Structure Function and Evolution of the

Graham Cromar and Dr. John Parkinson

Program in Molecular Structure and FunctionHospital for Sick ChildrenToronto, ON, CANADA

Committee Members: Dr. Johanna RommensDr. Andrew EmiliDr. Gary Bader

In the lab: Dr. Jose Peregrin-Alvarez, Dr. James Wasmuth, Chris Sanford, David He

Extracellular Matrix

Aims

Map known disease genes onto the functional map to understand how the ECM is involved in health and disease.

Methods

Database of ECM proteins

SearchIntAct

Mint

DIP

BioGRID

Interaction Databases

Ensembl

Cellular Component = ECMBiological ProcessMolecular Function

Gene Ontology

RefSeqUniprot

Protein Databases

Filter

Render

The network was constructed, then expanded using orthologues

1267

807

Rat

Mouse

Human4

69

190 35428

613

Rat

Mouse

Human

46369

166

1611

Mouse – 2268Rat – 1910Human - 1165

Human - 2252

Interesting biological results?

8,3,1,2,418,12

14,8,17,255,7,6,9

5,6,11,12,23