STRUTTURE IN SOLUZIONE VIA NMR

Rappresentazione alternativa di una struttura in Rappresentazione alternativa di una struttura in soluzione, ovvero di una famiglia di strutturesoluzione, ovvero di una famiglia di strutture

Cyt c oxidized Cyt c reduced

Banci, Bertini, Bren, Gray, Sompornpisut, Turano, Biochemistry, 1997

Baistrocchi, Banci, Bertini, Turano, Bren, Gray, Biochemistry, 1996

Solution structure of oxidized and Solution structure of oxidized and reduced Cytochrome creduced Cytochrome c

Active site channel of Reduced Monomeric Active site channel of Reduced Monomeric Q133 Copper Zinc Superoxide dismutaseQ133 Copper Zinc Superoxide dismutase

Reduced Reduced Q133M2SODQ133M2SOD

Oxidized human Oxidized human SODSOD

0 20 40 60 800.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

1.8

2.0

2.2

2.4

2.6

Paramagnetic structureDiamagnetic structure

RM

SD

back

bone

Residue Number

Bertini, Donaire, Jiménez, Luchinat, Parigi, Piccioli, Poggi, J.Biomol. NMR, 2001,21,85-98

Structure of CeStructure of Ce3+3+ substituted Calbindin D substituted Calbindin D9k9k

The solution structure of a human The solution structure of a human SOD mutant SOD mutant