meet- ings, who attended them and whether there are any notes, tran- scripts or documents about them, two of the people said. Among the matters Mr. Mueller wants to ask the officials about is President Trump’s decision in May to fire the F.B.I. director, James B. Comey, the two people said. That line of questioning will be important as Mr. Mueller contin- ues to investigate whether Mr. Trump obstructed justice in the dismissal of Mr. Comey. No interviews have been sched- uled, but in recent weeks Mr. Mueller’s investigation has ap- peared to intensify. Late last month, he took the aggressive step of executing a search war- rant at the Alexandria, Va., home of Paul J. Manafort, Mr. Trump’s WASHINGTON — In a sign that the investigation into Russian interference in the 2016 presiden- tial election will remain a continu- ing distraction for the White House, the special counsel, Robert Mueller Is Said to Seek White House Interviews in Russia Inquiry This article is by Michael S. Schmidt, Matt Apuzzo and Maggie Haberman. Continued on Page 15 With the arrival of two revolu- tionary treatment strategies, im- munotherapy and personalized medicine, cancer researchers have found new hope — and a problem that is perhaps unprece- dented in medical research. There are too many experi- mental cancer drugs in too many clinical trials, and not enough pa- tients to test them on. The logjam is caused partly by companies hoping to rush prof- itable new cancer drugs to mar- ket, and partly by the nature of these therapies, which can be spectacularly effective but only in select patients. In July, an expert panel of the Food and Drug Administration approved a groundbreaking new leukemia treatment, a type of im- munotherapy. Companies are scrambling to develop other drugs based on using the immune system itself to attack cancers. Many of these experimental candidates in trials are quite simi- lar. Yet each drug company wants to have its own proprietary ver- sion, seeing a potential windfall if As Cancer Drug Tests Multiply, Some Struggle to Find Patients By GINA KOLATA Continued on Page 13 ers were injured, at least 19 in the car crash, according to a spokes- woman for the University of Vir- ginia Medical Center. Col. Martin Kumer, the superin- tendent of the Albemarle-Char- lottesville Regional Jail, con- firmed Saturday evening that an Ohio man, James Alex Fields Jr., 20, of Maumee, had been arrested and charged with second-degree murder, three counts of malicious wounding and failing to stop at the scene of a crash that resulted in a death. But the authorities de- clined to say publicly that Mr. Fields was the driver of the car that plowed into the crowd. Witnesses to the crash said a gray sports car accelerated into a crowd of counterdemonstrators — who were marching jubilantly near the mall after the white na- tionalists had left — and hurled at least two people in the air. “It was probably the scariest thing I’ve ever seen in my life,” said Robert Armengol, who was at the scene reporting for a podcast he hosts with students at the Uni- CHARLOTTESVILLE, Va. — The city of Charlottesville was en- gulfed by violence on Saturday as white nationalists and counter- protesters clashed in one of the bloodiest fights to date over the removal of Confederate monu- ments across the South. White nationalists had long planned a demonstration over the city’s decision to remove a statue of Robert E. Lee. But the rally quickly exploded into racial taunt- ing, shoving and outright brawl- ing, prompting the governor to de- clare a state of emergency and the National Guard to join the police in clearing the area. Those skirmishes mostly re- sulted in cuts and bruises. But af- ter the rally at a city park was dis- persed, a car bearing Ohio license plates plowed into a crowd near the city’s downtown mall, killing a 32-year-old woman. Some 34 oth- White Nationalist Protest Leads to Deadly Violence Brawling Erupts in Virginia — Opponents Clash and a Car Plows Into a Crowd By SHERYL GAY STOLBERG and BRIAN M. ROSENTHAL A car slammed into a group of counterprotesters after a rally by white nationalists on Saturday in Charlottesville, Va. RYAN M. KELLY/THE DAILY PROGRESS, VIA ASSOCIATED PRESS Continued on Page 14 TRUMP ON HATRED The president blamed “many sides” for the Charlottesville unrest. PAGE 14 BRYAN ANSELM FOR THE NEW YORK TIMES An epidemic of “beach-spreading” has hit the Jersey Shore, as bountifully equipped encampments jockey for space. Page 15. More Than Just a Towel and a Book Today, mostly sunny, less humid, warmer, high 84. Tonight, mostly clear, seasonable, low 68. Tomorrow, several hours of sunshine, high 82. Details in SportsSunday, Page 8. $6.00

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Page 1: Some Struggle to Find Patients As Cancer Drug Tests ... · BEIJING n a diplomaticI gamble, President Trump is seek-ing to enlist China as a peacemak-er in the bristling nuclear-edged

C M Y K Nxxx,2017-08-13,A,001,Bs-4C,E3

Late Edition

VOL. CLXVI . . No. 57,688 © 2017 The New York Times Company NEW YORK, SUNDAY, AUGUST 13, 2017

HAMPTON, Iowa — It was quittingtime. Edith Rivera took one last lunch or-der, dropped off a basket of tortilla chipsand set off from work, heading out to thefarm roads where other immigrantsfeared to drive.

Like them, Ms. Rivera, 33, had no legalstatus in the country where she had livedfor 18 years. She had no driver’s license,apart from the long-expired North Car-olina identification she held safe, like a tal-isman, in her wallet.

But as she skimmed past the northernIowa cornfields on her way to her sonSteven’s seventh-grade track meet, shedid not share other immigrants’ fears. Notof being pulled over. Not of raids or depor-tation. Not of the man in the White House.Not of the new Franklin County sheriff’squest to make sure this rapidly diversi-fying community of hog barns and eggfarms would never again be known as animmigrant sanctuary.

Her American journey was waning, andshe had little left to lose.

Her husband, Jesús Canseco-Rodri-guez, was already gone — deported toMexico in 2015. Ms. Rivera had jettisonedtheir apartment and sold off what the fam-ily had built here in Hampton: their smallbusiness power-washing hog barns, Mr.Canseco’s work truck, their furniture.

Now, at this tense juncture for immi-grants and their adoptive hometowns

across the conservative swaths of ruralAmerica, Ms. Rivera planned to sever onelast tie. She was returning to Mexico —and to her husband — with Steven, 13years old and American-born.

Some politicians call it “self-deporta-tion.” She called it her family’s only hopeof being together.

Steven Canseco, 13, and his mother, Edith Rivera, in Hampton, Iowa. To re-unite the family, she took her American-born son to Mexico to join his father.

PHOTOGRAPHS BY TIM GRUBER FOR THE NEW YORK TIMES

LOVINGAND LEAVING

AMERICA

Stay, Hide, ‘Self-Deport’? Facing Hard Choices

in the Heartland

By JACK HEALY

Continued on Page 16

BEIJING — In a diplomaticgamble, President Trump is seek-ing to enlist China as a peacemak-er in the bristling nuclear-edgeddispute with North Korea at thevery moment he plans to ratchetup conflict with Beijing over tradeissues that have animated his poli-tical rise.

Mr. Trump spoke late Fridaywith his counterpart, President XiJinping of China, to press the Chi-nese to do more to rein in NorthKorea as it races toward develop-ment of long-range nuclear weap-ons that could reach the UnitedStates. Mr. Xi sought to lower thetemperature after Mr. Trump’svow to rain down “fire and fury”on North Korea, urging restraintand a political solution.

But the conversation came asMr. Trump’s administration waspreparing new trade actionagainst China that could inflamethe relationship. Mr. Trump plansto return to Washington on Mon-day to sign a memo determiningwhether China should be investi-gated for intellectual property vio-

Continued on Page 11

To Enlist China,Trump GamblesOn Dual Fronts

By JANE PERLEZand PETER BAKER

BRIDGEWATER, N.J. — Aftera four-day fusillade of apocalyp-tic threats against North Korea,President Trump left many inWashington and capitals

throughout thePacific wonderingwhether it was moremethod or madness.Among those won-

dering were members of Mr.Trump’s own administration.

It was not the first time in hisunconventional presidency thatMr. Trump had unnerved friendand foe alike, but never beforehad it seemed so consequential.Unrestrained attacks on uncoop-erative members of his ownparty, the “dishonest media” andthe cast of “Saturday Night Live”generally do not raise fears ofnuclear war. But as with so muchwith Mr. Trump, the line betweencalculation and impulse can beblurry.

In the broadest sense, Mr.Trump’s “fire and fury” and“locked and loaded” warnings fitthe strategic imperatives of the

Continued on Page 10

NEWSANALYSIS

Leader of U.S.Has New Role:The Wild Card

By GLENN THRUSHand PETER BAKER

Dupont Underground, in a long-vacantformer trolley tunnel, is part of a waveof spaces where artists can showcasetheir work in Washington. PAGE 12

NATIONAL 12-17

Art Goes UndergroundThe company’s troubles reflect thedeterioration in much of retail. But whatmay ultimately lead to its collapse isWall Street financial engineering. PAGE 1

SUNDAY BUSINESS

The Epic Decline of SearsGertrude Mokotoff and Alvin Mann metat the gym, as many young people do,and dated for eight years before shepopped the question. PAGE 10

SUNDAY STYLES

Newlyweds: She’s 98, He’s 94England bans betting in soccer but hasunwritten rules for team owners, likeBrighton & Hove Albion’s Tony Bloom,with major gambling interests. PAGE 1

SPORTSSUNDAY

Gambling Prohibited, Mostly Nuruddin Farah PAGE 7

SUNDAY REVIEW

U(D5E71D)x+%!@!/!=!/

S. Mueller III, is in talks with theWest Wing about interviewingcurrent and former senior admin-istration officials, including the re-cently ousted White House chiefof staff, Reince Priebus, accordingto three people briefed on the dis-cussions.

Mr. Mueller has asked theWhite House about specific meet-ings, who attended them and

whether there are any notes, tran-scripts or documents about them,two of the people said. Among thematters Mr. Mueller wants to askthe officials about is PresidentTrump’s decision in May to fire theF.B.I. director, James B. Comey,the two people said.

That line of questioning will beimportant as Mr. Mueller contin-ues to investigate whether Mr.

Trump obstructed justice in thedismissal of Mr. Comey.

No interviews have been sched-uled, but in recent weeks Mr.Mueller’s investigation has ap-peared to intensify. Late lastmonth, he took the aggressivestep of executing a search war-rant at the Alexandria, Va., homeof Paul J. Manafort, Mr. Trump’s

WASHINGTON — In a signthat the investigation into Russianinterference in the 2016 presiden-tial election will remain a continu-ing distraction for the WhiteHouse, the special counsel, Robert

Mueller Is Said to Seek White House Interviews in Russia InquiryThis article is by Michael S.

Schmidt, Matt Apuzzo and MaggieHaberman.

Continued on Page 15

With the arrival of two revolu-tionary treatment strategies, im-munotherapy and personalizedmedicine, cancer researchershave found new hope — and aproblem that is perhaps unprece-dented in medical research.

There are too many experi-mental cancer drugs in too manyclinical trials, and not enough pa-tients to test them on.

The logjam is caused partly bycompanies hoping to rush prof-itable new cancer drugs to mar-ket, and partly by the nature ofthese therapies, which can be

spectacularly effective but only inselect patients.

In July, an expert panel of theFood and Drug Administrationapproved a groundbreaking newleukemia treatment, a type of im-munotherapy. Companies arescrambling to develop otherdrugs based on using the immunesystem itself to attack cancers.

Many of these experimentalcandidates in trials are quite simi-lar. Yet each drug company wantsto have its own proprietary ver-sion, seeing a potential windfall if

As Cancer Drug Tests Multiply,Some Struggle to Find Patients

By GINA KOLATA

Continued on Page 13

ers were injured, at least 19 in thecar crash, according to a spokes-woman for the University of Vir-ginia Medical Center.

Col. Martin Kumer, the superin-tendent of the Albemarle-Char-lottesville Regional Jail, con-firmed Saturday evening that anOhio man, James Alex Fields Jr.,20, of Maumee, had been arrestedand charged with second-degreemurder, three counts of maliciouswounding and failing to stop at thescene of a crash that resulted in adeath. But the authorities de-clined to say publicly that Mr.Fields was the driver of the carthat plowed into the crowd.

Witnesses to the crash said agray sports car accelerated into acrowd of counterdemonstrators —who were marching jubilantlynear the mall after the white na-tionalists had left — and hurled atleast two people in the air.

“It was probably the scariestthing I’ve ever seen in my life,”said Robert Armengol, who was atthe scene reporting for a podcasthe hosts with students at the Uni-

CHARLOTTESVILLE, Va. —The city of Charlottesville was en-gulfed by violence on Saturday aswhite nationalists and counter-protesters clashed in one of thebloodiest fights to date over theremoval of Confederate monu-ments across the South.

White nationalists had longplanned a demonstration over thecity’s decision to remove a statueof Robert E. Lee. But the rallyquickly exploded into racial taunt-ing, shoving and outright brawl-ing, prompting the governor to de-clare a state of emergency and theNational Guard to join the policein clearing the area.

Those skirmishes mostly re-sulted in cuts and bruises. But af-ter the rally at a city park was dis-persed, a car bearing Ohio licenseplates plowed into a crowd nearthe city’s downtown mall, killing a32-year-old woman. Some 34 oth-

White Nationalist ProtestLeads to Deadly Violence

Brawling Erupts in Virginia — OpponentsClash and a Car Plows Into a Crowd

By SHERYL GAY STOLBERG and BRIAN M. ROSENTHAL

A car slammed into a group of counterprotesters after a rally bywhite nationalists on Saturday in Charlottesville, Va.

RYAN M. KELLY/THE DAILY PROGRESS, VIA ASSOCIATED PRESS

Continued on Page 14

TRUMP ON HATRED The presidentblamed “many sides” for theCharlottesville unrest. PAGE 14

BRYAN ANSELM FOR THE NEW YORK TIMES

An epidemic of “beach-spreading” has hit the Jersey Shore, asbountifully equipped encampments jockey for space. Page 15.

More Than Just a Towel and a Book

Today, mostly sunny, less humid,warmer, high 84. Tonight, mostlyclear, seasonable, low 68. Tomorrow,several hours of sunshine, high 82.Details in SportsSunday, Page 8.

$6.00