subs%tución+electro1lica+ aromáca ( sear)depa.fquim.unam.mx/amyd/archivero/sea_30683.pdf · 3h2...
TRANSCRIPT
Subs%tución Electro1lica Aromá%ca (SEAr)
What Is Coal?
Nomenclature of Benzene Deriva%ves
Polysubs%tuted Deriva%ves of Benzene
1. Iden%fy and name the parent. 2. Iden%fy and name the subs%tuents. 3. Assign a locant to each subs%tuent. 4. Arrange the subs%tuents alphabe%cally.
Structure of Benzene
A. Kekulé (1866)
Stability of Benzene
The Criteria for Aroma%city
1. The compound must contain a ring comprised of con%nuously overlapping p orbitals. 2. The number of π electrons in the ring must be a Hückel number.
Aroma%c Heterocycles
Reac%ons at the Benzylic Posi%on
Electrophilic Aroma%c Subs%tu%on
Mecanismo general
Halogena%on
Sulfona%on
Nitra%on
Friedel-‐CraZs Alkyla%on
Friedel-‐CraZs Acyla%on
Clemmensen reduc%on