Sources of hormones

Endocrinology terminology

• hormone:

• neuropeptide:

• non-peptide neurohormone:

• neurotransmitter:

Endocrinology terminology

• pheromone:

• lumone:

• growth factor:

• chalone:

• cytokine:

Classes of hormones

• Peptide hormones vary in size

Classes of hormones

• Peptide hormones vary in size

Classes of hormones

• Peptide hormones vary in form

Classes of hormones

• Peptide hormones vary in form

Classes of hormones

• Peptide hormones vary in subunits

Classes of hormones

• Tyrosine-derived hormones

Classes of hormones

• Sterol-derived hormones

• adrenal steroids

• gonadal steroids

cholesterol

Common steroid hormones

NGF

Growth factors

• usually stimulates cell proliferation and differentiation

Chalones

myo-/myo-myostatin wt myo+/myo-

Chalones

Chalones

Chalones

Eicosanoids

• fatty acid-derived

Biosynthesis of eicosanoids

arachidonic acid

Some biological activities of eicosanoids

Anti-inflammatory drugs & eisosanoids

thromboxane leukotriene

arachidonic acid

fatty acids

Current research in eicosanoid function

Prostaglandin receptor

• PGE2 EP3 receptor

Cytokines

• Cytokines

Interleukins

IL-2

Interferons

IFN-beta

IFN-alpha

IFN-gamma

Tumor necrosis factors

TNF- associated with TNF receptor

Colony stimulating factors

GM-CSF

Nitric oxide

N O