state research center of russian federation federal state unitary enterprise «karpov institute of...

State Research Center of Russian Federation State Research Center of Russian Federation Federal State Unitary Enterprise Federal State Unitary Enterprise

««Karpov Institute of Physical ChemistryKarpov Institute of Physical Chemistry»»

State Research Center of Russian Federation State Research Center of Russian Federation Federal State Unitary Enterprise Federal State Unitary Enterprise


Obninsk BranchObninsk BranchObninsk BranchObninsk Branch

Location: 109 km south-west of Moscow Area: more than 70 ha

Leading Center of radiation Chemistry in Russia

Branch of Federal State Unitary Enterprise Branch of Federal State Unitary Enterprise ««Karpov Institute of Physical ChemistryKarpov Institute of Physical Chemistry»»Branch of Federal State Unitary Enterprise Branch of Federal State Unitary Enterprise ««Karpov Institute of Physical ChemistryKarpov Institute of Physical Chemistry»»

Address:

109 km, Kievskoye Shosse, Obninsk Kaluga Region

Telephone: (48439)6-39-32, 7-47-50Fax: (48439)6-39-11

E-mail: [email protected]

Branch of Federal State Unitary Enterprise Branch of Federal State Unitary Enterprise ««Karpov Institute of Physical ChemistryKarpov Institute of Physical Chemistry»»

- high-energy chemistry;

- radiochemistry;

- nuclear chemistry and physics;

- development of new radiopharmaceuticals;

- chemistry of high-molecular weight compounds;

- solid state physics;

- radiation-chemical technologies;

- radiation and space materials technology;

- neutron diffraction investigation and dynamics of different

class crystals.

Areas of scientific research and development:


Up-to-date experimental and technological facilities, including:

- nuclear reactor WWR-c;

- electron beam accelerators;

- powerful radionuclide sources of gamma radiation;

- wide range of technological facilities;

- testing and research units to investigate organic and inorganic materials in the frames of radiation and space materials technology projects;

- experimental-production shop.

Nuclear-chemical technologies


•Leading producer and supplier of Leading producer and supplier of radiopharmaceuticals and technetium-radiopharmaceuticals and technetium-99m generators in Russia. 99m generators in Russia.

•Karpov’s radionuclide and Karpov’s radionuclide and radiopharmaceutical products are radiopharmaceutical products are delivered to all Russian clinics.delivered to all Russian clinics.

•Development and production of Development and production of radiopharmaceuticals for diagnostics and radiopharmaceuticals for diagnostics and therapy are realized as an integrated therapy are realized as an integrated production cycleproduction cycle


•Leading producer and supplier of Leading producer and supplier of radiopharmaceuticals and technetium-radiopharmaceuticals and technetium-99m generators in Russia. 99m generators in Russia.

•Karpov’s radionuclide and Karpov’s radionuclide and radiopharmaceutical products are radiopharmaceutical products are delivered to all Russian clinics.delivered to all Russian clinics.

•Development and production of Development and production of radiopharmaceuticals for diagnostics and radiopharmaceuticals for diagnostics and therapy are realized as an integrated therapy are realized as an integrated production cycleproduction cycle

.

Generator

Preparation of reagent kits

Preparation of radiopharmac

euticals

Nuclear reactor or cyclotron-based production of radionuclides

Recovery of radionuclides

Synthesis of carrier-

molecules

Labeling

Clinic

Production of radiopharmaceuticals

Reactor WWR-cReactor WWR-cReactor WWR-cReactor WWR-c

Number of hot cells – 9, each Number of hot cells – 9, each handling handling 10000 10000 gg--equequ. . RaRa Number of heavy chemical Number of heavy chemical boxes - boxes - 55

Number of hot cells – 9, each Number of hot cells – 9, each handling handling 10000 10000 gg--equequ. . RaRa Number of heavy chemical Number of heavy chemical boxes - boxes - 55

Power – 1Power – 100 MW MWFluenceFluence – 5× 10 – 5× 1013 13 nn//cmcm22··ss

Number of experimental Number of experimental channelschannels – 31 – 31, including 9 , including 9 horizontalhorizontal

Experimental and production facilities

Currently produced radiopharmaceuticals

Isotope Chemical form Application

Mo-99 T1/2=66.02 h

Sodium molybdate Technetium-99mGenerator

Tc-99mE=0.140 MeV

T1/2=6.01 h

Sodium pertechnetateTechnetium-99m

generator

Diagnostics with RIA kits

Iodine-131E=0.365 MeV

T1/2=8.04 day

Sodium iodide in isotonic solution

Thyroid gland, diagnostics and therapy

Sodium iodide for injections


Sodium iodide in capsules


Ortho-Iodohippurate of sodium

Kidney, diagnostics

Meta-Iodobenzyl Guanidine

Adrenal, diagnostics

Samarium-153Eβav.=0.233 MeV

T1/2=46.7 h

Samarium oxabiphor Palliative therapy of skeleton

Currently produced radiopharmaceuticalsCurrently produced radiopharmaceuticals

Isotope Chemical form Application

Ferrum-59E=1.2 MeV

T1/2=44.5 day“Ferrum Sulphate, 59Fe 29kBq”

Mammary gland, diagnostics`

Carbon-14Eβ av.=0.049 MeV

T1/2=5730 year

T1/2 bio=2.5 h

Urea-14C“Ureacaps, 14C 37 kBq”

Diagnostics of gastrointestinal diseases: ulcer, malignant tumours

Technetium-99m generatorTechnetium-99m generator

The design makes it possible The design makes it possible - to decrease the number of - to decrease the number of procedures, which ensure procedures, which ensure operation condition of the operation condition of the generator;generator;-to use light biological to use light biological shielding;shielding;-to install a bactericide filter to install a bactericide filter to obtain aseptic eluate of to obtain aseptic eluate of sodium pertechnetatesodium pertechnetate..

GMP production line GMP production line for loading Tc-99m for loading Tc-99m generators is under generators is under constructionconstruction

NC2H5O

P

P

OCH3H3CO

OCH3H3CO

Tc

NS

SN

OC2H5

OC2H5

123I

OH

O

Radiopharmaceuticals being developedRadiopharmaceuticals being developed

Diagnostics of myocardial infarction For diagnostics of myocardial

preinfarction condition

based on fat phenylmethylpentadecanoic acid labeled with 123I

99mTcN-DBODC5-heterocomplex composed of PNP5 and dithiocarbamate ligand

For diagnostics of myocardial preinfarction condition

based on fat phenylmethylpentadecanoic acid labeled with 123I

99mTcN-DBODC5-heterocomplex composed of PNP5 and dithiocarbamate ligand

Thermoselfcollapsing therapeutical radiopharmaceutical

Х = 153Sm, 188Re , 90Y, 117mSn

C

CHCH2

NH

O

CHH3C CH3

C

CCH2

O

O

CH2

HC

95 5

CH3

CH2

OH O

DTPA(PhA)

X

Nuclear-doped semiconductor materials (silicon, gallium arsenide, etc. for power electronics)

Nuclear-doped semiconductor materials (silicon, gallium arsenide, etc. for power electronics)

Radiation-modified minerals (topazes, etc.)Radiation-modified minerals (topazes, etc.)

Items produced by radiation-chemical Items produced by radiation-chemical technologytechnology


– to build up a facility for Technetium-99m generator loading in accordance with GMP requirements;

– to build-up an up-to-date facility for radiochemical production of radionuclides and radiopharmaceuticals (investment project developed);

– to develop a technology and build up a facility for production of alpha-emitters actinium-225 and radium-223;

– to launch molybdenum-99 production from low-enriched uranium targets.

Pilot projects:

RADIATION-CHEMICAL TECHNOLOGIES

curing of paint coatings curing of paint coatings on the surface of wooden, on the surface of wooden, metallic and gypsum productsmetallic and gypsum products;

modification of rubber productsmodification of rubber products (tires, etc. );

production of composite materials production of composite materials (binders and prepregs for further manufacturing high-strength and heat-resistant products);

modification of polyolefinsmodification of polyolefins (production of foamed polyethylene materials and products, hot water supply and heating pipes, gas distribution piping, heat –shrinkable tapes for electric insulation);

sterilization sterilization of medical productsof medical products, drugs, herbal raw material;

synthesis of polymer latexessynthesis of polymer latexes for wall-paper and tanning industry, gel production for perfumery and pharmaceuticals;

curing of paint coatings curing of paint coatings on the surface of wooden, on the surface of wooden, metallic and gypsum productsmetallic and gypsum products;

modification of rubber productsmodification of rubber products (tires, etc. );

production of composite materials production of composite materials (binders and prepregs for further manufacturing high-strength and heat-resistant products);

modification of polyolefinsmodification of polyolefins (production of foamed polyethylene materials and products, hot water supply and heating pipes, gas distribution piping, heat –shrinkable tapes for electric insulation);

sterilization sterilization of medical productsof medical products, drugs, herbal raw material;

synthesis of polymer latexessynthesis of polymer latexes for wall-paper and tanning industry, gel production for perfumery and pharmaceuticals;

Radiation-chemical technologies developed by Karpov Institute

monomer grafting onto polymer products monomer grafting onto polymer products (to obtain adhesion-bonding surfaces and separation materials for chemical current sources);

processing of minerals and microelectronic processing of minerals and microelectronic productsproducts (to obtain marketable semi-precious stones and to increase microchip characteristics);

destruction of Teflondestruction of Teflon;; radiation-chemical modification of Teflon;radiation-chemical modification of Teflon; production of porous filters production of porous filters (to purify water, air,

fuel, aggressive liquids)

monomer grafting onto polymer products monomer grafting onto polymer products (to obtain adhesion-bonding surfaces and separation materials for chemical current sources);

processing of minerals and microelectronic processing of minerals and microelectronic productsproducts (to obtain marketable semi-precious stones and to increase microchip characteristics);

destruction of Teflondestruction of Teflon;; radiation-chemical modification of Teflon;radiation-chemical modification of Teflon; production of porous filters production of porous filters (to purify water, air,

fuel, aggressive liquids)

Radiation-chemical technologies developed by

Karpov Institute

AcceleratorAccelerator Developed byDeveloped byBasic technical Basic technical characteristicscharacteristics

Energy, MeV Power, kW

ЭЛВ-2 ИЯФ СО РАН 0,8 – 1,5 20

УЭВТ-0,5-20-Т-100-1 ИЯФ СО РАН 0,4 – 0,7 20

«Электроника У-003»ЦНИИ

«Электроника»4 - 8 5

ЭЛУ - 4ЦНИИ

«Электроника»3 - 5 5

«ЭЛЕКТРОН-3М»НИИЭФА им. Д.В.Ефремова

0,4 – 0,7 7

УЭЛР-10—10-Т-80НИИЭФА им. Д.В.Ефремова

8 - 10 10

Electron beam acceleratorsElectron beam accelerators

УЭЛР-10-10-Т-80 in a trench

Locally-shielded Locally-shielded accelerator accelerator “Electron-3M”“Electron-3M”

Experimental and production facilities

Technological facility for PE cross-linking. Technological facility for PE cross-linking. Production of foamed polyethylene and heat-Production of foamed polyethylene and heat-shrinkable insulation tapeshrinkable insulation tape..

Technological facility for PE cross-linking. Technological facility for PE cross-linking. Production of foamed polyethylene and heat-Production of foamed polyethylene and heat-shrinkable insulation tapeshrinkable insulation tape..

Technical characteristics of Co-60 Technical characteristics of Co-60

γγ--facilitiesfacilities, , total activitytotal activity 1490 1490 kCikCi

Technical characteristics of Co-60 Technical characteristics of Co-60

γγ--facilitiesfacilities, , total activitytotal activity 1490 1490 kCikCi

Сo-60 gamma ray facility

Activity, kCi

Max absorbed doze, rad/sec.

Irradiator dimensions. mm

Raise time, sec.

KCB-500 650 550 Ø 90, h=125 180

PARKET 300 170 300 x100 x90

240

PX-gamma-30 (Researcher)

20 70 Ø 20, h=20 60

K-120, Build. KU

80 70 Ø 50, h=40 120

K-200 140 200 Ø 30, h=40 120

UGRA 100 250 Ø 30, h=30 0.5

VULKAN1 100 250 Ø 50, h=100 0.5

VULKAN2 100 250 0.5

Products made from foamed polyethylene sheets



Heat-resistant polyethylene pipes



Radiation-modified heat-shrinkable items



Pore size, m 1 - 100Total porosity, % 50-55Efficiency of water purification from 1 m particles, % 99.55Tmax, OC 100

To purifyTo purify:: drinking water,drinking water, beverages,beverages, paints and resins,paints and resins, photoemulsions, photoemulsions, water and reagents for water and reagents for

microelectronics,microelectronics, magnetic paint, magnetic paint, lubricants and cooling liquids. lubricants and cooling liquids.

Polyethylene filters

Branch of Federal State Unitary Branch of Federal State Unitary Enterprise Enterprise


Branch of Federal State Unitary Branch of Federal State Unitary Enterprise Enterprise


PILOT PROJECTSPILOT PROJECTS

- center of radiation sterilization and decontamination center of radiation sterilization and decontamination of medical wastes;of medical wastes;

- specialized facility for radiation modification of specialized facility for radiation modification of polytetrafluoroethylenepolytetrafluoroethylene

state research center of russian federation federal state unitary enterprise «karpov institute of...

Documents

nuclear chemistry

frames of radiation

production facilitiescurrently

therapysodium iodide

injectionsthyroid gland

kbqmammary gland

capsulesthyroid gland

physics development