Stephen F. Matheson, Ph.D.

Education B.S. 1984, University of Arizona. Major Subjects: Cellular and Developmental Biology and

Mathematics M.S. 1990, Rutgers University/University of Medicine and Dentistry of New Jersey-Robert Wood

Johnson Medical School. Major Subject: Toxicology Ph.D. 1996, University of Arizona. Major Subject: Neuroscience Experience 2012-present, Scientific Editor, Cell Press, Cambridge, MA. 2011-2012, Freelance Scientific Editor, Cactus Communications, Trevose, PA. 2009, Interim Assistant Dean, Van Andel Institute Graduate School, Grand Rapids, MI. 2002-2011, Visiting Scientist and Adjunct Instructor, Van Andel Institute, Grand Rapids, MI. 2001-2011, Assistant/Associate Professor, Biology Department, Calvin College, Grand Rapids, MI. 2000-2001, Teaching Assistant, Biology Department, Boston College. 1999-2001, Research Fellow in Medicine (Pathology), Massachusetts General Hospital, Research

Fellow in Neurology, Harvard Medical School. 1996-1999, Research Fellow in Medicine (Neurology), Brigham and Women’s Hospital, Research

Fellow in Neurology, Harvard Medical School. 1992-1996, Graduate Research Associate, Program in Neuroscience, University of Arizona. 1991-1992, Graduate Research Assistant/Associate, Program in Neuroscience, University of Arizona. 1989-1990, Graduate Fellow/Teaching Assistant, Program in Neuroscience, University of Arizona. 1986-1989, Graduate Fellow, Department of Pharmacology and Toxicology, Rutgers University. 1984-1986, Research Technician, Department of Pharmacology and Toxicology, University of Arizona. Articles (peer-reviewed) Regulation of axonal caliber, neurofilament content and nuclear localization in mature sensory

neurons by nerve growth factor. (1991) B.G. Gold, W.C. Mobley and S.F. Matheson. J. Neurosci. 11:943-955.

Steroid hormone enhancement of neurite outgrowth in identified insect motor neurons involves specific effects on growth cone form and function.. (1999) S.F. Matheson and R.B. Levine J. Neurobiol. 38:27-45.

Differential antigen expression during metamorphosis in the tripartite olfactory system of the African clawed frog, Xenopus laevis. (1999) M.A. Petti, S.F. Matheson and G.D. Burd. Cell Tissue Res. 297:383-396.

The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. (2000) M.R. Brouns, S.F. Matheson, I Delalle, V.S. Caviness, Jr., J. Silver, R.T. Bronson and J. Settleman. Development 127:4891-4903.

p190 RhoGAP is the major Src substrate in brain and regulates axon outgrowth, guidance, and fasciculation. (2001) M.R. Brouns*, S.F. Matheson* and J. Settleman. Nature Cell Biol. 3:361-367. (*co-first authors)

Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development. (2002) R. Sordella, M. Classon, K.-Q. Hu, S.F. Matheson, M.R. Brouns, B. Fine, L. Zhang, H. Takami, Y. Yamada and J. Settleman. Dev. Cell 2:553-565.

Distinct but overlapping functions for the closely related p190 RhoGAPs in neural development. (2006) S.F. Matheson, K.Q. Hu, M.R. Brouns, R. Sordella, J.D. VanderHeide and J. Settleman. Dev. Neurosci. 28:538-550.

Articles (continued) BlastEd: integrating biology and computation. (2008) J. Adams, S. Matheson and R. Pruim. J.

Computing Sciences in Colleges 24:47-54. 5q– myelodysplastic syndromes: chromosome 5q genes direct a tumor-suppression network sensing

actin dynamics. (2009) K.M. Eisenmann, K.J. Dykema, S.F. Matheson, N.F. Kent, A.D. DeWard, R.A. West, R. Tibes, K.A. Furge and A.S. Alberts. Oncogene 28:3429–3441.

The role of formins in human disease. (2010) A.D. DeWard, K.M. Eisenmann, S.F. Matheson and A.S. Alberts. Biochim Biophys Acta 1803:226-233.

Recent abstracts p190RhoGAP is the major tyrosine-phosphorylated protein in the mouse brain and is required for

normal neural development. M. Brouns, S.F. Matheson and J. Settleman. Soc. Neurosci. Abstr. 2:865, 1997.

Dual actin remodeling activities for the Diaphanous-related formins in Rho signaling: mDia2 regulates both Arp2/3 and eEF1A. S.F. Matheson, B.J. Wallar, N. Neuman, D. Odumosu and A.S. Alberts. Mol. Biol. Cell 13:316a, 2002.

Suppression of mDia1 (DRF1) protein expression inhibits neurite outgrowth in murine neuroblastoma cells. C. Ludema, R.E. Piegols and S.F. Matheson. Poster at the 2005 Meeting of the Michigan Chapter of the Society for Neuroscience, 20 May 2005.

Neuronal expression and localization of FHOD1 in murine neuroblastoma cells. C.J. Wenstrom, J. Glupker and S.F. Matheson. Poster at the 2006 Meeting of the Michigan Chapter of the Society for Neuroscience, 19 May 2006.

Expression patterns of mDia1 and mDia2 in the developing mouse brain. J. VanderHeide and S.F. Matheson. Poster at the 2006 Meeting of the Michigan Chapter of the Society for Neuroscience, 19 May 2006.

Formin expression in human and mouse neuroblastoma cells, before and after differentiation. L. Cesko and S.F. Matheson. Poster at the 2011 Meeting of the Chicago chapter of the Society for Neuroscience, 24 March 2011.

Evaluation of the neuroprotective potential of microtubule stabilization in a mouse model of ALS. A. Schepers, L. Lash-VanWyhe, S. Matheson and A. Alberts. Poster at the 2011 Meeting of the Chicago chapter of the Society for Neuroscience, 24 March 2011.

Other publications (selected) Review: Beyond the Firmament. (2008) Reports of the National Center for Science Education 28:37-

38. They selected teosinte and got corn…excellent! (2008) In The Open Laboratory: The Best Science

Writing on Blogs 2007 (R. Cartwright, Ed.). Lulu.com. Finches, bah! What about Darwin’s tomatoes? (2009) In The Open Laboratory: The Best Science

Writing on Blogs 2008 (J. Rohn, Ed.). Lulu.com. Grants and Awards National Science Foundation, MRI Grant, 2003. Acquisition of a Flow Cytometer for Cell Biology

Research and Undergraduate Research Training. Co-principal investigator. National Insitutes of Health, R15 AREA Grant, 2004. Roles of Diaphanous-Related Formins in

Neurite Outgrowth. Principal investigator. National Science Foundation, MRI Grant, 2004. Acquisition of a Fluorescence Microscope and

Imaging System for Faculty Research and Undergraduate Research Training. Principal investigator.

National Science Foundation, MRI Grant, 2005. Acquisition of Electrophysiology Patch-Clamp Equipment to Support Cross-Disciplinary Research and Undergraduate Research Training. Co-principal investigator.

Teaching and curricular development Taught numerous undergraduate courses (Calvin College): genetics, cell biology, general biology,

human physiology, research in developmental neurobiology Taught graduate course (Van Andel Institute Graduate School): Leukemia Designed/developed new undergraduate courses (Calvin College): Developmental biology, research in

developmental neurobiology, minds/brains/consciousness Developed several curricular modules (Calvin College): stem cells, Tuskegee experiment, genetic

engineering Presented numerous extracurricular lectures to various audiences Received exemplary teaching evaluations Prepared instructor’s manual for Van Andel Institute Graduate School Research interests and expertise My primary interests lie in neurobiology, cell biology, cancer biology, and developmental biology. I have a strong interest in human disease, and seek to combine intentionally translational approaches with a healthy respect for basic science and model systems. Writing, editing, and analysis:

• Superior writing and editing skills, strong clinical editing background • Extensive grant writing experience (NIH and NSF) • Extensive computing expertise • Superior communication skills • Expertise in biostatistics and data analysis

Laboratory skills:

• Mammalian cell culture, including primary neuronal culture and cell lines • Handling, surgery, and dissection of rodents (adult and prenatal); rodent

neuroanatomy and histology; basic behavioral analysis • Broad set of techniques in cell biology, including protein blotting, immunofluorescence,

light microscopy, confocal microscopy, transfection and viral transduction, morphometry, image analysis, basic flow cytometry

• Broad set of techniques in molecular biology, including subcloning, qPCR (TaqMan), design and use of plasmid vectors, design and use of lentiviral vectors, RNA interference (siRNA and lentiviral delivery), basic bioinformatics and sequence analysis

Selected honors General Academic Scholarship, University of Arizona, 1980-1984. Graduate Scholar’s Award, Rutgers University, 1986-1987. Walter C. Russell Fellowship, Rutgers University, 1986-1987. Marian Johnson Fellowship, Rutgers University, 1986-1988. Flinn Foundation Fellowship, University of Arizona, 1993-1994. Individual Postdoctoral National Research Service Award, 1996-1998. Professor of the Year, Calvin College (selected by senior class), 2005.