spinal cord-connectome-part-two-connectivity

Spinal Cord Map v1.0, slide 1. 6/2/2016. Copyright © 2010 Dr. Jeffrey E. Arle, Lahey Clinic. All rights reserved.

Jeffrey E. Arle1,2 MD PhD, Nicolae Iftimia3 BS, Longzhi Mei1 MS, Jay L. Shils4 PhD, and Kristen W. Carlson1*

1Dept. of Neurosurgery, Beth Israel Deaconess Medical Center, Boston, MA, USA 2Dept. of Neurosurgery, Harvard Medical School, Boston, MA, USA 3Tufts University School of Medicine, Boston, MA, USA 4Dept. of Anesthesiology, Rush Medical Center, Chicago, IL, USA

Principal Investigators

Jeffrey E. Arle Jay L. Shils

Nick Iftimia, Research Longzhi Mei, Software Kris Carlson*, Computational Modeling and Simulation

*Corresponding author: [email protected]

The Human Spine Connectome Part 2: Connectivity

http://www.brandeis.edu/

Main Circuit

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]

other segments, laminae

somDRG

[1]

somDRG

[1]

somDRG

[1]

Lamina I

I[4]

I[2]

I[5] I[3]

I[1]


AGONIST (HOMONYMOUS) & SYNERGIST SKELETAL MUSCLES ANTAGONIST (HETERONYMOUS) SKELETAL MUSCLES

lamina II S-L[exc]

lamina II S-L[inh], FIL, CUR, ARB

C3- NS[2]

C2- WDR

C3- NS[3]

C3- NS[1]

C1- PYR

sI-C [9]

sI-C [7]

sI-C [10]

sI-C [8]

sI-C [6]

sI-C [4]

sI-C [2]

sI-C [5]

sI-C [3]

sI-C [1]

lamina II FIL, CUR in other segments (ipsi

or contra)

excitatory inhibitory

lamina II-IV ANT in this & other segments

lamina II S-L[exc], RAD[2] in this & other segments

lamina II S-L[inh], FIL, CUR, RAD[1] in this & other segments


C, A-δ afferents

A-β afferent

CARDIAC & SMOOTH MUSCLES


visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

visDRG[1]

Main Circuit

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


somDRG

[1]

somDRG

[1]

somDRG

[1]

Lamina II


AGONIST (HOMONYMOUS) & SYNERGIST SKELETAL MUSCLES ANTAGONIST (HETERONYMOUS) SKELETAL MUSCLES excitatory inhibitory

lamina I, III-VI C1-3

lamina I, III-VI C1-3

somDRG[2] somDRG[2] somDRG[2] somDRG[2] somDRG[2] somDRG[2]

RAD [1]

ANT [1]

RAD [2]

ANT [2]

ARB

ANT [3]

BORD

ANT [4]

S-L [5]

S-L [1]

S-L [6]

S-L [2]

S-L [7]

S-L [3]

S-L [8]

S-L [4]

CUR

FIL

invC1- PYR

invC3- NS[2]

invC2- WDR

invC3- NS[3]

invC3- NS[1]

I[4]

I[2]

I[5] I[3]

I[1]

sI-C [9]

sI-C [7]

sI-C [10]

sI-C [8]

sI-C [6]

sI-C [4]

sI-C [2]

sI-C [5]

sI-C [3]

sI-C [1]

lamina II sI-C[inh] & I in other segments

lamina II sI-C[exc] in other segments

lamina I-III (inv)C1-3 in other segments

(ipsi or contra)

lamina II S-L[exc] in other segments

lamina III sI-C[exc] in this & other segments

lamina III, IV sI-C[inh], I, & MPOL[4]

in this & other segments

lamina II sI-C in other segments

lamina I sI-C in this & other segments

lamina III-V ANT in this & other segments

lamina II S-L[inh] in other segments

lamina I sI-C[inh] & I in this & other segments

lamina I sI-C[exc] in this & other segments

C, A-δ afferents

A-β afferent

visD

RG

[2]

visD

RG

[2]

visD

RG

[2]


A-β, A-δ, C afferents CARDIAC &

SMOOTH MUSCLES

visDRG[1]

visDRG[1]

visDRG[1]

lamina III S-L[exc] in this & other segments

lamina III S-L[inh] in this & other segments


lamina III, IV C1-3, sI-C in this & other segments

lamina III sI-C[inh] & I in this & other segments

lamina III RAD[1-2] in this & other segments

Main Circuit

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


somDRG

[1]

somDRG

[1]

somDRG

[1]

Lamina III



I[2]

I[1]

sI-C [7]

sI-C [6]

sI-C [2]

sI-C [1]



visDRG[1]

visDRG[1]

Afferents: A-δ A-β

ANT [1]

ANT [2]

ANT [3]

ANT [4]

RAD [1]

RAD [2]

S-L [5]

S-L [1]

C2- WDR

C1- PYR

MPOL[4]


lamina II S-L[5] in this & other segments

lamina II S-L[1] in this & other segments

lamina III S-L[exc] in other segments

lamina III S-L[inh] in other segments

lamina IV-V ANT in this & other segments

lamina III sI-C in other segments

lamina I, II sI-C in this & other segments

A-δ afferent

A-β, A-α afferents

lamina II sI-C[inh] & I in this & other segments

lamina II sI-C[exc] in this & other segments


lamina II S-L[inh], FIL, CUR

lamina II S-L[exc] lamina II FIL, CUR in other segments (ipsi

or contra)

lamina III, IV C1-3 & I in this & other segments

lamina II RAD[1] in this & other segments

lamina II RAD[2] in this & other segments

lamina II RAD[1-2] in this & other segments

lamina II FIL, CUR in other segments (ipsi

or contra)

lamina IV sI-C[inh], I, & MPOL[4] in this &

other segments

lamina IV sI-C[exc] in this & other segments

Lamina IV Main Circuit



I[2]

I[1]

sI-C [7]

sI-C [6]

sI-C [2]

sI-C [1]

ANT [1]

ANT [2]

ANT [3]

ANT [4]

S-L [5]

S-L [1]


lamina II, III S-L[5] in this & other segments

lamina IV S-L[exc] in other segments

lamina IV S-L[inh] in other segments

lamina V ANT in this & other segments

lamina IV sI-C in other segments

lamina I-III sI-C in this & other segments

C3- NS[2]

C2- WDR

C3- NS[3]

C3- NS[1]

C1- PYR



visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

visDRG[1]


lamina II RAD[1-2] in this & other segments

MPOL[4]

lamina II, III S-L[1] in this & other segments

lamina V C1-3 in this & other segments

lamina V C2 in this & other segments

C, A-δ afferents

A-α, II (A-β & A-γ) afferents

A-β

affe

rent

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


somDRG

[1]

somDRG

[1]

somDRG

[1]

somDRG[1] somDRG[1]

lamina III RAD[1-2] in this & other segments

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


Lamina VI Main Circuit



C3- NS[2]

C2- WDR

C3- NS[3]

C3- NS[1]

C1- PYR



visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

visDRG[1]


MPOL[4]

C, A-δ afferents


A-β

affe

rent

somDRG

[1]

somDRG

[1]

somDRG

[1]

somDRG[1] somDRG[1]



lamina V C2 in this & other segments

lamina V MPOL[4] in this & other segments

Ib [2]

Ib [4]

Ib [1]

Ib [3]

Ib [2]

Ib [4]

Ib [1]

Ib [3]

lamina VII ag V2a, V0[exc], V3, ant RC in this & other segments

som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


Lamina V Main Circuit



C3- NS[2]

C2- WDR

C3- NS[3]

C3- NS[1]

C1- PYR



visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

visDRG[1]


MPOL[4]

lamina VI C2 in this & other segments

C, A-δ afferents


A-β

affe

rent

somDRG

[1]

somDRG

[1]

somDRG

[1]

ANT [1]

ANT [2]

ANT [3]

ANT [4]

lamina VI C1-3 in this & other segments

lamina II-IV sI-C in this & other

segments

somDRG[1] somDRG[1]



lamina IV C2 in this & other segments

lamina IV MPOL[4] in this & other segments

Main Circuit

Lamina VII



Spinal Cord Map v1.0, slide 9. 6/2/2016. Copyright © 2010 Dr. Jeffrey E. Arle, Lahey Clinic. All rights reserved. Note: Contralateral, inter-laminar, and inter-segmental connections are not shown.

CC HYP

CBL THAL

MED PONS ME Brainstem

RF MLR

somDRG

[1]

somDRG

[1]

somDRG

[1]


som

DRG

[1]

som

DRG

[1]

som

DRG

[1]

Afferents: Ia Ib II (A-β & A-γ)


Efferents: A-γ (dynamic)

A-γ (static) A-β (static & dynamic) A-α (tonic & phasic)

C fiber, B fiber A-β

affe

rent

som

DRG

[1]

som

DRG

[1]

C, A-δ afferents

somDR

G[1]

somDR

G[1]


vis MN


visDRG[1]

visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

DNC (C8-L3)

IML (T1-L2)

SPN (S2-S4)

IMM

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V0 [2]

V0 [1]

V0 [4]

V0 [3]

V0 [10]

V0 [9]

V0 [12]

V0 [11]

V0 [1]

V0 [4]

V0 [9]

V0 [12]

V0 [3]

V0 [10]

V0 [2]

V0 [11]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

C2/ WDR

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

vis MN

vis MN

vis MN

MPOL [1]

MPOL [3]

Ib [2]

Ib [4]

Ib [1]

Ib [3]

Ia [2]

Ia [4]

Ia [1]

Ia [3]

Ib [2]

Ib [4]

Ib [1]

Ib [3]

Ia [2]

Ia [4]

Ia [1]

Ia [3]

Endogenous bursters Endogenous bursters

RC [1]

RC [2]

RC [1]

RC [2]

Main Circuit

Lamina VIII




som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


somDRG

[1]

somDRG

[1]

somDRG

[1] A-

β af

fere

nt

som

DRG

[1]

som

DRG

[1]

C, A-δ afferents

somDR

G[1]

somDR

G[1]


Efferents: A-β (static & dynamic)

A-γ (static) A-γ (dynamic)

A-α (tonic & phasic)


CC HYP

CBL THAL


RF MLR

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V0 [2]

V0 [1]

V0 [4]

V0 [3]

V0 [10]

V0 [9]

V0 [12]

V0 [11]

V0 [1]

V0 [4]

V0 [9]

V0 [12]

V0 [3]

V0 [10]

V0 [2]

V0 [11]

Ib [2]

Ib [4]

Ib [1]

Ib [3]

Ia [2]

Ia [4]

Ia [1]

Ia [3]

Ib [2]

Ib [4]

Ib [1]

Ib [3]

Ia [2]

Ia [4]

Ia [1]

Ia [3]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

C2/ WDR

γMN [2]

γMN [1]

βMN [2]

βMN [1]

γMN [2]

γMN [1]

βMN [2]

βMN [1]

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]


RC [1]

RC [2]

RC [1]

RC [2]

Main Circuit

Lamina IX




som

DRG

[1]

som

DRG

[1]

som

DRG

[1]


somDRG

[1]

somDRG

[1]

somDRG

[1] A-

β af

fere

nt Efferents:

A-α (tonic & phasic) A-β (static & dynamic)

A-γ (static) A-γ (dynamic)

B fiber C fiber


CC HYP

CBL THAL


RF MLR



vis MN

A-β afferent visDRG[1]

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V0 [5]

V0 [6]

V0 [7]

V0 [8]

V0 [13]

V0 [14]

V0 [15]

V0 [16]

V3 [1]

V3 [2]

V3 [3]

V3 [4]

V3 [5]

V3 [6]

V3 [7]

V3 [8]

V3 [9]

V3 [10]

V3 [11]

V3 [12]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

γMN [2]

γMN [1]

βMN [2]

βMN [1]

γMN [2]

γMN [1]

βMN [2]

βMN [1]

αMN [1]

αMN [2]

αMN [1]

αMN [2]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2a [3]

V2a [1]

V2a [2]

V2a [4]

vis MN

V2b [2]

V2b [4]

V2b [1]

V2b [3]

V2b [2]

V2b [4]

V2b [1]

V2b [3]

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]

MPOL[1]

FUS [1]

FUS [3]

MPOL[3]

MPOL[1]

MPOL[3]

FUS [3]

FUS [1]


RC [1]

RC [2]

RC [1]

RC [2]

Main Circuit

Lamina X




CC HYP

CBL THAL


RF MLR

somDRG

[1]

Afferents: II (A-β & A-γ), Ia, Ib

othe

r seg

men

ts,

lam

inae

so

mDR

G[1

]


Efferents: A-γ (dynamic)

A-γ (static) A-β (static & dynamic) A-α (tonic & phasic)

C fiber, B fiber A-β

affe

rent

som

DRG

[1]

som

DRG

[1]

C, A-δ afferents

somDR

G[1]

somDR

G[1]


vis MN


visDRG[1]

visDRG[1]

visDRG[1]

Afferents: C fiber

A-δ A-β

V2b [3]

V2b [3]

V3 [3]

V3 [4]

V3 [7]

V3 [8]

V3 [11]

V3 [12]

V2b [3]

V2b [3]

V3 [3]

V3 [4]

V3 [7]

V3 [8]

V3 [11]

V3 [12]

V2a [3]

V2a [3]

vis MN

FUS [1]

FUS [1]

FUS [1]

FUS [1]

Endogenous burster Endogenous burster

C3/ NS[2]

C2/ WDR

WHITE MATTER

Body Skin & Body

DRG primary neurons

B fibers

A-β fibers

A-α fibers

A-δ fibers

A-β fibers

C fibers

A-α fibers

interneurons in other

segments

HTHAL SC MC

tertiary neurons

MDvc

VMpo VPI VPL VPM

CL VL Pf

THAL tertiary neurons

CBL

BS

NRM RF

ME

Spinal Cord Map. Copyright © 2016 Arle Neurosimulation Lab, BIDMC/Harvard Medical School.. All rights reserved.

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