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Substance Use Issues and Serious Mental Illness in the United States: An Update from SAMHSA Mental Health Association of Essex and Morris, Inc., West Orange, NJ October 4, 2019 Elinore F. McCance-Katz, MD, PhD Assistant Secretary for Mental Health and Substance Use Substance Abuse and Mental Health Services Administration U.S. Department of Health and Human Services

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Page 1: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Substance Use Issues and Serious Mental Illness in the United States: An Update from

SAMHSA

Mental Health Association of Essex and Morris, Inc., West Orange, NJOctober 4, 2019

Elinore F. McCance-Katz, MD, PhD

Assistant Secretary for Mental Health and Substance Use

Substance Abuse and Mental Health Services Administration

U.S. Department of Health and Human Services

Page 2: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

• Epidemiology of substance use and mental disorders in the United States

– High rates of co-occurring disorders

• Status of Opioid Epidemic

• Marijuana

• Vaping

• Serious Mental Illness

• SAMHSA resources

2

Overview

Page 3: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Mental Illness and Substance Use Disorders in America

Among those with a substance use disorder:3 IN 8 (38.3% or 7.4M) struggled with illicit drugs3 IN 4 (74.5% or 14.4M) struggled with alcohol use1 IN 8 (12.9% or 2.5M) struggled with illicit drugs and alcohol

Among those with a mental illness:1 IN 4 (23.9% or 11.4M) had a serious mental illness

7.8%(19.3 MILLION) People aged 18 or older had a substance use disorder (SUD)

19.1% (47.6 MILLION)People aged 18 or older had a mental illness

3.7% (9.2 MILLION)

People 18+ had BOTH an SUD and a

mental illness

PAST YEAR, 2018 NSDUH, 18+

In 2018, 57.8M Americans had a mental and/or substance use disorder.

Page 4: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Illicit Drug Use: Marijuana Most Used Drug

PAST YEAR, 2018 NSDUH, 12+

0.3%

0.7%

0.7%

2.0%

2.0%

6.2%

15.9% 43.5M

16.9M

5.5M

5.6M

1.9M

2.0M

808K

0% 2% 4% 6% 8% 10% 12% 14% 16% 18%

Heroin

Inhalants

Methamphetamines

Hallucinogens

Cocaine

Psychotherapeutic Drugs

Marijuana

Significant decrease from 2017 (6.6%)

Significant increase from 2017 (15%)

Page 5: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

THE OPIOIDS CRISIS

Status and Strategy

Page 6: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Opioids Crisis: Overview

• State Targeted Response to Opioids implemented in 2017 as part of Cures Act• $1B added in 2018 to opioids prevention, treatment and recovery services (State

Opioid Response) and $6 overall to HHS to help American communities combat the crisis

• SAMHSA has provided funding to the states and through discretionary grant programs to address opioids issues and has provided ongoing guidance to states on use of funding for the allowed purposes

• Opioid misuser numbers have dropped from 11.4M in 2017 to 10.3M in 2018• Opioid Use Disorder dropped from 2.1M in 2017 to 2.0M in 2018• Overdose deaths declined by 2.8% in 2018 (47,608) from 2017 (48,958)• Fentanyl and potent synthetic opioids remain the major source of toxicity and

death.• There is still much to be done, but progress is being made.

Page 7: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Opioid Misuse

0%

2%

4%

6%

8%

10%

2015 2016 2017 2018

5.6% 18-251.9M

3.6% 26+7.7M

3.9%980K

8.7%3.0M

4.2%8.7M

PAST YEAR, 2015-2018 NSDUH, 12+

. + Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

2.8% 12-17699K

Page 8: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Prescription Pain Reliever Misuse and Heroin Use PAST YEAR, 2015-2018 NSDUH, 12+

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

12.5M+

2.0M 2.1M

11.5M+

1.8M 2.1M

11.1M+

1.7M 2.0M

9.9M

1.7M 1.9M

0M

5M

10M

15M

Pain Reliever Misuse Pain Reliever Use Disorder Pain Reliever MisuseInitiates

2015

2016

2017

2018828K

591K

135K

948K

626K

170K

886K

652K

81K

808K

526K

117K

0K

250K

500K

750K

1,000K

Heroin Use Heroin Use Disorder Heroin Initiates

1M

Page 9: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Sources Where Pain Relievers Were Obtained for Most Recent Misuse among

People Who Misused Prescription Pain Relievers

PAST YEAR, 2018 NSDUH, 12+

83.2% of the friends or relatives were prescribed

the pain reliever by a single doctor

Page 10: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

3 out of 4 people who used heroin in the past year misused prescription opioids first

7 out of 10 people who used heroin in the past year also misused prescription opioids in the past year

Source: Jones, C.M., Heroin use and heroin use risk behaviors among nonmedical users of prescription opioid

pain relievers – United States, 2002–2004 and 2008–2010. Drug Alcohol Depend. (2013). Slide credit – Grant

Baldwin, CDC

2018: 2 million with opioid use disorder

Nonmedical Use of Prescription Opioids Significant Risk Factor for Heroin Use

Page 11: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

0

5,000

10,000

15,000

20,000

25,000

30,000

35,000

40,000

2010 2011 2012 2013 2014 2015 2016

Synthetic Opioids Overdose Deaths

Fentanyl Reports DEA NFLIS

Known or suspected exposure to fentanyl in past year (n = 121)Behavior or experience APR 95% CI pRegular heroin use 4.07 1.24–13.3 0.020

Source: Carroll et al, Int. J. Drug Policy, 2017 and CDC Epi-Aid 2015-2016

Synthetic Opioid Deaths Closely Linked to Illicit Fentanyl Supply

Page 12: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Opioid Use Disorder

PAST YEAR, 2015-2018 NSDUH, 12+

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

0.9%+

0.5%

1.5%+

0.8%0.8%

0.6%

1.1%

0.8%0.8%

0.4%

1.3%+

0.7%0.7%

0.4%

0.9%

0.7%

2.4M

127K

515K

1.7M2.1M

153K

392K

1.6M2.1M

103K

445K

1.6M2.0M

108K

312K

1.6M

0.0%

0.2%

0.4%

0.6%

0.8%

1.0%

1.2%

1.4%

1.6%

12 or Older 12-17 18-25 26 or Older

2015 2016 2017 2018

Page 13: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Opioid Misuse Related to Other Substance Use, MDE and SMI

PAST YEAR/MONTH, 2018 NSDUH, 12+

+ Difference between this estimate and the estimate for people with past year opioid misuse is statistically significant at the .05 level.

14.6%+ 5.7%+1.5%+

49.0%

16.0% 16.0%

38.5M 14.9M3.9M

5.0M

1.6M 1.6M

0%

10%

20%

30%

40%

50%

Past Year Marijuana Use Past Month HeavyAlcohol Use

Past Year Cocaine Use

0.4%+ 7.3%+4.1%+

8.9%

21.3%

17.3%

9…19.1M

9.7M912K

2.1M1.7M

0%

5%

10%

15%

20%

25%

Past YearMethamphetamine Use

Past Year MDE, 12+ Past Year SMI, 18+

No Past YearOpioid Misuse

Any Past YearOpioid Misuse

Page 14: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

SAMHSA Response: Combatting the Opioids Crisis

STR/SOR grants to states: Prevention, Treatment and Recovery Services for OUD FY 19: 1.5 B• 50 M set-aside for tribes/15% set aside for 10 hardest hit states• Established STR Technical Assistance and Training Program: national program that places

teams with clinical expertise in OUD on the ground in every state; training available on request, assists with implementation

Naloxone distribution and first responder training FY 19: $49MMAT PDOA program to assist with OUD pharmacotherapy implementation FY 19: $89MPPW program: residential and outpatient services FY 19: $29.9MHigh Quality, Targeted Resources:

• PPW Factsheets, Healthy Pregnancy/Healthy Baby • TIP 63• Finding Quality Treatment• MAT in Criminal Justice Settings

Reinstatement of Drug Abuse Warning Network (DAWN) $10MCollaboration with USDA to establish recovery housing in rural areas

Page 15: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

CJ programs with MAT; FY 19: $89M Drug Courts: Adult, Juvenile, Family, Offender Re-entry

• Guidance on Recovery Housing Recovery Coaches training and placement in communities/EDs

Pain management: Support dissemination of CDC clinical practice guidelines, BZD/opioids

guidance, PCSS MAT training, co-occurring disorders: mental disorders, suicide prevention

Practitioner training programs: ATTCs, MHTTCs, Prevention TTCs, PCSSMAT, PCSS Universities

DATA waiver trainings: over 62,000 trained, >10,000 NP/PAs to expand access to OUD

treatment

Outcomes Data: Diagnosis, engagement/retention in treatment; reduced ED use, reduced

hospitalizations, reduced CJ interactions, medication treatment/type of

medication/indication

Block grants to states FY 19: $1.86B

SAMHSA Response: Combatting the Opioids Crisis

Page 16: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Treatment Gains: Number of Individuals Receiving Pharmacotherapy for Opioid Use Disorder (MAT)

345,443

520,398

46,860

382,867

581,613

64,020

450,247

648,864

73,260

0

100000

200000

300000

400000

500000

600000

700000

Methadone Buprenorphine Naltrexone

2016 2017 2018

921,692

1,028,500

1,172,371

0

200000

400000

600000

800000

1000000

1200000

1400000

2016 2017 2018

Total Number receiving MAT (all types)

Page 17: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

0

2E+09

4E+09

6E+09

8E+09

1E+10

1.2E+10

1.4E+10

1.6E+10

Mar

-17

Ap

r-1

7

May

-17

Jun

-17

Jul-

17

Au

g-1

7

Sep

-17

Oct

-17

No

v-1

7

Dec

-17

Jan

-18

Feb

-18

Mar

-18

Ap

r-1

8

May

-18

Jun

-18

Jul-

18

Au

g-1

8

Sep

-18

Oct

-18

No

v-1

8

Dec

-18

Jan

-19

Feb

-19

Mar

-19

Ap

r-1

9

May

-19

Jun

-19

Jul-

19

Au

g-1

9

31% Decrease Since January 2017

31% Decrease Since

January 2017

OPIOID MORPHINE MILLIGRAM EQUIVALENTS (MME) PRESCRIBED PER MONTH (U.S.)Rolling 3-month Average

Source: IQVIA National Prescription Audit.

Data presented for the retail and mail channels only

Page 18: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

0

20,000

40,000

60,000

80,000

100,000

120,000

1Q

20

10

2Q

10

3Q

10

4Q

10

1Q

11

2Q

11

3Q

11

4Q

11

1Q

12

2Q

12

3Q

12

4Q

12

1Q

13

2Q

13

3Q

13

4Q

13

1Q

14

2Q

14

3Q

14

4Q

14

1Q

15

2Q

15

3Q

15

4Q

15

1Q

16

2Q

16

3Q

16

4Q

16

1Q

17

2Q

17

3Q

17

4Q

17

State laws changing on naloxone at rapid pace

Source: IQVIA National Prescription Audit, data extracted 2016-2018

Signs of Progress: Dramatic Increases in Naloxone Dispensing from U.S. Pharmacies

Page 19: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Marijuana

The Need to Educate the Public About Health Risks Associated with Use

Page 20: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

The Issue

Marijuana is rapidly becoming more widely available in the U.S.: 33 states: allow medical marijuana use; 10 states plus DC have legalized recreational use

Huge and profitable industry that markets heavily with health claims that have little to nobasis and which have had virtually no counter arguments put forward until the present time

Numerous forms: smoked, edibles, oil for vaping, lotions, transdermal patches

THC content has greatly increased in recent years (4% in 1990s; 12% in 2014); MJ extracts: 24-76% THC

Page 21: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Risks and Adverse Outcomes

• Downplayed by industry; ignored by states

– Low birth weight

– Pulmonary symptoms

– MVAs

– Cognitive impairment

– Poor performance in school and at work

– Addiction

– Risk of adverse outcomes to our children and young adults

Page 22: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Marijuana Legalization Status Range of Past Year Marijuana Use (2015-16)

No Legalization 9-13%

Medical Marijuana only 11-21.8%

Medical and Recreational Use 13-25%

What Happens as State Laws Liberalize?

Source: National Survey on Drug Use and Health, 2015-16

Page 23: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Perceived Great Risk from Substance Use among Youth

PAST YEAR, 2015-2018 NSDUH, 12-17

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

40.6%+

80.2%82.9%

64.1%68.2%+

40.0%+

80.6%83.4%

65.5%69.3%+

37.7%+

80.1%84.0%

65.2%67.2%+

34.9%

79.6%83.0%

64.4% 65.3%

9.9M

19.4M20.0M

15.7M16.7M

9.8M

19.6M20.1M

16.1M17.0M

9.2M

19.4M20.3M

16.0M16.5M

8.5M

19.3M20.0M

15.7M 16.0M

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

SmokingMarijuana Once or

Twice a Week

Using CocaineOnce or Twice a

Week

Using Heroin Onceor Twice a Week

Having 4 or 5Drinks of AlcoholNearly Every Day

Smoking One orMore Packs of

Cigarettes per Day

2015 2016 2017 2018

Significant Decrease

Page 24: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Perceived Great Risk from Substance Use among Young Adults

PAST YEAR, 2015-2018 NSDUH, 18-25

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

19.1%+

84.3%+

94.0%+

62.1%

68.0%

17.2%+

83.6%

93.5%

62.3%

68.6%

15.4%

83.3%

93.9%

63.2%66.6%

15.4%

82.6%

93.3%

63.4%67.5%

6.6M

29.1M

32.5M

21.6M

23.6M

5.9M

28.6M

32.0M

21.4M

23.6M

5.2M

28.2M

31.8M

21.6M22.7M

5.2M

27.8M

31.3M

21.4M22.8M

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

SmokingMarijuana Once or

Twice a Week

Using CocaineOnce or Twice a

Week

Using HeroinOnce or Twice a

Week

Having 4 or 5Drinks of AlcoholNearly Every Day

Smoking One orMore Packs of

Cigarettes per Day

2015 2016 2017 2018

Page 25: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Perceived Great Risk from Substance Use among Adults Aged 26+

PAST YEAR, 2015-2018 NSDUH, 26 or Older

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

Page 26: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Marijuana Use

PAST MONTH, 2015-2018 NSDUH, 12+

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

7.0%

19.8%+

6.5%+6.5%

20.8%+

7.2%+6.5%

22.1%

7.9%+6.7%

22.1%

8.6%1.8M

6.9M

13.6M1.6M

7.2M

15.2M1.6M

7.6M

16.8M1.7M

7.5M

18.5M

0%

5%

10%

15%

20%

25%

12-17 18-25 26 or Older

2015 2016 2017 2018

Significant Increase

Page 27: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Marijuana Use Disorder

PAST YEAR, 2015-2018 NSDUH, 12+

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

1.5%

2.6%+

5.1%+

0.8%

1.5%

2.3%

5.0%+

0.8%

1.5%

2.2%

5.2%

0.8%

1.6%

2.1%

5.9%

0.9%

4.0M

651K

1.8M

1.6M

4.0M

584K

1.7M

1.7M

4.1M

557K

1.8M

1.7M

4.4M

512K

2.0M

1.9M

0%

1%

2%

3%

4%

5%

6%

7%

12 or Older 12-17 18-25 26 or Older

2015 2016 2017 2018

Page 28: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Past Month Substance Use among Pregnant Women

PAST MONTH, 2015-2018 NSDUH, 15-44

* Estimate not shown due to low precision.

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

4.7%

13.9%

9.3%

6.3%

10.6%

8.3%8.5%+

14.7%

11.5%

5.4%

11.6%9.9%

109K

319K

214K

143K

239K

187K194K

334K

261K

128K

271K233K

0%

4%

8%

12%

16%

Illicit Drugs Tobacco Products Alcohol

2015201620172018

3.4% 0.8%<0.05%

4.9% 1.2%0.1%

7.1%

1.4%0.4%

4.7% 0.9%0.0%

78K 19K1K

111K26K

2K

161K

32K8K

111K22K

*0%

4%

8%

12%

16%

Marijuana Opioids Cocaine

Marijuana use in Pregnancy:Fetal growth restrictionStillbirthPreterm birthNeurological development issues in exposed children:HyperactivityCognitive deficits (Metz TD and Stickrath EH, 2015)

Page 29: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Marijuana Use Related to Other Substance Use, MDE and SMI

PAST YEAR/MONTH, 2018 NSDUH, 12+

+ Difference between this estimate and the estimate for people with past year marijuana use is statistically significant at the .05 level.

0.2%+

6.2%+

3.3%+3.1%

16.7%

10.9%

4.1%+

17.9%

14.0%+

510K

14.1M

7.0M1 .4M

7.1M

4.4M

354K

1 .5M

1 .2M

0%

5%

10%

15%

20%

Past Year Methamphetamine Use Past Year MDE, 1 2+ Past Year SMI, 18+

No Past Year Marijuana Use

Any Past Year Marijuana Use

Past Year Daily or Almost

Daily Marijuana Use

2.3%+4.1%+

0.4%+

11.5%

16.5%

10.6%

15.4%+

19.1%+

17.1%+

5.2M

9.4M

903K

5.0M

7.2M

4.6M

1 .3M

1 .6M

1 .5M

0%

5%

10%

15%

20%

Past Year Opioid Misuse Past Month Heavy Alcohol Use Past Year Cocaine Use

Page 30: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

Ave

rag

e P

oin

t D

iffe

ren

ce in

IQ S

core

(I

Q a

t a

ge

38

–IQ

at

ag

e 1

3)

Intelligence: PERSISTENT CANNABIS (MARIJUANA) USE DISORDER

LINKED TO SIGNIFICANT IQ DROP BETWEEN CHILDHOOD AND MIDLIFE

Source: Meier MH et al., PNAS Early Edition 2012

Followed 1,037 individuals from birth to age 38 Tested marijuana use and disorders at 18, 21, 26, 32 and 38 years of age Tested for IQ at ages 13 and 38

-8

-6

-4

-2

0

2

Never UsedMarijuana

CannabisDependence in 1

Study Wave

CannabisDependence in 2

Study Waves

CannabisDependence in 3

Study Waves

All groups started with roughly equivalent IQ scores at age 13

By age 38, those diagnosed with cannabis dependence in 3 study waves (the most persistent users of cannabis) had lost nearly 6 IQ points

There was a consistent dose-response relationship across the groups

Page 31: Substance Use Issues and Serious Mental Illness in …...Mental Illness and Substance Use Disorders in America Among those with a substance use disorder: 3 IN 8 (38.3% or 7.4M) struggled

31

2.62 2.78

0

1

2

3

4

5

Risk of incident prescriptionopioid misuse

Risk of incident prescriptionopioid use disorder

Risk of subsequent prescription opioid misuse and use disorder was increased

among people who reported marijuana use 5 years earlier

0 1 2 10 <50 >50

30

20

10

0

Number of times marijuana takenAndreasson et al. 1987

Risk of schizophrenia increases as marijuana use increases

Marijuana Major Risks: Addiction to Opioid Analgesics and Serious Mental Illness

Association between state medical marijuana laws and opioid overdose mortality reversed direction from-21% (1999-2010) to +23% (1999-2017) Shover, et al., 2019

Olfson, et al., 2017

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ALTERED BRAIN STRUCTURE AND FUNCTION IN YOUTH WHO REGULARLY USE MARIJUANA

Early (<18y) Marijuana Use Decreases Brain Fiber Connectivity

Decreases in brain fiber connectivity may help explain the cognitive impairment and vulnerability to certain

mental health conditions seen among people with early onset and regular use.

Source: Zalesky et al Brain 2012

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33

Policy Considerations

• Make Americans aware of marijuana risks with focus on adverse impact on youth• Prevention campaign

• Public service announcements• Train practitioners on screening, evaluation, referral, treatment/co-occurring

conditions• Community prevention funding aimed at marijuana• Surgeon General Advisory

• Research• Safety issues: drug-drug interactions, clinical pharmacology based on route

of administration, field testing• Treatment research

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34

Build A Brain

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Vaping

An Emerging Problem

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9.8

21.2

31.2

36.5

50.3

53.5

44.946.7

45.2

2.5

7.4 5.7

9.614.7

16.3 17.819.3

24.7

1.31.3 2.3 1.2

4.7 5.9 6.7 6.1 8.6

0

10

20

30

40

50

60

2010 2011 2012 2013 2014 2015 2016 2017 2018

Pe

rce

nta

ge (

%)

Current Cigarette Smoker

Former Cigarette Smoker

Never Cigarette Smoker

Source: CDC licensed data fielded by Porter Novelli Services. Summer Styles Survey. 2010-2018

E-Cigarette Use on the Rise: Adult Ever Use of E-Cigarettes by Cigarette Smoking Status – U.S., 2010-2018

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Cigarette Smoking Status Among Current Adult E-Cigarette Users, by Age Group

Source: QuickStats: Cigarette Smoking Status Among Current Adult E-cigarette Users, by Age Group — National Health Interview Survey, United States, 2015. MMWR Morb Mortal Wkly Rep 2016;65:1177.

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High school students reporting use within 30 days preceding administration of the National Youth Tobacco Survey.* 2019 preliminary data

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Source: FDA News Release: Trump Administration Combating Epidemic of Youth E-Cigarette Use with Plan to Clear Market of Unauthorized, Non-Tobacco-Flavored E-Cigarette Products, Sept. 11, 2019.

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• To help reverse the deeply concerning epidemic of youth e-cigarette use FDA announced on September 11, 2019 that it intends to clear the market of unauthorized, non-tobacco-flavored e-cigarette products, including mint and menthol.

• FDA will be sharing more on the specific details of the plan and its implementation soon.

40

FDA Intends to Clear the Market of Flavored E-cigarettes

Source: Food and Drug Administration, https://www.fda.gov/news-events/press-announcements/trump-administration-combating-epidemic-youth-e-cigarette-use-plan-clear-market-unauthorized-non

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41

Health Effects

• Nicotine exposure during adolescence can cause addiction and can harm the developing adolescent brain.

• Nicotine delivered by e-cigarettes during pregnancy can result in multiple adverse consequences, including sudden infant death syndrome, altered brain structure (corpus callosum) and function (deficits in auditory processing), and obesity.

• Ingestion of e-cigarette liquids containing nicotine can cause acute toxicity and possibly death if the contents of refill cartridges or bottles containing nicotine are consumed.

Source: U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016.

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42

Health Effects, Continued…

• There’s more in vaping fluid than nicotine:

• E-cigarettes can expose users to several chemicals, including nicotine, carbonyl compounds, and volatile organic compounds, known to have adverse health effects.

• The health effects and potentially harmful doses of heated and aerosolized constituents of e-cigarette liquids, including solvents, flavorants, and toxicants, are not completely understood.

• E-cigarettes can also be used to deliver other drugs, including marijuana. In 2016, one-third of U.S. middle and high school students who ever used e-cigarettes had used marijuana in e-cigarettes.

Sources (Bullets 1-2): U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016. Bullet 3: Trivers KF, Phillips E, Gentzke AS, Tynan MA, Neff LJ. Prevalence of Cannabis Use in Electronic Cigarettes Among US Youth. JAMA pediatrics. 2018;172(11):1097-1099.

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“E-cigarette products can be used as a delivery system for cannabinoids and potentially for other illicit drugs.”

Sources: Singh T, Kennedy S, Marynak K, Persoskie A, Melstrom P, King BA. Characteristics of Electronic Cigarette Use Among Middle and High School Students — United States, 2015. MMWR Morb Mortal Wkly Rep 2016;65:1425–1429.. Trivers KF et al. Prevalence of Cannabis Use in Electronic Cigarettes Among US Youth. JAMA Pediatr. 2018;172(11):1097-1099.

33.3% of high school e-cigarette users report using marijuana in the device.

23.1% of middle school e-cigarette users report using marijuana in the device.

E-cigarettes and Marijuana

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• The Centers for Disease Control and Prevention (CDC), the U.S. Food and Drug Administration (FDA), state and local health departments, and other clinical and public health partners are currently investigating a multistate outbreak of lung disease associated with e-cigarette product use (devices, liquids, refill pods, and/or cartridges).

• There are 380+ confirmed and probable cases of lung illness reported from 36 states and 1 U.S. territory. Six deaths have been reported from 6 states.

• All reported cases have a history of e-cigarette product use or vaping.

• Most patients have reported a history of using e-cigarette products containing THC, the psychoactive ingredient in marijuana. Many patients have reported using THC and nicotine. Some have reported the use of e-cigarette products containing only nicotine.

• The CDC does not yet know the specific cause of these illnesses. The investigation has not identified any specific e-cigarette or vaping product or substance that is linked to all cases.

44

Outbreak of Lung Disease Associated with E-Cigarette Use (Vaping)

Source: Centers for Disease Control and Prevention: Outbreak of Lung Disease Associated withE-Cigarette Use, or Vaping, https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html

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• Until the CDC knows more, if you are concerned about these specific health risks, CDC recommends that you consider refraining from using e-cigarette or vaping products.

• If you are an adult who used e-cigarettes containing nicotine to quit cigarette smoking, do not return to smoking cigarettes. There are other approaches to smoking cessation: medication/support groups

• If you have recently used an e-cigarette or vaping product and you have symptoms like those reported in this outbreak (cough, shortness of breath or chest pain, nausea, vomiting, diarrhea, fatigue, fever or abdominal pain), see a healthcare provider.

• Regardless of the ongoing investigation:

-- Anyone who uses an e-cigarette or vaping product should not buy these products (e.g., e-cigarette or vaping products with THC, other cannabinoids) off the street and should not modify or add any substances to these products that are not intended by the manufacturer.

-- Youth and young adults should not use e-cigarette products.

-- Women who are pregnant should not use e-cigarette products.

-- Adults who do not currently use tobacco products should not start using e-cigarette products.

45

What CDC Recommends:

Sources: (Bullet 1):Schier JG, Melman JG, Layden J et al: Severe pulmonary disease associated with electronic-cigarette-product use–interim guidance, MMWR, Sept. 6, 2019. Bullets 2-5: Centers for Disease Control and Prevention: Outbreak of Lung Disease

Associated with E-Cigarette Use, or Vaping, https://www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html

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Serious Mental Illness

Increasing Prevalence

Increases in Co-Occurring Disorders

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Serious Mental Illness (SMI) Rising among Young Adults (18-25 y.o.) and Adults (26-49 y.o.)

0%

2%

4%

6%

8%

2008 2010 2012 2014 2016 2018

53.8%1.4M young adults with SMI received treatment in 201846.2% got NO treatment

5.9% 26-495.9M

2.5% 50+2.8M

3.8%1.2M

4.8%4.8M

2.5%2.3M

PAST YEAR, 2008-2018 NSDUH, 18+

.

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

7.7% 18-252.6M

63.7%3.8M adults (26-49 y.o.) with SMI received treatment;36.3% got NO treatment

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Major Depressive Episodes

PAST YEAR, 2015-2018 NSDUH, 12+

Note: The adult and youth MDE estimates are not directly comparable.

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

12.5%+

10.3%+

7.5%

4.8%

12.8%+

10.9%+

7.4%+

4.8%

13.3%+ 13.1%

7.7%

4.7%

14.4%13.8%

8.0%

4.5%

3.0M

3.6M

7.3M

5.2M

3.1M

3.7M

7.2M

5.3M

3.2M 4.4M

7.6M

5.2M

3.5M4.6M

8.0M

5.1M

0%

2%

4%

6%

8%

10%

12%

14%

16%

12-17 18-25 26-49 50 or Older

2015 2016 2017 2018

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Suicidal Thoughts, Plans, and Attempts Increase for Young Adults (18-25 y.o)

PAST YEAR, 2008 and 2018 NSDUH, 18-25

+ Difference between this estimate and the 2018 estimate is statistically significant at the .05 level.

6.8%+

2.0%+1.2%+

11.0%

3.4%

1.9%

2.2M

643K395K

3.7M

1.2M

647K

0%

2%

4%

6%

8%

10%

12%

Serious Thoughts Made a Plan Attempted

2008 2018

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Co-Occurring Issues: Substance Use Is More Frequent among Adults (>18 y.o.) with Mental Illness

PAST MONTH, 2018 NSDUH, 18+

+ Difference between this estimate and the estimate for adults without mental illness is statistically significant at the .05 level.

16.3%

9.6%

25.3%

28.1%+

16.7%+

31.3%+

37.2%+

24.2%+

32.3%+

32.9M

19.3M

51.0M13.4M

7.9M

14.9M

4.2M

2.7M

3.7M

0%

5%

10%

15%

20%

25%

30%

35%

40%

Cigarette Daily Cigarette Binge Drinking

No Mental Illness Any Mental Illness Serious Mental Illness

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Co-Occurring Issues: Substance Use Is More Frequent among Adults (>18 y.o.) with Mental Illness

PAST YEAR, 2018 NSDUH, 18+

+ Difference between this estimate and the estimate for adults without mental illness is statistically significant at the .05 level.

15.7%13.2%

2.6% 2.5%0.2%

36.7%+

29.2%+

9.2%+ 8.9%+0.9%+

49.4%+

38.9%+

14.6%+ 13.9%+

1.8%+

31.5M26.5M

5.2M 5.0M367K

17.5M

13.9M

4.4M 4.2M

430K

5.6M

4.4M

1.7M 1.6M

206K

0%

10%

20%

30%

40%

50%

60%

Illicit Drugs Marijuana Opioid Misuse Prescription PainReliever Misuse

Heroin

No Mental Illness Any Mental Illness Serious Mental Illness

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52

Suicide Lies

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Summary

• Opioids• Marijuana• Serious Mental Illness• Ongoing and significant threats to our people• Polysubstance use is the rule—not the exception• Substance misuse/abuse is strongly correlated with

serious mental illness• Vaping is an emerging issue that we are still learning

about, but which clearly carries major risks already

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New Approach to Training and Technical AssistanceEstablishment of a national system of Technology Transfer Centers: MH with supplements for children’s issues/school-based programs, Substance Abuse Prevention, and Addiction Clinical Support System for Serious Mental Illness (CSS-SMI), Privacy TTC, Eating Disorders TTC• PCSS Universities • State Targeted Response to Opioids (STR/SOR) TA program• Project ECHO type training, Centers of Excellence: Practical experience • Education on assessment/treatment of SUDs by healthcare profession• Evidence-Based Practices Website• SAMHSA Products (e.g.: TIP 63, Pregnant/Post Partum Women with

OUD Factsheets, NSDUH presentation, Prevention Day, MAT in jails/prisons)

What SAMHSA is Doing: Strengthening Healthcare Practitioner Training and Education

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Evidence-Based Practice Repository in NMHSUPL

National Technical Assistance/Training Centers:State Targeted Response to Opioids, Providers’ Clinical Support System for Medication Assisted Treatment, Clinical Support System for Serious Mental Illness/Supplements for School-Based Mental Health Programs,

National Child Traumatic Stress Network, National Center on Substance Abuse and Child Welfare, Center for Integrated Health Services, Veterans, GAINS (Criminal Justice), Disaster, Social Inclusion/Public

Education, Suicide Prevention, SOAR, Privacy (HIPAA, 42 CFR), Eating Disorders

Combined Efforts at the State, Regional, and Local Levels Oriented to All Health Professionals

Regional Substance Abuse Prevention, Addiction, Mental Health, Collaborating Technology Transfer Centers

SAMHSA: Technical Assistance and TrainingEVIDENCE-BASED, LOCAL TRAINING, NATION-WIDE SCOPE

Region 1

Region 2

Region 3

Region 4

Region 5

Region 6

Region 7

Region 8

Region 9

Region 10

National Hispanic/Latino TTCs National American Indian/Alaska Native TTCs

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Integration of Peers into the Healthcare Workforce

Support use of credentialed peer providers and other paraprofessionals as an integrated component of comprehensive carePeers can provide an important component of care in the form of:• Links between psychiatric and medical systems with recovery support systems in

communities• Supports to assist individuals in obtaining needed medical and recovery support services

SAMHSA goals:• Support the establishment of national credentialing, licensing and certification programs that

provide training recognized in all states• Encourage better understanding of peer professionals in mental and substance use disorder

treatment and recovery resources by healthcare professionals• Encourage peer professionals to obtain training and education on psychiatric medicine and

evidence-based approaches to care and treatment of mental and substance use disorders• Utilize TTCs to provide needed education and trainingPolicy Lab to explore evidence for effectiveness of peer support interventions

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• Changes to redisclosure regulations to allow recording of substance use disorder treatment information in non-Part 2 medical records

• Release to an entity (e.g.: SSA) with patient consent• Prescribers can check central registries; dispensed scheduled

medications can be recorded in PDMP according to state law• Sharing of information by a Part 2 program in time of declared natural

disaster• Change to sanitizing requirements• Research disclosures under Part 2 by HIPAA covered entity to entities not

covered by HIPAA.• Extension of court-ordered placement of undercover agents/informants

in course of investigation to 12 months

57

Importance of Provider Communication: Change to 42 CFR

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Findtreatment.samhsa.gov

SAMHSA’s mission is to reduce the impact of mental illness and substance use issues

on America’s communities.

Thank You!

SAMHSA National Lifeline: 800-273-TALK (8255)