sudden cardiac death syndrome
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Sudden Cardiac Death Syndrome. Alexis Cortez-Bautista University of California, Merced. What is SCD?. SCD has a broad definition depending on who is studying it. Who does it affect. - PowerPoint PPT PresentationTRANSCRIPT
Sudden Cardiac Death Syndrome
Alexis Cortez-BautistaUniversity of California, Merced
SCD has a broad definition depending on who is studying it
What is SCD?
Anyone can be affected by this disorder and is most of the time unexpected, however a group that has seem to be commonly affected is Athletes and active healthy people
Who does it affect
Studies have shown that there are many risk factors that may contribute to Sudden Cardiac Death including◦ Congenital heart disease◦ Mutations in SQTS genes◦ Epilepsy
Risk Factors
Hamilton, Leslie E., Lew,Emma O., Matshes, Evan W. (2011) ‘‘Grown-Up’’ Congenital Heart Disease and Sudden Death in a Medical Examiner’s Population. Journal of Forensic
Sciences. 56:1206-1213 Koyak, Zeliha. Harris, Louise,. de Groot,,Joris R.,
Silversides, Candice K., Oechslin,Erwin N., Bouma, Berto J., Budts, Werner., Zwinderman, Aeilko H., Van Gelder, Isabelle C., Mulder, Barbara J.M.(2012). Sudden Cardiac Death in Adult Congenital Heart Disease.Circulation. 1944-1954.
Congenital Heart Disease
Lahtinen, Annukka M., Noseworthy , Peter A., Havulinna, Aki S., Jula, Antti , Pekka J. Karhunen, Kettunen, Johannes, Perola, Markus., Kontula, Kimmo, Newton-Cheh, Christopher.,Salomaa, Veikko. Common Genetic Variants Associated with Sudden Cardiac Death: The FinSCDgen Study. PLOS ONE. 7.7:1-7
Wisten, Aase., Bostrom, Ida Maria., Morner, Stellan., Stattin, Eva Lenna. (2012) Mutation analysis of cases of sudden unexplained death, 15 years after death:Prompt genetic evaluation after resuscitation can save future lives. Resuscitation. 83:1129-1234
Mutations
Bardai, Abdennasser., Lamberts, Robert J., Blom, Marieke., Spanjaart, Anne M., Berdowski Jocelyn., van der Staal, Sebastiaan R., Brouwer, Henk J., Koster, Rudolph W., Sander, Josemir W., Thijs Roland D., Hanno L. Tan. (2012) Epilepsy Is a Risk Factor for Sudden Cardiac Arrest in the General Population. Plos one. 7.8:1-5
Epilepsy
Because this disorder is so spontaneous, the most common approach to study this disorder is through retrospective observations
There might be an advantage to performing research on people with the risk factors
Approaches
Screenings using ECG have the potential to identify changes in the heart that could lead to SCD
Screenings
Questions