speaker bios pub edit[5] - washington university in st....

Presented by: The Musculoskeletal Research

Center and the Center for Regenerative Medicine

May 4-6, 2017 Eric P. Newman Educational Center (EPNEC)

SpeakerBiographies

OlivierPourquie|HarvardUniversityhttp://hsci.harvard.edu/people/olivier-pourqui%C3%A9-phd OlivierPourquieisProfessorintheDepartmentofGeneticsatHarvardMedicalSchoolandProfessorofPathologyattheBrighamandWomen’sHospital.HewasthedirectoroftheInstituteforGeneticsandMolecularandCellularBiology(IGBMC)inFranceandbeforethataHowardHughesMedicalInstituteInvestigatorattheStowersInstituteforMedicalResearchinKansasCity.HegraduatedasanengineerinFranceandtrainedwithNicoleLeDouarin.Heis

theEditorinChiefofthejournal Development.HeisanelectedmemberoftheEuropeanMolecularBiologyOrganizationandoftheAcademiaEuropea.Hisworkonthesegmentationclockthatcontrolstheperiodicityofvertebraewasrecognizedasoneofthemilestonesindevelopmentalbiologyofthe20thcenturybyNatureMagazine. Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro.ChalJ,AlTanouryZ,HestinM,GobertB,AivioS,HickA,CherrierT,NesmithAP,ParkerKK,PourquiéO.Nat Protoc.2016Oct;11(10):1833-50.doi:10.1038/nprot.2016.110.Epub2016Sep1.PMID:27583644 Lookinginwards:openingawindowontohumandevelopment.PourquiéO,BruneauB,KellerG,SmithA.Development.2015Jan1;142(1):1-2.doi:10.1242/dev.119727.




BradleyOlwin|UniversityofColorado,Boulderhttps://mcdb.colorado.edu/directory/Brad_Olwin ResearchInterests:Geneticsandcellbiology;membranetraffickingandphosphoinositideMolecularanddevelopmentalbiologyofskeletalmuscle;skeletalmuscleregenerationandaging;skeletalmusclestemcellsandgenetherapy;growthfactorsandsignaltransduction.ResearchProfile:

Theorganizationoftheskeletalmusculaturerequirespreciseregulationofcellulardetermination,migration,proliferation,differentiation,andpatterning.Thesecellulareventsarethoughttobemediatedbyextracellularfactors.Weareinterestedinelucidatingthemolecularmechanismsinvolvedinskeletalmuscledevelopment.

Lossofniche-satellitecellinteractionsinsyndecan-3nullmicealtersmuscleprogenitorcellhomeostasisimprovingmuscleregeneration.PiscontiA,BanksGB,BabaeijandaghiF,BettaND,RossiFM,ChamberlainJS,OlwinBB.SkeletMuscle.2016Oct4;6:34.




LiliannaSolnica-Krezel | WashingtonUniversityhttp://devbio.wustl.edu/faculty/faculty-members/lilianna-solnica-krezelhttp://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=6250 Weareinvestigatingthecellularandmoleculargeneticmechanismsunderlyingvertebrategastrulation,acrucialperiodofembryogenesisduringwhichthegermlayersareformedandthenshapedintothevertebratebodyplanwithorganrudiments.Weareaddressingthemechanismsofgastrulationinthezebrafish(Daniorerio),asystemthataffordsapowerful

combinationofforwardandreversegeneticanalyseswithembryological,cellularandmolecularmethods. SepichDS,Solnica-KrezelL.IntracellularGolgiComplexorganizationrevealstissuespecificpolarityduringzebrafishembryogenesis.DevDyn.2016Jun;245(6):678-91.GrayRS,WilmT,SmithJ,BagnatM,DaleRM,TopczewskiJ,JohnsonSL,Solnica-KrezelL.(2014)Lossofcol8a1aFunctionduringzebrafishembryogenesisresultsincongenitalvertebralmalformations.DevelopmentalBiology386,72-85.




EricOlson|UTSouthwesternUniversityhttp://profiles.utsouthwestern.edu/profile/15426/eric-olson.htmlhttps://en.wikipedia.org/wiki/Eric_N._Olson EricOlsonhasdedicatedhiscareertodecipheringthemechanismsthatcontroldevelopmentanddiseaseoftheheart,cardiovascularsystemandskeletalmuscletissue.Heandhiscolleaguesdiscoveredmanyofthekeytranscriptionfactorsandmechanismsresponsiblefor

cardiacgeneregulationandformationoftheheartand,insodoing,unveiledthemolecularunderpinningsofcongenitalandacquireddiseasesoftheheart.Mostrecently,OlsonhasfocusedonepigeneticmechanismsandmicroRNAsasregulatorsofmuscledevelopmentanddisease.Dr.Olsonco-foundedmultiplebiotechnologycompaniestotranslatebasicdiscoveriesintonewtherapeuticsformuscledisease.Hewasco-founderofMyogen,Inc.,abiotechnologycompanyfocusingontherapiesforheartmuscledisease.In2007,heco-foundedmiRagenTherapeutics,whichisdevelopingnewtherapeuticsforcardiovasculardisease,basedonmicroRNAs.In2010,heandhiscolleaguesfoundedLoneStarHeart,whichisworkingtodevelopnewapproachesforheartregenerationandrepair. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN Science 2016 Jan 351 6271 400-3 Muscle physiology. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.




CharlesGersbach|DukeUniversityhttp://gersbach.bme.duke.edu/https://bme.duke.edu/faculty/charles-gersbach Dr.Gersbach'sresearchinterestsareingenetherapy,biomolecularandcellularengineering,regenerativemedicine,andsyntheticbiology. Black,JB;Adler,AF;Wang,HG;D'Ippolito,AM;Hutchinson,HA;Reddy,TE;Pitt,GS;Leong,KW;

Gersbach,CA, Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells.,CellStemCell,vol19no.3(2016),pp.406-414[abs].




AndrewYoo|WashingtonUniversityhttp://devbio.wustl.edu/faculty/faculty-members/andrew-yoo Thegeneralgoalofmyresearchistounderstandmolecularmechanismsunderlyingthespecificationofcelltypesanddevelopingmethodstoalterthefatesofcellsinvitroandinvivo.WerecentlydiscoveredthatsmallRNAmolecules,microRNAs,couldpromotegenerationofpost-mitoticneuronsbydemonstratingthatexpressionofneuron-specificmicroRNAsandneuralfactorsinnon-neuronalcelltypescoulddirectly

reprogramtheircellfatesintofunctionalneurons.Wecurrentlyaimto1)developtissueculturemodelsofneurologicaldiseasesusingpatient-specificneuronsandtostudycellautonomouspropertiesassociatedwithdiseasestatesininducedneurons,and2)toidentifymolecularmechanismsunderlyingtheneurogenicactivityofneuron-specificmicroRNAs.Wewillusemultipleinterdisciplinaryapproaches(includingmoleculargenetics,genomicsandbiochemistry)todelineatehowthesemicroRNAspromoteneuronalfates. Richner M, Victor MB, Liu Y, Abernathy D, Yoo AS. MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons. Nat Protoc. 2015 Oct;10(10):1543-55. Yu, H., Yoo, A.S.*, and Greenwald, I. (2004). Cluster Analyzer for Transcription Sites (CATS): a C++- based program for identifying clustered transcription factor binding sites. Bioinformatics 20, 1198-1200. *: corresponding author Yoo, A.S., Cheng, I., Chung, S., Grenfell, T.Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. (2000). Presenilin-mediated modulation of capacitative calcium entry. Neuron 27, 561-572.




GuillermoAmeer|NorthwesternUniversityhttp://www.ameerlab.northwestern.edu/w_ameer.htmlDr.Ameer'sresearchinterestsincludebiomaterials,vascularandorthopaedictissueengineering,controlleddrugandgenedelivery,stemcellengineeringandbio/nanotechnologyforimprovedtherapeuticsanddiagnostics.Hehasco-authoredover100peer-reviewedjournalpublicationsandconferenceabstracts,severalbookchapters,andmultiplepatentsissuedandpending(>25).Moreover,heis(Co-)Founderof3companies:ProSorpBiotech,VesselTekBiomedicalandCitricsBiomedical.Hehasservedonseveralscientificreviewcommitteesforfundingresearchatthestate

andfederallevelsandwasoneof100inviteesbytheNationalAcademyofEngineeringtoattendthe10thannualFrontiersofEngineeringSymposium(2004).Dr.AmeerservedasapermanentmemberoftheMusculoskeletalTissueEngineeringstudysectionoftheNationalInstitutesofHealth.Ameer,GuillermoA.;Wertheim,JasonA.;Jiang,Bin;Akgun,Berke;Lam,RyanC.,“Apolymer-extracellularmatrixcompositewithimprovedthromboresistanceandrecellularizationproperties”,ActaBiomaterialia,(2015)




SamanthaMorris|WashingtonUniversityhttp://morrislab.wustl.edu/lab-members/ SamanthajoinedtheDepartmentsofGenetics,andDevelopmentalBiologyatWashUinJuly2015withacontinuedinterestinengineeringclinicallyrelevantcellpopulationsandtranslatingnewinsightsincellfatespecificationintobettermodelsofdiseaseanddevelopment.

Morris,SA.Directlineagereprogrammingviapioneerfactors;adetourthroughdevelopmentalgeneregulatorynetworks.Development.2016143:2696-2705;doi:10.1242/dev.138263.Single-CellRNA-SeqStepsUptotheGrowthPlate.TrendsBiotechnol.2016;34(7):525-7.




RolandBaron|HarvardUniversityhttp://hsdm.harvard.edu/people/roland-baron Dr.BaroniscurrentlyPresidentofASBMR(AmericanSocietyofBoneandMineralResearch).Dr.BaronischairoftheDepartmentofOralMedicine,Infection,andImmunityatHarvardSchoolofDentalMedicine.Inadditiontobeingchair,Dr.Baronisalsoaprofessoroforalmedicine,infection,andimmunityandaprofessorofinternalmedicineatHarvardMedicalSchoolandattheEndocrineUnitatMassachusettsGeneralHospital.

Dr.Baronisthefounderandcurrenteditor-in-chiefof Bone,theOfficialJournaloftheInternationalBoneandMineralSociety.Between1994and2002,healsoheldthepositionofvicepresidentandheadoftheBoneDiseasesGroupatHoechstMarionRousselandthenAventis.In2002hefoundedProSkelia,asmallpharmaceuticalcompanydevotedtothediscoveryanddevelopmentofnewdrugsforboneandhormonaldependentdiseases.HeheldthepositionsofpresidentandchiefscientificofficerofProSkeliaandthenProStrakan,amergerbetweenProSkeliaandStrakan,untilApril2006.Dr.Baronisinternationallyknownforhisgroundbreakingadvancesinbonebiology. SIKscontrolosteocyteresponsestoparathyroidhormone.WeinMN,LiangY,GoranssonO,SundbergTB,WangJ,WilliamsEA,O'MearaMJ,GoveaN,BeqoB,NishimoriS,NaganoK,BrooksDJ,MartinsJS,CorbinB,AnselmoA,SadreyevR,WuJY,SakamotoK,ForetzM,XavierRJ,BaronR,BouxseinML,GardellaTJ,Divieti-PajevicP,GrayNS,KronenbergHM.NatCommun.2016Oct19;7:13176.doi:10.1038/ncomms13176.




StephenJohnson|WashingtonUniversityhttp://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=3163http://genetics.wustl.edu/sjlab/Mylabisinterestedinhowanimalsgrow,maintain,andregeneratetheirform,orthediseasesconsequenttoabnormalgrowthcontrolsuchascancer.Weusethefreshwaterzebrafishasageneticmodelsystemtostudygrowthcontrolmechanisms.Ourworkconcentratesonthebiologyofstemcellsofmelanocytesandneuralcrest,

controloforgansize,andtissueregeneration.Weusemutational,genomicandmicroarrayanalysistounderstandhowthesedifferentgrowthcontrolsystemswork.

IovineMK,HigginsEP,HindesA,CoblitzB,JohnsonSL.Mutationsinconnexin43(GJA1)perturbbonegrowthinzebrafishfins.DevBiol2005278:208-219.




JennaGalloway|HarvardUniversityhttp://hsci.harvard.edu/people/jenna-galloway-phd

Dr.GallowayisanAssistantProfessorofBiologyattheCenterforRegenerativeMedicineandtheDepartmentofOrthopaedicSurgeryatMassachusettsGeneralHospitalandHarvardMedicalSchool.Herlaboratoryuseszebrafishgeneticsandstemcellstounderstandhowtendonsandligamentsform,organize,andregeneratewiththeultimategoalofapplyingthisknowledgetowardsthedevelopmentofimprovedtherapiesfortendonandligamentinjuries.

CAT7andcat7lLongNon-codingRNAsTunePolycombRepressiveComplex1FunctionduringHumanandZebrafishDevelopment.RayMK,WiskowO,KingMJ,IsmailN,ErgunA,WangY,PlysAJ,DavisCP,KathreinK,SadreyevR,BorowskyML,EgganK,ZonL,GallowayJL,KingstonRE.JBiolChem.2016Sep9;291(37):19558-72.doi:10.1074/jbc.M116.730853.Epub2016Jul12.Regenerativebiologyoftendon:mechanismsforrenewalandrepair.DymentNA,GallowayJL.CurrMolBiolRep.2015Sep;1(3):124-131.




MichaelRudnicki|UniversityofOttowahttp://rudnickilab.ca/people/mrudnickihttp://www.ohri.ca/profile/mrudnicki

Dr.MichaelRudnickiisaSeniorScientistandtheDirectoroftheRegenerativeMedicineProgramandtheSprottCentreforStemCellResearchattheOttawaHealthResearchInstitute.HeisaProfessorintheDepartmentofMedicineattheUniversityofOttawa.Dr.RudnickiistheScientificDirectoroftheCanadianStemCellNetworkandtheInternationalRegulomeConsortium.

Satellite Cells in Muscular Dystrophy - Lost in Polarity. Chang NC, Chevalier FP, Rudnicki MA. Trends Mol Med. 2016 Jun;22(6):479-96. doi: 10.1016/j.molmed.2016.04.002. Review.




RonenSchweitzer|OregonHealthSciencesUniversityhttp://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-studies/faculty/grad-studies-faculty.cfm?facultyid=324http://www.shcc.org/index.php/research/schweitzer-laboratory/ Thegoalofmyresearchistocharacterizeandstudytheembryonicoriginofthesetissues,thesignalsthatdirectcellstoassumethetendoncellfateandthesubsequentsignalsregulatingtheexquisitepatterningofthetendonsandtheirinteractionswiththeirrespectivemuscleandskeletalelements.

Musculoskeletalintegrationatthewristunderliesthemodulardevelopmentoflimbtendons.HuangAH,RiordanTJ,PryceB,WeibelJL,WatsonSS,LongF,LefebvreV,HarfeBD,StadlerHS,AkiyamaH,TufaSF,KeeneDR,SchweitzerR.Development.2015Jul15;142(14):2431-41.Molecularregulationoftendoncellfateduringdevelopment.HuangAH,LuHH,SchweitzerR.JOrthopRes.2015Jun;33(6):800-12.doi:10.1002/jor.22834.Epub2015Mar18.Review.




EllyTanaka|DresdenUniversity https://www.crt-dresden.de/research/research-groups/core-groups/group-leaders/prof-elly-tanaka-phd/ Dr.Tanakaisinternationallyrecognizedforherworkrejuvenatingthestudyofregenerationbiology.Bydevelopingmoleculargeneticsandimagingtechniquesinthesalamander,shehasdefinedthestemcellsthatundertakelimbregenerationandtheirpotency.

Dr.Tanaka’shonorsincludetheBiofuturesAwardfromtheGermanFederalMinistryofBiotechnologyandResearch(2003),aswellasaEuropeanResearchCouncilAdvancedInvestigatorAward(2011). FeiJF,SchuezM,TazakiA,TaniguchiY,RoenschK,TanakaEM.CRISPR-mediatedgenomicdeletionofSox2intheaxolotlshowsarequirementinspinalcordneuralstemcellamplificationduringtailregeneration.StemCellReports,3:444–459(2014)




WilliamMurphy|UWMadisonUniversityhttp://bioinspired.engr.wisc.edu/Facultypage Dr.Murphy'sfieldsofinterestandpracticeincludecreationofnewbiomaterialsusingbioinspiredapproaches,usingbiomaterialstodefinethestemcellmicroenvironment,thedevelopmentofbiomaterialsfortissueregeneration(tissueengineering)andnewapproachesfordrugdeliveryandgenetherapy.W.L.MurphyEd.HandbookofBiomaterialProperties.Springer,2016.

Human iPSC-derived endothelial cell sprouting assay in synthetic hydrogel arrays. Belair DG, Schwartz MP, Knudsen T, Murphy WL. Acta Biomater. 2016 Jul 15;39:12-2




SamStupp|NorthwesternUniversityhttp://www.chemistry.northwestern.edu/people/core-faculty/profiles/samuel-stupp.htmlhttp://stupp.northwestern.edu/ Dr.Stuppisbestknownforhisworkonself-assemblingmaterialsandsupramolecularchemistry.Oneofhismostnotablediscoveriesisabroadclassofpeptideamphiphilesthatself-assembleintohighaspectrationanofiberswithextensiveapplicationsinregenerativemedicine.Hehasalsomadesignificantcontributionstothe

fieldsofsupramolecularchemistry,nanotechnology,andorganicelectronicmaterials.Hehasover300peer-reviewedpublicationsandwasoneofthe100mostcitedchemistsinthe2000-2010decade. Tantakitti,F.;Boekhoven,J.;Wang,X.;Kazantsev,R.;Yu,T.;Li,J.;Zhuang,E.;Zandi,R.;Ortony,J.H.;Newcomb,C.J.;Palmer,L.C.;Shekhawat,G.S.;OlveradelaCruz,M.;Schatz,G.C.;Stupp,S.I.“EnergyLandscapesandFunctionofSupramolecularSystems”NatureMaterials2016,15(4),469-476.




LoriSetton|WashingtonUniversityhttps://engineering.wustl.edu/Profiles/Pages/Lori-Setton.aspxhttp://settonlab.wustl.edu/ In2015,LoriA.SettonjoinedWashingtonUniversityinSt.LouisastheLucyandStanleyLopataDistinguishedProfessorofBiomedicalEngineeringfromDukeUniversity,whereshewastheWilliamBevanProfessorofBiomedicalEngineeringandBassFellowandassociateprofessoroforthopaedicsurgery.Herresearchfocusesontheroleof

mechanicalfactorsinthedegenerationandrepairofsofttissuesofthemusculoskeletalsystem,includingtheintervertebraldisc,articularcartilageandmeniscus.Inthelab,herworkfocusesonengineeringandevaluatingnovelmaterialsfortissueregenerationanddrugdeliverytotreatmusculoskeletaldisease. InvivoluminescentimagingofNF-κBactivityandNF-κB-relatedserumcytokinelevelspredictpainsensitivitiesinarodentmodelofperipheralneuropathy.BowlesRD,KarikariIO,VanDerwerkenDN,SinclairMS,BellRD,RiebeKJ,HuebnerJL,KrausVB,SempowskiGD,SettonLA.Europeanjournalofpain(London,England).2016;20(3):365-76

speaker bios pub edit[5] - washington university in st....

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