study program 2018/2019 subjects of the 5-6...

UP FP Pharmacy major – obligatory subjects of the 5-6. semester - Course descriptions – academic year of 2018/2019

1

University of Pécs Faculty of Pharmacy

PHARMACY Major

STUDY PROGRAM 2018/2019

Subjects of the 5-6. semesters

(obligatory subjects and criterion requirements)


2

5th semester

OPA-GE2-T ____ Pharmaceutical Biochemistry 2 ________________________________________________________________ 3

OPG-BFR-T ____ Biopharmacy ______________________________________________________________________________ 6

OPG-C1E-T ____ Pharmaceutical Technology 1 - Theory __________________________________________________________ 8

OPG-C1G-T ____ Pharmaceutical Technology 1 - Practice ________________________________________________________ 11

OPG-O1E-T ____ Pharmacognosy 1 - Theory __________________________________________________________________ 14

OPG-O1G-T ____ Pharmacognosy 1 - Practice _________________________________________________________________ 18

OPG-R1E-T ____ Pharmaceutical Chemistry 1 - Theory __________________________________________________________ 21

OPG-R1G-T ____ Pharmaceutical Chemistry 1 - Practice _________________________________________________________ 23

OPO-IMM-T ___ Basic Immunology ________________________________________________________________________ 26

OPO-MI1-T ____ Microbiology 1 ___________________________________________________________________________ 28

6th semester

OPG-C2E-T ____ Pharmaceutical Technology 2 - Theory _________________________________________________________ 30

OPG-C2G-T ____ Pharmaceutical Technology 2 - Practice ________________________________________________________ 32

OPG-O2E-T ____ Pharmacognosy 2 - Theory __________________________________________________________________ 34

OPG-O2G-T ____ Pharmacognosy 2 - Practice _________________________________________________________________ 39

OPG-R2E-T ____ Pharmaceutical Chemistry 2 - Theory __________________________________________________________ 41

OPG-R2G-T ____ Pharmaceutical Chemistry 2 - Practice _________________________________________________________ 43

OPO-I2E-T _____ Microbiology 2 - Theory ____________________________________________________________________ 45

OPO-I2G-T _____ Microbiology 2 - Practice ___________________________________________________________________ 47

OPO-KTN-T ____ Pathophysiology __________________________________________________________________________ 49

OPR-SG2-T ____ Professional Practice 2 _____________________________________________________________________ 54


3

OPA-GE2-T PHARMACEUTICAL BIOCHEMISTRY 2

Course director: DR. KATALIN SIPOS, associate professor

Department of Pharmaceutical Biology

4 credit ▪ final exam ▪ Basic subject ▪ autumn semester ▪ recommended semester: 5

Number of hours/semester: 42 lectures + 7 practices + 7 seminars = total of 56 hours

Course headcount limitations (min.-max.): 5 – 999 Prerequisites: OPA-G1B-T completed

Topic

The two-semester biochemistry course provides the essential fundamental biochemistry knowledge for the pharmaceutical students. This

course deals with the metabolic pathways of the living cell: the reactions, steps and regulation of these pathways. In the second semester

besides to learn the pathways of amino acid and nucleptid metabolism, students will synthetize their biochemical knowledge of the main

metabolic pathways, as well as the biochemistry of organs. We will pay special attention to the steps of biotransformations, which play

important role in the metabolism of drugs. In the second half of the semester students will study the most important chapters of

pathobiochemistry.

Conditions for acceptance of the semester

Maximum of 25 % absence allowed

Mid-term exams

There are two mid-term exams the results of which is included in the final exam.

Making up for missed classes

According to personal agreement

Reading material

- Obligatory literature

- Literature developed by the Department

The materials of the lectures and seminars will appear on Neptune.

- Notes

The e-notes of Biochemistry will be uploaded to Neptune.

- Recommended literature

Ch. P. Woodbury: Biochemistry for the Pharmaceutical Sciences

Raymond S. Ochs: Biochemistry

Thomas M. Devlin: Textbook of Biochemistry with Clinical Correlations

Lectures

1 Absorption and synthesis of amino acids I.

Dr. Farkas Viktória

2 Absorption and synthesis of amino acids II.


3 Break down of amino acids.


4 Importance of ammonia. Urea cycle.

Dr. Sipos Katalin

5 Clinical applications of amino acid metabolism

Dr. Sipos Katalin

6 Purine biosynthesis


7 Pyrimidine biosynthesis


8 Degradation of nucleotides. Gout I.


9 Degradation of nucleotides. Gout II.



4

10 Biochemistry of iron metabolism I.

Dr. Pandur Edina

11 Biochemistry of iron metabolism II.

Dr. Pandur Edina

12 Biochemistry of vitamins.

Dr. Sipos Katalin

13 Microsomal mono-oxygenase system. Cytochrome P450 I.

Dr. Sipos Katalin

14 Microsomal mono-oxygenase system. Cytochrome P450 II.

Dr. Sipos Katalin

15 Metabolic integration: caloric intake.


16 Metabolic integration: the functions of the liver I.

Dr. Sipos Katalin

17 Metabolic integration: the functions of the liver II.

Dr. Sipos Katalin

18 Metabolic integration: tissues of brain, muscle, heart. Sport activity. Pregnancy.


19 Macronutrients: carbohydrates.

Dr. Sipos Katalin

20 Macronutrients: proteins.


21 Macronutrients: lipids.

Dr. Sipos Katalin

22 Metabolism of alcohol.

Pap Ramóna

23 Diabetes mellitus I.


24 Diabetes mellitus II.


25 Genes and biochemistry I.

Pap Ramóna

26 Genes and biochemistry II.

Pap Ramóna

27 Pathobiochemistry of hemoglobin.

Dr. Pandur Edina

28 Biochemistry of hormones: amino acid derivatives, peptides.

Dr. Sipos Katalin

29 Biochemistry of hormones: proteins


30 Biochemistry of hormones: steroids.

Dr. Pandur Edina

31 Digestion and transport of proteins.

Dr. Sipos Katalin

32 Digestion and fate of carbohydrates.


33 Digestion and fate of lipids.

Dr. Sipos Katalin

34 Biochemistry of sensory system I.


35 Biochemistry of sensory system II.


36 Pathobiochemistry of blood clotting

Dr. Sipos Katalin

37 Regulation of carbohydrate metabolism I.


38 Regulation of carbohydrate metabolism II.



5

39 Regulation of lipid metabolism.

Dr. Sipos Katalin

40 Regulation of amino acid and nucleotide metabolisms.

Dr. Sipos Katalin

41 Preparation for exam

Dr. Sipos Katalin

42 Preparation for exam

Dr. Sipos Katalin

Practices

1 Enzyme activity measurement: LDH.

2 Enzyme activity determination: ALP.

3 Basic prinsiples of enzymatic analyses.

4 Determination of blood glucose concentration with enzymatic analysis.

5 Clinical laboratory methods I.

6 Clinical laboratory methods II.

7 Biochemical methods of protein analyses.

Seminars

1 Photosynthesis I.

2 Photosynthesis II.

3 Principles of enzyme activity measurements.

4 Biochemical laboratory methods: enzymes.

5 Biochemical laboratory methods: proteins.

6 Biochemical methods of drug discovery.

7 Biochemical methods of drug development.

Exam topics/questions

There are no given exam questions. The topics of the exam will be the materials of lectures and seminars.

Information – The following skills of the Booklet for Clinical Skills shall be accomplished in the framework of the subject

Participants

Dr. Farkas Viktória (FAVSAAP.PTE), Dr. Pandur Edina (PAEFAA.T.JPTE), Pap Ramóna (PARTAAT.PTE)


6

OPG-BFR-T BIOPHARMACY

Course director: DR. SZILÁRD PÁL, assistant professor

Institute of Pharmaceutical Technology and Biopharmacy

2 credit ▪ semester exam ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5


Course headcount limitations (min.-max.): 1 – 80 Prerequisites: OPG-C1E-T parallel + OPO-H1E-T completed

Topic

Aim of this course is to introduce biopharmaceutical aspects of medicines taking into account dosage forms and routes of administration.

Basic pharmacokinetic aspects (kinetics of active agents, compartmental analysis, routes of administration), some in vitro and in silico

biopharmaceutical practices (using special biopharmaceutical softwares) are presented, bioequivalence studies of medicines are

discussed. Students learn to design and develop pharmaceutical dosage forms according to biopharmaceutical requirements. Single and repeated dosing calculations are discussed according to pharmaceutical and physiological aspects.


Requirements determined by the Code of Studies and Examinations.

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60,1 % after average calculation. After two

assessments if students reach average 60,1 % taking into account both tests, writing the third assesment it not compulsory. The third

assessments (which is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance

for the 2nd retake, where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment,

re-take chance is possible for the student. Missing the re-take results 0 % assessment.


Students must fulfil requirements determined by the Code of Studies and Examinations.

Reading material



- Notes


Leon Shargel, A. B.C: .Applied Biopharmaceutics and Pharmacokinetics, Yu, Stamford

Susanna Wu-Pong, Yon Rojanasakul: Biopharmaceutical Drug Design and Development, Humana Press

Gilbert S. Banker, Christopher T. Rhodes: Modern Pharmaceutics, Marcel Dekker Inc., New York- Basel

www.gytk.pte.hu

www.sciencedirect.com

Lectures

1 Subject and general approach of biopharmacy

Dr. Pál Szilárd

2 Subject and general approach of biopharmacy

Dr. Pál Szilárd

3 Drug delivery systems and the input options

Dr. Pál Szilárd

4 Drug delivery systems and the input options

Dr. Pál Szilárd

5 Biopharmaceutical classification of substances and pharmaceutical preparations

Dr. Pál Szilárd

6 Biopharmaceutical classification of substances and pharmaceutical preparations

Dr. Pál Szilárd

7 Biopharmaceutical basics of drug qualification I (drug liberation studies)

Dr. Pál Szilárd

8 Biopharmaceutical basics of drug qualification I (drug liberation studies)

Dr. Pál Szilárd

9 Biopharmaceutical basics of drug qualification II (dissolution and absorption models)

Dr. Pál Szilárd

http://www.gytk.pte.hu/http://www.sciencedirect.com/


7

10 Written test

Dr. Pál Szilárd

11 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations)

Dr. Pál Szilárd

12 Biopharmaceutical basics of drug qualification II. (IVIVC, original and generic preparations)

Dr. Pál Szilárd

13 LADME system and its control options I

Dr. Pál Szilárd

14 LADME system and its control options I

Dr. Pál Szilárd

15 LADME system and its control options II

Dr. Pál Szilárd

16 LADME system and its control options II

Dr. Pál Szilárd

17 Written test

Dr. Pál Szilárd

18 Written test

Dr. Pál Szilárd

19 Biopharmaceutical basics of medicinal therapy I (dermal and transdermal therapy)

Dr. Kása Péter

20 Biopharmaceutical basics of medicinal therapy I (dermal and transdermal therapy)

Dr. Kása Péter

21 Biopharmaceutical basics of medicinal therapy II (eye, nasal and ear preparations)

Dr. Pál Szilárd

22 Biopharmaceutical basics of medicinal therapy II (eye, nasal and ear preparations)

Dr. Pál Szilárd

23 Biopharmaceutical basics of medicinal therapy III (hormonal disorders)

Dr. Pál Szilárd

24 Biopharmaceutical basics of medicinal therapy III (hormonal disorders)

Dr. Pál Szilárd

25 Biopharmaceutical basics of medicinal therapy IV (chronotherapy, cardiovascular diseases, asthma)

Dr. Pál Szilárd

26 Biopharmaceutical basics of medicinal therapy IV (chronotherapy, cardiovascular diseases, asthma)

Dr. Pál Szilárd

27 Biopharmaceutical basics of medicinal therapy V (specific medicinal therapy)

Dr. Kása Péter

28 Written test

Dr. Pál Szilárd

Practices

Seminars


Students will receive the topic lists in the Institute and/or on the website.

At the end of semesters, students take oral exam.Exams is preceded by the „Minimum Test” (MT). To write the MT, students have at

most 30 minutes, and will be evaluated by percentage. Those students, who achieve less than 60% in MT, will get unsatisfactory grade and cannot continue with the oral part of the exam.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.


Participants

Dr. Dévay Attila (DEAHABO.PTE), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)


8

OPG-C1E-T PHARMACEUTICAL TECHNOLOGY 1 - THEORY





Course headcount limitations (min.-max.): 1 – 80

Prerequisites: OPA-FZ2-T parallel + OPR-LAT-T completed + OPG-C1G-T parallel

Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical

Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients.

Further studies include review of national and international pharmacopoeias.

Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare

medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and

daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well.

Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal

drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.


Code of Studies and Regulations

Mid-term exams

Students have to write three assessments during the semester and they have to reach 60 % after average calculation. After two assessments

if students reach average 60 % taking into account both tests, writing the third assesment it not compulsory. The third assessments (which

is considered as the 1st retake) has to above 60,1 %. If the student fails on the 3rd assessment, there is still chance for the 2nd retake,

where student has to reach 60,1% for the acceptance of the semester. In case of confirmed absence from the assessment, re-take chance

is sossible for the student. Missing the re-take results 0 % assessment.



Reading material



- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London


Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu


Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

1 Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical technology, basic terms.

Dr. Pál Szilárd

2 Defination of medication and dosage form. History of preparation of medications. The subjects and tasks of pharmaceutical technology, basic terms.

Dr. Pál Szilárd

3 Dispensing and compounding at a pharmacy (measurement, treatment of substances)

Dr. Pál Szilárd

4 Dispensing and compounding at a pharmacy (measurement, treatment of substances)

Dr. Pál Szilárd



9

5 Basics of technological operations, biopharmaceutical aspects

Dr. Pál Szilárd

6 Basics of technological operations, biopharmaceutical aspects

Dr. Pál Szilárd

7 Technological importance of substances

Dr. Pál Szilárd

8 Technological importance of substances

Dr. Pál Szilárd

9 Dissolution

Dr. Secenji Aleksandar

10 Written test

Dr. Pál Szilárd

11 Excipients used to increase of API’s solubility

Dr. Pál Szilárd

12 Excipients used to increase of API’s solubility

Dr. Pál Szilárd

13 Mixing and stirring

Ámanné Dr. Takácsi-Nagy Anna

14 Mixing and stirring

Ámanné Dr. Takácsi-Nagy Anna

15 Heat transferes


16 Heat transferes


17 Interaction and incompatibility of pharmaceutical preparations

Dr. Pál Szilárd

18 Interaction and incompatibility of pharmaceutical preparations

Dr. Pál Szilárd

19 Written test

Dr. Pál Szilárd

20 Written test

Dr. Pál Szilárd

21 Sterilization, depyrogenation, aseptic working, eye preparations

Dr. Pál Szilárd

22 Sterilization, depyrogenation, aseptic working, eye preparations

Dr. Pál Szilárd

23 Preparation and examination of injection (API, excipients, solvents, containers, examination)

Dr. Pál Szilárd

24 Preparation and examination of injection (API, excipients, solvents, containers, examination)

Dr. Pál Szilárd

25 Infusions and implants. The most important class of injectable and plantable preparations

Dr. Pál Szilárd

26 Infusions and implants. The most important class of injectable and plantable preparations

Dr. Pál Szilárd

27 Written test

Dr. Pál Szilárd

28 Written test

Dr. Pál Szilárd

Practices

Seminars


The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from ?failed?).

The end-semester exam will be evaluated by a five-grade system. Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.The end-semester exam will be evaluated by a five-grade system.

Knowledge acquired is tested based on subject matter defined by a list of topics provided by the institute.


10

At the end of semester, students take oral exam. Chance „B” and „C” are also oral exams, which is preceded by the „Minimum Test”

(MT). To write the MT, students have at most 30 minutes, and will be evaluated percent rating. Those students, who achieve less

than 60% in MT, unsatisfactory grade will be assessed and cannot pass them to the oral part of the exam.

Oral part includes two topics. In the case of any part done with insufficient knowledge, will result in assessment of the exam to unsatisfactory grade.

In addition to the exam topics, part of the exam is answering questions that aim at assessing the general knowledge of the student.


Participants


11

OPG-C1G-T PHARMACEUTICAL TECHNOLOGY 1 - PRACTICE



5 credit ▪ midsemester grade ▪ Pharm. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5



Prerequisites: OPG-R1E-T parallel + OPR-LAT-T completed + OPR-SG1-T completed

Topic

Courses of pharmaceutical technology are taught in the 3rd and 4th years of school of pharmacy. Aim of courses of Pharmaceutical

Technology is introducing basic technological processes, preformulation and formulation of pharmaceutical dosage forms taking into

account physico-chemical, pharmaceutical and biopharmaceutical properties of active agents and pharmaceutical excipients.

Further studies include review of national and international pharmacopoeias.

Practices usually begin with seminars where basic introduction of the proper lesson takes place. After seminars students have to prepare

medicines according to the laws of pharmaceutical formulation technology in proper dosage forms including calculation of single and

daily maximal dose, preparation, labeling and pricing. Students also have to prepare galenic formulations according to the official formula. Practices of quality control of medicines are carried out as well.

Course Pharmaceutical Technology 1 includes practice with liquid dosage forms such as solution, syrup, elixir, oral drop, ear drop, nasal drop, parenteral solution and associated calculations with practices of quality control of mentioned dosage forms.


1. Accepted preparations made on practices.

2. Accepted work reports.

3. Accepted practical and theoretical assessments.

4. At the beginning of all practice classes students write short tests of different types (dose checking, synonim names and latin

expressions, calculations). Semester only can be accepted if students reach at least 50% from each short test type.

Evaluation of the practices is according to the semester work (practice work, assessments, work reports) by practice grade. In case of

fulfilled 1-3 sections, the requirement of the accepted semester is to reach at least satisfactory grade.

Mid-term exams



All missed or failed preparations manufactured on the practice should be made up on supplementary practices!

Reading material



- Notes


European Pharmacopoeia

Formulae Normales VII. (FoNo VII.)

James Swarbrick: Encyclopedia of Pharmaceutical Technology, Informa Healthcare, New York, London


Chris Langley, Dawn Belcher: Pharmaceutical Compounding and Dispensing, Pharmaceutical Press

www.gytk.pte.hu


Attila Dévay: The Theory and Practice of Pharmaceutical Technology, electronic book, PTE-Pécs

Attila Dévay: Investigation of Pharmaceutical Preparations, electronic book, PTE-Pécs

Lectures

Practices

1 General instructions, rules and regulations on practices, measuring, scales, introduction to reading prescriptions







12

6 Preparation of pure solutions, physical examination of solutions, diluting alcohol, pharmaceutical calculations





11 Complex solutions, mixtures, drops





16 Colloid solutions, examination of pure and colloid solutions, nasal drops and ear drops





21 Preparation and examination of pure solutions, alcoholic solutions





26 Preparation and examination of syrups and colloid solutions





31 Preparation and examination of mucilages and colloid solutions





36 Assessment

37 Assessment

38 Assessment

39 Assessment

40 Assessment

41 Sterilizing, isotonisation, calculations, eye drops





46 Preparation of eye drops, ointments





51 Preparation and examination of injections





56 Preparation and examination of infusions






13

61 Preparation and examination of emulsions and suspensions





66 End semester assessment





Seminars


The end-semester exam will be evaluated by a five-grade system.


Participants

Ámanné Dr. Takácsi-Nagy Anna (TAAMACO.PTE), Dr. Farkas Gyula (FAGTAAO.PTE), Dr. Kása Péter (ISWPRM), Dr. Pál Szilárd (PASMAAO.PTE)


14

OPG-O1E-T PHARMACOGNOSY 1 - THEORY

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy



Course headcount limitations (min.-max.): 5 – 50 Prerequisites: OPO-G2E-T completed + OPG-O1G-T parallel

Topic

Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene

technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical

composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and

drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with

medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are

required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary.

In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on processing information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective substances in general.


Maximum of 25 % absence allowed

Mid-term exams

Students need to write 1 written exam based on the lectures (acceptance: min. 60%). In the case of failed exam, there is one possibility

to rewrite it. In the case of failed practice result, there is no possibility to try the oral exam. At oral exam: 2 topics. Final results of oral

exam: oral communication + lecture written exam + practice result


There is no possibility to make up for the missed lectures.

Reading material



1. Farkas Á., Horváth Gy., Molnár P.: Pharmacognosy 1, digital learning material, 2014 TÁMOP-4.1.2.A/1-11/1-2011-0016

2. Farkas Á., Papp N., Bencsik T., Horváth Gy.: Digital Herbarium and Drug Atlas, digital learning material, 2014 TÁMOP-4.1.2.A/1-11/1-2011-0016

Course materials will be sent by Neptun for students.

- Notes


1. Evans W.C.: Trease and Evans Pharmacognosy, Saunders, London-New York, 2000

2. Aronson J.K. (ed.): Meyler’s Side Effects of Herbal Medicines, Elsevier, Amsterdam-Oxford-Tokyo, 2009

3. Barnes J., Anderson L.A., Phillipson J.D.: Herbal Medicines, 2nd edition, Pharmaceutical Press, London-Chicago, 2002

4. ESCOP Monographs, The Scientific Foundation for Herbal Medicinal Products, 2nd edition, Thieme, Exeter, Stuttgart, New York, 2003

5. Poole C.F., Poole S.K.: Chromatography Today, Elsevier, Amsterdam-Oxford-New York-Tokyo, 1991

6. WHO Guidelines on Good Agricultural and Collection Practices (GACP) for Medicinal Plants, 2003

7. Kayser O., Quax W. (eds.): Medicinal Plant Biotechnology, volume 1-2, Wiley, Weinheim, 2007.

Lectures

1 Scope and subject of pharmacognosy.

Dr. Horváth Györgyi

2 Scientific and Hungarian name of medicinal plants and drugs. Basic ethnobotany.

Dr. Papp Nóra

3 Wild, protected and cultivated medicinal plants; medicinal plant breeding.

Dr. Bencsik Tímea

4 Plant biotechnology.



15

5 Natural substances in pharmaceutical research.


6 (Traditional) herbal medicines and dietary supplements.


7 Tea drugs, primary processing of medicinal plants, plant extracts. Industrial medicinal plants.

Dr. Bencsik Tímea

8 Qualification and phytochemical evaluation of medicinal plants.

Dr. Bencsik Tímea

9 Phytotherapy.


10 Aromatherapy.


11 Medicinal plants in the homeopathy.


12 Drugs of fungus and animal origin.


13 Photosynthesis and related metabolic pathways of effective substances.

Dr. Molnár Péter

14 Role of nitrate- and sulphate-reduction in synthesis of effective substances.

Dr. Molnár Péter

15 Synthesis, role of carbohydrates.

Dr. Molnár Péter

16 Use of carbohydrates.

Dr. Molnár Péter

17 Synthesis, role and use of lipids.

Dr. Molnár Péter

18 Oils and waxes.

Dr. Molnár Péter

19 Biosynthesis of terpenoids.

Dr. Molnár Péter

20 Classification of terpenoids.

Dr. Molnár Péter

21 Test.


22 Test.


23 Biosynthesis and role of amino acids and proteins.

Dr. Molnár Péter

24 Biosynthesis and role of amino acids and proteins.

Dr. Molnár Péter

25 General features of alkaloids.

Dr. Molnár Péter

26 Classification of alkaloids.

Dr. Molnár Péter

27 General features of phenoloids.

Dr. Molnár Péter

28 Classification of phenoloids.

Dr. Molnár Péter

Practices

Seminars


The criterion of admission to the exam is the successful completion of the practice carried out in paralell (midsemester grade with the result different from ?failed?).

1. Definition of Pharmacognosy. Herbariums.

2. Ethno-pharmacobotany.

3. Natural substances in pharmaceutical research.

4. Hierarchy of herbal products traded Hungary: Herbal medicine, Traditional herbal medicinal product, Herbal tea, Dietary supplement.


16

5. Wild and protected medicinal plants, collection of medicinal plants.

6. Plant biotechnology and gene technology.

7. Tea drugs, primary processing, extracts.

8. Industrial medicinal plants.

9. Qualification and phytochemical evaluation of medicinal plants, requirements of the pharmacopoeia.

10. Phytotherapy.

11. Aromatherapy.

12. Homeopathy.

13. Drugs of fungus and animal origin: Secale cornutum, Tinder fungus, Laricis fungus, Reishi, Shii-take, Schizophyllum commune,

Lichen islandicus, Lichen quercus, Blatta orientalis, Cantharis, Cetylis palmitas, Gelatin, Hirudo medicinalis, Jecoris aselli oleum, Mel.

14. Significance of photosynthesis, structure and chemical composition of the chloroplast. Light reactions of photosynthesis.

15. The nitrogen cycle, nitrogen fixation.

16. Nitrogen assimilation and sulphate reduction. Nitrogen- and sulphur-containing compounds in the pharmaceutical practice.

17. Carbohydrate synthesis during photosynthesis: the Calvin-cycle; structure and role of phosphoenolpyruvate (PEP) and malic acid; C4 and CAM type plants.

18. Synthesis, role and usage of di- and polysaccharides [sucrose, maltose, starch (amylose, amylopectin), cellulose]. Pectins, mannans, gummi arabicum, heteropolysaccharides: occurrence, medicinal usage.

19. Biological functions and classes of lipids. Building blocks of phosphoglycerides: L-?-phosphatidic acid, cholamine, choline, serine,

inositol. Structure of cephalin, lecithine, phosphatidyl serine and phosphatidyl inositol. General characterisation of sphingosine, sphingo- and glycolipids.

20. Fats and oils. Biosynthesis of fatty acids. Structure of important saturated and unsaturated fatty acids occurring in plants.

21. Structure of arachidonic acid, ricinoleic acid, ricinine and ricin; occurrence, biological and medicinal importance. Physical and chemical parameters of fats and oils, occurrence in plants, medicinal usage.

22. Oils of animal origin: chemical structure of the most important compounds in cod-liver oil, medicinal usage. Structure and utilisation

of waxes.

23. Prostaglandins: discovery, occurrence; chemical structure; biosynthetic precursor; biological effects, medicinal usage.

Polyacetylenes: synthesis, features, occurrence in plants, biological role.

24. Isoprenoid compounds I. Isoprene rule; modes of linking of isoprene units; natural and artificial polyisoprenes.

25. Isoprenoid compounds II. General features of terpenes; occurrence; precursors of biosynthesis [mevalonic acid (MVA), isopentenyl pyrophosphate (IPP)]; main steps of biosynthesis.

26. Isoprenoid compounds III. Classification of terpenes. Chemical structure of linear and cyclic monoterpenes with a few examples; occurrence, biological role, medicinal usage.

27. Isoprenoid compounds IV. Iridoids, pyrethroids, sesquiterpenes: chemical structure of the cyclopenta-pyranoid skeleton; occurrence in plants, biological role, application in medicine.

28. Isoprenoid compounds V. Diterpenes, triterpenes. Chemical structure, occurrence and biological significance of phytol and squalene. Occurrence, biological role and medicinal usage of triterpenoid saponins.

29. Proteinogenic amino acids I.: structural formula and chemical name of alanine, arginine, aspartic acid, asparagine, cysteine, glycine, glutamic acid, glutamine, histidine, leucine, isoleucine.

30. Proteinogenic amino acids II: Structural formula and chemical name of lysine, methionine, phenylalanine, proline, hydroxyproline,

serine, threonine, tryptophan, tyrosine, valine.

31. Important amino acid reactions I. a.) Basic reaction of transamination; b.) reductive desamination ? formation of ?-amino acids from

?-keto acids ?-oxo acids); c.) formation of glutamine from glutamic acid.

32. Important amino acid reactions II: a.) Decarboxylation; b.) oxidative desamination; c.) formation of asparagine from aspartic acid.

33. Breakdown of xanthine, caffeine and other purine-derived effective substances: formation of ureids, glycolic acid, glyoxylic acid and

carbamide. Allantoin, as the most well-known plant ureid.

34. Specific amino acids: chemical structure of ?-amino-butyric acid (GABA), ?-amino-butyric acid (BABA) and ?-alanine; formation, significance in plants; chemical transformation.

35. Occurrence and significance of canavanine. Structure, occurrence and biological effect of L-dihydroxy-phenylalanine (L-DOPA-).

Occurrence of alkyl- and allyl-derivatives of cysteine; chemical structure and occurrence of diallyl-sulfide and diallyl-disulfide. Occurrence of propenyl-cysteine.

36. Peptids, proteins. Classification of proteins based on solubility relations. Biological and biochemical role of enzymes, classification according to their functions. Occurrence and medicinal usage of some enzymes (papain, bromelain, ficin).

37. The place and main steps of plant protein biosynthesis. Occurrence and biological role of stored proteins. Features, occurrence,

biological role and application of lectins (phytohemagglutinins), toxic (ricin) and other plant proteins.

38. Alkaloids I. Definition and general characteristics of alkaloids; natural occurrence. Structure of the most important amino acids in

their biosynthesis (ornitin, lysine, phenylalanine, tyrosine, tryptophan, histidine).

39. Alkaloids II. Structure of N-containing heterocyclic compounds, characteristic for alkaloids (pyrrole, pyrrolidine, pyridine, piperidine, indole, quinoline, isoquinoline, pyrimidine, imidazole, purine, sterane structure).

40. Alkaloids III. Phenylethylamine-type alkaloids: ephedrine as a protoalkaloid. Mescaline as a protoalkaloid. Occurrence, biological features, application.

41. Alkaloids IV. Alkaloids containing pyridine, pyrrolidine, piperidine cycle: chemical formula and name, biological effect of nicotine and coniine. Occurrence of other alkaloids with pyperidine cycle (piperine, lobeline).


17

42. Alkaloids V. Tropane alkaloids ? Alkaloids with a condensed pyrrolidine- and piperidine cycle. Structure of nortropane, tropane,

tropine (3?-hydroxi-tropane) and tropic acid. Atropine, hyosciamine, scopolamine ? structure, occurrence, biological effect,

application in medicine and elsewhere.

43. Alkaloids VI. Structure of pseudotropine (3 ?-hydroxi-tropane), ecgonine and cocaine; occurrence and biological effects of cocaine. Structural comparison of novocaine (non-alkaloid) and cocaine, focusing on the atom group responsible for biological effect.

44. Alkaloids VII. Alkaloids with quinoline structure. Structure, occurrence, biological effects and application of quinine.

45. Alkaloids VIII. Opium alkaloids: a.) Structure, biological effect and usage of papaverine as an isoquinoline structure alkaloid.

46. Alkaloids IX. Opium alkaloids: b.) Structure of morphine; biological effect, medical usage. Biological effects and medical application of some important morphine derivatives [codeine, tebaine, ethylmorphine (dionine), heroin].

47. Alkaloids X. LSD as the most important derivative of lysergic acid. Biological effects and medical application of important ergot alkaloids.

48. Alkaloids XI. Purine alkaloids: tautomeric lactam-lactim equilibrium of xanthine; structure of theophylline, theobromine and caffeine; occurrence, biological effects, usage.

49. Phenoloids I. Structure of amino acids in their biogenesis (phenylalanine, tyrosine). Structure of ?-phenyl-propionic acid, trans (E)-

cinnamic acid, cis (Z)-cinnamic acid (allo-cinnamic acid), para-coumaric acid, caffeic acid and chlorogenic acid (the ester of caffeic

acid and quinic acid).

50. Phenoloids II. The hydroquinone ? para-benzoquinone transformation. Quinone derivatives and their significance in plant

biochemistry. Phenol-carboxylic acids of benzoic acid origin, e.g. gallic acid: structure, occurrence in plants, significance in biology and medicine.

51. Phenoloids III. Structure and occurrence of salicin in plants. Chemical structure of salicylic alcohol, salicylic acid, acetylsalicylic acid (Aspirin) and its Ca-salt (Kalmopyrin); their significance in pharmacy.

52. Phenoloids IV. Structure of some unsaturated phenol alcohols. Trans (E)-cinnamic alcohol and its derivative: para-coumaryl alcohol. Features of lignins, lignans, flavonolignans: occurrence, biological and medicinal importance.

53. Phenoloids V. Coumarins. Chemical structure of coumarin and coumaric acid. Aesculin, dicoumarol and furanocoumarins; occurrence in plants; biological and medicinal significance.

54. Phenoloids VI. Flavonoids: Structure of ?- and ?-pyran, ?- and ?-pyrone and coumarin (?-pyrone condensed with benzol). Structure

of chromane, chromene, chromone, flavan, flavene, flavon, flavonol (3-hydroxi-flavon) and quercetin. Structure, occurrence and

isolation of rutin (vitamin P).

55. Phenoloids VIII. Tannins. Classification of tannins. Structure of gallic acid, pyrogallol, meta-digallic acid, penta-meta-digalloyl ?-D-glucose. Occurrence, features and application of tannins.

56. Phenoloids IX. Quinones and terpenophenols. Structure of juglone, anthraquinone (9,10-anthraquinone) and anthrone. Biological

effect, features and usage of juglone. Occurrence and medicinal significance of plant effective substances with anthraquinone and

anthrone (naphtho-dianthrone) structure. Terpenophenols (cannabinoids). Occurrence and biological effect of THC; effective substances of hop and their structure.


Participants


18

OPG-O1G-T PHARMACOGNOSY 1 - PRACTICE

Course director: DR. GYÖRGYI HORVÁTH, associate professor

Department of Pharmacognosy



Course headcount limitations (min.-max.): 3 – 50 Prerequisites: OPO-G2E-T completed + OPG-O1E-T parallel

Topic

Pharmacognosy covers general aspects of medicinal plants (such as industrial applications, research, cultivation and cultivars, gene

technology, critical evaluation of holistic medicine and homeopathy, possibilities of phytotherapy) and discusses the chemical

composition and other qualitative characteristics, as well as the most important areas of usage and pharmacology of herbal drugs and

drug fractions such as oils and essential oils. Based on their previous pharmacobotanic knowledge students become acquainted with

medicinal plants and drugs that are used in pharmacotherapy (especially in phytotherapy) both in Hungary and abroad. Students are

required to recognize the most important tea drugs and drugs with strong physiological effect that are traded and/or imported in Hungary.

In the frame of practices students obtain experience in drug analysis and identification methods and the ability to solve daily arising problems, with special emphasis on processing information from literature, databases and the internet.

Course objective and role in the curriculum: students should become familiar with plant materials and drugs, as well as their effective substances in general. During the practices, macroscopic and microscopic examinations of the drugs are organized.


Practices are compulsory.

Mid-term exams

In the case of failed practice result, there is no possibility to try the oral exam. Students need to take one practice oral presentation during

semester. Final result of the practice will be included in the result of oral exam. Preparation of practice notebook is compulsory. There

are 4 small written exams (drug identification practice) during semester.


There is possibility to make up for the missed practices but with the course supervisor’s permission.

Reading material



- Notes

Bencsik T, Ács K, Farkas Á, Molnár P, Papp N, Horváth Gy (2015): Pharmacobotanical and phytochemical investigation of herbal

drugs - Teaching supplement. University of Pécs


Lectures

Practices

1 Drugs with carbohydrate content. Microscopic distinction of starch grains. Identification of unknown drugs based on

pharmacopoeial descriptions.

2 Drugs with carbohydrate content. Microscopic distinction of starch grains. Identification of unknown drugs based on

pharmacopoeial descriptions.

3 Drugs with carbohydrate content. Microscopic distinction of starch grains. Identification of unknown drugs based on pharmacopoeial descriptions.

4 Methods of analysis for medicinal plants in the European Pharmacopoeia. Drugs containing inorganic and organic acids. Equiseti herba contamination with Equisetum palustre; analysis of the epidermis and other morpho-anatomical features.



7 Drugs with fatty oils. Reviewing requirements of the European Pharmacopoeia for fatty oils.



10 Drugs with essential oil I: Lamiaceae. Menthae piperitae folium. Identification of Thymi vulgaris herba and Serpylli herba on the basis of glandular trichomes. Organoleptic examination of essential oils.



19


13 First written test. Drugs with essential oil II: Apiaceae. Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus,

Coriandri fructus on the basis of histological features.

14 First written test. Drugs with essential oil II: Apiaceae. Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus,

Coriandri fructus on the basis of histological features.

15 First written test. Drugs with essential oil II: Apiaceae. Identification of Anisi vulgaris fructus, Carvi fructus, Foeniculi fructus, Coriandri fructus on the basis of histological features.

16 Drugs with essential oil III: Asteraceae. Investigation of Matricariae flos on the basis of the European Pharmacopoeia. Distinction

of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. Investigation of Lupuli flos. Identification of unknown drugs based on pharmacopoeial descriptions.


of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. Investigation of Lupuli flos.

Identification of unknown drugs based on pharmacopoeial descriptions.


of Solidaginis herba and Solidaginis virgaureae herba based on micromorphological features. Investigation of Lupuli flos. Identification of unknown drugs based on pharmacopoeial descriptions.

19 Second written test. Iridoids, diterpenes, triterpene saponins. Histological comparison of Valerianae radix and Primulae radix.



22 Alkaloid-containing drugs I: Solanaceae. Comparison of Belladonnae folium and Stramonii folium on the basis of cleared preparations.



25 Alkaloid-containing drugs II. Short lectures of the students.



28 Third written test. Cardenolic glycosides. Identification of components of unknown herbal teas (mixtures), and based on the results identification of their indications.



31 Phenoloids I. Morphological and histological investigation of Hyperici herba. Histological characterisation of Sennae folium,

Sennae fructus acutifoliae and Sennae fructus angustifoliae.

32 Phenoloids I. Morphological and histological investigation of Hyperici herba. Histological characterisation of Sennae folium,

Sennae fructus acutifoliae and Sennae fructus angustifoliae.

33 Phenoloids I. Morphological and histological investigation of Hyperici herba. Histological characterisation of Sennae folium, Sennae fructus acutifoliae and Sennae fructus angustifoliae.

34 Phenoloids II. Characterisation of Cotini folium with histochemical reactions. Cleared preparations of Juglandis folium.



37 Fourth written test. Amino acids, peptides, proteins. Identification of Phaseoli pericarpium by calcium-oxalate prisms. Steroid-

containing drugs. Investigation of Avenae herba. Identification of components of unknown herbal teas (mixtures), and based on the results identification of their indications.





40 Preparation of herbal teas of FoNo VII



Seminars


Not relevant.


20


Participants

Dr. Bencsik Tímea (BETMACO.PTE), Dr. Horváth Györgyi (HOGAAA.T.JPTE)


21

OPG-R1E-T PHARMACEUTICAL CHEMISTRY 1 - THEORY

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry




Prerequisites: OPA-L2E-T completed + OPA-V2E-T completed + OPG-R1G-T parallel

Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Introduction to the pharmacokinetics and

pharmacodynamics of drug action. Molecular aspects and structure activity relationship of selected groups of active pharmaceutical ingredients with central nervous system activity.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation is both the lectures and the

practices is obligatory. Maximum three absences can be accepted both from lectures and practices. Two compulsory midterm tests (on

the topics of the lectures and practices) will be written during the semester on the 7th and the 12th weeks. One of the test result should

be above 60%. One re-take chance is allowed at the 14th weak of the semester. Students have to write at least four mini-tests on the

practices. The average of the results must be at least 50%. The practical work (results of the written tests and the experimental work) is

evaluated by a practical grade. Satisfactory (2) evaluation is the minimum requirement of acknowledgement of the semester.

Mid-term exams


There is no opportunity to make up missed classes.

Reading material


D. A. Williams, T. L. Lemke (eds.): Foye’s Principles of Medicinal Chemistry, 7th edition, Lippincott Williams & Wilkins,

Philadelphia, 2013


Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic educational material, PTE 2014

Zsuzsanna Rozmer, Pál Perjési: Physico-Chemical Bases of Drug Action. Electronic educational material, PTE 2015

- Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015


European Pharmacopoeia, EDQM Publication

Lecture notes.

Lectures

1 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances.

Dr. Perjési Pál

2 Introduction. History and development of drug control. The European Pharmacopoeia. The pharmacopoeial nomenclature of substances.

Dr. Perjési Pál

3 Physical and physicochemical methods of the European Pharmacopoeia.

Dr. Kulcsár Győző Kornél

4 Physical and physicochemical methods of the European Pharmacopoeia.


5 Identification and qualitative tests of the European Pharmacopoeia.


6 Identification and qualitative tests of the European Pharmacopoeia.


7 Protein-specific test methods of the European Pharmacopoeia.

Dr. Perjési Pál


22

8 Protein-specific test methods of the European Pharmacopoeia.

Dr. Perjési Pál

9 The fate of xenobiotics in the body.

Dr. Perjési Pál

10 The fate of xenobiotics in the body.

Dr. Perjési Pál

11 The receptor theory.

Dr. Perjési Pál

12 The receptor theory.

Dr. Perjési Pál

13 Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

Dr. Perjési Pál

14 Molecular basis of drug action. Physico-chemical parameters affecting drug-target interactions.

Dr. Perjési Pál

15 Structural and physical chemical basis of drug action. Structure-activity relationships.

Dr. Perjési Pál

16 Structural and physical chemical basis of drug action. Structure-activity relationships.

Dr. Perjési Pál

17 Transport processes. Transporters and ion channels as drug targets.

Dr. Huber Imre

18 Transport processes. Transporters and ion channels as drug targets.

Dr. Huber Imre

19 Central and peripheral receptors. Receptors as drug targets.

Dr. Huber Imre

20 Central and peripheral receptors. Receptors as drug targets.

Dr. Huber Imre

21 Structure and functions of enzymes. Enzymes as drug targets.

Dr. Huber Imre

22 Structure and functions of enzymes. Enzymes as drug targets.

Dr. Huber Imre

23 Phase 1 metabolic transformations.

Dr. Almási Attila


Dr. Almási Attila


Dr. Almási Attila


Dr. Almási Attila

27 Drug metabolism and drug toxicity.

Dr. Perjési Pál

28 Drug metabolism and drug toxicity.

Dr. Perjési Pál

Practices

Seminars


Written exam covering the topics of the lectures and the laboratory practices. The result of the first part of the written exam (Minimum

Written Test) should be at least 80%. In the case of the third („C”) exam the written exam is evaluated regardless the result of the

Minimum Written Test. The list of the possible questions of the Minimum Written Test is announced on the Neptun system. The

result of the written exam must be above 60%. The final grade is based on results of the midterm tests and the written exam. Maximum

contribution of the results of the midterm tests to the total score of the written exam is 25%. Participation on the first exam is

compulsory.


Participants


23

OPG-R1G-T PHARMACEUTICAL CHEMISTRY 1 - PRACTICE

Course director: DR. PÁL PERJÉSI, professor

Department of Pharmaceutical Chemistry




Prerequisites: OPA-L2E-T completed + OPA-V2E-T completed + OPA-M2E-T completed

Topic

Introduction to the quality control of substances used in pharmaceutical compounding. Pharmacopoeal analysis of selected inorganic

substances.


Acknowledgement of the course is in accord with the Code of Studies and Examinations. Participation in the practices is obligatory.

Maximum three absences can be accepted. Students have to write at least four short tests on the practices. The average of the results must

be at least 50%. The practical work (results of the written tests and the experimental work) is evaluated by a practice grade.

Mid-term exams


There is no opportunity to make up missed practices.

Reading material



Attila Almási, Zsuzsanna Rozmer, Pál Perjési: Pharmaceutical Chemistry I. Laboratory Experiments and Commentary, electronic educational material, PTE 2014.

- Notes

Pharmaceutical Chemistry Practice I., Laboratory manual, University of Pécs, 2015.


Lectures

Practices

1 Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.

2 Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.

3 Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests

of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.

4 Laboratory safety and accident protection. The pharmacopoeial nomenclature of substances. Identification and qualitative tests

of the European Pharmacopoeia. Limit tests. Acidum hydrochloridum dilutum.

5 Calculation of results. Experimental errors. Acidum hydrochloridum dilutum, Natrii chloridum, Chloraminum.




9 Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.

10 Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii

chloridum.

11 Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii

chloridum.

12 Inorganic pharmacopoeial substances I. Halogens Iodum, Natrii bromidum., Kalii bromidum, Ammonii bromidum, Kalii chloridum.


24

13 Inorganic pharmacopoeial substances II. Oxygen group.. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.

14 Inorganic pharmacopoeial substances II. Oxygen group.. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii

hydroxidum.

15 Inorganic pharmacopoeial substances II. Oxygen group.. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii

hydroxidum.

16 Inorganic pharmacopoeial substances II. Oxygen group.. Aqua purificata, Hydrogenii peroxidum 30 per centum, Natrii hydroxidum.

17 Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad usum externum.



20 Inorganic pharmacopoeial substances III. Sulphur compounds. Natrii thiosulfas, Natrii metabisulfis, Natrii sulfas, Sulphur ad

usum externum.

21 Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi

subnitras.

22 Inorganic pharmacopoeial substances IV. Nitrogen compounds. Ammonii chloridum, Natrii nitris, Kalii nitras, Bismuthi subnitras.



25 Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas

26 Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii dihydrogenophosphas, Dinatrii phosphas

27 Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii

dihydrogenophosphas, Dinatrii phosphas

28 Inorganic pharmacopoeial substances V. Phosphorous compounds. Calcii hydrogenophosphas, Tricalcii phosphas, Natrii

dihydrogenophosphas, Dinatrii phosphas

29 Inorganic pharmacopoeial substances VI. Carbon compounds. Carbo activatus, Calcii carbonas, Natrii carbonas, Natrii hydrogencarbonas.




33 Inorganic pharmacopoeial substances VII. Pharmaceutical excipients (Seminars).




37 Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum, Magnesii trisilicas.



40 Inorganic pharmacopoeial substances VIII. Alkaline earth metals. Magnesii sulfas, Magnesii subcarbonas, Magnesii oxydum,

Magnesii trisilicas.

41 Inorganic pharmacopoeial substances IX. Silicon compounds. Earth metals. Silica, colloidal hydrated, Acidum boricum, Borax.





25

45 Inorganic pharmacopoeial substances X.Metals I. Aluminii oxidum hydricum, Aluminii sulfas, Alumen, Zinci oxydum, Zinci chloridum.

46 Inorganic pharmacopoeial substances X.Metals I. Aluminii oxidum hydricum, Aluminii sulfas, Alumen, Zinci oxydum, Zinci

chloridum.

47 Inorganic pharmacopoeial substances X.Metals I. Aluminii oxidum hydricum, Aluminii sulfas, Alumen, Zinci oxydum, Zinci

chloridum.

48 Inorganic pharmacopoeial substances X.Metals I. Aluminii oxidum hydricum, Aluminii sulfas, Alumen, Zinci oxydum, Zinci chloridum.

49 Inorganic pharmacopoeial substances XI. Metals II. Cupri sulfas, Ferrosi sulfas, Ferri chloridum, Kalii permanganas.




53 Identification and complete pharmacopoeial analysis of an inorganic substance.




Seminars


N/A


Participants

Dr. Almási Attila (ALAFAEO.PTE)


26

OPO-IMM-T BASIC IMMUNOLOGY

Course director: DR. PÉTER NÉMETH, professor

Department of Immunology and Biotechnology

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5


Course headcount limitations (min.-max.): 5 – 200 Prerequisites: OPA-G1B-T completed + OPO-GB2-T completed

Topic

Introduction to the current immunobiology. Organisation of the human immune system: organs, tissues, cellular and molecular

components. Regulation of immune functions: recognition, differentiation, effector functions, memory formation, suppression of the

immune response, immunological tolerance. Main aspects of the physiological and pathological immune response. Basic

immunopathological aspects of immune related diseases including allergy, autoimmune diseases, organ transplantation, immunity against tumours.


Participation on the lectures. No more absences as 3.

Mid-term exams

Practice performed with another group on the same week.


Not possible

Reading material



- Notes


A.K. Abbas, A.H. Lichtman and A. Pillai: Cellular and Molecular Immunology, 6th edition, Elsevier

Janis Kuby: Immunology

Jan Klein: Immunology

Lectures

1 Introduction, historical overview, main aspects and perspectives in the theoretical and practical immunology - immunobiology. Composition of the immune system: organs, tissues and cells.

Dr. Németh Péter

2 Molecular components of the immunological recognition: MHC, structure and genetics of the classes, their role in the immune functions.

Dr. Németh Péter

3 Antibodies and B cell receptors (molecular structure, functions, subclasses). Recognition of antigens by B cells and

immunoglobulins. Definition of the antigens, relations between the structure, feature, origin and the immunological recognition.

Antigen-antibody reactions.

Dr. Németh Péter

4 T cell receptors, co-receptors and adhesion molecules.

Dr. Németh Péter

5 Recognition of antigen by T-cells. Antigen presentation and MHC-restriction.

Dr. Németh Péter

6 Lymphocyte maturation and expression of antigen receptor genes.

Dr. Berki Timea

7 B cell development in the bone marrow. Maturation stages and environmental regulators.

Dr. Balogh Péter

8 T cell development in the thymus. Maturation stages and environmental regulators.

Dr. Berki Timea

9 Innate immunity. Inflammation.

Dr. Berki Timea

10 The early phase of T cell activation. The CD3 complex, and signal transduction, role of CD45 molecule, accessory molecules.

Immunological recognition of superantigens.

Dr. Berki Timea


27

11 T cell activation II. Th1, Th2 differentiation, the nature and role of the cytokines

Dr. Berki Timea

12 A brief overview of immune responses. Lymphocyte recirculation, role of the microenvironment.

Dr. Berki Timea

13 The central phase of the immune response, cellular interactions, B cell activation, T-B cell cooperation, antibody production, the role of adhesion molecules and cytokines.

Dr. Berki Timea

14 Regulation of immunoglobulin isotype expression, affinity maturation of B cells.

Dr. Boldizsár Ferenc

15 Maintenance of the immunological memory and its role in immune response regulation. Comparisons of the primary and secondary immune response.

Dr. Balogh Péter

16 Suppression of immune response. Role of the antigen, antigen presenting cells, T and B lymphocytes and cytokines. Immunoglobulin-immunoglobulin interactions, anti-idiotype network.

Dr. Németh Péter

17 Complement system (molecular components, activation pathways).

Dr. Berki Timea

18 Regulation of the effector functions. Immunoglobulin mediated immune reactions. Fc receptors.

Dr. Németh Péter

19 Effector mechanisms of cell mediated immunity (CMI): Cytotoxicity.

Dr. Engelmann Péter András

20 Systemic and local immunity. Mucosa and skin associated immune system.

Dr. Németh Péter

21 Cellular and molecular mechanism of the immunological tolerance and the tolerance induction.

Dr. Németh Péter

22 Hypersensitivities. Cellular and molecular mechanism of allergies. T cell mediated macrophage activation, delayed type hypersensitivity (DTH).

Dr. Németh Péter

23 Basic properties of the autoimmunity and the autoimmune reactions. Miss-regulation of the immune system: development of organ-specific and systemic autoimmune diseases

Dr. Németh Péter

24 Immundeficiency diseases: inherited and acquired.

Dr. Balogh Péter

25 HIV infection and the pathomechanism of AIDS

Dr. Najbauer József

26 Immunological aspects of organ transplantation.

Dr. Németh Péter

27 Immunity against tumors.

Dr. Németh Péter

28 New opportunities in the medical biotechnology: individual diagnostics and immune-based therapies.

Dr. Németh Péter

Practices

Seminars


Multiple choice questions prepared according to the subject of the lectures. Details see on www.immbio.hu. The written exam test might contain minimum requirement questions where the wrong answers could mean failure on the exam.


Participants

http://www.immbio.hu/


28

OPO-MI1-T MICROBIOLOGY 1

Course director: DR. ISTVÁNNÉ BÁTAI (DR. MÓNIKA KERÉNYI), associate professor

Department of Medical Microbiology and Immunology

2 credit ▪ semester exam ▪ Med.-biol. theoretical module and practical skills subject ▪ autumn semester ▪ recommended semester: 5


Course headcount limitations (min.-max.): 1 – 100 Prerequisites: OPA-G1B-T completed + OPO-GB2-T completed

Topic

During the course the morphology, physiology of microbes, the techniques of disinfection and sterilization, the basics of antimicrobial

therapy and the drugs used will be discussed. The host-parasite interactions, the factors playing roles in the pathogenesis of infections,

the defense mechanisms of the host and the modes of prevention will be detailed. In this semester some lecture from systematic

bacteriology are given. The objective is to provide a solid microbiological basis that will contribute to understanding detailed microbiology and further pharmacological studies.


Attendance of the lectures is up to the judgement of the student. The materials of the lectures will be a part of the examinations.

The students will have to successfully complete a written colloquium in the exam period

Mid-term exams

4 written exams in exam period


-

Reading material


Denyer SP ,Hodges NA, Gorman SP, Gilmore BF: Hugo and Russell’s Pharmaceutical Microbiology, 8th Edition, Blackwell Science Ltd 2011, ISBN: 978-1-118-77464-9


Lectures on the Neptun

- Notes


Dr. Patrick R. Murray, Dr. Ken S. Rosenthal and Dr. Michael A. Pfaller (eds.): Medical Microbiology, 8th edition, Elsevier Saunders

2016 ISBN:978-0-323-29956-5

F.H. Kayser, K.A. Bienz, J. Eckert, R.M. Zinkernagel: Medical Microbiology, Thieme Stuttgart 2005, ISBN: 3-13-131991-7

Lectures

1 Introduction the subject of microbiology, Taxonomy

Dr. Emődy Levente

2 Morphology and structure of bacteria - essential cell components

Dr. Tigyi Zoltán

3 Morphology and structure of bacteria - accessorial cell components

Dr. Tigyi Zoltán

4 The physiology of bacteria, nutration types and growth of bacteria

Dr. Kocsis Béla

5 Microbial genetics I

Dr. Tigyi Zoltán

6 Microbial genetics II

Dr. Tigyi Zoltán

7 Sterilization

Dr. Bátai Istvánné (Dr. Kerényi Mónika)

8 Disinfection


9 Microbiological evaluation of drugs. Pyrogenicity testing

Dr. Kocsis Béla

10 Antimicrobial drugs - general information. Pharmacodynamic and pharmacokinetic effects

Dr. Kocsis Béla


29

11 Inhibitors of bacterial cell wall synthesis

Dr. Kocsis Béla

12 Inhibitors of bacterial protein synthesis

Dr. Kocsis Béla

13 Antibiotics that inhibit nucleic acid synthesis. Drugs that inhibit other biochemical targets

Dr. Kocsis Béla

14 Mechanisms of Resistance

Dr. Emődy Levente

15 Pathogenicity and virulence

Dr. Emődy Levente

16 Immunology of infectious diseases I

Dr. Polgár Beáta

17 Immunology of infectious diseases II

Dr. Polgár Beáta

18 Immunology of infectious diseases III

Dr. Polgár Beáta

19 Immunotherapy I

Dr. Polgár Beáta

20 Immunotherapy II

Dr. Polgár Beáta

21 Vaccinology I

Dr. Emődy Levente

22 Vaccinology II

Dr. Emődy Levente

23 Pyogenic bacteria I


24 Pyogenic bacteria II


25 Pyogenic bacteria III


26 Enteric bacteria and gastrointestinal pathogens I

Dr. Tigyi Zoltán

27 Enteric bacteria and gastrointestinal pathogens II

Dr. Tigyi Zoltán

28 Enteric bacteria and gastrointestinal pathogens III

Dr. Tigyi Zoltán

Practices

Seminars


Written exam consists of multiple choice questions


Participants


30

OPG-C2E-T PHARMACEUTICAL TECHNOLOGY 2 - THEORY



2 credit ▪ semester exam ▪ Pharm. theoretical module and practi

study program 2018/2019 subjects of the 5-6...

Documents